PL2287302T3 - Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do regionu - Google Patents
Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do regionuInfo
- Publication number
- PL2287302T3 PL2287302T3 PL10178866T PL10178866T PL2287302T3 PL 2287302 T3 PL2287302 T3 PL 2287302T3 PL 10178866 T PL10178866 T PL 10178866T PL 10178866 T PL10178866 T PL 10178866T PL 2287302 T3 PL2287302 T3 PL 2287302T3
- Authority
- PL
- Poland
- Prior art keywords
- expression
- sequence
- high efficiency
- mammalian cells
- gene transfer
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Theoretical Computer Science (AREA)
- Medical Informatics (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51357403P | 2003-10-24 | 2003-10-24 | |
| EP04002722 | 2004-02-06 | ||
| EP04790766A EP1675952A2 (en) | 2003-10-24 | 2004-10-22 | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| EP08153753A EP1959011B1 (en) | 2003-10-24 | 2004-10-22 | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| EP10178866A EP2287302B1 (en) | 2003-10-24 | 2004-10-22 | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2287302T3 true PL2287302T3 (pl) | 2013-05-31 |
Family
ID=34524793
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10178866T PL2287302T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do regionu |
| PL10178873T PL2298898T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
| PL10178871T PL2292754T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
| PL08153753T PL1959011T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10178873T PL2298898T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
| PL10178871T PL2292754T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
| PL08153753T PL1959011T3 (pl) | 2003-10-24 | 2004-10-22 | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US8252917B2 (enExample) |
| EP (5) | EP2298898B1 (enExample) |
| JP (1) | JP5396653B2 (enExample) |
| KR (4) | KR101222025B1 (enExample) |
| CN (1) | CN1863913B (enExample) |
| AT (1) | ATE551420T1 (enExample) |
| AU (4) | AU2004284220B2 (enExample) |
| CA (1) | CA2535836C (enExample) |
| IL (2) | IL175142A0 (enExample) |
| IN (2) | IN2014DN02483A (enExample) |
| PL (4) | PL2287302T3 (enExample) |
| RU (1) | RU2375450C2 (enExample) |
| SG (1) | SG147468A1 (enExample) |
| WO (1) | WO2005040377A2 (enExample) |
| ZA (1) | ZA200604032B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056986A2 (en) | 2002-12-20 | 2004-07-08 | Chromagenics B.V. | Means and methods for producing a protein through chromatin openers that are capable of rendering chromatin more accessible to transcription factors |
| EP2298898B1 (en) | 2003-10-24 | 2012-12-26 | Selexis S.A. | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| DE102004043207C5 (de) * | 2004-09-03 | 2010-09-09 | Südzucker AG Mannheim/Ochsenfurt | Wurzel- und xylemparenchymspezifischer Promotor |
| US20060195935A1 (en) | 2004-11-08 | 2006-08-31 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| JP5291341B2 (ja) | 2004-11-08 | 2013-09-18 | クロマジェニックス ベー ヴェー | タンパク質を高レベルで発現する宿主細胞の選定 |
| US8999667B2 (en) | 2004-11-08 | 2015-04-07 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| US8039230B2 (en) | 2004-11-08 | 2011-10-18 | Chromagenics B.V. | Selection of host cells expressing protein at high levels |
