PT1490492E - Gene do factor de crescimento de hepatócitos híbrido com eficiência de expressão elevada de dois heterotipos do factor de crescimento de hepatócitos - Google Patents

Gene do factor de crescimento de hepatócitos híbrido com eficiência de expressão elevada de dois heterotipos do factor de crescimento de hepatócitos Download PDF

Info

Publication number
PT1490492E
PT1490492E PT03744561T PT03744561T PT1490492E PT 1490492 E PT1490492 E PT 1490492E PT 03744561 T PT03744561 T PT 03744561T PT 03744561 T PT03744561 T PT 03744561T PT 1490492 E PT1490492 E PT 1490492E
Authority
PT
Portugal
Prior art keywords
growth factor
hepatocyte growth
gene
heterotypes
high expression
Prior art date
Application number
PT03744561T
Other languages
English (en)
Inventor
Sunyoung Kim
Jong-Mook Kim
Eun-Jin Park
Woong Hahn
Seung-Shin Yu
Original Assignee
Viromed Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viromed Co Ltd filed Critical Viromed Co Ltd
Publication of PT1490492E publication Critical patent/PT1490492E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
PT03744561T 2002-03-20 2003-03-20 Gene do factor de crescimento de hepatócitos híbrido com eficiência de expressão elevada de dois heterotipos do factor de crescimento de hepatócitos PT1490492E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020020015074A KR100562824B1 (ko) 2002-03-20 2002-03-20 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자

Publications (1)

Publication Number Publication Date
PT1490492E true PT1490492E (pt) 2008-03-25

Family

ID=28036130

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03744561T PT1490492E (pt) 2002-03-20 2003-03-20 Gene do factor de crescimento de hepatócitos híbrido com eficiência de expressão elevada de dois heterotipos do factor de crescimento de hepatócitos

Country Status (14)

Country Link
US (5) US7812146B2 (pt)
EP (1) EP1490492B1 (pt)
JP (1) JP4057537B2 (pt)
KR (1) KR100562824B1 (pt)
CN (1) CN100378219C (pt)
AT (1) ATE380826T1 (pt)
AU (1) AU2003210053A1 (pt)
BR (1) BRPI0303570B8 (pt)
DE (1) DE60318026T2 (pt)
DK (1) DK1490492T3 (pt)
ES (1) ES2298538T3 (pt)
HK (1) HK1080895A1 (pt)
PT (1) PT1490492E (pt)
WO (1) WO2003078568A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100562824B1 (ko) 2002-03-20 2006-03-23 주식회사 바이로메드 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자
JP2009515520A (ja) * 2005-11-10 2009-04-16 レセプター バイオロジックス， インコーポレイテッド 肝細胞成長因子イントロン融合蛋白
US20090202606A1 (en) * 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
RU2470995C2 (ru) * 2008-04-09 2012-12-27 Вайромед Ко., Лтд. Лиофилизированные днк-составы для увеличенной экспрессии плазмидной днк
EP2216399A1 (en) * 2009-01-30 2010-08-11 Université de la Méditerranée Human soluble CD146, preparation and uses thereof
CN102120047A (zh) * 2010-01-11 2011-07-13 上海优益绩国际贸易有限公司 血运重建基因药物靶向投递缓释支架
BR112016008267A2 (pt) * 2013-10-22 2017-10-03 Viromed Co Ltd Composição para prevenir ou tratar esclerose lateral amiotrófica usando duas ou mais isoformas de fator de crescimento de hepatócito
CN107073078B (zh) * 2014-09-26 2021-07-06 赫利世弥斯株式会社 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物
KR101966057B1 (ko) * 2016-02-04 2019-04-05 주식회사 에스엘바이젠 간세포성장인자를 발현하는 중간엽줄기세포 및 이의 용도
CA3086046C (en) * 2017-12-29 2023-02-21 Helixmith Co., Ltd. Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto
KR102245539B1 (ko) 2018-02-12 2021-04-29 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
CN108611367B (zh) * 2018-04-24 2019-11-19 北京诺思兰德生物技术股份有限公司 一类通过质粒载体介导的基因治疗重组载体
US20190381138A1 (en) * 2018-05-17 2019-12-19 Helixmith Co., Ltd. Treatment of neuropathic pain associated with chemotherapy-induced peripheral neuropathy
KR20210052443A (ko) * 2018-07-17 2021-05-10 뉴로마이언 주식회사 Igf-1 이형체를 발현하는 dna 컨스트럭트를 이용한 신경병증의 치료
KR20210027493A (ko) 2018-07-19 2021-03-10 주식회사 헬릭스미스 네이키드 dna 유전자 요법을 위한 동결 건조된 약제학적 조성물
CN110747214B (zh) * 2019-03-13 2021-12-31 深圳市臻质医疗科技有限公司 DNA片段、具有长效表达和细胞特异性结合能力的mRNA-抗体融合分子及其制备方法
KR20210035126A (ko) 2021-03-18 2021-03-31 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
WO2022211454A1 (ko) * 2021-03-29 2022-10-06 주식회사 헬릭스미스 샤르코-마리-투스병 예방 또는 치료용 약제학적 조성물
US20230212603A1 (en) * 2021-10-06 2023-07-06 G&P Bioscience Co., Ltd. Development of optimized recombinant expression construct

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232813A (en) * 1989-03-10 1992-08-26 Snow Brand Milk Products Co Ltd Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons
US6673776B1 (en) * 1989-03-21 2004-01-06 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human
US5703055A (en) * 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5693622A (en) * 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
CA2022752C (en) * 1989-08-11 1998-07-07 Naomi Kitamura Hepatic parenchymal cell growth factor, gene encoding the same, process for producing the factor, and transformants producing the factor
US6706694B1 (en) * 1990-03-21 2004-03-16 Vical Incorporated Expression of exogenous polynucleotide sequences in a vertebrate
US5328836A (en) * 1990-07-13 1994-07-12 Snow Brand Milk Products Co., Ltd. Plasmids containing DNA encoding the amino acid sequence of TCF-II and use thereof
US5661133B1 (en) * 1991-11-12 1999-06-01 Univ Michigan Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
US5837676A (en) * 1993-10-18 1998-11-17 Long Island Jewish Medical Center Use of scatter factor to enhance angiogenesis
US6498144B1 (en) * 1993-10-18 2002-12-24 North Shore - Long Island Jewish Research Institute Use of scatter factor to enhance angiogenesis
US5652225A (en) * 1994-10-04 1997-07-29 St. Elizabeth's Medical Center Of Boston, Inc. Methods and products for nucleic acid delivery
US20030148968A1 (en) * 1995-02-28 2003-08-07 Hammond H. Kirk Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
ATE292476T1 (de) * 1995-08-29 2005-04-15 Anges Mg Inc Ein medikament,das hgf gen enthält
US5830879A (en) * 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
US6121246A (en) * 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
WO1998050079A2 (en) 1997-05-06 1998-11-12 The Regents Of The University Of California Techniques and compositions for treating heart failure and ventricular remodeling by in vivo delivery of angiogenic transgenes
JPH11246433A (ja) 1998-03-03 1999-09-14 Sumitomo Pharmaceut Co Ltd 心筋梗塞治療剤
EP1061800A4 (en) 1998-03-09 2004-10-06 Caritas St Elizabeths Boston COMPOSITIONS AND METHODS FOR MODULATING THE VASCULARIZATION
US20040228834A1 (en) * 1998-03-09 2004-11-18 Jeffrey Isner Compositions and methods for modulating vascularization
KR100761675B1 (ko) * 1998-08-05 2007-10-04 나카무라 도시카즈 간 실질세포 증식인자 투여용 제제
PT1142590E (pt) * 1999-10-29 2008-10-27 Anges Mg Inc Terapêutica génica para doença isquémica diabética
CA2389524A1 (en) 1999-11-05 2001-05-17 The Regents Of The University Of California Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
CN1142272C (zh) * 2000-02-02 2004-03-17 中国人民解放军军事医学科学院百环生物医学研究中心 携带人肝细胞生长因子基因的重组腺病毒的用途
ATE395071T1 (de) * 2000-06-27 2008-05-15 Anges Mg Inc Pharmazeutische zubereitungen zur angiogenese- therapie
EP1361896A2 (en) * 2001-01-23 2003-11-19 Boston Scientific Corporation Localized myocardial injection method for treating ischemic myocardium
KR100562824B1 (ko) 2002-03-20 2006-03-23 주식회사 바이로메드 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자
JP2008537942A (ja) * 2005-03-31 2008-10-02 マイトジェン， インコーポレイテッド 心疾患のための処置
US20090202606A1 (en) * 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
RU2470995C2 (ru) * 2008-04-09 2012-12-27 Вайромед Ко., Лтд. Лиофилизированные днк-составы для увеличенной экспрессии плазмидной днк

