PT2857404T - Derivados de imidazo[1,2-b]piridazina como inibidores da cinase - Google Patents
Derivados de imidazo[1,2-b]piridazina como inibidores da cinaseInfo
- Publication number
- PT2857404T PT2857404T PT138013206T PT13801320T PT2857404T PT 2857404 T PT2857404 T PT 2857404T PT 138013206 T PT138013206 T PT 138013206T PT 13801320 T PT13801320 T PT 13801320T PT 2857404 T PT2857404 T PT 2857404T
- Authority
- PT
- Portugal
- Prior art keywords
- imidazo
- kinase inhibitors
- pyridazine derivatives
- pyridazine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012127079 | 2012-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2857404T true PT2857404T (pt) | 2017-11-23 |
Family
ID=49711970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT138013206T PT2857404T (pt) | 2012-06-04 | 2013-06-03 | Derivados de imidazo[1,2-b]piridazina como inibidores da cinase |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9187489B2 (OSRAM) |
| EP (1) | EP2857404B1 (OSRAM) |
| JP (1) | JP5814467B2 (OSRAM) |
| KR (1) | KR101781255B1 (OSRAM) |
| CN (1) | CN104520300B (OSRAM) |
| AU (1) | AU2013272701B2 (OSRAM) |
| BR (1) | BR112014029851B1 (OSRAM) |
| CA (1) | CA2874819C (OSRAM) |
| CO (1) | CO7160119A2 (OSRAM) |
| CY (1) | CY1119607T1 (OSRAM) |
| DK (1) | DK2857404T3 (OSRAM) |
| ES (1) | ES2648228T3 (OSRAM) |
| HR (1) | HRP20171724T1 (OSRAM) |
| HU (1) | HUE037221T2 (OSRAM) |
| IL (1) | IL236075A (OSRAM) |
| IN (1) | IN2014MN02497A (OSRAM) |
| LT (1) | LT2857404T (OSRAM) |
| MX (1) | MX357021B (OSRAM) |
| MY (1) | MY170326A (OSRAM) |
| NO (1) | NO2857404T3 (OSRAM) |
| NZ (1) | NZ702574A (OSRAM) |
| PH (1) | PH12014502721A1 (OSRAM) |
| PL (1) | PL2857404T3 (OSRAM) |
| PT (1) | PT2857404T (OSRAM) |
| RS (1) | RS56625B1 (OSRAM) |
| RU (1) | RU2635917C2 (OSRAM) |
| SG (1) | SG11201408052WA (OSRAM) |
| SI (1) | SI2857404T1 (OSRAM) |
| SM (1) | SMT201700539T1 (OSRAM) |
| TW (1) | TWI585088B (OSRAM) |
| WO (1) | WO2013183578A1 (OSRAM) |
| ZA (1) | ZA201408843B (OSRAM) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2952692C (en) | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| PT3372605T (pt) | 2008-10-22 | 2021-12-09 | Array Biopharma Inc | Compostos de pirazolo[1,5-a]pirimidina substituídos como inibidores de quinase trk |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| SMT201900203T1 (it) | 2010-05-20 | 2019-05-10 | Array Biopharma Inc | Composti macrociclici come inibitori di trk chinasi |
| AU2013268400B2 (en) | 2012-05-30 | 2017-07-13 | Nippon Shinyaku Co., Ltd. | Aromatic heterocyclic derivative and pharmaceutical |
| ES2715676T3 (es) | 2014-03-27 | 2019-06-05 | Janssen Pharmaceutica Nv | Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirazina sustituidos y derivados de 5,6,7,8-tetrahidro-4h-pirazolo[1,5-a][1,4]diazepina como inhibidores de ros1 |
| WO2015144801A1 (en) * | 2014-03-27 | 2015-10-01 | Janssen Pharmaceutica Nv | SUBSTITUTED 4,5,6,7-TETRAHYDRO-PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND 2,3-DIHYDRO-1H-IMIDAZO[1,2-b]PYRAZOLE DERIVATIVES AS ROS1 INHIBITORS |
| AR100191A1 (es) * | 2014-04-25 | 2016-09-14 | Exelixis Inc | Método para tratar adenocarcinoma de pulmón |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| KR20180021745A (ko) | 2015-06-01 | 2018-03-05 | 록쏘 온콜로지, 인코포레이티드 | 암을 진단하고 치료하는 방법 |
| EP3310441B1 (en) | 2015-06-18 | 2020-07-29 | 89Bio Ltd. | 1, 4-substituted piperidine derivatives |
