PL110392B1 - Method of producing new derivatives of 9-chloroprednisolone - Google Patents

Method of producing new derivatives of 9-chloroprednisolone Download PDF

Info

Publication number
PL110392B1
PL110392B1 PL1977201161A PL20116177A PL110392B1 PL 110392 B1 PL110392 B1 PL 110392B1 PL 1977201161 A PL1977201161 A PL 1977201161A PL 20116177 A PL20116177 A PL 20116177A PL 110392 B1 PL110392 B1 PL 110392B1
Authority
PL
Poland
Prior art keywords
dione
hydroxy
pregnadiene
chloro
butyryloxy
Prior art date
Application number
PL1977201161A
Other languages
English (en)
Polish (pl)
Other versions
PL201161A1 (pl
Inventor
Klaus Annen
Henry Laurent
Helmut Hofmeister
Rudolf Wiechert
Hans Wendt
Joachim F Kapp
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2645105A external-priority patent/DE2645105C2/de
Priority claimed from DE19772742982 external-priority patent/DE2742982C2/de
Application filed by Schering Ag filed Critical Schering Ag
Publication of PL201161A1 publication Critical patent/PL201161A1/xx
Publication of PL110392B1 publication Critical patent/PL110392B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL1977201161A 1976-10-04 1977-09-30 Method of producing new derivatives of 9-chloroprednisolone PL110392B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2645105A DE2645105C2 (de) 1976-10-04 1976-10-04 Derivate des 9-Chlorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat
DE19772742982 DE2742982C2 (de) 1977-09-21 1977-09-21 9-Chlorprednisolon-Derivate, Verfahren zu deren Herstellung und diese enthaltendes pharmazeutisches Präparat

Publications (2)

Publication Number Publication Date
PL201161A1 PL201161A1 (pl) 1979-01-29
PL110392B1 true PL110392B1 (en) 1980-07-31

Family

ID=25770978

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1977201161A PL110392B1 (en) 1976-10-04 1977-09-30 Method of producing new derivatives of 9-chloroprednisolone

Country Status (21)

Country Link
JP (1) JPS5359654A (de)
AT (1) AT358202B (de)
CH (4) CH630098A5 (de)
DK (1) DK438277A (de)
ES (1) ES462887A1 (de)
FI (1) FI58645C (de)
FR (1) FR2366313A1 (de)
GB (1) GB1594852A (de)
GR (1) GR73041B (de)
HU (1) HU179593B (de)
IE (1) IE45877B1 (de)
IL (1) IL53030A (de)
IT (1) IT1113623B (de)
LU (1) LU78223A1 (de)
NL (1) NL7710869A (de)
NO (1) NO148597C (de)
NZ (1) NZ185295A (de)
PL (1) PL110392B1 (de)
PT (1) PT67109B (de)
SE (1) SE431655B (de)
SU (2) SU743581A3 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2853785A1 (de) * 1978-12-11 1980-06-19 Schering Ag Neue prednison-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende pharmazeutische praeparate und deren verwendung
JPH0374245A (ja) * 1989-08-12 1991-03-28 Mk Seiko Co Ltd 洗車機
KR20170018974A (ko) 2010-03-26 2017-02-20 갈데르마 리써어치 앤드 디벨로프먼트 홍반의 유효하고 안전한 치료를 위한 개선된 방법 및 조성물
BR112014009210A2 (pt) 2011-10-19 2017-04-18 Galderma Sa método para a redução da vermelhidão facial cutânea
CN106632561A (zh) * 2016-12-16 2017-05-10 广州仁恒医药科技股份有限公司 一种二氟泼尼酯的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1195748B (de) * 1961-06-24 1965-07-01 Vismara Francesco Spa Verfahren zur Herstellung von 1'-substituierten 17alpha, 21-(1'-Alkoxy)-methylendioxysterioden
DE2055221A1 (en) * 1970-11-10 1972-05-18 Laboratorio Chimico Farmaceutico Dr. P. Blasina S.R.L., Mailand (Italien) 17-acyloxy-3-keto-pregn-4-enes prepn - by acylating 17-hydroxy steroids in presence ofstannic chloride

Also Published As

Publication number Publication date
ATA703577A (de) 1980-01-15
NO148597B (no) 1983-08-01
GR73041B (de) 1984-01-26
LU78223A1 (de) 1978-02-01
FI58645C (fi) 1981-03-10
AT358202B (de) 1980-08-25
SE431655B (sv) 1984-02-20
ES462887A1 (es) 1978-12-16
JPS5359654A (en) 1978-05-29
IE45877B1 (en) 1982-12-15
CH632772A5 (en) 1982-10-29
HU179593B (en) 1982-11-29
JPS6129960B2 (de) 1986-07-10
PT67109B (de) 1979-03-14
DK438277A (da) 1978-04-05
NZ185295A (en) 1980-04-28
FI772922A7 (fi) 1978-04-05
CH630098A5 (en) 1982-05-28
IL53030A (en) 1982-11-30
SE7711039L (sv) 1978-04-05
SU743581A3 (ru) 1980-06-25
FR2366313B1 (de) 1980-02-01
NL7710869A (nl) 1978-04-06
FI58645B (fi) 1980-11-28
GB1594852A (en) 1981-08-05
FR2366313A1 (fr) 1978-04-28
SU751327A3 (ru) 1980-07-23
PT67109A (de) 1977-11-01
IL53030A0 (en) 1977-11-30
CH631997A5 (en) 1982-09-15
NO773362L (no) 1978-04-05
CH632278A5 (en) 1982-09-30
PL201161A1 (pl) 1979-01-29
NO148597C (no) 1983-11-09
IE45877L (en) 1978-04-04
IT1113623B (it) 1986-01-20

Similar Documents

Publication Publication Date Title
CA2081205C (en) Steroids which inhibit angiogenesis
DE69710065T2 (de) Androsten-derivate
JP4388600B2 (ja) コルチコイド化合物の硝酸エステル類およびその薬学的使用
JP3333210B2 (ja) 新規プレドニソロン誘導体および該化合物を含有する薬剤
CZ149693A3 (en) Novel steroids
US5972922A (en) Steroids which inhibit angiogenesis
US4910192A (en) Topically active steroidal anti-inflammatory agents
US5801165A (en) Antiinflammatory, immunosuppressive and antialleric 16, 17-alkylidioxy-steroids
HU190746B (en) Process for producing 6-alpha-methyl-corticoides and pharmaceutical compositions containing them
PL110392B1 (en) Method of producing new derivatives of 9-chloroprednisolone
CA1251784A (en) Steroids esterified in position 17 and thioesterified in position 21, a process for preparing them and their use as medicaments
US4777165A (en) 6α, 16β-dimethyl corticoids and their anti-inflammatory use
EP0387091A2 (de) Steroiddiole, Verfahren zu deren Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten
DE3687239T2 (de) 16,17-acetal-substituierte androstane-17-beta-carbonsaeureester, verfahren zu deren herstellung und pharmazeutische praeparate die diese enthalten.
JPH0419238B2 (de)
US4232013A (en) 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives
GB1603281A (en) Derivatives of 9-fluoroprednisolone
DE2645105C2 (de) Derivate des 9-Chlorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat
CS244663B2 (cs) Způsob výroby nových derivátů 9-chlorprednisolonu
EP0019763B1 (de) Neue Kortikoide, ihre Herstellung und Verwendung
CS244662B2 (cs) Způsob výroby nových derivátů 9-chlorprednisolonu
DE2809732A1 (de) Neue derivate des 9-fluorprednisolons
AT373604B (de) Verfahren zur herstellung von neuen derivaten des 9-chlorprednisolons
CS199512B2 (cs) Způsob výroby kortikoidfi
CS207756B2 (cs) Způsob výroby v poloze 17 substituovaných 11β-bydroxysteroidů pregnanové řady