Also Published As

Publication number Publication date
AU2003210053A1 (en) 2003-09-29
US20090131350A1 (en) 2009-05-21
US20050079581A1 (en) 2005-04-14
AU2003210053A8 (en) 2003-09-29
US7745174B2 (en) 2010-06-29
CN1643149A (zh) 2005-07-20
US8338385B2 (en) 2012-12-25
US7812146B2 (en) 2010-10-12
BRPI0303570B8 (pt) 2021-05-25
CN100378219C (zh) 2008-04-02
USRE48404E1 (en) 2021-01-26
JP2005520512A (ja) 2005-07-14
DE60318026D1 (de) 2008-01-24
ATE380826T1 (de) 2007-12-15
ES2298538T3 (es) 2008-05-16
DE60318026T2 (de) 2008-11-20
JP4057537B2 (ja) 2008-03-05
DK1490492T3 (da) 2008-03-17
US7838505B2 (en) 2010-11-23
US20100105878A1 (en) 2010-04-29
EP1490492A2 (en) 2004-12-29
KR20030075718A (ko) 2003-09-26
WO2003078568A2 (en) 2003-09-25
US20120010273A1 (en) 2012-01-12
EP1490492A4 (en) 2006-05-31
KR100562824B1 (ko) 2006-03-23
BR0303570A (pt) 2005-07-19
WO2003078568A3 (en) 2003-11-27
BRPI0303570B1 (pt) 2018-04-24
EP1490492B1 (en) 2007-12-12
HK1080895A1 (en) 2006-05-04

Similar Documents

Publication Publication Date Title
HK1080895A1 (en) Hybrid hepatocyte growth factor gene having high expression efficiency of two heterotypes of hepatocyte growth factor
ATE291616T1 (de) Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben
DE69731834D1 (de) Agouti verwandtes gen
EA200600746A1 (ru) Конструкции нуклеиновых кислот
DE602005020165D1 (de) Verfahren zur herstellung von l-arginin, l-ornithin oder l-citrullin
ATE293696T1 (de) Mutierte alpha-amylase enzyme mit erhöhter stabilität
ATE342962T1 (de) Zusammensetzungen und verfahren für verbesserte zellkultur
SI1546174T1 (sl) Metode in sestavki za rna interferenco
DE60030988D1 (de) Verfahren zur Herstellung Von L-Aminosäuren durch Erhöhung des zellulären NADPH
DE60023860D1 (de) Verfahren zur herstellung von rekombinanten peptiden
CA2461443A1 (en) Nucleic acid and amino acid sequences encoding high-level expressor factor viii polypeptides and methods of use
ATE334199T1 (de) Modifizierte faktor viii cdna
AU2099301A (en) Method for obtaining proteins having improved functional characteristics
AU2002307510A1 (en) Cytokine protein family
IL152406A0 (en) Anti-freeze proteins, their production and use
DE69810934D1 (de) Ribonukleosid-derivat und verfahren zu seiner herstellung
HK1038572A1 (en) Growth differentiation factor promoter and uses therefor
DE60239670D1 (de) Verwendung von oxytocin zur herstellung einer pharmazeutischen zusammensetzung gegen karzinom in situ und zervizitis
MXPA05006983A (es) Promotor artificial para la expresion de secuencias de acido desoxirribonucleico en celulas vegetales.
ATE310823T1 (de) Expressionssystem zur produktion von proteinen in pilzen
EP1321473A4 (en) METHOD FOR PREVENTING FROZEN ACTIVITY OF PROTEIN INDUCED BY FREEZING, AND USE OF POLYPEPTIDE IN THE PRODUCTION OF PREVENTIVE AGENT AGAINST SUCH ACTIVITY
ATE278784T1 (de) Polypeptide
DE50006815D1 (de) Verfahren zur herstellung antitumoraler th1-zellen
ATE301199T1 (de) Beta-primeverosidase gen
WO2003016531A1 (en) RNA-BINDING PROTEIN Musashi 2