US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
US4476301A
(en)
|
1982-04-29 |
1984-10-09 |
Centre National De La Recherche Scientifique |
Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
USRE34036E
(en)
|
1984-06-06 |
1992-08-18 |
National Research Development Corporation |
Data transmission using a transparent tone-in band system
|
US5550111A
(en)
|
1984-07-11 |
1996-08-27 |
Temple University-Of The Commonwealth System Of Higher Education |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
US4751219A
(en)
|
1985-02-05 |
1988-06-14 |
Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek |
Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
US5405938A
(en)
|
1989-12-20 |
1995-04-11 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
US5235033A
(en)
|
1985-03-15 |
1993-08-10 |
Anti-Gene Development Group |
Alpha-morpholino ribonucleoside derivatives and polymers thereof
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
EP0260032B1
(en)
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
JP2828642B2
(ja)
|
1987-06-24 |
1998-11-25 |
ハワード フローレイ インスティテュト オブ イクスペリメンタル フィジオロジー アンド メディシン |
ヌクレオシド誘導体
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
DE3855864T2
(de)
|
1987-11-30 |
1997-09-25 |
Univ Iowa Res Found |
Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
|
US5403711A
(en)
|
1987-11-30 |
1995-04-04 |
University Of Iowa Research Foundation |
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
|
JPH03503894A
(ja)
|
1988-03-25 |
1991-08-29 |
ユニバーシィティ オブ バージニア アランミ パテンツ ファウンデイション |
オリゴヌクレオチド n‐アルキルホスホラミデート
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
US5216141A
(en)
|
1988-06-06 |
1993-06-01 |
Benner Steven A |
Oligonucleotide analogs containing sulfur linkages
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
US5194599A
(en)
|
1988-09-23 |
1993-03-16 |
Gilead Sciences, Inc. |
Hydrogen phosphonodithioate compositions
|
US5176996A
(en)
|
1988-12-20 |
1993-01-05 |
Baylor College Of Medicine |
Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
|
FR2645345A1
(fr)
|
1989-03-31 |
1990-10-05 |
Thomson Csf |
Procede de modulation dirigee de la composition ou du dopage de semi-conducteurs, notamment pour la realisation de composants electroniques monolithiques de type planar, utilisation et produits correspondants
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
US5721218A
(en)
|
1989-10-23 |
1998-02-24 |
Gilead Sciences, Inc. |
Oligonucleotides with inverted polarity
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
EP0497875B1
(en)
|
1989-10-24 |
2000-03-22 |
Isis Pharmaceuticals, Inc. |
2' modified oligonucleotides
|
US5264564A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences |
Oligonucleotide analogs with novel linkages
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
US5859221A
(en)
|
1990-01-11 |
1999-01-12 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US5220007A
(en)
|
1990-02-15 |
1993-06-15 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of RNA and production of encoded polypeptides
|
US5149797A
(en)
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
US5321131A
(en)
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
US5470967A
(en)
|
1990-04-10 |
1995-11-28 |
The Dupont Merck Pharmaceutical Company |
Oligonucleotide analogs with sulfamate linkages
|
GB9009980D0
(en)
|
1990-05-03 |
1990-06-27 |
Amersham Int Plc |
Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
|
DK0455905T3
(da)
|
1990-05-11 |
1998-12-07 |
Microprobe Corp |
Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
US5614617A
(en)
|
1990-07-27 |
1997-03-25 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
MY107332A
(en)
|
1990-08-03 |
1995-11-30 |
Sterling Drug Inc |
Compounds and methods for inhibiting gene expression.
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
US5214134A
(en)
|
1990-09-12 |
1993-05-25 |
Sterling Winthrop Inc. |
Process of linking nucleosides with a siloxane bridge
|
US5561225A
(en)
|
1990-09-19 |
1996-10-01 |
Southern Research Institute |
Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
|
US5596086A
(en)
|
1990-09-20 |
1997-01-21 |
Gilead Sciences, Inc. |
Modified internucleoside linkages having one nitrogen and two carbon atoms
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
US6582908B2
(en)
|
1990-12-06 |
2003-06-24 |
Affymetrix, Inc. |
Oligonucleotides
|
US5948903A
(en)
|
1991-01-11 |
1999-09-07 |
Isis Pharmaceuticals, Inc. |
Synthesis of 3-deazapurines
|
US5672697A
(en)
|
1991-02-08 |
1997-09-30 |
Gilead Sciences, Inc. |
Nucleoside 5'-methylene phosphonates
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US5571799A
(en)
|
1991-08-12 |
1996-11-05 |
Basco, Ltd. |
(2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
|
EP0538194B1
(de)
|
1991-10-17 |
1997-06-04 |
Novartis AG |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
EP1256589A3
(en)
|
1991-11-26 |
2003-09-17 |
Isis Pharmaceuticals, Inc. |
Oligomers containing modified pyrimidines
|
TW393513B
(en)
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
US5792608A
(en)
|
1991-12-12 |
1998-08-11 |
Gilead Sciences, Inc. |
Nuclease stable and binding competent oligomers and methods for their use
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
FR2687679B1
(fr)
|
1992-02-05 |
1994-10-28 |
Centre Nat Rech Scient |
Oligothionucleotides.
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
US5434257A
(en)
|
1992-06-01 |
1995-07-18 |
Gilead Sciences, Inc. |
Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
GB9304620D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Compounds
|
GB9304618D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Chemical compounds
|
AU6449394A
(en)
|
1993-03-30 |
1994-10-24 |
Sterling Winthrop Inc. |
Acyclic nucleoside analogs and oligonucleotide sequences containing them
|
JPH08508491A
(ja)
|
1993-03-31 |
1996-09-10 |
スターリング ウインスロップ インコーポレイティド |
ホスホジエステル結合をアミド結合に置き換えたオリゴヌクレオチド
|
AU6786594A
(en)
|
1993-05-11 |
1994-12-12 |
University Of North Carolina At Chapel Hill, The |
Antisense oligonucleotides which combat aberrant splicing and methods of using the same
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
EP0733059B1
(en)
|
1993-12-09 |
2000-09-13 |
Thomas Jefferson University |
Compounds and methods for site-directed mutations in eukaryotic cells
|
US5446137B1
(en)
|
1993-12-09 |
1998-10-06 |
Behringwerke Ag |
Oligonucleotides containing 4'-substituted nucleotides
|
US5519134A
(en)
|
1994-01-11 |
1996-05-21 |
Isis Pharmaceuticals, Inc. |
Pyrrolidine-containing monomers and oligomers
|
JPH09510702A
(ja)
|
1994-02-28 |
1997-10-28 |
アグリテック テクノロジーズ,リミテッド. |
インヒビン組成物およびそれらの使用方法
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
US5646269A
(en)
|
1994-04-28 |
1997-07-08 |
Gilead Sciences, Inc. |
Method for oligonucleotide analog synthesis
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
US5597909A
(en)
|
1994-08-25 |
1997-01-28 |
Chiron Corporation |
Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
|
EP0708178A1
(en)
|
1994-10-19 |
1996-04-24 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
Survival motor neuron (SMN) gene: a gene for spinal muscular atrophy
|
US6908903B1
(en)
|
1994-12-07 |
2005-06-21 |
Aletheon Pharmaceuticals, Inc. |
Cluster clearing agents
|
US6172045B1
(en)
|
1994-12-07 |
2001-01-09 |
Neorx Corporation |
Cluster clearing agents
|
US5652356A
