GB2020280A - 4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines - Google Patents
4,5-Dihydroimidazol-Z-yl Amino Substituted IsoquinolinesInfo
- Publication number
- GB2020280A GB2020280A GB7913821A GB7913821A GB2020280A GB 2020280 A GB2020280 A GB 2020280A GB 7913821 A GB7913821 A GB 7913821A GB 7913821 A GB7913821 A GB 7913821A GB 2020280 A GB2020280 A GB 2020280A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- radical containing
- dihydroimidazol
- alkyl
- attached
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
New isoquinoline derivatives of the general formula; <IMAGE> wherein R1 represents a hydrogen atom or a hydroxyalkyl radical containing 1 to 4 carbon atoms, the imidazolin-2-ylamino group is attached to the 4-, 5-, 6-, 7- or 8- position of the isoquinoline nucleus, and the symbols R2 and R3, which have the same or different significances, are attached to carbon atoms in the remaining positions of the isoquinoline nucleus and each represents a hydrogen or halogen atom, an alkyl radical containing 1 to 4 carbon atoms, an alkoxy radical containing 1 to 4 carbon atoms, an alkoxyalkyl group in which the alkyl and alkoxy moieties each contain 1 to 4 carbon atoms; an alkylthio radical containing 1 to 4 carbon atoms, or a dialkylamino group in which each alkyl radical contains 1 to 4 carbon atoms, are useful as anti-hypertensive agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7812026A FR2424270A1 (en) | 1978-04-24 | 1978-04-24 | 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects |
FR7904004A FR2449087A2 (en) | 1979-02-16 | 1979-02-16 | 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2020280A true GB2020280A (en) | 1979-11-14 |
GB2020280B GB2020280B (en) | 1982-07-28 |
Family
ID=26220560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7913821A Expired GB2020280B (en) | 1978-04-24 | 1979-04-20 | 4,5-dihydroimidazol-z-yl amino substatuted isoquinolines |
Country Status (10)
Country | Link |
---|---|
AU (1) | AU4621979A (en) |
DE (1) | DE2916577A1 (en) |
DK (1) | DK166979A (en) |
ES (2) | ES479878A1 (en) |
GB (1) | GB2020280B (en) |
IT (1) | IT1112581B (en) |
LU (1) | LU81182A1 (en) |
NL (1) | NL7902993A (en) |
NZ (1) | NZ190245A (en) |
SE (1) | SE7903554L (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786364A (en) * | 1995-02-11 | 1998-07-28 | Astra Aktiebolag | Bicyclic isothiourea derivatives useful in therapy |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
US7767705B2 (en) | 2006-08-25 | 2010-08-03 | Abbott Laboratories | Compounds that inhibit TRPV1 and uses thereof |
US8030504B2 (en) | 2006-12-20 | 2011-10-04 | Abbott Laboratories | Antagonists of the TRPV1 receptor and uses thereof |
US8232411B2 (en) | 2008-03-20 | 2012-07-31 | Abbott Laboratories | Methods for making central nervous system agents that are TRPV1 antagonists |
-
1979
- 1979-04-17 NL NL7902993A patent/NL7902993A/en not_active Application Discontinuation
- 1979-04-20 GB GB7913821A patent/GB2020280B/en not_active Expired
- 1979-04-20 AU AU46219/79A patent/AU4621979A/en not_active Abandoned
- 1979-04-20 NZ NZ190245A patent/NZ190245A/en unknown
- 1979-04-23 SE SE7903554A patent/SE7903554L/en not_active Application Discontinuation
- 1979-04-23 LU LU81182A patent/LU81182A1/en unknown
- 1979-04-23 DK DK166979A patent/DK166979A/en active IP Right Grant
- 1979-04-24 ES ES479878A patent/ES479878A1/en not_active Expired
- 1979-04-24 DE DE19792916577 patent/DE2916577A1/en not_active Withdrawn
- 1979-04-24 IT IT22150/79A patent/IT1112581B/en active
- 1979-06-29 ES ES482070A patent/ES482070A1/en not_active Expired
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786364A (en) * | 1995-02-11 | 1998-07-28 | Astra Aktiebolag | Bicyclic isothiourea derivatives useful in therapy |
US6040314A (en) * | 1995-02-11 | 2000-03-21 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
US7217722B2 (en) * | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US8247413B2 (en) | 2002-02-20 | 2012-08-21 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US6933311B2 (en) | 2003-02-11 | 2005-08-23 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7767705B2 (en) | 2006-08-25 | 2010-08-03 | Abbott Laboratories | Compounds that inhibit TRPV1 and uses thereof |
US8815930B2 (en) | 2006-08-25 | 2014-08-26 | Abbvie Inc. | Compounds that inhibit TRPV1 and uses thereof |
US8030504B2 (en) | 2006-12-20 | 2011-10-04 | Abbott Laboratories | Antagonists of the TRPV1 receptor and uses thereof |
US8350083B2 (en) | 2006-12-20 | 2013-01-08 | Abbvie Inc. | Antagonists of the TRPV1 receptor and uses thereof |
US8232411B2 (en) | 2008-03-20 | 2012-07-31 | Abbott Laboratories | Methods for making central nervous system agents that are TRPV1 antagonists |
Also Published As
Publication number | Publication date |
---|---|
DK166979A (en) | 1979-10-25 |
LU81182A1 (en) | 1979-11-07 |
ES479878A1 (en) | 1980-08-16 |
IT7922150A0 (en) | 1979-04-24 |
DE2916577A1 (en) | 1979-10-31 |
ES482070A1 (en) | 1980-04-01 |
NZ190245A (en) | 1981-03-16 |
GB2020280B (en) | 1982-07-28 |
SE7903554L (en) | 1979-10-25 |
IT1112581B (en) | 1986-01-20 |
AU4621979A (en) | 1979-11-01 |
NL7902993A (en) | 1979-10-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |