PL344517A1 - Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery - Google Patents

Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery

Info

Publication number
PL344517A1
PL344517A1 PL99344517A PL34451799A PL344517A1 PL 344517 A1 PL344517 A1 PL 344517A1 PL 99344517 A PL99344517 A PL 99344517A PL 34451799 A PL34451799 A PL 34451799A PL 344517 A1 PL344517 A1 PL 344517A1
Authority
PL
Poland
Prior art keywords
ifn
delivery
coding region
protein production
genomic sequences
Prior art date
Application number
PL99344517A
Inventor
Douglas A Treco
Michael W Heartlein
Richard F Selden
Original Assignee
Transkaryotic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transkaryotic Therapies filed Critical Transkaryotic Therapies
Publication of PL344517A1 publication Critical patent/PL344517A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL99344517A 1998-05-07 1999-05-05 Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery PL344517A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8464898P 1998-05-07 1998-05-07
US8655598P 1998-05-21 1998-05-21
PCT/US1999/009925 WO1999057292A1 (en) 1998-05-07 1999-05-05 Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery

Publications (1)

Publication Number Publication Date
PL344517A1 true PL344517A1 (en) 2001-11-05

Family

ID=26771248

Family Applications (1)

Application Number Title Priority Date Filing Date
PL99344517A PL344517A1 (en) 1998-05-07 1999-05-05 Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery

Country Status (14)

Country Link
EP (1) EP1075531A1 (en)
JP (1) JP2002513580A (en)
KR (1) KR20010052278A (en)
CN (1) CN1309710A (en)
AR (1) AR016264A1 (en)
AU (1) AU3788899A (en)
CA (1) CA2328459A1 (en)
CZ (1) CZ299418B6 (en)
HU (1) HUP0102517A3 (en)
IL (1) IL139433A0 (en)
NO (1) NO20005585L (en)
PL (1) PL344517A1 (en)
TR (1) TR200003271T2 (en)
WO (1) WO1999057292A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042442A2 (en) 1999-12-10 2001-06-14 Cytos Biotechnology Ag Activation of endogenous genes by genomic introduction of a replicon
FR2817559B1 (en) * 2000-12-06 2003-12-12 Genodyssee METHOD FOR DETERMINING ONE OR MORE FUNCTIONAL POLYMORPHISM (S) IN THE NUCLEIC SEQUENCE OF A PRESELECTED FUNCTIONAL "CANDIDATE" GENE AND ITS APPLICATIONS
DK2697375T3 (en) * 2011-04-13 2018-01-15 Nat Res Council Canada EXPRESSION SYSTEM WITH A SAR (SCAFFOLD ATTACHMENT REGION) ELEMENT OF INTERFERON 2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery

Also Published As

Publication number Publication date
CZ299418B6 (en) 2008-07-16
CN1309710A (en) 2001-08-22
AU3788899A (en) 1999-11-23
WO1999057292A9 (en) 1999-12-16
NO20005585L (en) 2001-01-05
HUP0102517A3 (en) 2004-06-28
IL139433A0 (en) 2001-11-25
WO1999057292A1 (en) 1999-11-11
JP2002513580A (en) 2002-05-14
HUP0102517A2 (en) 2001-11-28
TR200003271T2 (en) 2001-03-21
NO20005585D0 (en) 2000-11-06
EP1075531A1 (en) 2001-02-14
AR016264A1 (en) 2001-06-20
CZ20003705A3 (en) 2001-04-11
CA2328459A1 (en) 1999-11-11
KR20010052278A (en) 2001-06-25

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Legal Events

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