| JP6986972B2 (ja) | 2015-06-18 | 2021-12-22 | エイティナイン バイオ リミテッド | 置換４−ベンジル及び４−ベンゾイルピペリジン誘導体 |
| SI3322706T1 (sl) | 2015-07-16 | 2021-04-30 | Array Biopharma, Inc. | Substituirane pirazolo(1,5-A)piridinske spojine kot zaviralci ret-kinaze |
| CA3003153A1 (en) | 2015-10-26 | 2017-05-04 | Loxo Oncology, Inc. | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| CN106854174A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种4位取代哌啶衍生物的制备方法 |
| PH12018502124B1 (en) | 2016-04-04 | 2024-04-12 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| JP7057343B2 (ja) | 2016-04-04 | 2022-04-19 | ロクソ オンコロジー， インコーポレイテッド | 小児癌の処置方法 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PT3458456T (pt) | 2016-05-18 | 2020-12-07 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida |
| CN107400082A (zh) * | 2016-05-19 | 2017-11-28 | 湖南华腾制药有限公司 | 一种取代哌啶衍生物的制备方法 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| JOP20190072A1 (ar) * | 2016-10-13 | 2019-04-07 | Glaxosmithkline Ip Dev Ltd | مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| CA3049136C (en) | 2017-01-18 | 2022-06-14 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| JP7082608B2 (ja) * | 2017-03-14 | 2022-06-08 | 第一三共株式会社 | ３，６－ジ置換イミダゾ［１，２－ｂ］ピリダジン誘導体の製造方法 |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| US20190247398A1 (en) | 2017-10-26 | 2019-08-15 | Array Biopharma Inc. | Formulations of a macrocyclic trk kinase inhibitor |
| CN109748902B (zh) * | 2017-11-02 | 2020-11-06 | 杭州科巢生物科技有限公司 | 一种盐酸安罗替尼的制备方法 |
| WO2019107671A1 (ko) * | 2017-11-29 | 2019-06-06 | 서울대학교 산학협력단 | 항-ros1 항체 및 그의 용도 |
| CN108129288B (zh) * | 2017-12-27 | 2021-01-22 | 上海毕得医药科技股份有限公司 | 一种反式-3-羟基环丁基甲酸的合成方法 |
| JP6997876B2 (ja) | 2018-01-18 | 2022-02-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物 |
| US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CA3095366A1 (en) | 2018-03-29 | 2019-10-03 | Loxo Oncology, Inc. | Treatment of trk-associated cancers |
| JP7174143B2 (ja) | 2018-07-24 | 2022-11-17 | 大鵬薬品工業株式会社 | Ｓｈｐ２活性を阻害するヘテロ二環性化合物 |
| US12109193B2 (en) | 2018-07-31 | 2024-10-08 | Loxo Oncology Inc. | Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide |
| ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
| JP2022515198A (ja) | 2018-12-19 | 2022-02-17 | アレイ バイオファーマ インコーポレイテッド | ＦＧＦＲチロシンキナーゼの阻害剤としての置換ピラゾロ［１，５－ａ］ピリジン化合物 |
| US12351571B2 (en) | 2018-12-19 | 2025-07-08 | Array Biopharma Inc. | Substituted quinoxaline compounds as inhibitors of FGFR tyrosine kinases |
| TW202100526A (zh) | 2019-03-06 | 2021-01-01 | 日商第一三共股份有限公司 | 吡咯并吡唑衍生物 |
| JP2022526713A (ja) | 2019-03-21 | 2022-05-26 | オンクセオ | がんの処置のための、キナーゼ阻害剤と組み合わせたＤｂａｉｔ分子 |
| MX2021013576A (es) * | 2019-05-08 | 2021-12-15 | Tyk Medicines Inc | Compuesto utilizado como inhibidor de la quinasa y aplicación del mismo. |
| GB201911928D0 (en) | 2019-08-20 | 2019-10-02 | Otsuka Pharma Co Ltd | Pharmaceutical compounds |
| JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| AR122159A1 (es) * | 2020-05-28 | 2022-08-17 | Novartis Ag | Inhibidores de mll1 y agentes antineoplásicos |
| CN114957259A (zh) * | 2021-02-25 | 2022-08-30 | 南京明德新药研发有限公司 | 氰基取代的芳香双环类化合物及其应用 |
| US20240309007A1 (en) * | 2021-07-01 | 2024-09-19 | Anheart Therapeutics (Hangzhou) Co., Ltd. | Crystalline forms of 3-{4-[(2r)-2-aminopropoxy]phenyl}-n-[(1r)- 1-(3-fluorophenyl) ethyl]imidazo[1,2-b]pyridazin-6-amine and salts thereof |
| WO2023220967A1 (en) * | 2022-05-18 | 2023-11-23 | Anheart Therapeutics (Hangzhou) Co., Ltd. | Method for producing 3,6-disubstituted-imidazo[1,2-b]pyridazine compounds |
| CN114989176B (zh) * | 2022-07-08 | 2024-08-27 | 深圳市新樾生物科技有限公司 | 咪唑并哒嗪类衍生物及其应用 |
| CN115197115B (zh) * | 2022-08-25 | 2024-11-08 | 成都金博汇康医药科技有限公司 | 一种手性5-氧代吡咯烷-3-甲酸的制备方法与应用 |
| KR20250056969A (ko) | 2022-09-07 | 2025-04-28 | 수저우 랑루이 바이오파마슈티컬 씨오 엘티디 | 마크로시클릭 이미다조[1,2-b]피리다진 유도체 및 이의 제조 방법과 용도 |
| CN117659020A (zh) * | 2022-09-07 | 2024-03-08 | 苏州朗睿生物医药有限公司 | 一种咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
| JP2004508366A (ja) | 2000-09-01 | 2004-03-18 | グラクソ グループ リミテッド | オキシインドール誘導体 |
| EP1339680A1 (en) | 2000-09-01 | 2003-09-03 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
| JP2003231687A (ja) | 2002-02-04 | 2003-08-19 | Japan Tobacco Inc | ピラゾリル縮合環化合物及びその医薬用途 |
| MY141220A (en) | 2003-11-17 | 2010-03-31 | Astrazeneca Ab | Pyrazole derivatives as inhibitors of receptor tyrosine kinases |
| US20090227648A1 (en) | 2004-04-21 | 2009-09-10 | Astrazeneca Ab | Pyrazole derivatives useful for the treatment of cancer |
| EP1832588A4 (en) * | 2004-12-28 | 2009-09-02 | Takeda Pharmaceutical | CONDENSED IMIDAZOLE COMPOUND AND ITS USE |
| ES2555063T3 (es) | 2005-02-04 | 2015-12-28 | Astrazeneca Ab | Derivados de pirazolilaminopiridina útiles como inhibidores de quinasas |
| ES2308731T3 (es) | 2005-02-16 | 2008-12-01 | Astrazeneca Ab | Compuestos quimicos. |
| ATE473975T1 (de) | 2005-02-16 | 2010-07-15 | Astrazeneca Ab | Chemische verbindungen |
| JP2009502734A (ja) | 2005-07-29 | 2009-01-29 | アステラス製薬株式会社 | Ｌｃｋ阻害剤としての縮合複素環 |
| WO2007014707A1 (en) * | 2005-08-01 | 2007-02-08 | F. Hoffmann-La Roche Ag | Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents |
| DE102005042742A1 (de) | 2005-09-02 | 2007-03-08 | Schering Ag | Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel |
| DE102006029447A1 (de) * | 2006-06-21 | 2007-12-27 | Bayer Schering Pharma Ag | Oxo-substituierte Imidazo[1,2b]pyridazine, deren Herstellung und Verwendung als Arzneimittel |
| AU2007315234A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
| MX2009004700A (es) * | 2006-11-06 | 2009-05-15 | Supergen Inc | Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa. |
| WO2008072682A1 (ja) | 2006-12-15 | 2008-06-19 | Daiichi Sankyo Company, Limited | イミダゾ［１，２－ｂ］ピリダジン誘導体 |
| JP2009227599A (ja) * | 2008-03-21 | 2009-10-08 | Daiichi Sankyo Co Ltd | イミダゾピリダジン誘導体 |
| AU2009246687B2 (en) * | 2008-05-13 | 2012-08-09 | Irm Llc | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| CA2952692C (en) * | 2008-09-22 | 2020-04-28 | Array Biopharma Inc. | Substituted imidazo[1,2b]pyridazine compounds |
| KR101147550B1 (ko) * | 2009-10-22 | 2012-05-17 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 가지는 2,7-치환된 티에노［3,2-ｄ］피리미딘 화합물 |
| JPWO2012005299A1 (ja) | 2010-07-07 | 2013-09-05 | 日本新薬株式会社 | Ｒｏｓチロシンキナーゼ阻害剤 |
| WO2012125667A1 (en) | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
-
2013
- 2013-05-31 TW TW102119261A patent/TWI585088B/zh active
- 2013-06-03 NO NO13801320A patent/NO2857404T3/no unknown
- 2013-06-03 JP JP2014519977A patent/JP5814467B2/ja active Active
- 2013-06-03 DK DK13801320.6T patent/DK2857404T3/en active
- 2013-06-03 ES ES13801320.6T patent/ES2648228T3/es active Active
- 2013-06-03 WO PCT/JP2013/065328 patent/WO2013183578A1/ja not_active Ceased
- 2013-06-03 RU RU2014153627A patent/RU2635917C2/ru active
- 2013-06-03 BR BR112014029851-3A patent/BR112014029851B1/pt active IP Right Grant
- 2013-06-03 CA CA2874819A patent/CA2874819C/en active Active
- 2013-06-03 RS RS20171198A patent/RS56625B1/sr unknown
- 2013-06-03 MY MYPI2014003346A patent/MY170326A/en unknown
- 2013-06-03 SG SG11201408052WA patent/SG11201408052WA/en unknown
- 2013-06-03 HR HRP20171724TT patent/HRP20171724T1/hr unknown
- 2013-06-03 LT LTEP13801320.6T patent/LT2857404T/lt unknown
- 2013-06-03 PL PL13801320T patent/PL2857404T3/pl unknown
- 2013-06-03 PT PT138013206T patent/PT2857404T/pt unknown
- 2013-06-03 HU HUE13801320A patent/HUE037221T2/hu unknown
- 2013-06-03 MX MX2014014803A patent/MX357021B/es active IP Right Grant
- 2013-06-03 KR KR1020147033351A patent/KR101781255B1/ko active Active
- 2013-06-03 US US14/378,318 patent/US9187489B2/en active Active
- 2013-06-03 CN CN201380041498.XA patent/CN104520300B/zh active Active
- 2013-06-03 SM SM20170539T patent/SMT201700539T1/it unknown
- 2013-06-03 NZ NZ702574A patent/NZ702574A/en unknown
- 2013-06-03 EP EP13801320.6A patent/EP2857404B1/en active Active
- 2013-06-03 AU AU2013272701A patent/AU2013272701B2/en active Active
- 2013-06-03 IN IN2497MUN2014 patent/IN2014MN02497A/en unknown
- 2013-06-03 SI SI201330798T patent/SI2857404T1/sl unknown
-
2014
- 2014-12-02 ZA ZA2014/08843A patent/ZA201408843B/en unknown
- 2014-12-04 IL IL236075A patent/IL236075A/en active IP Right Grant
- 2014-12-04 PH PH12014502721A patent/PH12014502721A1/en unknown
- 2014-12-30 CO CO14286593A patent/CO7160119A2/es unknown
-
2015
- 2015-10-29 US US14/926,973 patent/US9751887B2/en active Active
-
2017
- 2017-11-15 CY CY20171101204T patent/CY1119607T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LT2857404T (lt) | Imidazo[1,2-b]piridazino dariniai, kaip kinazės inhibitoriai | |
| IL234485A (en) | Compounds based on imidazo [2,1 – b] pyridazine | |
| ZA201307839B (en) | Pyrazolo[4,3-d] pyrimidines useful as kinase inhibitors | |
| IL235819A0 (en) | Preparation of pyrrolo[b–3,2]pyridines | |
| SG11201404969YA (en) | 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors | |
| ZA201405070B (en) | 1h-pyrrolo[2,3-b] pyridine derivatives and their use as kinase inhibitors | |
| EP2668190A1 (en) | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | |
| AP2013007159A0 (en) | Pyrrolo [2,3-D] pyrimidine derivatives as inhibitors of tropomyosin-related kinase | |
| PL2812337T3 (pl) | Pochodne furo[3,2-b]pirydynowe jako inhibitory tbk1 oraz ikk | |
| IL227526A0 (en) | Derivatives of 6-cyclobutyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidine-4-one and their use as a9pde inhibitors | |
| IL243092A0 (en) | New triazolo[d–4,5]pyrimidine histories | |
| ZA201406323B (en) | Triazolo[4,5-d]pyrimidine derivatives | |
| ZA201105896B (en) | [1,2,4] triazolo [1,5-a] pyridines as kinase inhibitors | |
| ZA201406777B (en) | 3,5-diaminopyrazole kinase inhibitors | |
| SG11201503977PA (en) | Azaindole derivatives as jak3 inhibitors | |
| EP2970278A4 (en) | Pyrrolo [2,3] PYRIDINE KINASE INHIBITORS CDK9- | |
| SG11201408816QA (en) | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | |
| SG10201408059QA (en) | 5-oxo-5, 8-dihydropyrido [2, 3-d] pyrimidine derivatives as camkii kinase inhibitors for treating cardiovascular diseases | |
| SG11201500883YA (en) | 5-(1H-PYRAZOL-4-YL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | |
| AP3582A (en) | (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases | |
| HK1176060A (en) | Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors |