PE8398A1 - Compuestos antibacterianos - Google Patents

Compuestos antibacterianos

Info

Publication number
PE8398A1
PE8398A1 PE1996000335A PE00033596A PE8398A1 PE 8398 A1 PE8398 A1 PE 8398A1 PE 1996000335 A PE1996000335 A PE 1996000335A PE 00033596 A PE00033596 A PE 00033596A PE 8398 A1 PE8398 A1 PE 8398A1
Authority
PE
Peru
Prior art keywords
cyclloalkyl
alkyl
group
heterociclo
aryl
Prior art date
Application number
PE1996000335A
Other languages
English (en)
Inventor
Gerd Ascher
Johannes Ludescher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT79495A external-priority patent/AT402820B/de
Priority claimed from AT99295A external-priority patent/AT402821B/de
Priority claimed from AT69896A external-priority patent/AT403283B/de
Priority claimed from AT73396A external-priority patent/AT403284B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Publication of PE8398A1 publication Critical patent/PE8398A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N3/00—Preservation of plants or parts thereof, e.g. inhibiting evaporation, improvement of the appearance of leaves or protection against physical influences such as UV radiation using chemical compositions; Grafting wax
    • A01N3/02—Keeping cut flowers fresh chemically
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A01N37/04—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof polybasic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/46—N-acyl derivatives
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • A01N57/20—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds containing acyclic or cycloaliphatic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05F—ORGANIC FERTILISERS NOT COVERED BY SUBCLASSES C05B, C05C, e.g. FERTILISERS FROM WASTE OR REFUSE
    • C05F11/00—Other organic fertilisers
    • C05F11/10—Fertilisers containing plant vitamins or hormones
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G3/00—Mixtures of one or more fertilisers with additives not having a specially fertilising activity
    • C—CHEMISTRY; METALLURGY
    • C05—FERTILISERS; MANUFACTURE THEREOF
    • C05G—MIXTURES OF FERTILISERS COVERED INDIVIDUALLY BY DIFFERENT SUBCLASSES OF CLASS C05; MIXTURES OF ONE OR MORE FERTILISERS WITH MATERIALS NOT HAVING A SPECIFIC FERTILISING ACTIVITY, e.g. PESTICIDES, SOIL-CONDITIONERS, WETTING AGENTS; FERTILISERS CHARACTERISED BY THEIR FORM
    • C05G5/00—Fertilisers characterised by their form
    • C05G5/20—Liquid fertilisers
    • C05G5/23—Solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W30/00—Technologies for solid waste management
    • Y02W30/40—Bio-organic fraction processing; Production of fertilisers from the organic fraction of waste or refuse

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE AL 7-AMINO Y AL 7-ACILAMINO-3-(IMINO)METILCEFALOSPORINA DE FORMULA (I) EN DONDE: R1 ES H O ESTER; R2 ES -OY, -NR4R5 O -N=R6, EN DONDE: "Y" ES H, ALQUILO O ALQUENILO, ENTRE OTROS; R4 ES H, ALQUILO O CICLOALQUILO, ENTRE OTROS; R5 ES R4 O UN GRUPO DE FORMULA -C(SR7)(=NR8), -C(Z)(NR8R10) O -C(Z)(R11), EN DONDE: R7 ES ALQUILO O ARILO; R8 ES R9 O CICLOALQUILO; R9 ES H O ALQUILO; R10 ES R8, HETEROCICLO O -N=CH-ARILO, ENTRE OTROS; "Z" ES O, S O NR13, EN DONDE: R13 ES R8; R11 ES R8, ARILO O HETEROCICLO; R6 ES HETEROCICLO; AC ES -CO-C(Z1)=CZ2Z3 o -CO-C(Z1)=B-D-Z4, ENTRE OTROS, EN DONDE: "B" ES N o CH; "D" ES O o CH2; "Z1" ES ARILO O CICLOALQUILO, ENTRE OTROS; "Z2" ES R9 o -CH2COOZ5, EN DONDE "Z5" ES R8; "Z3" ES R9; "Z4" ES H O RADICAL ORGANICO. TAMBIEN SE REFIERE A LOS PROCEDIMIENTOS QUE COMPRENDEN: PARA OBTENER EL DERIVADO 7-AMINO: HACER REACCIONAR H2N-R2, PREFERENTEMENTE H2N-N(Rz)-C(=Ry)(Rx), DONDE: Rz ES H; Ry ES NH, NC4H9 O CICLOALQUILO, ENTRE OTROS; Rx ES PIPERAZINILO, PIRROLIDINILO o -N=CH-FENILO, ENTRE OTROS; CON EL COMPUESTO DE FORMULA (IV), DONDE: a) Rb ES OH; Rc Y Rd FORMAN UN ENLACE; O b) Rd ES H, UN CATION, UN GRUPO QUE FORMA ESTER O UN GRUPO SILILO; Rb Y Rc JUNTOS SIGNIFICAN OXO; Y PARA OBTENER EL COMPUESTO (I): HACER REACCIONAR EL DERIVADO 7-AMINO CON AC-X, EN DONDE "X" ES UN GRUPO SALIENTE
PE1996000335A 1995-05-11 1996-05-13 Compuestos antibacterianos PE8398A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT79495A AT402820B (de) 1995-05-11 1995-05-11 Organische verbindungen
AT99295A AT402821B (de) 1995-06-12 1995-06-12 Organische verbindungen
AT69896A AT403283B (de) 1996-04-17 1996-04-17 3-methylimino-3-cephemderivate
AT73396A AT403284B (de) 1996-04-23 1996-04-23 3-methylimino-3-cephemderivate

Publications (1)

Publication Number Publication Date
PE8398A1 true PE8398A1 (es) 1998-03-13

Family

ID=27421316

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000335A PE8398A1 (es) 1995-05-11 1996-05-13 Compuestos antibacterianos

Country Status (30)

