TR200003271T2 - Protein üretimi ve verilmesi için genomik sekanslar. - Google Patents

Protein üretimi ve verilmesi için genomik sekanslar.

Info

Publication number
TR200003271T2
TR200003271T2 TR2000/03271T TR200003271T TR200003271T2 TR 200003271 T2 TR200003271 T2 TR 200003271T2 TR 2000/03271 T TR2000/03271 T TR 2000/03271T TR 200003271 T TR200003271 T TR 200003271T TR 200003271 T2 TR200003271 T2 TR 200003271T2
Authority
TR
Turkey
Prior art keywords
delivery
protein production
genomic sequences
dna
nucleic acid
Prior art date
Application number
TR2000/03271T
Other languages
English (en)
Inventor
A. Treco Douglas
W. Heartlein Michael
F. Selden Richard
Original Assignee
Transkaryotic Therapies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transkaryotic Therapies, Inc. filed Critical Transkaryotic Therapies, Inc.
Publication of TR200003271T2 publication Critical patent/TR200003271T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Abstract

IFNA2 geninin sifreleme bölgesinin üst kisminda tanimlanmis bir genomik bölge ile çok kati kosullar altinda melezlesen ve en azindan %80 sekans benzerligi paylasan izole edilmis bir nükleik asit molekülü ve homolog yeniden birlestirme için hedef sekansi olarak bu DNA molekülünü içeren bir DNA yapisi.
TR2000/03271T 1998-05-07 1999-05-05 Protein üretimi ve verilmesi için genomik sekanslar. TR200003271T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8464898P 1998-05-07 1998-05-07
US8655598P 1998-05-21 1998-05-21

Publications (1)

Publication Number Publication Date
TR200003271T2 true TR200003271T2 (tr) 2001-03-21

Family

ID=26771248

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03271T TR200003271T2 (tr) 1998-05-07 1999-05-05 Protein üretimi ve verilmesi için genomik sekanslar.

Country Status (14)

Country Link
EP (1) EP1075531A1 (tr)
JP (1) JP2002513580A (tr)
KR (1) KR20010052278A (tr)
CN (1) CN1309710A (tr)
AR (1) AR016264A1 (tr)
AU (1) AU3788899A (tr)
CA (1) CA2328459A1 (tr)
CZ (1) CZ299418B6 (tr)
HU (1) HUP0102517A3 (tr)
IL (1) IL139433A0 (tr)
NO (1) NO20005585L (tr)
PL (1) PL344517A1 (tr)
TR (1) TR200003271T2 (tr)
WO (1) WO1999057292A1 (tr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042442A2 (en) 1999-12-10 2001-06-14 Cytos Biotechnology Ag Activation of endogenous genes by genomic introduction of a replicon
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
CN103620034B (zh) * 2011-04-13 2016-12-14 加拿大国家研究委员会 具有来自IFNα2的SAR元件的表达系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery

Also Published As

Publication number Publication date
HUP0102517A2 (hu) 2001-11-28
AU3788899A (en) 1999-11-23
JP2002513580A (ja) 2002-05-14
IL139433A0 (en) 2001-11-25
CN1309710A (zh) 2001-08-22
CZ299418B6 (cs) 2008-07-16
NO20005585D0 (no) 2000-11-06
NO20005585L (no) 2001-01-05
HUP0102517A3 (en) 2004-06-28
AR016264A1 (es) 2001-06-20
WO1999057292A1 (en) 1999-11-11
CA2328459A1 (en) 1999-11-11
PL344517A1 (en) 2001-11-05
CZ20003705A3 (cs) 2001-04-11
EP1075531A1 (en) 2001-02-14
WO1999057292A9 (en) 1999-12-16
KR20010052278A (ko) 2001-06-25

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