EA200600746A1 - Конструкции нуклеиновых кислот - Google Patents
Конструкции нуклеиновых кислотInfo
- Publication number
- EA200600746A1 EA200600746A1 EA200600746A EA200600746A EA200600746A1 EA 200600746 A1 EA200600746 A1 EA 200600746A1 EA 200600746 A EA200600746 A EA 200600746A EA 200600746 A EA200600746 A EA 200600746A EA 200600746 A1 EA200600746 A1 EA 200600746A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- site
- constructions
- early
- nucleic acids
- promoter sequence
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4741—Keratin; Cytokeratin
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Конструкция нуклеиновой кислоты, содержащая последовательность химерного промотора и сайт для встраивания кодирующей последовательности в функциональной связи с химерным промотором, где последовательность химерного промотора содержит: (а) последовательность предраннего промотора hCMV; (b) экзон 1 и по меньшей мере часть экзона 2 основного предраннего гена hCMV; (с) гетерологичный интрон, расположенный на месте участка интрона А в основном предраннем гене hCMV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50993603P | 2003-10-10 | 2003-10-10 | |
PCT/GB2004/004279 WO2005035771A2 (en) | 2003-10-10 | 2004-10-11 | Nucleic acid constructs |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600746A1 true EA200600746A1 (ru) | 2006-10-27 |
EA010056B1 EA010056B1 (ru) | 2008-06-30 |
Family
ID=34435038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600746A EA010056B1 (ru) | 2003-10-10 | 2004-10-11 | Конструкции нуклеиновых кислот |
Country Status (21)
Country | Link |
---|---|
US (1) | US8663657B2 (ru) |
EP (1) | EP1685251B1 (ru) |
JP (1) | JP4814099B2 (ru) |
KR (2) | KR101234981B1 (ru) |
CN (1) | CN1890375B (ru) |
AU (1) | AU2004279991B2 (ru) |
BR (1) | BRPI0415204A (ru) |
CA (1) | CA2542288A1 (ru) |
DK (1) | DK1685251T3 (ru) |
EA (1) | EA010056B1 (ru) |
ES (1) | ES2457022T3 (ru) |
IL (1) | IL174848A (ru) |
MX (1) | MXPA06003978A (ru) |
NO (1) | NO20062080L (ru) |
NZ (1) | NZ546554A (ru) |
PL (1) | PL1685251T3 (ru) |
PT (1) | PT1685251E (ru) |
SG (1) | SG147430A1 (ru) |
SI (1) | SI1685251T1 (ru) |
WO (1) | WO2005035771A2 (ru) |
ZA (1) | ZA200603685B (ru) |
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WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
CN101993878B (zh) * | 2010-10-14 | 2012-04-18 | 南京农业大学 | 一种rRNA嵌合启动子及含有该嵌合启动子的表达载体 |
WO2012075040A2 (en) | 2010-11-30 | 2012-06-07 | Shire Human Genetic Therapies, Inc. | mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES |
BR112013031553A2 (pt) | 2011-06-08 | 2020-11-10 | Shire Human Genetic Therapies, Inc. | composições, mrna que codifica para uma hgla e seu uso, uso de pelo menos uma molécula de mrna e um veículo de transferência e uso de um mrna que codifica para proteína exógena |
WO2013120500A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
WO2013120498A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
ES2660129T3 (es) * | 2012-03-27 | 2018-03-20 | Curevac Ag | Moléculas de ácido nucleico artificiales que comprenden un 5'UTR-TOP |
AU2013242404B2 (en) | 2012-03-27 | 2018-08-30 | CureVac SE | Artificial nucleic acid molecules for improved protein or peptide expression |
SG10201607962RA (en) * | 2012-03-27 | 2016-11-29 | Curevac Ag | Artificial nucleic acid molecules |
EP2859102A4 (en) | 2012-06-08 | 2016-05-11 | Shire Human Genetic Therapies | NUCLEASE RESISTANT POLYNUCLEOTIDES AND USES THEREOF |
DK2711426T3 (en) * | 2012-09-24 | 2015-07-13 | Lonza Biologics Plc | Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences |
EP2938725B1 (en) | 2012-12-31 | 2017-08-23 | Boehringer Ingelheim International GmbH | Heterologous intron within an immunoglobulin domain |
EP2938728B1 (en) * | 2012-12-31 | 2020-12-09 | Boehringer Ingelheim International GmbH | Artificial introns |
