PL1863448T3 - Nowe kompozycje liposomowe - Google Patents
Nowe kompozycje liposomoweInfo
- Publication number
- PL1863448T3 PL1863448T3 PL06737793T PL06737793T PL1863448T3 PL 1863448 T3 PL1863448 T3 PL 1863448T3 PL 06737793 T PL06737793 T PL 06737793T PL 06737793 T PL06737793 T PL 06737793T PL 1863448 T3 PL1863448 T3 PL 1863448T3
- Authority
- PL
- Poland
- Prior art keywords
- liposome compositions
- novel liposome
- novel
- compositions
- liposome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005067469A JP2006248978A (ja) | 2005-03-10 | 2005-03-10 | 新規なリポソーム製剤 |
| PCT/US2006/008650 WO2006099169A2 (en) | 2005-03-10 | 2006-03-08 | Novel liposome compositions |
| EP06737793.7A EP1863448B1 (de) | 2005-03-10 | 2006-03-08 | Neue liposom-zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1863448T3 true PL1863448T3 (pl) | 2015-05-29 |
Family
ID=36992280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06737793T PL1863448T3 (pl) | 2005-03-10 | 2006-03-08 | Nowe kompozycje liposomowe |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7829113B2 (de) |
| EP (1) | EP1863448B1 (de) |
| JP (2) | JP2006248978A (de) |
| KR (1) | KR101352490B1 (de) |
| CN (1) | CN101170995B (de) |
| AU (1) | AU2006223329B2 (de) |
| BR (1) | BRPI0608297A2 (de) |
| CA (1) | CA2600446A1 (de) |
| CY (1) | CY1116075T1 (de) |
| DK (1) | DK1863448T3 (de) |
| ES (1) | ES2529453T3 (de) |
| HU (1) | HUE024290T2 (de) |
| MX (1) | MX2007010996A (de) |
| NO (1) | NO20075136L (de) |
| NZ (1) | NZ561569A (de) |
| PL (1) | PL1863448T3 (de) |
| PT (1) | PT1863448E (de) |
| RU (1) | RU2454229C2 (de) |
| SI (1) | SI1863448T1 (de) |
| WO (1) | WO2006099169A2 (de) |
| ZA (1) | ZA200708600B (de) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948545B (zh) | 2004-05-03 | 2017-10-03 | 益普生生物制药公司 | 用于药物输送的脂质体 |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| CN101209243B (zh) * | 2006-12-29 | 2010-12-08 | 石药集团中奇制药技术(石家庄)有限公司 | 一种脂质体药物及其制备方法 |
| EP2187869B1 (de) * | 2007-08-17 | 2015-10-14 | Celator Pharmaceuticals, Inc. | Verbesserte platin-arzneimittelformulierungen |
| HRP20160949T1 (hr) | 2007-09-10 | 2016-10-07 | Boston Biomedical, Inc. | Novi sastavi i metode za liječenje karcinoma |
| TWI468188B (zh) | 2008-01-30 | 2015-01-11 | Univ Tokushima | Anti-cancer effect enhancers consisting of oxaliplatin liposomal preparations and anticancer agents comprising the formulation |
| WO2011005769A1 (en) * | 2009-07-06 | 2011-01-13 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US8956600B2 (en) * | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| US20110070293A1 (en) * | 2009-09-23 | 2011-03-24 | Javeri Indu | Methods for the Preparation of Liposomes Comprising Docetaxel |
| US10143652B2 (en) * | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| WO2011102904A1 (en) * | 2010-02-19 | 2011-08-25 | Robert Shorr | Imageable lipid-oil-water nanoemulsion therapeutic delivery system |
| EP3366280A1 (de) * | 2010-03-12 | 2018-08-29 | Berg LLC | Intravenöse formulierungen aus dem coenzym q10 (coq10) und verfahren zur verwendung davon |
| CA2793527A1 (en) | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Use of naphthofuran derivatives in the treatment of cancer |
| WO2011128896A1 (en) * | 2010-04-12 | 2011-10-20 | Ramot At Tel-Aviv University Ltd. | Iron oxide nanoparticles for use in treating non-infectious inflammatory disorders |
| KR101819688B1 (ko) | 2010-11-12 | 2018-01-17 | 코어 파마슈티칼스 디벨롭먼트 컴퍼니 | 변형된 면역-조절 입자 |
| WO2012153616A1 (ja) * | 2011-05-10 | 2012-11-15 | 国立大学法人北海道大学 | 標的細胞移行能を有する脂質膜構造体、その製造方法および標的細胞において効果を示す物質のスクリーニング方法 |
| US20140161876A1 (en) * | 2011-07-15 | 2014-06-12 | Konica Minolta, Inc. | Liposome-containing preparation utilizing dissolution aid, and method for producing same |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| JP2015509085A (ja) * | 2012-01-01 | 2015-03-26 | キュービーアイ エンタープライゼズ リミテッドQbi Enterprises Ltd. | 治療剤および診断剤の選択的送達のためのendo180を標的とする粒子 |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| KR20220166879A (ko) * | 2012-06-21 | 2022-12-19 | 노쓰웨스턴유니버시티 | 펩티드 접합된 입자 |
| ES2733061T3 (es) | 2012-08-10 | 2019-11-27 | Taiho Pharmaceutical Co Ltd | Dispersión acuosa de liposomas encapsulantes de oxaliplatino estable y método para estabilización de la misma |
| US10188728B2 (en) | 2012-12-12 | 2019-01-29 | Temple University—Of the Commonwealth System of Higher Education | Compositions and methods for treatment of cancer |
| CN103083239B (zh) * | 2012-12-26 | 2015-11-25 | 中国人民解放军第四军医大学 | 一种蟾毒灵脂质体及其制备方法和应用 |
| TWI726291B (zh) | 2013-01-07 | 2021-05-01 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| US9468681B2 (en) | 2013-03-01 | 2016-10-18 | California Institute Of Technology | Targeted nanoparticles |
| BR112015022415A2 (pt) * | 2013-03-13 | 2017-07-18 | Mallinckrodt Llc | composições de cisplatina lipossômica para terapia contra câncer |
| IL303425A (en) | 2013-03-13 | 2023-08-01 | Cour Pharmaceuticals Dev Company | Secondary vaccine particles for the treatment of inflammation |
| WO2014159760A1 (en) * | 2013-03-13 | 2014-10-02 | Mallinckrodt Llc | Liposome oxaliplatin compositions for cancer therapy |
| WO2014169078A2 (en) | 2013-04-09 | 2014-10-16 | Boston Biomedical, Inc. | Methods for treating cancer |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| MX372849B (es) | 2013-08-13 | 2020-07-06 | Univ Northwestern | Partículas conjugadas con péptidos. |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| PT3066201T (pt) | 2013-11-07 | 2018-06-04 | Massachusetts Inst Technology | Métodos e composições relacionadas com crispr com arng reguladores |
| US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
| US20170007700A1 (en) * | 2014-02-21 | 2017-01-12 | The Curators Of The University Of Missouri | Compositions and methods for boron neutron capture therapy |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| US10098813B2 (en) * | 2014-09-03 | 2018-10-16 | Sun Pharmaceutical Industries Limited | Perfusion dosage form |
| EP4434997A3 (de) | 2014-10-30 | 2025-01-01 | President And Fellows Of Harvard College | Freisetzung von negativ geladenen proteinen unter verwendung von kationischen lipiden |
| US9816080B2 (en) | 2014-10-31 | 2017-11-14 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| KR20180019536A (ko) | 2015-06-24 | 2018-02-26 | 니폰 가야꾸 가부시끼가이샤 | 신규한 백금(ⅳ) 착물 |
| SG10201913073YA (en) | 2015-08-20 | 2020-03-30 | Ipsen Biopharm Ltd | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| SG10201913077QA (en) | 2015-08-21 | 2020-02-27 | Ipsen Biopharm Ltd | Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin |
| WO2017047497A1 (ja) | 2015-09-14 | 2017-03-23 | 日本化薬株式会社 | 6配位白金錯体の高分子結合体 |
| CN114073678A (zh) | 2015-10-16 | 2022-02-22 | 易普森生物制药有限公司 | 稳定喜树碱药物组合物 |
| EP3365356B1 (de) | 2015-10-23 | 2023-06-28 | President and Fellows of Harvard College | Nukleobaseeditoren und deren verwendungen |
| WO2017087685A1 (en) * | 2015-11-20 | 2017-05-26 | The Regents Of The University Of California | Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery |
| WO2017110669A1 (ja) | 2015-12-22 | 2017-06-29 | 日本化薬株式会社 | スルホキシド誘導体配位白金(ii)錯体の高分子結合体 |
| CN109678910B (zh) * | 2016-01-25 | 2021-09-07 | 沈阳药科大学 | 一种化合物及其应用以及一种铂类配合物及其脂质体 |
| CN109312341B (zh) | 2016-03-07 | 2024-02-27 | 美国政府(由卫生和人类服务部的部长所代表) | 微小rna及其使用方法 |
| AU2017251040B2 (en) * | 2016-04-15 | 2019-07-18 | Fujifilm Corporation | Microneedle array |
| AU2017284499A1 (en) * | 2016-06-17 | 2019-01-31 | Osaka University | Intratumoral vein formation promoter |
| EP3493790A4 (de) * | 2016-08-02 | 2020-03-25 | Curirx Inc. | Verfahren zur herstellung von liposomen |
| JP7231935B2 (ja) | 2016-08-03 | 2023-03-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | アデノシン核酸塩基編集因子およびそれらの使用 |
| EP3497214B1 (de) | 2016-08-09 | 2023-06-28 | President and Fellows of Harvard College | Programmierbare cas9-rekombinase-fusionsproteine und verwendungen davon |
| WO2018031967A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| CA3177187A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (de) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav-abgabe von nukleobasen-editoren |
| BR112019007844A2 (pt) | 2016-11-02 | 2019-07-16 | Ipsen Biopharm Ltd | tratamento de câncer gástrico usando terapias de combinação compreendendo irinotecano lipossômico, oxaliplatina, 5-fluoroacila (e leucovorina) |
| US11339209B2 (en) | 2016-11-14 | 2022-05-24 | Novartis Ag | Compositions, methods, and therapeutic uses related to fusogenic protein minion |
| CA3045306A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN110869006A (zh) * | 2017-05-12 | 2020-03-06 | 库里纳尔克斯有限公司 | 制备含药脂质体的方法 |
| JP2020520923A (ja) | 2017-05-17 | 2020-07-16 | ボストン バイオメディカル, インコーポレイテッド | がんを処置するための方法 |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (de) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | Hocheffiziente baseneditoren mit gam |
| CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3749320A4 (de) | 2018-02-07 | 2022-03-09 | L.E.A.F Holdings Group LLC | Alpha-polyglutamatiertes aminopterin und dessen verwendungen |
| US12128046B2 (en) | 2018-02-07 | 2024-10-29 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated methotrexate and uses thereof |
| EP3749317A4 (de) | 2018-02-07 | 2022-06-22 | L.E.A.F Holdings Group LLC | Alpha-polyglutamiertes pemetrexed und dessen verwendungen |
| CA3090506A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated tetrahydrofolates and uses thereof |
| WO2019157145A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated pemetrexed and uses thereof |
| CA3090391A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated raltitrexed and uses thereof |
| US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| CA3090381A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated lometrexol and uses thereof |
| WO2019157133A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| WO2019157129A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pralatrexate and uses thereof |
| WO2019160732A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| CA3090992A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| EP3752156A4 (de) | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | Gamma-polyglutamiertse pralatrexat und verwendungen davon |
| EP3752157A4 (de) | 2018-02-14 | 2022-07-06 | L.E.A.F Holdings Group LLC | Gamma-polyglutamatiertes lometrexol und verwendungen davon |
| CN111936145A (zh) | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
| WO2019200043A1 (en) * | 2018-04-11 | 2019-10-17 | New Mexico Tech University Research Park Coporation | Lipid prodrugs for use in drug delivery |
| CN108524450A (zh) * | 2018-04-16 | 2018-09-14 | 温州医科大学 | 基于磁性热敏阳离子脂质体的奥沙利铂和mdc1-as共传递药物载体的制备及应用 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2019241327A1 (en) | 2018-06-13 | 2019-12-19 | California Institute Of Technology | Nanoparticles for crossing the blood brain barrier and methods of treatment using the same |
| EP3856226A1 (de) | 2018-09-28 | 2021-08-04 | President and Fellows of Harvard College | Zelluläre umprogrammierung zur umkehrung der alterung und zur förderung der organ- und geweberegeneration |
| PT3864163T (pt) | 2018-10-09 | 2024-04-30 | Univ British Columbia | Composições e sistemas que compreendem vesículas competentes para transfeção isentas de solventes orgânicos e detergentes e métodos relacionados com as mesmas |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| WO2020154500A1 (en) | 2019-01-23 | 2020-07-30 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN111721841B (zh) * | 2019-03-19 | 2022-07-12 | 海南长安国际制药有限公司 | 与洛铂有关物质的检测 |
| MX2021011426A (es) | 2019-03-19 | 2022-03-11 | Broad Inst Inc | Metodos y composiciones para editar secuencias de nucleótidos. |
| EP3956349A1 (de) | 2019-04-17 | 2022-02-23 | The Broad Institute, Inc. | Adeninbaseneditoren mit reduzierten off-target-effekten |
| CN110292563B (zh) * | 2019-06-12 | 2021-07-16 | 兰州大学 | 基于叶酸热敏脂质体的阴离子载体诱导癌细胞凋亡的方法 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| JP7660132B2 (ja) * | 2020-03-04 | 2025-04-10 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 修飾リポソームを使用する組成物および方法 |
| JP2023521042A (ja) | 2020-04-02 | 2023-05-23 | ミレキュール インコーポレイテッド | 操作されたオリゴヌクレオチドを使用する標的化された阻害 |
| MX2022014008A (es) | 2020-05-08 | 2023-02-09 | Broad Inst Inc | Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo. |
| CN112129871B (zh) * | 2020-09-04 | 2021-06-15 | 斯微(上海)生物科技有限公司 | 复合磷脂脂质体中dope和m5两种磷脂含量的检测方法 |
| CN112870164B (zh) * | 2021-01-25 | 2021-12-17 | 山东大学 | 一种双靶向载药脂质体及其制备方法和应用 |
| WO2023196851A1 (en) | 2022-04-06 | 2023-10-12 | President And Fellows Of Harvard College | Reversing aging of the central nervous system |
| KR20250146635A (ko) | 2024-04-01 | 2025-10-13 | 고려대학교 산학협력단 | 리포좀 폴록사머 복합체를 포함하는 통증 질환 치료 조성물 |
Family Cites Families (156)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6041077B2 (ja) | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| GR75598B (de) | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
| US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4565696A (en) | 1983-08-03 | 1986-01-21 | The Regents Of The University Of California | Production of immunogens by antigen conjugation to liposomes |
| US4925661A (en) | 1984-04-19 | 1990-05-15 | Leaf Huang | Target-specific cytotoxic liposomes |
| US4789633A (en) | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4762915A (en) * | 1985-01-18 | 1988-08-09 | Liposome Technology, Inc. | Protein-liposome conjugates |
| WO1986004232A1 (en) * | 1985-01-18 | 1986-07-31 | Cooper-Lipotech, Inc. | Liposome composition and method |
| US5026651A (en) | 1985-04-25 | 1991-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the production of human transferrin |
| PH26160A (en) * | 1985-08-19 | 1992-03-18 | Univ Texas | Pharmaceutical compositions consisting of acylated phospholipids |
| US4983397A (en) | 1985-08-19 | 1991-01-08 | Board Of Regents, University Of Texas System | Pharmaceutical compositions consisting of acylated phospholipids |
| US5384127A (en) | 1985-10-18 | 1995-01-24 | Board Of Regents, The University Of Texas System | Stable liposomal formulations of lipophilic platinum compounds |
| JPH0714865B2 (ja) | 1986-10-28 | 1995-02-22 | 武田薬品工業株式会社 | リポソ−ム製剤およびその製造法 |
| US5049390A (en) | 1987-09-02 | 1991-09-17 | Allergy Immuno Technologies, Inc. | Liposome containing immunotherapy agents for treating IgE mediated allergies |
| US4853224A (en) | 1987-12-22 | 1989-08-01 | Visionex | Biodegradable ocular implants |
| FR2631826B1 (fr) | 1988-05-27 | 1992-06-19 | Centre Nat Rech Scient | Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation |
| JPH0720857B2 (ja) | 1988-08-11 | 1995-03-08 | テルモ株式会社 | リポソームおよびその製法 |
| DE69034042T2 (de) | 1989-08-02 | 2003-07-17 | Mitra Medical Technology Ab, Lund | System zur verwendung in einem verfahren zur therapeutischen und diagnostischen behandlung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| DE69108254T2 (de) * | 1990-10-09 | 1995-10-19 | Vestar Inc | Vesikel aus phospholipidderivaten mit einem succinimidylsubstituenten. |
| US5554728A (en) | 1991-07-23 | 1996-09-10 | Nexstar Pharmaceuticals, Inc. | Lipid conjugates of therapeutic peptides and protease inhibitors |
| US6509032B1 (en) | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
| US5292524A (en) | 1991-09-06 | 1994-03-08 | California Institute Of Technology | Blood platelet loaded with diagnostic or therapeutic-containing liposome or reconstituted Sendai virus |
| JPH0776230B2 (ja) | 1992-01-13 | 1995-08-16 | 田中貴金属工業株式会社 | 白金化合物の製造方法 |
| JPH06287021A (ja) | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| JP2673331B2 (ja) | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート(トランス―1―1,2―シクロヘキサンジアミン)白金(▲ii▼) |
| US20030190638A1 (en) | 1992-05-13 | 2003-10-09 | Board Of Regents, The University Of Texas System | Methods of screening for compounds that derepress or increase telomerase activity |
| US5962316A (en) | 1992-10-16 | 1999-10-05 | Cold Spring Harbor Laboratory | Cell-cycle regulatory proteins, and uses related thereto |
| US20030100489A1 (en) | 1992-10-16 | 2003-05-29 | Beach David H. | Cell-cycle regulatory proteins, and uses related thereto |
| WO1994026254A1 (en) | 1993-05-17 | 1994-11-24 | The Liposome Company, Inc. | Incorporation of taxol into liposomes and gels |
| JP3025602B2 (ja) | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
| US5534241A (en) | 1993-07-23 | 1996-07-09 | Torchilin; Vladimir P. | Amphipathic polychelating compounds and methods of use |
| PT671905E (pt) * | 1993-10-06 | 2002-12-31 | Amgen Inc | Composicoes estaveis de proteinas: fosfolipidos e respectivos metodos |
| CA2179014C (en) | 1993-12-17 | 2003-07-29 | Spinal Cord Society | Method for inducing dna synthesis in neurons |
| US6057299A (en) | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
| US5830686A (en) | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| IL113139A0 (en) | 1994-03-28 | 1995-06-29 | Nycomed Imaging As | Diagnostic compositions comprising imaging agents encapsulated in liposomes |
| EP0773921B1 (de) | 1994-07-29 | 1999-12-01 | Abbott Laboratories | Verfahren zur herstellung eines substituierten 2,5-diamino-3-hydroxy hexanes |
| KR100365171B1 (ko) | 1994-08-08 | 2003-02-19 | 드바이오팜 에스.아. | 약학적으로안정한옥살리플라티늄제제 |
| ES2153053T3 (es) * | 1994-10-14 | 2001-02-16 | Liposome Co Inc | Liposomas de eter-lipido y su uso terapeutico. |
| DE69531722T2 (de) | 1994-11-11 | 2004-07-01 | Debiopharm S.A. | Karzinostatische Zusammensetzungen, welche Cis-Oxaliplatin und eine oder mehrere andere verträgliche Karzinostatika enthalten |
| US5786214A (en) | 1994-12-15 | 1998-07-28 | Spinal Cord Society | pH-sensitive immunoliposomes and method of gene delivery to the mammalian central nervous system |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| US6008202A (en) | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| TW319763B (de) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US5780052A (en) | 1995-04-24 | 1998-07-14 | Northeastern University | Compositions and methods useful for inhibiting cell death and for delivering an agent into a cell |
| US5834012A (en) * | 1995-05-03 | 1998-11-10 | Roman Perez-Soler | Lipid complexed topoisomerase I inhibitors |
| US20020022264A1 (en) | 1995-05-26 | 2002-02-21 | Sullivan Sean M. | Delivery vehicles comprising stable lipid/nucleic acid complexes |
| US6825174B2 (en) | 1995-06-07 | 2004-11-30 | East Carolina University | Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation |
| JP3154399B2 (ja) | 1996-07-04 | 2001-04-09 | デビオファーム エス.アー. | 白金化合物の製造方法 |
| JPH09278785A (ja) | 1996-04-10 | 1997-10-28 | Tanaka Kikinzoku Kogyo Kk | 白金化合物の製造方法 |
| FR2740686B1 (fr) | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
| US6428977B1 (en) | 1995-12-20 | 2002-08-06 | Curis, Inc. | Signalin family of TGFβ signal transduction proteins, and uses related thereto |
| JP3735921B2 (ja) | 1996-02-07 | 2006-01-18 | 三菱ウェルファーマ株式会社 | GPIb・脂質複合体およびその用途 |
| US6077834A (en) | 1996-02-09 | 2000-06-20 | Cheng; Pi-Wan | Receptor ligand-facilitated delivery of biologically active molecules |
| WO1997033894A1 (fr) | 1996-03-11 | 1997-09-18 | Debiopharm Sa | Complexes de platine dinucleaires, procede pour leur preparation et compositions pharmaceutiques en contenant |
| JP2001521486A (ja) | 1996-03-28 | 2001-11-06 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ | 改良リポソーム組成物を製造するための材料および方法 |
| WO1997042166A1 (fr) | 1996-05-02 | 1997-11-13 | Terumo Kabushiki Kaisha | Derives amidines et vecteurs de medicaments les contenant |
| EP0929293B1 (de) | 1996-08-23 | 2003-10-22 | Sequus Pharmaceuticals, Inc. | Liposome enthaltend cisplatin |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| TW520297B (en) | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
| WO1998016240A1 (en) * | 1996-10-15 | 1998-04-23 | The Liposome Company, Inc. | Peptide-lipid conjugates, liposomes and liposomal drug delivery |
| NZ336538A (en) | 1996-10-15 | 2001-11-30 | Liposome Co Inc | N-acyl phosphatidylethanolamine-mediated liposomal drug delivery |
| WO1998027209A1 (en) | 1996-12-18 | 1998-06-25 | Emory University | Polycationic oligomers |
| DE69835824T2 (de) | 1997-03-07 | 2007-03-29 | Sanofi-Aventis U.S. Llc | Antitumorkombination aus 3-amino-1,2,4-benzotriazine 1,4-dioxid/paclitaxel/platin |
| DE19709704C2 (de) | 1997-03-10 | 1999-11-04 | Michael Georgieff | Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie |
| JPH10253632A (ja) | 1997-03-10 | 1998-09-25 | Nissui Pharm Co Ltd | 分析方法、キット及び装置 |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| US6060082A (en) | 1997-04-18 | 2000-05-09 | Massachusetts Institute Of Technology | Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery |
| US6524613B1 (en) | 1997-04-30 | 2003-02-25 | Regents Of The University Of Minnesota | Hepatocellular chimeraplasty |
| US6272370B1 (en) | 1998-08-07 | 2001-08-07 | The Regents Of University Of Minnesota | MR-visible medical device for neurological interventions using nonlinear magnetic stereotaxis and a method imaging |
| AU7984498A (en) | 1997-06-25 | 1999-01-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Serum-free cell growth medium |
| EP1007564A4 (de) | 1997-07-15 | 2002-09-18 | Univ California | Isolierte dns, die für einen menschlichen, durch kalzium aktivierbaren kaliumkanal kodiert |
| DE69838584T2 (de) | 1997-08-04 | 2008-06-26 | Cell Genesys, Inc., Foster City | Enhancer des menschlichen glandulären kallikreingens, vektoren die ihn enthalten und methoden für seine verwendung |
| DK1019094T3 (da) | 1997-10-02 | 2004-02-16 | Epix Medical Inc | Kontrastforstærket diagnostisk afbildningsmetode til monitorering af interventionelle terapier |
| US6749863B1 (en) | 1997-11-19 | 2004-06-15 | Georgetown University | Targeted liposome gene delivery |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| WO1999041403A1 (en) | 1998-02-12 | 1999-08-19 | The Regents Of The University Of California | Compositions for receptor/liposome mediated transfection and methods of using same |
| GB9804013D0 (en) | 1998-02-25 | 1998-04-22 | Sanofi Sa | Formulations |
| US6245427B1 (en) | 1998-07-06 | 2001-06-12 | DüZGüNES NEJAT | Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles |
| WO2000021527A2 (fr) | 1998-10-14 | 2000-04-20 | Debiopharm S.A. | Conditionnement d'une preparation d'oxaliplatine |
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| US7311924B2 (en) | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| JP2003502025A (ja) | 1999-05-17 | 2003-01-21 | エイブイアイ バイオファーマ, インコーポレイテッド | hcGワクチンを用いた癌の処置のための併用アプローチ |
| JP2001002592A (ja) | 1999-06-18 | 2001-01-09 | Dai Ichi Seiyaku Co Ltd | 遺伝子導入用組成物 |
| US6280054B1 (en) * | 1999-07-02 | 2001-08-28 | Zight Corporation | Image generator having an improved illumination system |
| US6242188B1 (en) | 1999-07-30 | 2001-06-05 | Applied Gene Technologies, Inc. | Sample processing to release nucleic acids for direct detection |
| EP1204241A1 (de) * | 1999-08-09 | 2002-05-08 | Fujitsu Limited | Vorrichtung und verfahren zur steuerung von baugruppen |
| DK1207875T3 (da) | 1999-08-30 | 2004-01-19 | Debiopharm Sa | Farmaceutisk stabilt oxaliplatin-præparat til parenteral administration |
| EP1242609A2 (de) | 1999-12-30 | 2002-09-25 | Novartis AG | Neue kolloidale synthetische vektoren zur gentherapie |
| US6960560B2 (en) | 1999-12-30 | 2005-11-01 | Gwathmey, Inc. | Iron chelator delivery system |
| US7034006B2 (en) * | 2000-01-10 | 2006-04-25 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of lipid conjugates in the treatment of disease |
| US6530944B2 (en) | 2000-02-08 | 2003-03-11 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
| US7001735B2 (en) | 2000-03-01 | 2006-02-21 | Albert Einstein College Of Medicine Of Yeshiva University | Glucose transporter/sensor protein and uses thereof |
| US6926884B2 (en) | 2000-03-02 | 2005-08-09 | Mitsubishi Pharma Corporation | GPIb-lipid bond construct and use thereof |
| JP4449147B2 (ja) | 2000-03-22 | 2010-04-14 | 日油株式会社 | ホスファチジルエタノールアミン誘導体の製造方法 |
| FR2806727A1 (fr) | 2000-03-23 | 2001-09-28 | Pf Medicament | Molecule d'interet pharmaceutique comprotant en son extremite n-terminale un acide glutamique ou une glutamine sous forme de sel d'addition d'acide fort physiologiquement acceptable |
| US20030170297A1 (en) | 2000-04-12 | 2003-09-11 | Kent Jorgensen | Lipid-based drug delivery systems containing phospholipase a2 degradable lipid derivatives for topical application to the skin |
| AU6627201A (en) | 2000-05-03 | 2001-11-12 | Mbt Munich Biotechnology Gmbh | Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites |
| US20030059461A1 (en) | 2000-06-06 | 2003-03-27 | Sibtech, Inc. | Molecular delivery vehicle for delivery of selected compounds to targets |
| US20030072794A1 (en) | 2000-06-09 | 2003-04-17 | Teni Boulikas | Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes |
| AU2002215004A1 (en) | 2000-09-11 | 2002-03-22 | Centre National De La Recherche Scientifique | Mitochondrial membrane permeabilization bv hiv-1 vpr and methods of screening |
| US20040234588A1 (en) | 2000-09-21 | 2004-11-25 | University Of Georgia Research Foundation, Inc. | Artificial lipoprotein carrier system for bioactive materials |
| DE60108405D1 (de) | 2000-10-03 | 2005-02-17 | Debiopharm Sa | Plga/pla-typ mikrokugeln enthaltend eine wasserlösliche verbindung und herstellungsverfahren dafür |
| US20030129223A1 (en) * | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| EP1209469A1 (de) * | 2000-11-22 | 2002-05-29 | Vectron Therapeutics AG | Herstellung und Verwendung eines gezielten diagnostischen Systems |
| NZ526300A (en) | 2000-12-12 | 2004-12-24 | Australian Inst Marine Science | Detecting the presence of toxins (PSTs) in marine organisms by biochemical, physiological or chemical assays |
| US7012072B2 (en) * | 2000-12-12 | 2006-03-14 | Debiopharm S.A. | Pharmaceutical oxaliplatinum preparation for parenteral administration and method for obtaining same |
| US6897196B1 (en) | 2001-02-07 | 2005-05-24 | The Regents Of The University Of California | pH sensitive lipids based on ortho ester linkers, composition and method |
| US6703524B2 (en) | 2001-02-20 | 2004-03-09 | Lkt Laboratories, Inc. | Organoselenium compounds for cancer chemoprevention |
| DK1368022T3 (da) | 2001-03-02 | 2007-10-01 | Debiopharm Sa | Anvendelse af en flaske indeholdende en oxaliplatinoplösning |
| FI113840B (fi) | 2001-03-26 | 2004-06-30 | Ctt Cancer Targeting Tech Oy | Matriisi-metalloproteinaasi-inhibiittorien käyttö liposomien kohdentamisessa |
| US20040049022A1 (en) | 2001-04-24 | 2004-03-11 | Nyce Jonathan W. | Composition & methods for treatment and screening |
| US20030203865A1 (en) | 2001-04-30 | 2003-10-30 | Pierrot Harvie | Lipid-comprising drug delivery complexes and methods for their production |
| US20030082228A1 (en) | 2001-05-09 | 2003-05-01 | Inex Pharmaceuticals Corporation | Anti-angiogenic therapy using liposome-encapsulated chemotherapeutic agents |
| US20030108986A1 (en) | 2001-06-21 | 2003-06-12 | Euroscreen, S.A. | Compositions and methods comprising G-protein coupled receptors |
| WO2003004505A1 (en) | 2001-07-02 | 2003-01-16 | Debiopharm S.A. | Oxaliplatin active substance with a very low content of oxalic acid |
| US20030096299A1 (en) | 2001-07-09 | 2003-05-22 | Valerie Wittamer | Natural ligand of G protein coupled receptor ChemR23 and uses thereof |
| WO2003015521A1 (en) | 2001-08-20 | 2003-02-27 | Transave, Inc. | Treatment of cancers by inhalation of stable platinum-containing formulations |
| DE10144252A1 (de) | 2001-08-31 | 2003-03-27 | Fraunhofer Ges Forschung | Nanopartikel mit daran immobilisiertem biologisch aktivem TNF |
| WO2003028640A2 (en) | 2001-10-03 | 2003-04-10 | Vanderbilt University | In vivo panning for ligands to radiation-induced molecules |
| WO2003044214A2 (en) | 2001-11-20 | 2003-05-30 | Baylor College Of Medicine | Methods and compositions in checkpoint signaling |
| JP4468617B2 (ja) | 2001-12-04 | 2010-05-26 | デビオファーム エス.アー. | 抗癌剤の併用投与方法及び併用可能な抗癌剤 |
| US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| AU2003202542A1 (en) | 2002-01-07 | 2003-07-24 | Euroscreen S.A. | Ligand for g-protein coupled receptor gpr43 and uses thereof |
| US20030220284A1 (en) | 2002-02-22 | 2003-11-27 | Patricia Yotnda | Delivery of adenoviral DNA in a liposomal formulation for treatment of disease |
| WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| EP1483294B2 (de) | 2002-03-01 | 2019-10-30 | Immunomedics, Inc. | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen |
| WO2003082907A1 (en) | 2002-03-29 | 2003-10-09 | Euroscreen Sa | Ligands for g protein coupled receptor gpr7 and uses thereof |
| CA2391438A1 (en) | 2002-05-01 | 2003-11-01 | Procyon Biopharma Inc. | Psp94 diagnostic reagents and assays |
| US20030228285A1 (en) | 2002-05-03 | 2003-12-11 | Mien-Chie Hung | Bipartite T-cell factor (Tcf)-responsive promoter |
| US7460960B2 (en) | 2002-05-10 | 2008-12-02 | Epitome Biosystems, Inc. | Proteome epitope tags and methods of use thereof in protein modification analysis |
| US20040022842A1 (en) | 2002-06-03 | 2004-02-05 | Mebiopharm Co., Ltd. | Liposome preparations containing oxaliplatin |
| FR2840236B1 (fr) | 2002-06-03 | 2005-02-04 | Inst Francais Du Petrole | Membrane zeolithique de faible epaisseur, sa preparation et son utilisation en separation |
| JP3415131B1 (ja) | 2002-06-03 | 2003-06-09 | メビオファーム株式会社 | リポソーム製剤 |
| WO2003103723A2 (en) | 2002-06-07 | 2003-12-18 | Immunomedics, Inc. | Neutrophil imaging methods in cyctic fibrosis |
| KR101228124B1 (ko) | 2002-06-14 | 2013-01-31 | 이뮤노메딕스, 인코오포레이티드 | 단클론 항체 pam4 및 췌장암의 진단 및 치료를 위한이들의 용도 |
| MXPA04012656A (es) | 2002-06-14 | 2005-08-15 | Immunomedics Inc | Anticuerpo hpam4 monoclonal humanizado. |
| US6790632B2 (en) | 2002-06-17 | 2004-09-14 | Stephen Eliot Zweig | Membrane receptor reagent and assay |
| ATE485031T1 (de) | 2002-06-28 | 2010-11-15 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| EP1546203B1 (de) | 2002-08-01 | 2012-06-20 | Immunomedics, Inc. | Alpha-fetoprotein-immu31-antikörper und fusionsproteine und verfahren zu deren anwendung |
| US20040132652A1 (en) | 2002-08-30 | 2004-07-08 | Shire Biochem Inc. | Pharmaceutical compositions |
| WO2004045519A2 (en) | 2002-11-14 | 2004-06-03 | Kirk Sperber | Induction of apoptosis by hiv-1 infected monocytic cells |
| US20060141019A1 (en) | 2002-11-15 | 2006-06-29 | Toshiya Kai | Liposome |
| US20060062766A1 (en) | 2003-02-17 | 2006-03-23 | Naoki Utoguchi | Remedy for cancer |
| WO2004094613A2 (en) | 2003-04-22 | 2004-11-04 | Ibc Pharmaceuticals | Polyvalent protein complex |
| CA2529027C (en) | 2003-06-13 | 2013-09-10 | Immunomedics, Inc. | D-amino acid peptides |
| US7109304B2 (en) | 2003-07-31 | 2006-09-19 | Immunomedics, Inc. | Humanized anti-CD19 antibodies |
| JP2005154282A (ja) | 2003-11-20 | 2005-06-16 | Mebiopharm Co Ltd | ガス封入リポソームの製造法 |
| US7582430B2 (en) * | 2004-01-20 | 2009-09-01 | United States Of America As Represented By The Secretary Of The Army | Immunoliposome-nucleic acid amplification (ILNAA) assay |
| US7212869B2 (en) * | 2004-02-04 | 2007-05-01 | Medtronic, Inc. | Lead retention means |
| CN1679957B (zh) | 2004-03-15 | 2010-06-09 | 尼普洛株式会社 | 含脂质体的癌症治疗用药物组合物 |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| WO2008030818A2 (en) | 2006-09-05 | 2008-03-13 | Mebiopharm Co., Ltd. | Novel liposome compositions |
-
2005
- 2005-03-10 JP JP2005067469A patent/JP2006248978A/ja active Pending
-
2006
- 2006-03-08 BR BRPI0608297-1A patent/BRPI0608297A2/pt not_active IP Right Cessation
- 2006-03-08 AU AU2006223329A patent/AU2006223329B2/en not_active Ceased
- 2006-03-08 KR KR1020077023219A patent/KR101352490B1/ko not_active Expired - Fee Related
- 2006-03-08 PL PL06737793T patent/PL1863448T3/pl unknown
- 2006-03-08 SI SI200631892T patent/SI1863448T1/sl unknown
- 2006-03-08 HU HUE06737793A patent/HUE024290T2/en unknown
- 2006-03-08 ES ES06737793.7T patent/ES2529453T3/es active Active
- 2006-03-08 WO PCT/US2006/008650 patent/WO2006099169A2/en not_active Ceased
- 2006-03-08 MX MX2007010996A patent/MX2007010996A/es active IP Right Grant
- 2006-03-08 NZ NZ561569A patent/NZ561569A/en not_active IP Right Cessation
- 2006-03-08 JP JP2008500977A patent/JP5438317B2/ja not_active Expired - Fee Related
- 2006-03-08 ZA ZA200708600A patent/ZA200708600B/xx unknown
- 2006-03-08 RU RU2007137492/15A patent/RU2454229C2/ru not_active IP Right Cessation
- 2006-03-08 CA CA002600446A patent/CA2600446A1/en not_active Abandoned
- 2006-03-08 EP EP06737793.7A patent/EP1863448B1/de active Active
- 2006-03-08 US US11/371,586 patent/US7829113B2/en not_active Expired - Fee Related
- 2006-03-08 PT PT67377937T patent/PT1863448E/pt unknown
- 2006-03-08 CN CN2006800159670A patent/CN101170995B/zh not_active Expired - Fee Related
- 2006-03-08 DK DK06737793.7T patent/DK1863448T3/en active
-
2007
- 2007-10-09 NO NO20075136A patent/NO20075136L/no not_active Application Discontinuation
-
2010
- 2010-09-27 US US12/891,568 patent/US8758810B2/en not_active Expired - Fee Related
-
2014
- 2014-05-09 US US14/274,377 patent/US20140363491A1/en not_active Abandoned
-
2015
- 2015-02-06 CY CY20151100123T patent/CY1116075T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101170995A (zh) | 2008-04-30 |
| WO2006099169A2 (en) | 2006-09-21 |
| BRPI0608297A2 (pt) | 2009-12-08 |
| US20110081404A1 (en) | 2011-04-07 |
| KR101352490B1 (ko) | 2014-02-04 |
| US8758810B2 (en) | 2014-06-24 |
| JP2006248978A (ja) | 2006-09-21 |
| EP1863448A2 (de) | 2007-12-12 |
| CY1116075T1 (el) | 2017-02-08 |
| DK1863448T3 (en) | 2015-02-16 |
| ZA200708600B (en) | 2009-01-28 |
| JP2008538105A (ja) | 2008-10-09 |
| PT1863448E (pt) | 2015-02-10 |
| ES2529453T3 (es) | 2015-02-20 |
| CN101170995B (zh) | 2013-01-16 |
| US7829113B2 (en) | 2010-11-09 |
| US20140363491A1 (en) | 2014-12-11 |
| CA2600446A1 (en) | 2006-09-21 |
| AU2006223329A1 (en) | 2006-09-21 |
| NO20075136L (no) | 2007-12-07 |
| RU2007137492A (ru) | 2009-04-20 |
| SI1863448T1 (sl) | 2015-03-31 |
| US20060222696A1 (en) | 2006-10-05 |
| KR20080002819A (ko) | 2008-01-04 |
| HUE024290T2 (en) | 2016-01-28 |
| MX2007010996A (es) | 2007-11-07 |
| AU2006223329B2 (en) | 2011-11-17 |
| HK1111625A1 (en) | 2008-08-15 |
| WO2006099169A3 (en) | 2007-02-22 |
| RU2454229C2 (ru) | 2012-06-27 |
| JP5438317B2 (ja) | 2014-03-12 |
| NZ561569A (en) | 2011-03-31 |
| EP1863448B1 (de) | 2014-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA200708600B (en) | Novel liposome compositions | |
| IL229521A0 (en) | A new preparation | |
| IL185901A0 (en) | Novel composition | |
| IL191572A0 (en) | Pestcidal compositions | |
| IL186721A0 (en) | Bioenhanced compositions | |
| GB0503337D0 (en) | Compositions | |
| IL186093A0 (en) | Lignan-containing compositions | |
| GB0526283D0 (en) | Compositions | |
| GB0501365D0 (en) | Compositions | |
| GB0524128D0 (en) | Compositions | |
| GB0506044D0 (en) | Composition | |
| GB0507167D0 (en) | Composition | |
| EP1847249A4 (de) | Haarfärbezusammensetzung | |
| GB0502479D0 (en) | Novel compositions | |
| GB0502475D0 (en) | Novel compositions | |
| ZA200709913B (en) | Bioenhanced compositions | |
| EP1947129A4 (de) | Photoradikal- und photokationenhärtbare zusammensetzung | |
| GB0525321D0 (en) | Novel compositions | |
| GB0505760D0 (en) | Novel composition | |
| GB0526282D0 (en) | Compositions | |
| GB0524803D0 (en) | Novel compositions | |
| GB0502341D0 (en) | Composition | |
| GB0513367D0 (en) | Novel composition | |
| GB0425445D0 (en) | Novel compositions | |
| GB0501364D0 (en) | Compositions |