(en)
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
US7034009B2
(en)
|
1995-10-26 |
2006-04-25 |
Sirna Therapeutics, Inc. |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
|
CN1120707C
(zh)
|
1995-11-22 |
2003-09-10 |
约翰斯·霍普金斯大学 |
增强生物分子的细胞摄取的配体
|
US20030119724A1
(en)
|
1995-11-22 |
2003-06-26 |
Ts`O Paul O.P. |
Ligands to enhance cellular uptake of biomolecules
|
WO1998013381A1
(fr)
|
1996-09-26 |
1998-04-02 |
Ajinomoto Co., Inc. |
Proteines modifiees physiologiquement actives et compositions medicamenteuses les contenant
|
USRE44779E1
(en)
|
1997-03-07 |
2014-02-25 |
Santaris Pharma A/S |
Bicyclonucleoside and oligonucleotide analogues
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
US6770748B2
(en)
|
1997-03-07 |
2004-08-03 |
Takeshi Imanishi |
Bicyclonucleoside and oligonucleotide analogue
|
US7572582B2
(en)
|
1997-09-12 |
2009-08-11 |
Exiqon A/S |
Oligonucleotide analogues
|
NZ503765A
(en)
|
1997-09-12 |
2002-04-26 |
Exiqon As |
Bi-cyclic and tri-cyclic nucleotide analogues
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
US20010049436A1
(en)
*
|
1998-04-01 |
2001-12-06 |
Wen-Qiang Zhou |
Mixed-backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
US20030228597A1
(en)
|
1998-04-13 |
2003-12-11 |
Cowsert Lex M. |
Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
US6210892B1
(en)
|
1998-10-07 |
2001-04-03 |
Isis Pharmaceuticals, Inc. |
Alteration of cellular behavior by antisense modulation of mRNA processing
|
US6172216B1
(en)
|
1998-10-07 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Antisense modulation of BCL-X expression
|
US6214986B1
(en)
|
1998-10-07 |
2001-04-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of bcl-x expression
|
CA2372085C
(en)
|
1999-05-04 |
2009-10-27 |
Exiqon A/S |
L-ribo-lna analogues
|
US6525191B1
(en)
|
1999-05-11 |
2003-02-25 |
Kanda S. Ramasamy |
Conformationally constrained L-nucleosides
|
US6998259B1
(en)
|
1999-05-20 |
2006-02-14 |
Davisco Foods International |
Enzymatic treatment of whey proteins for the production of antihypertensive peptides and the resulting products
|
US6383812B1
(en)
|
1999-05-28 |
2002-05-07 |
Academia Sinica |
Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins
|
US20080281041A1
(en)
|
1999-06-07 |
2008-11-13 |
Rozema David B |
Reversibly Masked Polymers
|
US8541548B2
(en)
|
1999-06-07 |
2013-09-24 |
Arrowhead Madison Inc. |
Compounds and methods for reversible modification of biologically active molecules
|
US6649411B2
(en)
|
1999-07-30 |
2003-11-18 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting cancer cells with ADNF III antisense oligonucleotides
|
US6770633B1
(en)
|
1999-10-26 |
2004-08-03 |
Immusol, Inc. |
Ribozyme therapy for the treatment of proliferative skin and eye diseases
|
US20030100505A1
(en)
|
1999-11-01 |
2003-05-29 |
Chiron Corporation |
Compositions and methods of therapy for IGF-I-responsive conditions
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
EP1133993A1
(en)
|
2000-03-10 |
2001-09-19 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Substances for the treatment of spinal muscular atrophy
|
US6962906B2
(en)
|
2000-03-14 |
2005-11-08 |
Active Motif |
Oligonucleotide analogues, methods of synthesis and methods of use
|
WO2001085751A1
(en)
|
2000-05-09 |
2001-11-15 |
Reliable Biopharmaceutical, Inc. |
Polymeric compounds useful as prodrugs
|
US6426220B1
(en)
|
2000-10-30 |
2002-07-30 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of calreticulin expression
|
EP1416972B1
(en)
|
2000-11-09 |
2012-02-08 |
Cold Spring Harbor Laboratory |
