PT2173751E - Metabolitos do inibidor de quinase janus (r)-3-(4-(th-pirrolo[2,3-d]pirimidina-4-il)ih-pirazol-1-il)-3-ciclopentilpropanenitrilo - Google Patents

Metabolitos do inibidor de quinase janus (r)-3-(4-(th-pirrolo[2,3-d]pirimidina-4-il)ih-pirazol-1-il)-3-ciclopentilpropanenitrilo Download PDF

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Publication number
PT2173751E
PT2173751E PT87707915T PT08770791T PT2173751E PT 2173751 E PT2173751 E PT 2173751E PT 87707915 T PT87707915 T PT 87707915T PT 08770791 T PT08770791 T PT 08770791T PT 2173751 E PT2173751 E PT 2173751E
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Prior art keywords
cyclopentylpropanenitrile
pyrrolo
pyrazol
pyrimidin
metabolites
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PT87707915T
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English (en)
Portuguese (pt)
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James David Rodgers
Argyrios Georgious Arvanitis
Jack Guoen Shi
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
PT87707915T 2007-06-13 2008-06-12 Metabolitos do inibidor de quinase janus (r)-3-(4-(th-pirrolo[2,3-d]pirimidina-4-il)ih-pirazol-1-il)-3-ciclopentilpropanenitrilo PT2173751E (pt)

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US94369507P 2007-06-13 2007-06-13

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PT2173751E true PT2173751E (pt) 2014-02-14

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PT87707915T PT2173751E (pt) 2007-06-13 2008-06-12 Metabolitos do inibidor de quinase janus (r)-3-(4-(th-pirrolo[2,3-d]pirimidina-4-il)ih-pirazol-1-il)-3-ciclopentilpropanenitrilo

Country Status (25)

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US (5) US7834022B2 (OSRAM)
EP (1) EP2173751B1 (OSRAM)
JP (1) JP5479331B2 (OSRAM)
KR (1) KR20100049008A (OSRAM)
CN (1) CN101815717B (OSRAM)
AR (1) AR067024A1 (OSRAM)
AU (1) AU2008266182B8 (OSRAM)
BR (1) BRPI0812563A2 (OSRAM)
CA (1) CA2689158C (OSRAM)
CL (1) CL2008001709A1 (OSRAM)
CO (1) CO6251255A2 (OSRAM)
CR (1) CR11149A (OSRAM)
EA (1) EA017790B1 (OSRAM)
EC (1) ECSP099821A (OSRAM)
ES (1) ES2448868T3 (OSRAM)
GE (1) GEP20125534B (OSRAM)
IL (1) IL202429A0 (OSRAM)
MX (2) MX339139B (OSRAM)
NZ (1) NZ581801A (OSRAM)
PL (1) PL2173751T3 (OSRAM)
PT (1) PT2173751E (OSRAM)
TW (1) TWI426911B (OSRAM)
UA (1) UA99465C2 (OSRAM)
WO (1) WO2008157207A2 (OSRAM)
ZA (1) ZA200908820B (OSRAM)

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