Country Link
US (2) US6531465B1 (es)
EP (2) EP0824535B1 (es)
JP (2) JPH11506429A (es)
KR (1) KR100451336B1 (es)
CN (1) CN1142937C (es)
AR (1) AR001931A1 (es)
AT (2) ATE292637T1 (es)
AU (1) AU712814B2 (es)
BR (1) BR9608517A (es)
CA (1) CA2219656C (es)
CO (1) CO4750666A1 (es)
CY (1) CY2445B1 (es)
CZ (1) CZ352997A3 (es)
DE (2) DE69626389T2 (es)
DK (1) DK0824535T3 (es)
ES (1) ES2193246T3 (es)
HK (1) HK1008993A1 (es)
HU (1) HUP9801387A3 (es)
IL (2) IL132532A (es)
MX (1) MX9708696A (es)
NO (1) NO326126B1 (es)
NZ (1) NZ308518A (es)
PE (1) PE8398A1 (es)
PL (1) PL193133B1 (es)
PT (1) PT824535E (es)
RU (1) RU2183212C2 (es)
SK (1) SK284962B6 (es)
TW (1) TW452579B (es)
WO (1) WO1996035692A1 (es)
ZA (1) ZA963758B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405180B (de) * 1997-04-01 1999-06-25 Biochemie Gmbh Neue derivate von substituierten 3-cephem-4-carbonsäurederivaten und verfahren zu deren herstellung
CA2284501C (en) * 1997-04-01 2007-07-17 Biochemie Gesellschaft M.B.H. Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
US20020115852A1 (en) * 1997-04-01 2002-08-22 Gerd Ascher Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates
AT406772B (de) * 1998-03-23 2000-08-25 Biochemie Gmbh Antibakterielle 7-acylamino-3-iminomethyl- cephalosporine und verfahren zu deren herstellung
ATE285821T1 (de) * 1999-10-08 2005-01-15 Affinium Pharm Inc Fab i inhibitoren
KR100739830B1 (ko) * 2001-03-23 2007-07-13 주식회사 하원제약 세파로스포린 유도체의 제조방법
CA2444597A1 (en) * 2001-04-06 2002-10-06 Affinium Pharmaceuticals, Inc. Fab i inhibitors
AR040545A1 (es) 2002-07-15 2005-04-13 Sandoz Ag Cefalosporinas
JP4859460B2 (ja) 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
ATE409485T1 (de) * 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
KR101299399B1 (ko) * 2004-06-04 2013-08-22 아피늄 파마슈티컬스, 인크. 치료제, 및 그의 제조 및 사용 방법
JP2009518399A (ja) * 2005-12-05 2009-05-07 アフィニウム ファーマシューティカルズ， インク． Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
EP3255045A1 (en) 2007-02-16 2017-12-13 Debiopharm International SA Salts, prodrugs and polymorphs of fab i inhibitors
JP6085026B2 (ja) 2012-06-19 2017-02-22 デビオファーム インターナショナル エスエーＤｅｂｉｏｐｈａｒｍ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｓａ （ｅ）−ｎ−メチル−ｎ−（（３−メチルベンゾフラン−２−イル）メチル）−３−（７−オキソ−５，６，７，８−テトラヒドロ−１，８−ナフチリジン−３−イル）アクリルアミドのプロドラッグ誘導体
CA3014541A1 (en) 2016-02-26 2017-08-31 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
TW202126664A (zh) 2019-09-06 2021-07-16 奧地利商納畢瓦治療有限責任公司 鐵載體頭孢菌素共軛物及其用途
CN110590814A (zh) * 2019-09-29 2019-12-20 天津力生制药股份有限公司 一种生产头孢唑林钠产生的二聚体杂质的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2333263A1 (de) * 1972-07-07 1974-01-24 Ciba Geigy Ag 7 beta-amino-3-oximinomethyl-cephem-4carbonsaeureverbindungen und verfahren zu ihrer herstellung
JPS5417030B2 (es) 1972-12-06 1979-06-27
DE2262500A1 (de) * 1972-12-20 1973-07-05 Lilly Co Eli 3-oxyiminomethylcephalosporinverbindungen
US4053469A (en) 1973-02-28 1977-10-11 Shionogi & Co., Ltd. Intermediates for the preparation of 7-acylamino-3-oxyiminomethyl-3-cephem-4-carboxylic acids
JPS49109391A (es) * 1973-02-28 1974-10-17
JPS49124091A (es) * 1973-03-30 1974-11-27
JPS5013389A (es) * 1973-06-08 1975-02-12
JPS5093989A (es) * 1973-10-25 1975-07-26
JPS5076085A (es) * 1973-10-31 1975-06-21
JPS5083391A (es) * 1973-11-28 1975-07-05
JPS5715597B2 (es) * 1973-12-20 1982-03-31
JPS50131982A (es) * 1974-04-05 1975-10-18
US4101658A (en) 1975-06-04 1978-07-18 Shionogi & Co., Ltd. Antibacterial hydrazono cephalosporins
JPS5283865A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Cephalosporin derivatives
JPS5470294A (en) * 1977-11-09 1979-06-05 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
US4258181A (en) * 1978-09-05 1981-03-24 American Cyanamid Company Substituted 9,10-anthracenebishydrazones
JPS56118085A (en) * 1980-02-25 1981-09-16 Takeda Chem Ind Ltd 2-methylcephalosporin derivative and its preparation
US20020115852A1 (en) * 1997-04-01 2002-08-22 Gerd Ascher Antibacterial substituted 7-acylamino-3-(methylhydrazono) methyl-cephalosporins and intermediates

