JPS5470294A - Cephalosporin derivative and its preparation - Google Patents

Cephalosporin derivative and its preparation

Info

Publication number
JPS5470294A
JPS5470294A JP13493977A JP13493977A JPS5470294A JP S5470294 A JPS5470294 A JP S5470294A JP 13493977 A JP13493977 A JP 13493977A JP 13493977 A JP13493977 A JP 13493977A JP S5470294 A JPS5470294 A JP S5470294A
Authority
JP
Japan
Prior art keywords
formula
compound
cephalosporin
derivative
antibiotic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13493977A
Other languages
Japanese (ja)
Other versions
JPS636551B2 (en
Inventor
Taisuke Matsuo
Toru Sugawara
Yutaka Kuwata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP13493977A priority Critical patent/JPS5470294A/en
Publication of JPS5470294A publication Critical patent/JPS5470294A/en
Publication of JPS636551B2 publication Critical patent/JPS636551B2/ja
Granted legal-status Critical Current

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  • Cephalosporin Compounds (AREA)

Abstract

PURPOSE: The halogenation of a novel silyl derivative of cephalosporin is conducted to form a novel halogen derivative, which is then hydrolyzed or reacted with a hydrazine to prepare cephalosporin derivative useful as an antibiotic in high yield.
CONSTITUTION: The silylation product of a compound of formula I (R1 is H, lower alkoxy; R2 is amino, acylamino, imide) is subjected to halogenaton with molecular chlorine or bromine to form a compound of formula II. The hydrolysis of the product of formula II is conducted in a solvent of dioxane or acetone to obtain the compound of formula III. Or a compound of formula II is reacted with a compound of formula IV (Y is O,S, imino that may be substituted; B is H, OH, amino, hydrocarbyl) to produce the compound of formula V. USE;The compound of formula III is an antibiotic that is effective against bacteria resisting penicillin. The compound of formula II is useful as an intermeadiate for synthesizing a variety of cephalosporin derivatives.
COPYRIGHT: (C)1979,JPO&Japio
JP13493977A 1977-11-09 1977-11-09 Cephalosporin derivative and its preparation Granted JPS5470294A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13493977A JPS5470294A (en) 1977-11-09 1977-11-09 Cephalosporin derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13493977A JPS5470294A (en) 1977-11-09 1977-11-09 Cephalosporin derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5470294A true JPS5470294A (en) 1979-06-05
JPS636551B2 JPS636551B2 (en) 1988-02-10

Family

ID=15140078

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13493977A Granted JPS5470294A (en) 1977-11-09 1977-11-09 Cephalosporin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5470294A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996035692A1 (en) * 1995-05-11 1996-11-14 Biochemie Gesellschaft Mbh Antibacterial cephalosporins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996035692A1 (en) * 1995-05-11 1996-11-14 Biochemie Gesellschaft Mbh Antibacterial cephalosporins

Also Published As

Publication number Publication date
JPS636551B2 (en) 1988-02-10

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