JPS57140776A - Preparation of 2-aminothiazol-4-yl-alpha-oximinoacetic acid derivative - Google Patents
Preparation of 2-aminothiazol-4-yl-alpha-oximinoacetic acid derivativeInfo
- Publication number
- JPS57140776A JPS57140776A JP56197327A JP19732781A JPS57140776A JP S57140776 A JPS57140776 A JP S57140776A JP 56197327 A JP56197327 A JP 56197327A JP 19732781 A JP19732781 A JP 19732781A JP S57140776 A JPS57140776 A JP S57140776A
- Authority
- JP
- Japan
- Prior art keywords
- aminothiazol
- alpha
- preparation
- acid derivative
- oximino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
Abstract
PURPOSE: To prepare the titled substance useful as a synthetic intermediate of penicillins and cephalosporins having antimicrobial activity, easily, by reacting α-oximino-β-keto-γ-halogenobutyric acid ester with a thiourea compound.
CONSTITUTION: The objective compound of formula III (COOR1 is carboxyl group which may be protected; R2NH is amino group which may be protected) is prepared by reacting the α-oximino-β-keto-γ-halogenobutyric acid ester of formulaI(X is halogen) with a thiourea compound of formula II in an organic solvent such as ethanol, tetrahydrofuran, etc. preferably in the presence of a base such as pyridine, triethylamine, etc. (the base is not necessary when R2 is H) at room temperature or under refluxing condition, and if necessary, removing the protecting groups.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56197327A JPS5919945B2 (en) | 1981-12-07 | 1981-12-07 | Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56197327A JPS5919945B2 (en) | 1981-12-07 | 1981-12-07 | Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP49146567A Division JPS5760345B2 (en) | 1974-12-19 | 1974-12-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57140776A true JPS57140776A (en) | 1982-08-31 |
JPS5919945B2 JPS5919945B2 (en) | 1984-05-09 |
Family
ID=16372616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP56197327A Expired JPS5919945B2 (en) | 1981-12-07 | 1981-12-07 | Method for producing 2-aminothiazol-4-yl-α-oximinoacetic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5919945B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010002705A (en) * | 1999-06-17 | 2001-01-15 | 고두모 | A new method for preparation of reactive phosphate derivatives of thiazole carboxylic acid |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61184807U (en) * | 1985-05-09 | 1986-11-18 | ||
JPH0419693U (en) * | 1990-06-05 | 1992-02-19 | ||
JPH0419694U (en) * | 1990-06-05 | 1992-02-19 | ||
JPH0430296U (en) * | 1990-07-07 | 1992-03-11 |
-
1981
- 1981-12-07 JP JP56197327A patent/JPS5919945B2/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010002705A (en) * | 1999-06-17 | 2001-01-15 | 고두모 | A new method for preparation of reactive phosphate derivatives of thiazole carboxylic acid |
Also Published As
Publication number | Publication date |
---|---|
JPS5919945B2 (en) | 1984-05-09 |
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