| EP1996705B1 (en) | 2006-03-20 | 2011-08-31 | ChromaGenics B.V. | Expression augmenting dna fragments, use thereof, and methods for finding thereof |
| EP2061883A2 (en) * | 2006-08-23 | 2009-05-27 | Selexis S.A. | Matrix attachment regions (mars) for increasing transcription and uses thereof |
| EP1975228A1 (en) | 2007-03-28 | 2008-10-01 | Fachhochschule Mannheim | Polynucleotides for enhancing expression of a polynucleotide of interest |
| ES2719406T3 (es) | 2007-12-24 | 2019-07-10 | Id Biomedical Corp Quebec | Antígenos recombinantes del VSR |
| CN101580842B (zh) * | 2008-05-15 | 2011-02-09 | 中国农业科学院生物技术研究所 | 一种增强基因表达的dna分子及其应用 |
| WO2010081890A1 (en) | 2009-01-19 | 2010-07-22 | Innate Pharma | Anti-kir3d antibodies |
| AU2010264686A1 (en) | 2009-06-24 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine |
| WO2010149745A1 (en) | 2009-06-24 | 2010-12-29 | Glaxosmithkline Biologicals S.A. | Recombinant rsv antigens |
| EP4218799A1 (en) | 2009-07-15 | 2023-08-02 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| SG178940A1 (en) | 2009-09-18 | 2012-04-27 | Selexis Sa | Products and methods for enhanced transgene expression and processing |
| WO2011070405A1 (en) * | 2009-12-07 | 2011-06-16 | Avesthagen Limited | An expression vector carrying scaffold/matrix attachment region(s) |
| RU2422512C1 (ru) * | 2010-02-16 | 2011-06-27 | Автономная некоммерческая организация "Институт молекулярной диагностики" (АНО "ИнМоДи") | ШТАММ Escherichia coli BL21(DE3)/pAFP11D3 - ПРОДУЦЕНТ ФРАГМЕНТА С 404 ПО 609 АМИНОКИСЛОТУ АЛЬФА-ФЕТОПРОТЕИНА ЧЕЛОВЕКА |
| WO2012019630A1 (en) | 2010-08-13 | 2012-02-16 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein |
| WO2012095514A1 (en) | 2011-01-14 | 2012-07-19 | Vivalis | Recombinant protein production system |
| SG194473A1 (en) | 2011-04-13 | 2013-12-30 | Ca Nat Research Council | EXPRESSION SYSTEM WITH SAR ELEMENT FROM IFNa2 |
| WO2012158613A1 (en) | 2011-05-13 | 2012-11-22 | Novartis Ag | Pre-fusion rsv f antigens |
| WO2013120500A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| WO2013120497A1 (en) * | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| WO2013120498A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded allergenic antigen or an autoimmune self-antigen |
| WO2013120499A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly (a) sequence or a polyadenylation signal for increasing the expression of an encoded pathogenic antigen |
| AU2013242404B2 (en) | 2012-03-27 | 2018-08-30 | CureVac SE | Artificial nucleic acid molecules for improved protein or peptide expression |
| CN105073995A (zh) | 2013-02-01 | 2015-11-18 | 瑟莱克斯公司 | 增强的转基因表达和加工 |
| CN103667440A (zh) * | 2013-09-05 | 2014-03-26 | 谢小冬 | Gata4基因snp位点的用途 |
| WO2015060935A1 (en) | 2013-10-22 | 2015-04-30 | Lubris, Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
| CN104975009B (zh) * | 2014-04-01 | 2019-10-18 | 三生国健药业(上海)股份有限公司 | 一种新型的含mar核心片段的动物细胞表达载体 |
| CN104974933B (zh) * | 2014-04-04 | 2017-08-15 | 上海泰因生物技术有限公司 | 一种大规模连续多次悬浮瞬转表达重组蛋白的装置和方法 |
| WO2017202776A1 (en) * | 2016-05-23 | 2017-11-30 | Luxembourg Institute Of Health (Lih) | Multifunctional heteromultimeric constructs. |
