JPS57140776A - Preparation of 2-aminothiazol-4-yl-alpha-oximinoacetic acid derivative - Google Patents

Preparation of 2-aminothiazol-4-yl-alpha-oximinoacetic acid derivative

Info

Publication number
JPS57140776A
JPS57140776A JP56197327A JP19732781A JPS57140776A JP S57140776 A JPS57140776 A JP S57140776A JP 56197327 A JP56197327 A JP 56197327A JP 19732781 A JP19732781 A JP 19732781A JP S57140776 A JPS57140776 A JP S57140776A
Authority
JP
Japan
Prior art keywords
aminothiazol
alpha
preparation
acid derivative
oximino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56197327A
Other languages
Japanese (ja)
Other versions
JPS5919945B2 (en
Inventor
Michihiko Ochiai
Taiichi Okada
Nobuchika Aki
Akira Morimoto
Kenji Kawakita
Yoshihiro Matsushita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP56197327A priority Critical patent/JPS5919945B2/en
Publication of JPS57140776A publication Critical patent/JPS57140776A/en
Publication of JPS5919945B2 publication Critical patent/JPS5919945B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Thiazole And Isothizaole Compounds (AREA)

Abstract

PURPOSE: To prepare the titled substance useful as a synthetic intermediate of penicillins and cephalosporins having antimicrobial activity, easily, by reacting α-oximino-β-keto-γ-halogenobutyric acid ester with a thiourea compound.
CONSTITUTION: The objective compound of formula III (COOR1 is carboxyl group which may be protected; R2NH is amino group which may be protected) is prepared by reacting the α-oximino-β-keto-γ-halogenobutyric acid ester of formulaI(X is halogen) with a thiourea compound of formula II in an organic solvent such as ethanol, tetrahydrofuran, etc. preferably in the presence of a base such as pyridine, triethylamine, etc. (the base is not necessary when R2 is H) at room temperature or under refluxing condition, and if necessary, removing the protecting groups.
COPYRIGHT: (C)1982,JPO&Japio
JP56197327A 1981-12-07 1981-12-07 Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative Expired JPS5919945B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56197327A JPS5919945B2 (en) 1981-12-07 1981-12-07 Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56197327A JPS5919945B2 (en) 1981-12-07 1981-12-07 Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP49146567A Division JPS5760345B2 (en) 1974-12-19 1974-12-19

Publications (2)

Publication Number Publication Date
JPS57140776A true JPS57140776A (en) 1982-08-31
JPS5919945B2 JPS5919945B2 (en) 1984-05-09

Family

ID=16372616

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56197327A Expired JPS5919945B2 (en) 1981-12-07 1981-12-07 Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative

Country Status (1)

Country Link
JP (1) JPS5919945B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010002705A (en) * 1999-06-17 2001-01-15 고두모 A new method for preparation of reactive phosphate derivatives of thiazole carboxylic acid

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61184807U (en) * 1985-05-09 1986-11-18
JPH0419693U (en) * 1990-06-05 1992-02-19
JPH0419694U (en) * 1990-06-05 1992-02-19
JPH0430296U (en) * 1990-07-07 1992-03-11

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010002705A (en) * 1999-06-17 2001-01-15 고두모 A new method for preparation of reactive phosphate derivatives of thiazole carboxylic acid

Also Published As

Publication number Publication date
JPS5919945B2 (en) 1984-05-09

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