AR003915A1 - Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre - Google Patents

Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Info

Publication number
AR003915A1
AR003915A1 ARP950100165A AR10016595A AR003915A1 AR 003915 A1 AR003915 A1 AR 003915A1 AR P950100165 A ARP950100165 A AR P950100165A AR 10016595 A AR10016595 A AR 10016595A AR 003915 A1 AR003915 A1 AR 003915A1
Authority
AR
Argentina
Prior art keywords
amino group
insulin
free
proinsulin
epsilon
Prior art date
Application number
ARP950100165A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR003915A1 publication Critical patent/AR003915A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ARP950100165A 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre AR003915A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/341,231 US5646242A (en) 1994-11-17 1994-11-17 Selective acylation of epsilon-amino groups

Publications (1)

Publication Number Publication Date
AR003915A1 true AR003915A1 (es) 1998-09-30

Family

ID=23336740

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100165A AR003915A1 (es) 1994-11-17 1995-11-14 Procedimiento para acilar selectivamente con acidos grasos proinsulina, insulina o analogos de insulina que tienen un grupo epsilon-amino libre y ungrupo alfa-amino libre

Country Status (27)

Country Link
US (2) US5646242A (OSRAM)
EP (2) EP1227107A1 (OSRAM)
JP (1) JP4312828B2 (OSRAM)
CN (1) CN1171742A (OSRAM)
AR (1) AR003915A1 (OSRAM)
AT (1) ATE328902T1 (OSRAM)
AU (2) AU691066B2 (OSRAM)
BR (1) BR9509652A (OSRAM)
CA (1) CA2205061A1 (OSRAM)
CO (1) CO4520285A1 (OSRAM)
CZ (1) CZ287731B6 (OSRAM)
DE (1) DE69535031T2 (OSRAM)
DK (1) DK0712862T3 (OSRAM)
ES (1) ES2264124T3 (OSRAM)
HU (2) HU217585B (OSRAM)
IL (1) IL115972A (OSRAM)
IN (1) IN179820B (OSRAM)
NO (1) NO972185L (OSRAM)
NZ (1) NZ297256A (OSRAM)
PL (1) PL320556A1 (OSRAM)
PT (1) PT712862E (OSRAM)
RU (1) RU2155773C2 (OSRAM)
SI (1) SI0712862T1 (OSRAM)
TR (1) TR199501421A2 (OSRAM)
WO (1) WO1996015803A1 (OSRAM)
YU (1) YU71495A (OSRAM)
ZA (1) ZA959680B (OSRAM)