Chimeric molecules to modulate gene expression
|
US6906182B2
(en)
|
2000-12-01 |
2005-06-14 |
Cell Works Therapeutics, Inc. |
Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and method of use
|
US6376508B1
(en)
|
2000-12-13 |
2002-04-23 |
Academia Sinica |
Treatments for spinal muscular atrophy
|
CZ303658B6
(cs)
|
2001-02-01 |
2013-02-06 |
F. Hoffmann-La Roche Ag |
Zpusob rekombinantní produkce trypsinu
|
ATE328596T1
(de)
|
2001-03-16 |
2006-06-15 |
Suntory Ltd |
Autonomsystem kontrollagentien und gesundheitsgetränke und -nahrungsmittel
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
US20030175906A1
(en)
|
2001-07-03 |
2003-09-18 |
Muthiah Manoharan |
Nuclease resistant chimeric oligonucleotides
|
US20030158403A1
(en)
|
2001-07-03 |
2003-08-21 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
JP2003063992A
(ja)
|
2001-08-28 |
2003-03-05 |
Fujisawa Pharmaceut Co Ltd |
N型Ca2+チャネル電流特異的増強剤
|
WO2003037909A1
(en)
|
2001-10-29 |
2003-05-08 |
Mcgill University |
Acyclic linker-containing oligonucleotides and uses thereof
|
US20100240730A1
(en)
|
2002-02-20 |
2010-09-23 |
Merck Sharp And Dohme Corp. |
RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA)
|
GB0219143D0
(en)
|
2002-08-16 |
2002-09-25 |
Univ Leicester |
Modified tailed oligonucleotides
|
WO2004024757A2
(en)
|
2002-09-11 |
2004-03-25 |
Santaris Pharma A/S |
Modified pna molecules
|
AU2003290596B2
(en)
|
2002-11-05 |
2011-05-12 |
Isis Pharmaceuticals, Inc. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
AU2003291753B2
(en)
|
2002-11-05 |
2010-07-08 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
EP2213738B1
(en)
|
2002-11-14 |
2012-10-10 |
Dharmacon, Inc. |
siRNA molecules targeting Bcl-2
|
US7851615B2
(en)
|
2003-04-17 |
2010-12-14 |
Alnylam Pharmaceuticals, Inc. |
Lipophilic conjugated iRNA agents
|
US7723509B2
(en)
|
2003-04-17 |
2010-05-25 |
Alnylam Pharmaceuticals |
IRNA agents with biocleavable tethers
|
EP2666858A1
(en)
|
2003-04-17 |
2013-11-27 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
WO2004101619A1
(ja)
|
2003-05-15 |
2004-11-25 |
Shionogi Co., Ltd. |
機能的糖ペプチドの合理的設計および合成
|
WO2004106356A1
(en)
|
2003-05-27 |
2004-12-09 |
Syddansk Universitet |
Functionalized nucleotide derivatives
|
WO2004113867A2
(en)
|
2003-06-16 |
2004-12-29 |
University Of Massachusetts |
Exon analysis
|
ATE555118T1
(de)
|
2003-08-28 |
2012-05-15 |
Takeshi Imanishi |
Neue synthetische nukleidsäuren vom typ mit quervernetzter n-o-bindung
|
EP1677822B1
(en)
|
2003-09-18 |
2014-04-23 |
Isis Pharmaceuticals, Inc. |
4'-thionucleosides and oligomeric compounds
|
US20050214288A1
(en)
|
2004-03-26 |
2005-09-29 |
Human Genome Sciences, Inc. |
Antibodies against Nogo receptor
|
WO2006020768A2
(en)
|
2004-08-10 |
2006-02-23 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides
|
WO2006031461A2
(en)
|
2004-09-09 |
2006-03-23 |
Isis Pharmaceuticals, Inc. |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
GB0425625D0
(en)
|
2004-11-22 |
2004-12-22 |
Royal College Of Surgeons Ie |
Treatment of disease
|
US7838657B2
(en)
|
2004-12-03 |
2010-11-23 |
University Of Massachusetts |
Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences
|
US20060148740A1
(en)
|
2005-01-05 |
2006-07-06 |
Prosensa B.V. |
Mannose-6-phosphate receptor mediated gene transfer into muscle cells
|
WO2006078217A1
(en)
|
2005-01-24 |
2006-07-27 |
Avaris Ab |
COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY
|
LT3308788T
(lt)
|
2005-06-23 |
2018-12-10 |
Biogen Ma Inc. |
Kompozicijos ir būdai, skirti smn2 splaisingo moduliavimui
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
