FR2424270A1 - 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects - Google Patents
4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effectsInfo
- Publication number
- FR2424270A1 FR2424270A1 FR7812026A FR7812026A FR2424270A1 FR 2424270 A1 FR2424270 A1 FR 2424270A1 FR 7812026 A FR7812026 A FR 7812026A FR 7812026 A FR7812026 A FR 7812026A FR 2424270 A1 FR2424270 A1 FR 2424270A1
- Authority
- FR
- France
- Prior art keywords
- amino
- antihypertensives
- free
- low toxicity
- imidazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
derivs. of formula (I) and their acid salts are new. In (I), R1 = H or 1-4C hydroxyalkyl, the imidazolinyl-2-amino gp. is joined to posn 4, 5, 6, 7 or 8 of the isoquinoline ring and R2, R3 independently = H, halo, 1-4C alkyl, 1-4C alkoxy, 1-4C alkoxy-1-4C alkyl, 1-4C alkylthio or di(1-4C alkyl)amino. (I) are antihypertensives free of sedative side-effects which have low toxicity (oral LD50 in mice is greater than 150-200 mg/kg). They may be administered orally (4-200 mg daily for adults) or parenterally.
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7812026A FR2424270A1 (en) | 1978-04-24 | 1978-04-24 | 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects |
NL7902993A NL7902993A (en) | 1978-04-24 | 1979-04-17 | NEW ISOQUEINOLINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THE NEW ISOQUEINOLINE DERIVATIVES. |
GB7913821A GB2020280B (en) | 1978-04-24 | 1979-04-20 | 4,5-dihydroimidazol-z-yl amino substatuted isoquinolines |
NZ190245A NZ190245A (en) | 1978-04-24 | 1979-04-20 | Isoquinoline derivatives and pharmaceutical compositions containing them |
JP4889579A JPS557260A (en) | 1978-04-24 | 1979-04-20 | Isoquinoline derivative |
AU46219/79A AU4621979A (en) | 1978-04-24 | 1979-04-20 | Isoquinoline derivatives |
ZA791893A ZA791893B (en) | 1978-04-24 | 1979-04-20 | Isoquinoline derivatives |
BE0/194791A BE875797A (en) | 1978-04-24 | 1979-04-23 | NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
SE7903554A SE7903554L (en) | 1978-04-24 | 1979-04-23 | NEW ISOKINOLIN DERIVATIVES, PROCEDURES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
DK166979A DK166979A (en) | 1978-04-24 | 1979-04-23 | Agricultural roller with a working position and a transport position |
LU81182A LU81182A1 (en) | 1978-04-24 | 1979-04-23 | NEW ISOQUINOLEINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
DE19792916577 DE2916577A1 (en) | 1978-04-24 | 1979-04-24 | NEW DERIVATIVES OF ISOCHINOLINE, THEIR MANUFACTURING AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
IT22150/79A IT1112581B (en) | 1978-04-24 | 1979-04-24 | ISOKINOLINE DERIVATIVES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
ES479878A ES479878A1 (en) | 1978-04-24 | 1979-04-24 | 4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines |
ES482070A ES482070A1 (en) | 1978-04-24 | 1979-06-29 | 4,5-Dihydroimidazol-Z-yl Amino Substituted Isoquinolines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7812026A FR2424270A1 (en) | 1978-04-24 | 1978-04-24 | 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2424270A1 true FR2424270A1 (en) | 1979-11-23 |
FR2424270B1 FR2424270B1 (en) | 1980-09-19 |
Family
ID=9207497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7812026A Granted FR2424270A1 (en) | 1978-04-24 | 1978-04-24 | 4,5-Di:hydro-2-imidazolyl-amino-isoquinoline derivs. - useful as antihypertensives having low toxicity and free from sedative side effects |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS557260A (en) |
BE (1) | BE875797A (en) |
FR (1) | FR2424270A1 (en) |
ZA (1) | ZA791893B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3233424A1 (en) * | 1982-09-09 | 1984-03-15 | Hoechst Ag, 6230 Frankfurt | ISOCHINOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE |
-
1978
- 1978-04-24 FR FR7812026A patent/FR2424270A1/en active Granted
-
1979
- 1979-04-20 JP JP4889579A patent/JPS557260A/en active Pending
- 1979-04-20 ZA ZA791893A patent/ZA791893B/en unknown
- 1979-04-23 BE BE0/194791A patent/BE875797A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA791893B (en) | 1980-04-30 |
BE875797A (en) | 1979-10-23 |
JPS557260A (en) | 1980-01-19 |
FR2424270B1 (en) | 1980-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |