PT3154959T - 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka - Google Patents

1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka

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Publication number
PT3154959T
PT3154959T PT15726455T PT15726455T PT3154959T PT 3154959 T PT3154959 T PT 3154959T PT 15726455 T PT15726455 T PT 15726455T PT 15726455 T PT15726455 T PT 15726455T PT 3154959 T PT3154959 T PT 3154959T
Authority
PT
Portugal
Prior art keywords
methylpyrimidin
pyrazol
pyrrolidin
methoxyethyl
fluorophenyl
Prior art date
Application number
PT15726455T
Other languages
English (en)
Portuguese (pt)
Inventor
Allen Shelley
W Andrews Steven
Baer Brian
Crane Zackary
Liu Weidong
John WATSON Daniel
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of PT3154959T publication Critical patent/PT3154959T/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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PT15726455T 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka PT3154959T (pt)

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US201461993426P 2014-05-15 2014-05-15

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PT3154959T true PT3154959T (pt) 2019-09-24

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PT15726455T PT3154959T (pt) 2014-05-15 2015-05-14 1-((3s,4r)-4-(3-fluorofenil)-1-(2-metoxietil)-pirrolidin-3-il)-3-(4-metil-3-(2-metilpirimidin-5-il)-1-fenil-1h-pirazol-5-il)ureia como inibidor da cinase trka

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US (1) US10835533B2 (OSRAM)
EP (2) EP3154959B1 (OSRAM)
JP (2) JP6499672B2 (OSRAM)
KR (2) KR102321883B1 (OSRAM)
CN (2) CN109970614B (OSRAM)
AU (2) AU2015259075B2 (OSRAM)
CA (1) CA2949160C (OSRAM)
CL (1) CL2016002900A1 (OSRAM)
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DK (1) DK3154959T3 (OSRAM)
ES (1) ES2746530T3 (OSRAM)
HR (1) HRP20191593T1 (OSRAM)
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IL (1) IL248924B (OSRAM)
LT (1) LT3154959T (OSRAM)
MA (1) MA40434B1 (OSRAM)
MX (2) MX2016014945A (OSRAM)
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PH (2) PH12016502242B1 (OSRAM)
PL (1) PL3154959T3 (OSRAM)
PT (1) PT3154959T (OSRAM)
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SI (1) SI3154959T1 (OSRAM)
SM (1) SMT201900522T1 (OSRAM)
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Families Citing this family (56)

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Publication number Priority date Publication date Assignee Title
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MX2016014945A (es) 2017-03-27
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HUE045340T2 (hu) 2019-12-30
PH12020500171A1 (en) 2021-02-08
RS59286B1 (sr) 2019-10-31
KR20170005856A (ko) 2017-01-16
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AU2015259075B2 (en) 2019-01-24
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