EP1984381B1
(en)
|
2006-01-27 |
2010-09-29 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
ES2389737T3
(es)
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en 5'
|
WO2008022309A2
(en)
|
2006-08-18 |
2008-02-21 |
F. Hoffmann-La Roche Ag |
Polyconjugates for in vivo delivery of polynucleotides
|
US8658211B2
(en)
|
2006-08-18 |
2014-02-25 |
Arrowhead Madison Inc. |
Polyconjugates for in vivo delivery of polynucleotides
|
DK2410053T4
(da)
|
2006-10-18 |
2020-08-31 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser
|
EP2125852B1
(en)
|
2007-02-15 |
2016-04-06 |
Ionis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
EP2609934A1
(en)
|
2007-02-16 |
2013-07-03 |
KTB Tumorforschungsgesellschaft mbH |
Receptor And Antigen Targeted Prodrug
|
US8877917B2
(en)
|
2007-04-23 |
2014-11-04 |
Alnylam Pharmaceuticals, Inc. |
Glycoconjugates of RNA interference agents
|
CA2688321A1
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
WO2008154401A2
(en)
|
2007-06-08 |
2008-12-18 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
ATE538127T1
(de)
|
2007-07-05 |
2012-01-15 |
Isis Pharmaceuticals Inc |
6-disubstituierte bicyclische nukleinsäureanaloga
|
EP2167135A2
(en)
|
2007-07-12 |
2010-03-31 |
Prosensa Technologies B.V. |
Molecules for targeting compounds to various selected organs, tissues or tumor cells
|
CN101821277B
(zh)
|
2007-08-15 |
2014-05-07 |
Isis制药公司 |
四氢吡喃核酸类似物
|
WO2009067647A1
(en)
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
WO2009068689A2
(en)
|
2007-11-30 |
2009-06-04 |
Novartis Ag |
Combination of protein tyrosine phosphatase inhibitors and human growth hormone for the treatment of muscle atrophy and related disorders
|
CA2708173C
(en)
|
2007-12-04 |
2016-02-02 |
Alnylam Pharmaceuticals, Inc. |
Targeting lipids
|
WO2009134487A2
(en)
|
2008-01-31 |
2009-11-05 |
Alnylam Pharmaceuticals, Inc. |
Optimized methods for delivery of dsrna targeting the pcsk9 gene
|
US8530640B2
(en)
|
2008-02-07 |
2013-09-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
WO2009120878A2
(en)
|
2008-03-26 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Non-natural ribonucleotides, and methods of use thereof
|
WO2009120700A2
(en)
|
2008-03-26 |
2009-10-01 |
Families Of Spinal Muscular Atrophy |
Inhibition of dcps
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
AU2009298802A1
(en)
|
2008-09-23 |
2010-04-08 |
Alnylam Pharmaceuticals, Inc. |
Chemical modifications of monomers and oligonucleotides with cycloaddition
|
EP2356129B1
(en)
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
CA2743139C
(en)
|
2008-11-10 |
2019-04-02 |
Alnylam Pharmaceuticals, Inc. |
Novel lipids and compositions for the delivery of therapeutics
|
WO2010123594A2
(en)
|
2009-01-15 |
2010-10-28 |
Children's Medical Center Corporation |
Device for filtration of fluids there through and accompanying method
|
EP3243504A1
(en)
|
2009-01-29 |
2017-11-15 |
Arbutus Biopharma Corporation |
Improved lipid formulation
|
EP2393825A2
(en)
|
2009-02-06 |
2011-12-14 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
DK2417257T3
(da)
|
2009-04-10 |
2016-06-06 |
Ass Inst De Myologie |
Tricyclo-dna-antisense-oligonukleotider, sammensætninger, og fremgangsmåder til behandlingen af sygdom
|
WO2010120820A1
(en)
|
2009-04-13 |
2010-10-21 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of smn2 splicing
|
EP3097908A1
(en)
|
2009-05-05 |
2016-11-30 |
Arbutus Biopharma Corporation |
Lipid compositions
|
TR201811076T4
(tr)
|
2009-06-10 |
2018-08-27 |
Arbutus Biopharma Corp |
Geliştirilmiş lipit formulasyonu.
|
EA201270019A1
(ru)
|
2009-06-15 |
2012-06-29 |
Элнилэм Фармасьютикалз, Инк. |
Двуцепочечная рнк, включенная в липидный состав и мишенью которой является ген pcsk9
|
CN102665731A
(zh)
|
2009-06-17 |
2012-09-12 |
Isis制药公司 |
用于在对象中调节smn2剪接的组合物和方法
|
EP2462153B1
(en)
|
2009-08-06 |
2015-07-29 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
WO2011032109A1
(en)
|
2009-09-11 |
2011-03-17 |
Sma Foundation |
Biomarkers for spinal muscular atrophy
|
US8552163B2
(en)
|
2009-09-25 |
2013-10-08 |
Johns Hopkins University |
Liver-targeting agents and their synthesis
|
TWI388338B
(zh)
|
2009-10-26 |
2013-03-11 |
Iner Aec Executive Yuan |
對聚合醣鏈進行放射標誌以作為肝受體造影劑之方法
|
TWI391144B
(zh)
|
2009-10-26 |
2013-04-01 |
Iner Aec Executive Yuan |
一種定量肝殘餘功能的檢驗方法與其新穎肝受體造影檢驗藥劑
|
US8183002B2
(en)
|
2009-12-03 |
2012-05-22 |
Abbott Laboratories |
Autoantibody enhanced immunoassays and kits
|
WO2011072290A2
(en)
|
2009-12-11 |
2011-06-16 |
The Regents Of The University Of Michigan |
Targeted dendrimer-drug conjugates
|
US9198972B2
(en)
|
2010-01-28 |
2015-12-01 |
Alnylam Pharmaceuticals, Inc. |
Monomers and oligonucleotides comprising cycloaddition adduct(s)
|
JP6137834B2
(ja)
|
2010-02-24 |
2017-05-31 |
アローヘッド ファーマシューティカルズ インコーポレイテッド |
siRNAの標的化送達のための組成物
|
US8349308B2
(en)
|
2010-03-26 |
2013-01-08 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
US20130109817A1
(en)
|
2010-03-26 |
2013-05-02 |
Mersana Therapeutics, Inc. |
Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
WO2011133876A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
US8802642B2
(en)
|
2010-04-28 |
2014-08-12 |
Iowa State University Research Foundation, Inc. |
Spinal muscular atrophy treatment via targeting SMN2 catalytic core
|
KR20180026798A
(ko)
|
2010-04-29 |
2018-03-13 |
아이오니스 파마수티컬즈, 인코포레이티드 |
트랜스티레틴 발현의 조절
|
JP2013530154A
(ja)
|
2010-05-28 |
2013-07-25 |
サレプタ セラピューティクス, インコーポレイテッド |
修飾されたサブユニット間結合および/または末端基を有するオリゴヌクレオチドアナログ
|
US9518259B2
(en)
|
2010-06-15 |
2016-12-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating interaction between proteins and target nucleic acids
|
US20130236968A1
(en)
|
2010-06-21 |
2013-09-12 |
Alnylam Pharmaceuticals, Inc. |
Multifunctional copolymers for nucleic acid delivery
|
WO2012012443A2
(en)
|
2010-07-19 |
2012-01-26 |
Bennett C Frank |
Modulation of dystrophia myotonica-protein kinase (dmpk) expression
|
US9290760B2
(en)
|
2010-09-15 |
2016-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
US10653713B2
(en)
|
2010-10-06 |
2020-05-19 |
Medtronic, Inc. |
Methods for distributing agents to areas of brain
|
WO2012058462A2
(en)
|
2010-10-29 |
2012-05-03 |
Isis Pharmaceuticals, Inc. |
Combination therapy for the treatment of cancer
|
WO2012068187A1
(en)
|
2010-11-19 |
2012-05-24 |
Merck Sharp & Dohme Corp. |
Poly(amide) polymers for the delivery of oligonucleotides
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
BR112013013434A2
(pt)
|
2010-12-17 |
2016-08-16 |
Arrowhead Res Corp |
metade que tem por alvo modulador fármaco cinético em cacho de galactose para sirna
|
BR122020024394B1
(pt)
|
2010-12-29 |
2021-05-11 |
F. Hoffmann-La Roche Ag |
conjugado e composição farmacêutica
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US20140128449A1
(en)
|
2011-04-07 |
2014-05-08 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
JP6478632B2
(ja)
|
2011-05-05 |
2019-03-06 |
サレプタ セラピューティクス, インコーポレイテッド |
ペプチドオリゴヌクレオチドコンジュゲート
|
AU2012272860A1
(en)
|
2011-06-21 |
2013-12-19 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
|