| EP3456821B2 (en) * | 2017-09-19 | 2024-01-24 | Deutsches Krebsforschungszentrum | Non-integrating dna vectors for the genetic modification of cells |
| US20230193341A1 (en) | 2018-10-24 | 2023-06-22 | Selexis Sa | Expression systems, recombinant cells and uses thereof |
| JP2022511077A (ja) | 2018-12-07 | 2022-01-28 | セルテオン コーポレイション | マトリックス付着領域および遺伝子発現の促進における使用 |
| JP2023515504A (ja) | 2020-02-24 | 2023-04-13 | ノバルティス アーゲー | 組み換え産生されたポリペプチドの精製 |
| US20230192893A1 (en) * | 2020-05-11 | 2023-06-22 | Samsung Bioepis Co., Ltd. | Human genome-derived polynucleotide and method for producing polypeptide of interest using same |
| US20230293690A1 (en) * | 2020-07-22 | 2023-09-21 | Deutsches Krebsforschungszentrum | 5' s/mar applications |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1077994A (en) * | 1963-04-18 | 1967-08-02 | Kobe Steel Ltd | Process for producing cold-forged products from tempered steel wire |
| DE2605560C3 (de) | 1976-02-12 | 1979-08-30 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Aufschlußverfahren für Biomaterialien |
| EP0113551B1 (en) | 1982-12-23 | 1988-04-27 | Britax Weathershields Limited | Vehicle sliding roof |
| DE122007000007I2 (de) | 1986-04-09 | 2010-12-30 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| GB8925590D0 (en) | 1989-11-13 | 1990-01-04 | Central Blood Lab Authority | Monoclonal antibodies |
| US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| AU673859B2 (en) | 1992-10-05 | 1996-11-28 | North Carolina State University | Method for increasing expression and reducing expression variability of foreign genes in plant cells |
| US5610053A (en) | 1993-04-07 | 1997-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | DNA sequence which acts as a chromatin insulator element to protect expressed genes from cis-acting regulatory sequences in mammalian cells |
| US5888981A (en) | 1993-06-14 | 1999-03-30 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| US5464758A (en) | 1993-06-14 | 1995-11-07 | Gossen; Manfred | Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters |
| US5907078A (en) | 1994-12-09 | 1999-05-25 | Greenberg; Norman M. | Transgenic mouse model for prostate cancer |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| DE19541450C2 (de) * | 1995-11-07 | 1997-10-02 | Gsf Forschungszentrum Umwelt | Genkonstrukt und dessen Verwendung |
| US6596514B2 (en) | 1996-01-11 | 2003-07-22 | Immunex Corporation | Expression augmenting sequence elements (EASE) for eukaryotic expression systems |
| US5773695A (en) | 1996-01-26 | 1998-06-30 | North Carolina State University | Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells |
| EP0914421A2 (en) | 1996-02-29 | 1999-05-12 | Immusol, Inc. | Hepatitis c virus ribozymes |
| WO1997046687A1 (en) | 1996-06-06 | 1997-12-11 | Novartis Ag | Vectors comprising sar elements |
| EP1471144B1 (en) | 1996-12-02 | 2010-06-23 | Genaera Corporation | Biological variability of asthma associated factor AAF2 (IL-9 receptor) useful in treating and diagnosing atopic allergies including asthma and related disorders |
| US6245974B1 (en) * | 1997-08-06 | 2001-06-12 | North Carolina State University | Matrix attachment regions |
| US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| AU734476B2 (en) | 1997-11-05 | 2001-06-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
