PL2826776T3 - Dyspersja stała postaci amorficznej (R)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-N-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1H-indol-5-ilo)-cyklopropanokarboksyamidu - Google Patents

Dyspersja stała postaci amorficznej (R)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-N-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1H-indol-5-ilo)-cyklopropanokarboksyamidu

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Publication number
PL2826776T3
PL2826776T3 PL14172991T PL14172991T PL2826776T3 PL 2826776 T3 PL2826776 T3 PL 2826776T3 PL 14172991 T PL14172991 T PL 14172991T PL 14172991 T PL14172991 T PL 14172991T PL 2826776 T3 PL2826776 T3 PL 2826776T3
Authority
PL
Poland
Prior art keywords
difluorobenzo
cyclopropanecarboxamide
methylpropan
dioxol
dihydroxypropyl
Prior art date
Application number
PL14172991T
Other languages
English (en)
Polish (pl)
Inventor
Ali Keshavarz-Shokri
Beili Zhang
Tim Edward Alcacio
Elaine Chungmin Lee
Yuegang Zhang
Mariusz Krawiec
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43903962&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2826776(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of PL2826776T3 publication Critical patent/PL2826776T3/pl

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
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PL14172991T 2010-03-25 2011-03-25 Dyspersja stała postaci amorficznej (R)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-N-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1H-indol-5-ilo)-cyklopropanokarboksyamidu PL2826776T3 (pl)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31737610P 2010-03-25 2010-03-25
US31995310P 2010-04-01 2010-04-01
US32163610P 2010-04-07 2010-04-07
US32156110P 2010-04-07 2010-04-07
EP11713134.2A EP2563778B1 (en) 2010-03-25 2011-03-25 Crystalline form of (r)-1(2,2 -difluorobenzo[d][1,3]dioxol-5yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2yl)-1h-indol-5yl)cyclopropanecarboxamide
EP14172991.3A EP2826776B1 (en) 2010-03-25 2011-03-25 Solid dispersion of amorphous form of (r)-1(2,2-difluorobenzo(d)(1,3)dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl)-cyclopropanecarboxamide
PCT/US2011/030032 WO2011119984A1 (en) 2010-03-25 2011-03-25 Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihyderoxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide

Publications (1)

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PL2826776T3 true PL2826776T3 (pl) 2021-05-31

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PL14172991T PL2826776T3 (pl) 2010-03-25 2011-03-25 Dyspersja stała postaci amorficznej (R)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-N-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1H-indol-5-ilo)-cyklopropanokarboksyamidu
PL20206423.4T PL3835297T3 (pl) 2010-03-25 2011-03-25 Synteza i związki pośrednie (r)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-n-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1h-indol-5-ilo)-cyklopropanokarboksyamidu

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PL20206423.4T PL3835297T3 (pl) 2010-03-25 2011-03-25 Synteza i związki pośrednie (r)-1-(2,2-difluorobenzo[d][1,3]-dioksol-5-ilo)-n-(1-(2,3-dihydroksypropylo)-6-fluoro-2-(1-hydroksy-2-metylopropan-2-ylo)-1h-indol-5-ilo)-cyklopropanokarboksyamidu

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US (1) US20110251253A1 (enExample)
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