US20140357558A1
(en)
|
2011-06-24 |
2014-12-04 |
Cold Spring Harbor Laboratory |
Compositions and methods for treatment of spinal muscular atrophy
|
JP2014521089A
(ja)
|
2011-07-13 |
2014-08-25 |
メルク・シャープ・アンド・ドーム・コーポレーション |
液体試料中のアミロイドベータオリゴマーの検出方法およびその使用
|
AU2012300476B2
(en)
|
2011-08-26 |
2016-03-24 |
Arrowhead Research Corporation |
Poly(vinyl ester) polymers for in vivo nucleic acid delivery
|
WO2013033230A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
PL2581448T3
(pl)
|
2011-10-13 |
2015-08-31 |
Association Inst De Myologie |
Tricyklo-tiofosforanowy DNA
|
SG189598A1
(en)
*
|
2011-11-03 |
2013-05-31 |
Singapore Health Serv Pte Ltd |
Antisense oligonucleotides for modulating survival motor neuron 2 (smn2) splicing
|
KR20140091587A
(ko)
|
2011-11-11 |
2014-07-21 |
산타리스 팔마 에이/에스 |
Smn2 스플라이싱의 조절을 위한 화합물
|
ES2800065T3
(es)
|
2011-11-18 |
2020-12-23 |
Alnylam Pharmaceuticals Inc |
Agentes de iARN, composiciones y métodos de uso de los mismos para tratar enfermedades asociadas con transtiretina (TTR)
|
CA2857664A1
(en)
|
2011-11-30 |
2013-06-06 |
Sarepta Therapeutics, Inc. |
Antisense oligonucleotides targeting within the smn2 pre-mrna for use ininduced exon inclusion in spinal muscle atrophy
|
EP2788087A4
(en)
|
2011-12-06 |
2015-08-26 |
Ohio State Innovation Foundation |
NON-IONIC LOW OSMOLARITY CONTRAST AGENTS FOR THE ADMINISTRATION OF ANTISENSE OLIGONUCLEOTIDES AND THE TREATMENT OF DISEASE
|
JP6092897B2
(ja)
|
2012-02-10 |
2017-03-08 |
ピーティーシー セラピューティクス, インコーポレイテッド |
脊髄性筋萎縮症を治療するための化合物
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
AR090906A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y procedimientos para la administracion de oligonucleotidos
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
DK2850186T3
(en)
|
2012-05-16 |
2019-04-08 |
Translate Bio Ma Inc |
COMPOSITIONS AND PROCEDURES FOR MODULATING SMN GENFAMILY EXPRESSION
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
WO2013188881A1
(en)
|
2012-06-15 |
2013-12-19 |
President And Fellows Of Harvard College |
Compounds, compositions and methods for treating or preventing neurodegenerative disorders
|
WO2014016830A1
(en)
|
2012-07-25 |
2014-01-30 |
Mapi Pharma Ltd. |
Process and intermediates for the preparation of abiraterone acetate
|
EP2906699A4
(en)
|
2012-10-11 |
2016-06-08 |
Ionis Pharmaceuticals Inc |
OLIGOMER COMPOUNDS WITH BICYCLIC NUCLEOSIDES AND USES THEREOF
|
EP2906255B1
(en)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
CA2889596C
(en)
|
2012-11-15 |
2022-08-23 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
WO2014110291A1
(en)
|
2013-01-09 |
2014-07-17 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of smn2 splicing in a subject
|
WO2014113540A1
(en)
|
2013-01-16 |
2014-07-24 |
Iowa State University Research Foundation, Inc. |
A deep intronic target for splicing correction on spinal muscular atrophy gene
|
US9474792B2
(en)
|
2013-03-15 |
2016-10-25 |
Amgen Inc. |
Method of treating metabolic disorders using PLA2G12A polypeptides and PLA2G12A mutant polypeptides
|
EP3560502A1
(en)
|
2013-04-12 |
2019-10-30 |
The Curators of the University of Missouri |
Smn2 element 1 antisense compositions and methods and uses thereof
|
CN105378085B
(zh)
|
2013-05-01 |
2019-02-15 |
Ionis制药公司 |
用于调节hbv和ttr表达的组合物和方法
|
KR102116378B1
(ko)
|
2013-05-01 |
2020-06-01 |
젠자임 코포레이션 |
척수성 근위축증을 치료하기 위한 조성물 및 방법
|
US20140367278A1
(en)
|
2013-06-12 |
2014-12-18 |
PharmOptima, LLC |
Methods for Detecting Survival Motor Neuron (SMN) Protein in Whole Blood or Cerebral Spinal Fluid
