MX2022011048A - Formas solidas de tezacaftor y procedimientos para la preparacion de las mismas. - Google Patents

Formas solidas de tezacaftor y procedimientos para la preparacion de las mismas.

Info

Publication number
MX2022011048A
MX2022011048A MX2022011048A MX2022011048A MX2022011048A MX 2022011048 A MX2022011048 A MX 2022011048A MX 2022011048 A MX2022011048 A MX 2022011048A MX 2022011048 A MX2022011048 A MX 2022011048A MX 2022011048 A MX2022011048 A MX 2022011048A
Authority
MX
Mexico
Prior art keywords
tezacaftor
preparation
processes
solid forms
advantageous process
Prior art date
Application number
MX2022011048A
Other languages
English (en)
Inventor
Silvano Ronzoni
Massimo Zampieri
Piero Paravidino
Giuseppe Barreca
Luca Carcone
Marianna Coppola
Cristina Pesenti
Davide Bordone
Original Assignee
Quim Sintetica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quim Sintetica S A filed Critical Quim Sintetica S A
Publication of MX2022011048A publication Critical patent/MX2022011048A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se describen una forma cristalina de tezacaftor y un procedimiento industrialmente viable y ventajoso para su preparación y un método para la preparación de una forma amorfa de tezacaftor.
MX2022011048A 2020-03-06 2021-03-05 Formas solidas de tezacaftor y procedimientos para la preparacion de las mismas. MX2022011048A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20382165 2020-03-06
EP20382811 2020-09-15
PCT/EP2021/055612 WO2021176064A1 (en) 2020-03-06 2021-03-05 Solid forms of tezacaftor and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
MX2022011048A true MX2022011048A (es) 2022-09-19

Family

ID=74844925

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022011048A MX2022011048A (es) 2020-03-06 2021-03-05 Formas solidas de tezacaftor y procedimientos para la preparacion de las mismas.

Country Status (5)

Country Link
US (1) US20230092495A1 (es)
EP (1) EP4114832A1 (es)
CA (1) CA3170214A1 (es)
MX (1) MX2022011048A (es)
WO (1) WO2021176064A1 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
PT2826776T (pt) 2010-03-25 2021-02-01 Vertex Pharma Forma amorfa sólida de (r)-1(2,2-difluorobenzo(d)(1,3)dioxol-5-ilo)-n-(1-(2,3-dihidroxipropilo)-6-fluoro-2-(1-hidroxi-2-metilpropan-2-ilo)-1h-indol-5-ilo)-ciclopropanocarboxamida

Also Published As

Publication number Publication date
WO2021176064A1 (en) 2021-09-10
CA3170214A1 (en) 2021-09-10
EP4114832A1 (en) 2023-01-11
US20230092495A1 (en) 2023-03-23

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