JP5814467B2 - キナーゼ阻害剤としてのイミダゾ［１，２−ｂ］ピリダジン誘導体 - Google Patents

キナーゼ阻害剤としてのイミダゾ［１，２−ｂ］ピリダジン誘導体 Download PDF

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Publication number
JP5814467B2
JP5814467B2 JP2014519977A JP2014519977A JP5814467B2 JP 5814467 B2 JP5814467 B2 JP 5814467B2 JP 2014519977 A JP2014519977 A JP 2014519977A JP 2014519977 A JP2014519977 A JP 2014519977A JP 5814467 B2 JP5814467 B2 JP 5814467B2
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group
compound
imidazo
phenyl
amino
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JPWO2013183578A1 (ja
Inventor
泰幸 武田
泰幸 武田
謙次 吉川
謙次 吉川
佳子 神子島
佳子 神子島
裕子 山本
裕子 山本
亮一 田中
亮一 田中
裕一 冨永
裕一 冨永
真基 木我
真基 木我
義人 浜田
義人 浜田
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014519977A 2012-06-04 2013-06-03 キナーゼ阻害剤としてのイミダゾ［１，２−ｂ］ピリダジン誘導体 Active JP5814467B2 (ja)

Priority Applications (1)

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JP2014519977A JP5814467B2 (ja) 2012-06-04 2013-06-03 キナーゼ阻害剤としてのイミダゾ［１，２−ｂ］ピリダジン誘導体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012127079 2012-06-04
JP2012127079 2012-06-04
JP2014519977A JP5814467B2 (ja) 2012-06-04 2013-06-03 キナーゼ阻害剤としてのイミダゾ［１，２−ｂ］ピリダジン誘導体
PCT/JP2013/065328 WO2013183578A1 (ja) 2012-06-04 2013-06-03 キナーゼ阻害剤としてのイミダゾ[１，２－ｂ]ピリダジン誘導体

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JP5814467B2 true JP5814467B2 (ja) 2015-11-17
JPWO2013183578A1 JPWO2013183578A1 (ja) 2016-01-28

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US (2) US9187489B2 (OSRAM)
EP (1) EP2857404B1 (OSRAM)
JP (1) JP5814467B2 (OSRAM)
KR (1) KR101781255B1 (OSRAM)
CN (1) CN104520300B (OSRAM)
AU (1) AU2013272701B2 (OSRAM)
BR (1) BR112014029851B1 (OSRAM)
CA (1) CA2874819C (OSRAM)
CO (1) CO7160119A2 (OSRAM)
CY (1) CY1119607T1 (OSRAM)
DK (1) DK2857404T3 (OSRAM)
ES (1) ES2648228T3 (OSRAM)
HR (1) HRP20171724T1 (OSRAM)
HU (1) HUE037221T2 (OSRAM)
IL (1) IL236075A (OSRAM)
IN (1) IN2014MN02497A (OSRAM)
LT (1) LT2857404T (OSRAM)
MX (1) MX357021B (OSRAM)
MY (1) MY170326A (OSRAM)
NO (1) NO2857404T3 (OSRAM)
NZ (1) NZ702574A (OSRAM)
PH (1) PH12014502721A1 (OSRAM)
PL (1) PL2857404T3 (OSRAM)
PT (1) PT2857404T (OSRAM)
RS (1) RS56625B1 (OSRAM)
RU (1) RU2635917C2 (OSRAM)
SG (1) SG11201408052WA (OSRAM)
SI (1) SI2857404T1 (OSRAM)
SM (1) SMT201700539T1 (OSRAM)
TW (1) TWI585088B (OSRAM)
WO (1) WO2013183578A1 (OSRAM)
ZA (1) ZA201408843B (OSRAM)

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RU2635917C2 (ru) 2017-11-17
ES2648228T3 (es) 2017-12-29
US9187489B2 (en) 2015-11-17
CY1119607T1 (el) 2018-04-04
EP2857404A4 (en) 2016-01-20
MX2014014803A (es) 2015-02-12
SG11201408052WA (en) 2015-01-29
MX357021B (es) 2018-06-25
RS56625B1 (sr) 2018-03-30
US20150051190A1 (en) 2015-02-19
LT2857404T (lt) 2017-11-10
HRP20171724T1 (hr) 2018-01-12
ZA201408843B (en) 2016-01-27
PH12014502721B1 (en) 2015-02-02
JPWO2013183578A1 (ja) 2016-01-28
US9751887B2 (en) 2017-09-05
KR101781255B1 (ko) 2017-09-22
DK2857404T3 (en) 2017-12-04
EP2857404B1 (en) 2017-08-23
AU2013272701B2 (en) 2017-12-21
IN2014MN02497A (OSRAM) 2015-07-17
WO2013183578A1 (ja) 2013-12-12
PT2857404T (pt) 2017-11-23
PL2857404T3 (pl) 2018-04-30
TW201400486A (zh) 2014-01-01
BR112014029851B1 (pt) 2023-01-03
TWI585088B (zh) 2017-06-01
PH12014502721A1 (en) 2015-02-02
NO2857404T3 (OSRAM) 2018-01-20
KR20150014942A (ko) 2015-02-09
CO7160119A2 (es) 2015-01-15
SI2857404T1 (sl) 2017-11-30
RU2014153627A (ru) 2016-08-10
BR112014029851A2 (pt) 2017-06-27
CA2874819A1 (en) 2013-12-12
IL236075A0 (en) 2015-02-01
US20160046639A1 (en) 2016-02-18
NZ702574A (en) 2016-07-29
IL236075A (en) 2017-10-31
AU2013272701A2 (en) 2015-01-22
CN104520300A (zh) 2015-04-15
EP2857404A1 (en) 2015-04-08
HUE037221T2 (hu) 2018-08-28
CA2874819C (en) 2017-06-20
HK1207374A1 (en) 2016-01-29
MY170326A (en) 2019-07-17
CN104520300B (zh) 2016-12-21
AU2013272701A1 (en) 2015-01-15
SMT201700539T1 (it) 2018-01-11

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