| US6635806B1 (en) | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| US6004284A (en) | 1998-06-04 | 1999-12-21 | Alcon Laboratories, Inc. | Surgical handpiece |
| CA2333852C (en) | 1998-07-21 | 2007-05-29 | Cobra Therapeutics Limited | A polynucleotide comprising a ubiquitous chromatin opening element (ucoe) |
| US6338066B1 (en) * | 1998-09-25 | 2002-01-08 | International Business Machines Corporation | Surfaid predictor: web-based system for predicting surfer behavior |
| DE69904744T2 (de) | 1998-10-07 | 2003-10-23 | Adobe Systems, Inc. | Zuteilung des zugriffs auf einen datensatz |
| DE19848017A1 (de) | 1998-10-17 | 2000-04-20 | Multigene Biotech Gmbh | Episomal replizierender Vektor zur Expression eines Transgens in Säugerzellen |
| WO2000032800A1 (en) * | 1998-12-01 | 2000-06-08 | Dow Agrosciences Llc | Artificial matrix attachment region for increasing expression of genes introduced in plant cells |
| US6225113B1 (en) | 1998-12-04 | 2001-05-01 | Genvec, Inc. | Use of trans-activation and cis-activation to modulate the persistence of expression of a transgene in an at least E4-deficient adenovirus |
| US6194636B1 (en) | 1999-05-14 | 2001-02-27 | Dekalb Genetics Corp. | Maize RS324 promoter and methods for use thereof |
| US6207879B1 (en) | 1999-05-14 | 2001-03-27 | Dekalb Genetics Corporation | Maize RS81 promoter and methods for use thereof |
| US6429357B1 (en) | 1999-05-14 | 2002-08-06 | Dekalb Genetics Corp. | Rice actin 2 promoter and intron and methods for use thereof |
| US6232526B1 (en) | 1999-05-14 | 2001-05-15 | Dekalb Genetics Corp. | Maize A3 promoter and methods for use thereof |
| CA2374365A1 (en) | 1999-05-28 | 2000-12-07 | Sangamo Biosciences, Inc. | Gene switches |
| US20050129669A1 (en) | 1999-06-21 | 2005-06-16 | Transkaryotic Therapies, Inc., A Massachusetts Corporation | DNA construct for effecting homologous recombination and uses thereof |
| US6972349B1 (en) | 1999-11-12 | 2005-12-06 | University Of South Carolina | Control of post-transcriptional gene silencing in plants |
| JP3507858B2 (ja) | 1999-11-19 | 2004-03-15 | 奈良先端科学技術大学院大学長 | 植物において外来遺伝子の発現を安定化させるdna断片、外来遺伝子を植物において安定に発現させる遺伝子導入方法、外来遺伝子を安定に発現させた形質転換植物 |
| WO2001040488A1 (en) | 1999-11-30 | 2001-06-07 | Novartis Ag | Increased transgene expression in retroviral vectors having scaffold attachment region |
| US6864085B2 (en) | 1999-12-14 | 2005-03-08 | Novartis Ag | Bovine immunodeficiency virus (BIV) based vectors |
| US20020127199A1 (en) | 2000-02-03 | 2002-09-12 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US6821775B1 (en) | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| DE10006886A1 (de) | 2000-02-16 | 2001-08-23 | Hepavec Ag Fuer Gentherapie | Nichthumaner helferabhängiger Virusvektor |
| US6569681B1 (en) | 2000-03-14 | 2003-05-27 | Transkaryotic Therapies, Inc. | Methods of improving homologous recombination |
| US6747189B1 (en) | 2000-03-21 | 2004-06-08 | Dekalb Genetics Corporation | Maize glycine rich protein promoter compositions and methods for use thereof |
| US6730826B2 (en) | 2000-03-22 | 2004-05-04 | University Of Kentucky Research Foundation | Plant trichome gland specific promoter sequence |