Also Published As

Publication number Publication date
CA2219656A1 (en) 1996-11-14
PL193133B1 (pl) 2007-01-31
EP0824535B1 (en) 2003-02-26
HK1008993A1 (en) 1999-05-21
NO975151L (no) 1997-11-10
EP1221446B1 (en) 2005-04-06
MX9708696A (es) 1998-08-30
TW452579B (en) 2001-09-01
CN1186494A (zh) 1998-07-01
ATE292637T1 (de) 2005-04-15
HUP9801387A3 (en) 2000-12-28
NZ308518A (en) 2000-01-28
DK0824535T3 (da) 2003-06-02
JP2007023046A (ja) 2007-02-01
IL118221A (en) 2004-06-01
SK150397A3 (en) 1998-03-04
US6531465B1 (en) 2003-03-11
SK284962B6 (sk) 2006-03-02
CY2445B1 (en) 2004-11-12
NO326126B1 (no) 2008-09-29
BR9608517A (pt) 1999-06-08
PL323233A1 (en) 1998-03-16
EP0824535A1 (en) 1998-02-25
IL118221A0 (en) 1996-09-12
DE69634581T2 (de) 2006-02-09
EP1221446A1 (en) 2002-07-10
HUP9801387A2 (hu) 1999-01-28
CA2219656C (en) 2008-08-19
AR001931A1 (es) 1997-12-10
DE69626389D1 (de) 2003-04-03
JPH11506429A (ja) 1999-06-08
ZA963758B (en) 1997-11-10
IL132532A (en) 2003-06-24
PT824535E (pt) 2003-07-31
CN1142937C (zh) 2004-03-24
KR100451336B1 (ko) 2005-01-17
DE69626389T2 (de) 2003-10-09
WO1996035692A1 (en) 1996-11-14
ATE233268T1 (de) 2003-03-15
DE69634581D1 (de) 2005-05-12
CO4750666A1 (es) 1999-03-31
NO975151D0 (no) 1997-11-10
KR19990014669A (ko) 1999-02-25
US20030191105A1 (en) 2003-10-09
AU712814B2 (en) 1999-11-18
ES2193246T3 (es) 2003-11-01
RU2183212C2 (ru) 2002-06-10
AU5818496A (en) 1996-11-29
US7317101B2 (en) 2008-01-08
CZ352997A3 (cs) 1998-02-18

Similar Documents

Publication Publication Date Title
PE8398A1 (es) Compuestos antibacterianos
BR9607017A (pt) Composto e uso do mesmo
YU48390B (sh) Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate
AR043461A1 (es) Proceso para la manufactura de mercaptosilanos en bloque
CO4920223A1 (es) Derivados de 1,3,8-triaza-espiro[4,5]decan-4-ona 8- sustituidos
ES486991A1 (es) Un procedimiento para la preparacion de un derivado de car- boestirilo
AR240929A2 (es) "n-piridinsulfonil-n'-piridinil-y-triazinil-ureas procedimiento parasu preparacion, intermediarios para uso exclusivo en dicho procedimiento, y composiciones que contienen dichas ureas"
MY106366A (en) Bicyclic heterocyclic pryan derivatives and their use as inhibitors of 5-lipoxygenase
TW328089B (en) New azolidinediones as antihyperglycemic agents
MY101579A (en) Benzothiazolones, and their production and use
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
ES2063452T3 (es) Preparacion y uso de esteres y derivados de n-yodopropargil oxicarbonil aminoacido como agentes antimicrobianos.
ES2057834T3 (es) Compuestos de triazol de utilidad como desactivadores de metales.
GR3004629T3 (es)
ATE296300T1 (de) Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
CA2264065A1 (en) Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists
IE780139L (en) Isoquinolines and naphthyridines
ES2054806T3 (es) Cicloalquilamidas de (8beta)-1-alquil-6-(sustituido)-ergolinas.
SE8201214L (sv) Detergentforeningar och kompositioner
ES2093342T3 (es) Procedimiento para la preparacion de indanonas sustituidas.
EP0335979A4 (en) Thienopyrimidine derivatives
GB2020280A (en) 4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines
ES2002392A6 (es) Un procedimiento para la preparacion de esteres del acido 9,10- dihidrolisergico.
ATE6500T1 (de) 2-alpha-methyl-dopaminimino-6,7-dihydroxy-1,2,3 4-tetrahydronaphthalin, seine salze, und verfahren zu dessen herstellung.
FR2374316A1 (fr) Derives de morpholine utilisables comme fongicides

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed