ATE380826T1 - Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen - Google Patents

Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen

Info

Publication number
ATE380826T1
ATE380826T1 AT03744561T AT03744561T ATE380826T1 AT E380826 T1 ATE380826 T1 AT E380826T1 AT 03744561 T AT03744561 T AT 03744561T AT 03744561 T AT03744561 T AT 03744561T AT E380826 T1 ATE380826 T1 AT E380826T1
Authority
AT
Austria
Prior art keywords
growth factor
hepatocyte growth
gene
heterotypes
high expression
Prior art date
Application number
AT03744561T
Other languages
English (en)
Inventor
Jong-Mook Kim
Eun-Jin Park
Woong Hahn
Seung-Shin Yu
Sunyoung Kim
Original Assignee
Viromed Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viromed Co Ltd filed Critical Viromed Co Ltd
Application granted granted Critical
Publication of ATE380826T1 publication Critical patent/ATE380826T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AT03744561T 2002-03-20 2003-03-20 Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen ATE380826T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020020015074A KR100562824B1 (ko) 2002-03-20 2002-03-20 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자

Publications (1)

Publication Number Publication Date
ATE380826T1 true ATE380826T1 (de) 2007-12-15

Family

ID=28036130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03744561T ATE380826T1 (de) 2002-03-20 2003-03-20 Hybrid-hepatozyten-wachstumsfaktorgen mit hoher expressionseffizienz von zwei hepatozyten- wachstumsfaktor-heterotypen

Country Status (14)

Country Link
US (5) US7812146B2 (de)
EP (1) EP1490492B1 (de)
JP (1) JP4057537B2 (de)
KR (1) KR100562824B1 (de)
CN (1) CN100378219C (de)
AT (1) ATE380826T1 (de)
AU (1) AU2003210053A1 (de)
BR (1) BRPI0303570B8 (de)
DE (1) DE60318026T2 (de)
DK (1) DK1490492T3 (de)
ES (1) ES2298538T3 (de)
HK (1) HK1080895A1 (de)
PT (1) PT1490492E (de)
WO (1) WO2003078568A2 (de)

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EP2216399A1 (de) 2009-01-30 2010-08-11 Université de la Méditerranée Humanes, lösliches CD146, Herstellung und Verwendungen
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CN105682676B (zh) * 2013-10-22 2020-10-23 赫利世弥斯株式会社 利用肝细胞生长因子的两种以上的异构体的肌萎缩性侧索硬化症预防或治疗用组合物
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US20190038717A1 (en) * 2016-02-04 2019-02-07 Slbigen Inc. Mesenchymal stem cell expressing hepatocyte growth factor, and use thereof
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CN108611367B (zh) * 2018-04-24 2019-11-19 北京诺思兰德生物技术股份有限公司 一类通过质粒载体介导的基因治疗重组载体
WO2019221528A1 (en) * 2018-05-17 2019-11-21 Helixmith Co., Ltd. Treatment of neuropathic pain associated with chemotherapy-induced peripheral neuropathy
SG11202100139VA (en) * 2018-07-17 2021-02-25 Neuromyon Inc Treatment of neuropathy with dna constructs expressing igf-1 isoforms
SG11202100371RA (en) 2018-07-19 2021-02-25 Helixmith Co Ltd Lyophilized pharmaceutical compositions for naked dna gene therapy
CN110747214B (zh) * 2019-03-13 2021-12-31 深圳市臻质医疗科技有限公司 DNA片段、具有长效表达和细胞特异性结合能力的mRNA-抗体融合分子及其制备方法
KR20210035126A (ko) 2021-03-18 2021-03-31 주식회사 지앤피바이오사이언스 코어-쉘 구조의 마이크로 입자를 유효성분으로 포함하는 성장인자 유전자 발현 증가용 조성물
WO2022211454A1 (ko) * 2021-03-29 2022-10-06 주식회사 헬릭스미스 샤르코-마리-투스병 예방 또는 치료용 약제학적 조성물
US20230212603A1 (en) 2021-10-06 2023-07-06 G&P Bioscience Co., Ltd. Development of optimized recombinant expression construct

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Also Published As

Publication number Publication date
CN100378219C (zh) 2008-04-02
DE60318026D1 (de) 2008-01-24
DK1490492T3 (da) 2008-03-17
EP1490492A4 (de) 2006-05-31
US7745174B2 (en) 2010-06-29
JP4057537B2 (ja) 2008-03-05
US7838505B2 (en) 2010-11-23
KR20030075718A (ko) 2003-09-26
CN1643149A (zh) 2005-07-20
BRPI0303570B8 (pt) 2021-05-25
EP1490492A2 (de) 2004-12-29
US7812146B2 (en) 2010-10-12
USRE48404E1 (en) 2021-01-26
US20090131350A1 (en) 2009-05-21
KR100562824B1 (ko) 2006-03-23
US20050079581A1 (en) 2005-04-14
PT1490492E (pt) 2008-03-25
US20100105878A1 (en) 2010-04-29
US8338385B2 (en) 2012-12-25
ES2298538T3 (es) 2008-05-16
EP1490492B1 (de) 2007-12-12
AU2003210053A8 (en) 2003-09-29
WO2003078568A3 (en) 2003-11-27
WO2003078568A2 (en) 2003-09-25
BRPI0303570B1 (pt) 2018-04-24
US20120010273A1 (en) 2012-01-12
DE60318026T2 (de) 2008-11-20
AU2003210053A1 (en) 2003-09-29
JP2005520512A (ja) 2005-07-14
HK1080895A1 (en) 2006-05-04
BR0303570A (pt) 2005-07-19

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