| EP1294406A2 (en) | 2000-06-26 | 2003-03-26 | Universite De Geneve | Modulation of chromosome function by chromatin remodeling agents |
| US20030157715A1 (en) | 2000-06-26 | 2003-08-21 | Ulrich Laemmli | Modulation of chromosome function by chromatin remodeling agents |
| CA2416877C (en) | 2000-07-27 | 2013-03-12 | Apogene Gmbh & Co. Kg | Somatic cloning gene transfer for producing recombinant proteins, cells and organs |
| KR100408844B1 (ko) | 2000-07-29 | 2003-12-06 | 한국산업기술평가원 | 동물세포 발현벡터 |
| JP2004507250A (ja) | 2000-08-30 | 2004-03-11 | ノース・キャロライナ・ステイト・ユニヴァーシティ | タンパク質含量を変化させる分子デコイを含有するトランスジェニック植物 |
| AU9379801A (en) | 2000-09-09 | 2002-03-22 | Basf Plant Science Gmbh | Modified tet-inducible system for regulation of gene expression in plants |
| GB0022995D0 (en) | 2000-09-20 | 2000-11-01 | Cobra Therapeutics Ltd | Polynucleotide |
| US6919204B2 (en) | 2000-09-29 | 2005-07-19 | Sangamo Biosciences, Inc. | Modulation of gene expression using localization domains |
| AU4155602A (en) | 2000-11-01 | 2002-06-18 | Elusys Therapeutics Inc | Method of producing biospecific molecules by protein trans-splicing |
| DE10061150A1 (de) | 2000-12-08 | 2002-06-13 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| WO2002048379A1 (en) | 2000-12-15 | 2002-06-20 | Pangen Biotech Inc. | Expression vector for animal cell containing nuclear matrix attachment region fo interferon beta |
| US7151204B2 (en) | 2001-01-09 | 2006-12-19 | Monsanto Technology Llc | Maize chloroplast aldolase promoter compositions and methods for use thereof |
| SG141239A1 (en) | 2001-01-26 | 2008-04-28 | Selexis Sa | Matrix attachment regions and methods for use thereof |
| DE10109780A1 (de) | 2001-02-28 | 2002-09-05 | Cardion Ag | Episomale Vektoren enthaltend Matrix-Anheftungsregionen zur zellspezifischen Genexpression |
| EP1365801A4 (en) | 2001-03-08 | 2004-10-13 | Nuvelo Inc | METHODS AND MATERIALS RELATING TO FIBULIN-RELATED POLYPEPTIDES AND POLYNUCLEOTIDES |
| JP4817514B2 (ja) | 2001-03-09 | 2011-11-16 | 協和発酵キリン株式会社 | 新規動物細胞用ベクターおよびその使用 |
| US20040076954A1 (en) | 2001-03-12 | 2004-04-22 | Irm, Llc | Genomics-driven high speed cellular assays, development thereof, and collections of cellular reporters |
| NZ527937A (en) | 2001-03-13 | 2005-03-24 | Novartis Ag | Stable cell lines to express high levels of lentiviral Gag/Pol proteins for generation of HIV- or BIV- based lentiviral vectors |
| EP1478751A4 (en) | 2001-03-30 | 2005-10-19 | Avigenics Inc | LYSOZYM PROMOTER IN BIRDS |
| DE10129010A1 (de) | 2001-06-13 | 2002-12-19 | Icon Genetics Ag | Verfahren und Vektoren zur Erzeugung von transgenen Pflanzen |
| US20030032597A1 (en) | 2001-07-31 | 2003-02-13 | Sebestyen Magdolna G. | Targeting nucleic acids to a cellular nucleus |
| KR100464962B1 (ko) * | 2001-09-14 | 2005-01-05 | 삼화강봉주식회사 | 냉간압조 특성이 우수한 조질 강선 |
| US7122715B2 (en) | 2001-09-20 | 2006-10-17 | Monsanto Technology Llc | In vitro method to create circular molecules for use in transformation |
| AU2002341795A1 (en) | 2001-09-21 | 2003-04-01 | Avigenics, Inc. | Production of transgenic avians using sperm-mediated transfection |
| US7138278B2 (en) | 2001-11-20 | 2006-11-21 | Monsanto Technology, L.L.C. | Maize cytoplasmic glutamine synthetase promoter compositions and methods for use thereof |