WO2014102101A1 (en) * | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Novel intron sequences |
WO2014102103A2 (en) | 2012-12-31 | 2014-07-03 | Boehringer Ingelheim International Gmbh | Heterologous intron within a signal peptide |
US9957499B2 (en) | 2013-03-14 | 2018-05-01 | Translate Bio, Inc. | Methods for purification of messenger RNA |
IL305374A (en) | 2013-03-14 | 2023-10-01 | Ethris Gmbh | CFTR mRNA Assemblies and Related Methods and Uses |
CA2928188A1 (en) | 2013-10-22 | 2015-04-30 | Shire Human Genetic Therapies, Inc. | Mrna therapy for argininosuccinate synthetase deficiency |
EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
KR102399799B1 (ko) * | 2013-12-30 | 2022-05-18 | 큐어백 아게 | 인공 핵산 분자 |
US11254951B2 (en) | 2014-12-30 | 2022-02-22 | Curevac Ag | Artificial nucleic acid molecules |
CN103901209B (zh) * | 2014-02-18 | 2016-05-25 | 王明丽 | 一种重组蛋白ie1包被酶标反应板的制备方法及定量检测人血浆hcmv中和抗体试剂盒 |
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GB0118367D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxosmithkline Biolog Sa | Novel use |
AU2004280630A1 (en) | 2003-10-10 | 2005-04-21 | Powderject Vaccines, Inc. | Method |
GB0507997D0 (en) * | 2005-02-01 | 2005-05-25 | Powderject Vaccines Inc | Nucleic acid constructs |
-
2004
- 2004-10-11 NZ NZ546554A patent/NZ546554A/en not_active IP Right Cessation
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- 2004-10-11 JP JP2006530599A patent/JP4814099B2/ja not_active Expired - Fee Related
- 2004-10-11 SI SI200432144T patent/SI1685251T1/sl unknown
- 2004-10-11 EA EA200600746A patent/EA010056B1/ru not_active IP Right Cessation
- 2004-10-11 KR KR1020117024399A patent/KR101234981B1/ko not_active IP Right Cessation
- 2004-10-11 DK DK04768811.4T patent/DK1685251T3/en active
- 2004-10-11 MX MXPA06003978A patent/MXPA06003978A/es active IP Right Grant
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- 2004-10-11 CA CA002542288A patent/CA2542288A1/en not_active Abandoned
- 2004-10-11 ES ES04768811.4T patent/ES2457022T3/es active Active
- 2004-10-11 WO PCT/GB2004/004279 patent/WO2005035771A2/en active Application Filing
- 2004-10-11 BR BRPI0415204-2A patent/BRPI0415204A/pt active Search and Examination
- 2004-10-11 PL PL04768811T patent/PL1685251T3/pl unknown
- 2004-10-11 EP EP04768811.4A patent/EP1685251B1/en active Active
- 2004-10-11 US US10/575,087 patent/US8663657B2/en not_active Expired - Fee Related
- 2004-10-11 KR KR1020067009012A patent/KR101225395B1/ko not_active IP Right Cessation
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2006
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Also Published As
Publication number | Publication date |
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AU2004279991A1 (en) | 2005-04-21 |
EP1685251B1 (en) | 2014-03-05 |
CA2542288A1 (en) | 2005-04-21 |
NO20062080L (no) | 2006-05-09 |
JP2007509607A (ja) | 2007-04-19 |
PT1685251E (pt) | 2014-04-15 |
IL174848A (en) | 2011-06-30 |
ES2457022T3 (es) | 2014-04-24 |
AU2004279991B2 (en) | 2010-11-25 |
WO2005035771A2 (en) | 2005-04-21 |
EP1685251A2 (en) | 2006-08-02 |
KR20060125742A (ko) | 2006-12-06 |
MXPA06003978A (es) | 2006-06-27 |
IL174848A0 (en) | 2006-08-20 |
BRPI0415204A (pt) | 2006-12-05 |
WO2005035771A3 (en) | 2005-08-25 |
CN1890375B (zh) | 2011-12-07 |
US20080160048A1 (en) | 2008-07-03 |
SI1685251T1 (sl) | 2014-05-30 |
KR101225395B1 (ko) | 2013-01-28 |
PL1685251T3 (pl) | 2014-07-31 |
ZA200603685B (en) | 2007-09-26 |
CN1890375A (zh) | 2007-01-03 |
JP4814099B2 (ja) | 2011-11-09 |
US8663657B2 (en) | 2014-03-04 |
DK1685251T3 (en) | 2014-03-24 |
NZ546554A (en) | 2009-04-30 |
KR101234981B1 (ko) | 2013-02-21 |
KR20110120364A (ko) | 2011-11-03 |
SG147430A1 (en) | 2008-11-28 |
EA010056B1 (ru) | 2008-06-30 |
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