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US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
JP2003532691A (ja) * 2000-05-05 2003-11-05 ノボ ノルディスク アクティーゼルスカブ 重症疾患神経障害
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
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US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7595172B2 (en) * 2001-07-24 2009-09-29 Novo Nordisk A/S Method for making acylated polypeptides
US20030082671A1 (en) 2001-07-24 2003-05-01 Thomas Hoeg-Jensen Method for making acylated polypeptides
AU2002355160A1 (en) * 2001-07-24 2003-02-17 Novo Nordisk A/S Method for making acylated polypeptides
JP4386722B2 (ja) * 2001-07-24 2009-12-16 ノボ ノルディスク アクティーゼルスカブ アシル化されたポリペプチドの製造方法
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) * 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
UY27439A1 (es) 2001-09-07 2003-04-30 Nobex Corp Procedimiento para sintetizar un conjunto de oligomero-polipeptido insulina, conjugado oligomero-polipeptido de proinsulina, composicion de conjugado oligomero-insulina, procedimiento para sintetizar un conjugado oligomero-polipeptido c-peptido, conj
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US20030199445A1 (en) * 2002-02-07 2003-10-23 Knudsen Lotte Bjerre Use of GLP-1 compound for treatment of critically ill patients
WO2003105768A2 (en) 2002-06-13 2003-12-24 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7273921B2 (en) 2002-09-25 2007-09-25 Novo Nordisk A/S Method for producing acylated peptides
CN100586926C (zh) * 2002-09-25 2010-02-03 诺沃娜第克公司 制备酰化肽的方法
EP2264065B1 (en) * 2003-08-05 2017-03-08 Novo Nordisk A/S Novel insulin derivatives
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
CN101027318B (zh) 2004-07-19 2016-05-25 比奥孔有限公司 胰岛素-低聚物共轭物，制剂及其用途
CN102660614A (zh) 2005-08-16 2012-09-12 诺沃-诺迪斯克有限公司 制备成熟胰岛素多肽的方法
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US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
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ES2607003T3 (es) * 2008-10-30 2017-03-28 Novo Nordisk A/S Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
KR101396951B1 (ko) * 2009-02-20 2014-06-27 입센 파마 에스.에이.에스 34번 위치에 프롤린 치환이 있는 뉴로펩타이드 ｙ의 유사체
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BR112013010345A2 (pt) 2010-10-27 2017-07-25 Novo Nordisk As tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
JP2016519127A (ja) 2013-04-30 2016-06-30 ノヴォ ノルディスク アー／エス 新規投与レジメン
WO2015052088A1 (en) 2013-10-07 2015-04-16 Novo Nordisk A/S Novel derivative of an insulin analogue
FR3013049B1 (fr) 2013-11-14 2015-11-13 You-Ping Chan Analogue de l'insuline glargine
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104558097A (zh) * 2014-05-20 2015-04-29 广东东阳光药业有限公司 肽的酰化方法
CN105111305B (zh) * 2015-10-10 2018-12-14 山东阿华生物药业有限公司 酰化胰岛素的色谱纯化方法
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
NZ747064A (en) * 2016-05-05 2025-05-02 Codexis Inc Penicillin-g acylases
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ES2930149T3 (es) 2016-12-16 2022-12-07 Novo Nordisk As Composiciones farmacéuticas que contienen insulina
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
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Also Published As

Publication number Publication date
CO4520285A1 (es) 1997-10-15
JPH10509176A (ja) 1998-09-08
US5646242A (en) 1997-07-08
JP4312828B2 (ja) 2009-08-12
SI0712862T1 (sl) 2006-10-31
AU4237296A (en) 1996-06-17
CN1171742A (zh) 1998-01-28
HU9903007D0 (en) 1999-11-29
HK1014007A1 (en) 1999-09-17
CZ145697A3 (en) 1997-12-17
WO1996015803A1 (en) 1996-05-30
CA2205061A1 (en) 1996-05-30
AU691066B2 (en) 1998-05-07
ATE328902T1 (de) 2006-06-15
NO972185D0 (no) 1997-05-13
HU217585B (hu) 2000-02-28
ES2264124T3 (es) 2006-12-16
EP1227107A1 (en) 2002-07-31
AU7885498A (en) 1998-11-05
MX9703506A (es) 1997-07-31
NO972185L (no) 1997-05-13
IN179820B (OSRAM) 1997-12-13
IL115972A0 (en) 1996-01-31
CZ287731B6 (en) 2001-01-17
ZA959680B (en) 1997-05-14
EP0712862A3 (en) 1998-03-04
DE69535031D1 (de) 2006-07-20
HUT77737A (hu) 1998-07-28
AU720820B2 (en) 2000-06-15
EP0712862A2 (en) 1996-05-22
PT712862E (pt) 2006-08-31
RU2155773C2 (ru) 2000-09-10
IL115972A (en) 2000-09-28
TR199501421A2 (tr) 1996-06-21
PL320556A1 (en) 1997-10-13
BR9509652A (pt) 1997-09-16
DK0712862T3 (da) 2006-09-25
DE69535031T2 (de) 2006-12-28
NZ297256A (en) 2000-01-28
YU71495A (sh) 1998-09-18
USRE37971E1 (en) 2003-01-28
EP0712862B1 (en) 2006-06-07

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