| FR2832423B1 (fr) | 2001-11-22 | 2004-10-08 | Vivalis | Systeme d'expression de proteines exogenes dans un systeme aviaire |
| US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
| CA2427190A1 (en) | 2002-04-30 | 2003-10-30 | Alberta Research Council Inc. | Production of recombinant epidermal growth factor in plants |
| US20030224477A1 (en) | 2002-05-31 | 2003-12-04 | Heartlein Michael W. | Optimized promoter constructs |
| EP1513929A4 (en) | 2002-06-18 | 2006-04-19 | Zymogenetics Inc | HYBRID VECTOR WITH A CYTOMEGALOVIRUS ENHANCER AND PROMOTER OF MYELOPROLIFERATIVE SARCOMA VIRUS |
| US20040016015A1 (en) | 2002-07-17 | 2004-01-22 | Nguyen Thanh-Tuyen T. | High efficiency germline transformation system |
| US6933136B2 (en) | 2002-09-20 | 2005-08-23 | Novo Nordisk A/S | Method for making recombinant proteins |
| CN1263860C (zh) | 2002-09-30 | 2006-07-12 | 华南农业大学 | 多基因载体的构建方法与应用 |
| AU2003302777A1 (en) | 2002-12-05 | 2004-06-30 | Regulome Corporation | Profiled regulatory sites useful for gene control |
| WO2004053137A2 (en) | 2002-12-11 | 2004-06-24 | Cytos Biotechnology Ag | Method for protein production |
| AU2002953381A0 (en) | 2002-12-18 | 2003-01-09 | Diatech Pty Ltd | In vivo affinity maturation scheme |
| EP1445320A1 (en) | 2003-02-05 | 2004-08-11 | ARTEMIS Pharmaceuticals GmbH | Automated gene-targeting using non-toxic detectable markers |
| WO2004094640A1 (en) | 2003-04-15 | 2004-11-04 | University Of Georgia Research Foundation, Inc. | Avian transgenesis using a chicken ovalbumin gene region |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| WO2005005644A1 (en) * | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| CN1842601A (zh) | 2003-08-27 | 2006-10-04 | 奥夫莱夫塔埃克尼公司 | 通过靶向抑制内源贮藏蛋白增强植物种子中异源多肽的累积 |
| ES2354160T3 (es) | 2003-10-21 | 2011-03-10 | Merck Serono Sa | Secuencia de adn mínima que actúa como un aislante de cromatina, y su uso en la expresión de proteínas. |
| EP2298898B1 (en) | 2003-10-24 | 2012-12-26 | Selexis S.A. | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
| EP2061883A2 (en) | 2006-08-23 | 2009-05-27 | Selexis S.A. | Matrix attachment regions (mars) for increasing transcription and uses thereof |
| EP2097538A4 (en) * | 2006-12-07 | 2011-11-30 | Switchgear Genomics | TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS |
-
2004
- 2004-10-22 EP EP10178873A patent/EP2298898B1/en not_active Expired - Lifetime
- 2004-10-22 EP EP04790766A patent/EP1675952A2/en not_active Withdrawn
- 2004-10-22 WO PCT/EP2004/011974 patent/WO2005040377A2/en not_active Ceased
- 2004-10-22 EP EP08153753A patent/EP1959011B1/en not_active Expired - Lifetime
- 2004-10-22 PL PL10178866T patent/PL2287302T3/pl unknown
- 2004-10-22 SG SG200807906-3A patent/SG147468A1/en unknown
- 2004-10-22 KR KR1020067006395A patent/KR101222025B1/ko not_active Expired - Fee Related
- 2004-10-22 PL PL10178873T patent/PL2298898T3/pl unknown
- 2004-10-22 EP EP10178866A patent/EP2287302B1/en not_active Expired - Lifetime
- 2004-10-22 KR KR1020117023131A patent/KR101230838B1/ko not_active Expired - Fee Related
- 2004-10-22 IN IN2483DEN2014 patent/IN2014DN02483A/en unknown
- 2004-10-22 IN IN2484DEN2014 patent/IN2014DN02484A/en unknown
- 2004-10-22 KR KR1020117023132A patent/KR101229989B1/ko not_active Expired - Fee Related
- 2004-10-22 PL PL10178871T patent/PL2292754T3/pl unknown
- 2004-10-22 EP EP10178871A patent/EP2292754B1/en not_active Expired - Lifetime
- 2004-10-22 US US10/595,495 patent/US8252917B2/en active Active
- 2004-10-22 JP JP2006536060A patent/JP5396653B2/ja not_active Expired - Lifetime
- 2004-10-22 KR KR1020117023134A patent/KR101269656B1/ko not_active Expired - Lifetime
- 2004-10-22 CA CA2535836A patent/CA2535836C/en not_active Expired - Lifetime
- 2004-10-22 RU RU2006117757/13A patent/RU2375450C2/ru active
- 2004-10-22 PL PL08153753T patent/PL1959011T3/pl unknown
- 2004-10-22 AT AT08153753T patent/ATE551420T1/de active
- 2004-10-22 AU AU2004284220A patent/AU2004284220B2/en not_active Ceased
- 2004-10-22 CN CN2004800292606A patent/CN1863913B/zh not_active Expired - Lifetime
-
2006
- 2006-04-24 IL IL175142A patent/IL175142A0/en unknown
- 2006-05-19 ZA ZA200604032A patent/ZA200604032B/en unknown
-
2009
- 2009-05-21 IL IL198863A patent/IL198863A/en active IP Right Grant
-
2010
- 2010-10-27 AU AU2010236091A patent/AU2010236091B2/en not_active Expired
- 2010-10-27 AU AU2010236093A patent/AU2010236093B2/en not_active Ceased
- 2010-10-27 AU AU2010236072A patent/AU2010236072B2/en not_active Ceased
-
2012
- 2012-06-28 US US13/536,383 patent/US9879297B2/en active Active
-
2017
- 2017-12-19 US US15/846,279 patent/US10669562B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL2298898T3 (pl) | Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy | |
| DK1622921T3 (da) | Varianter af beta-glucosidaser | |
| GB9922124D0 (en) | Phosphodiesterase enzymes | |
| BR0003943A (pt) | Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma | |
| MX350551B (es) | Polipeptidos aislados, polinucleotidos que los codifican, plantas transgenicas que expresan los mismos y metodos para usarlos. | |
| MXPA01008372A (es) | Gen de fucosil transferasa. | |
| CY1106041T1 (el) | Καινοφανης συλλεκτινη | |
| CY1106978T1 (el) | Ενζυμα φωσφοδιεστερασης | |
| NZ508439A (en) | Novel endometriosis-associated gene | |
| ZA200102385B (en) | Nucleotide sequences coding for the dapC gene and process for the production of L-lysine. | |
| GB0020331D0 (en) | Enzyme | |
| DK1235916T3 (da) | Isolerede polynukleotider med et formindsket indhold af 5'CpG3' epigenitiske kontrolmotiver og anvendelser deraf | |
| ATE346153T1 (de) | Endogene retrovirale sequenzen, verwandten mit auto-immune krankheiten oder mit schwangerschaftsstörungen | |
| NO20011995D0 (no) | Fremgangsmåte for å produsere koenzymet Q10 | |
| SG128684A1 (en) | Novel sequence and utilization thereof | |
| DE50212612D1 (de) | Gene, die fuer kohlenstoffmetabolismus- und energieproduktions-proteine codieren | |
| EP1728859A4 (en) | SEQUENCE CAPABLE OF ACCELERATING GENE EXPRESSION AT A MODERATELY LOW TEMPERATURE | |
| TR200003271T2 (tr) | Protein üretimi ve verilmesi için genomik sekanslar. | |
| ATE339508T1 (de) | Mites-ähnliches element und an trankriptionsaktivierung beteiligtes element | |
| ATE458043T1 (de) | Mn-gen und -protein | |
| ES2178608A1 (es) | Molecula de adn con actividad aisladora de efectos de posicion cromosomales en procesos de transferencia genica en celulas de animales. | |
| TH48289A3 (th) | ลำดับลักษณะทางพันธุกรรม สำหรับการผลิตโปรตีนและการปล่อย |