|
EP3027753B1
(en)
|
2013-07-29 |
2018-09-12 |
Universität zu Köln |
Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
|
WO2015023941A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Oligonucleotides targeting euchromatin regions of genes
|
EP3044317A1
(en)
|
2013-09-13 |
2016-07-20 |
The University Of Western Australia |
Antisense oligomers and methods for treating smn-related pathologies
|
US10174328B2
(en)
|
2013-10-04 |
2019-01-08 |
Translate Bio Ma, Inc. |
Compositions and methods for treating amyotrophic lateral sclerosis
|
WO2015106128A2
(en)
|
2014-01-09 |
2015-07-16 |
Alnylam Pharmaceuticals, Inc. |
MODIFIED RNAi AGENTS
|
EP4162940A1
(en)
|
2014-04-17 |
2023-04-12 |
Biogen MA Inc. |
Compositions and methods for modulation of smn2 splicing in a subject
|
EP3137476B1
(en)
*
|
2014-04-28 |
2019-10-09 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
US10436802B2
(en)
*
|
2014-09-12 |
2019-10-08 |
Biogen Ma Inc. |
Methods for treating spinal muscular atrophy
|
US10851371B2
(en)
|
2015-04-10 |
2020-12-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of SMN expression
|
CA2996164A1
(en)
|
2015-08-28 |
2017-03-09 |
Sarepta Therapeutics, Inc. |
Modified antisense oligomers for exon inclusion in spinal muscular atrophy
|
WO2017053995A1
(en)
|
2015-09-25 |
2017-03-30 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
EP3368671A1
(en)
|
2015-10-26 |
2018-09-05 |
Translate Bio Ma, Inc. |
Methods and compositions for increasing smn expression
|
CA3027288A1
(en)
|
2016-06-14 |
2017-12-21 |
Biogen Ma Inc. |
Hydrophobic interaction chromatography for purification of oligonucleotides
|
US11198867B2
(en)
*
|
2016-06-16 |
2021-12-14 |
Ionis Pharmaceuticals, Inc. |
Combinations for the modulation of SMN expression
|
KR20190020743A
(ko)
|
2016-06-24 |
2019-03-04 |
바이오젠 엠에이 인코포레이티드 |
캡핑 단계 없이 티올화된 올리고뉴클레오타이드의 합성
|
KR20230175313A
(ko)
|
2016-07-05 |
2023-12-29 |
바이오마린 테크놀로지스 비.브이. |
유전적 장애 치료를 위한, 특징이 개선된, 비사이클릭 스캐폴드 모이어티를 포함하는 프리-mrna 스플라이스 스위칭 또는 조정 올리고뉴클레오티드
|
US20190330626A1
(en)
|
2016-07-15 |
2019-10-31 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for use in dystrophin transcript
|
US20190321387A1
(en)
|
2016-07-15 |
2019-10-24 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of transcript processing
|
PT3484524T
(pt)
*
|
2016-07-15 |
2023-02-15 |
Ionis Pharmaceuticals Inc |
Composições e métodos para a modulação de smn2
|
WO2018055577A1
(en)
|
2016-09-23 |
2018-03-29 |
Synthena Ag |
Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof
|
GB2563964A
(en)
|
2017-02-17 |
2019-01-02 |
Res & Innovation Uk |
Cell penetrating peptides
|
WO2018193428A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
EP3406719A1
(en)
|
2017-05-24 |
2018-11-28 |
Universität zu Köln |
Calcineurin b homologous protein 1 inhibitors and therapeutic and non-therapeutic uses thereof
|
WO2019075357A1
(en)
*
|
2017-10-12 |
2019-04-18 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
|
AU2018355237A1
(en)
*
|
2017-10-23 |
2020-05-21 |
Stoke Therapeutics, Inc. |
Antisense oligomers for treatment of non-sense mediated RNA decay based conditions and diseases
|
WO2019169203A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|
WO2019168558A1
(en)
|
2018-02-28 |
2019-09-06 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs for survival of motor neuron (sma) inhibitors
|
US20220064638A1
(en)
|
2020-02-28 |
2022-03-03 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating smn2
|
EP4110924A4
(en)
*
|
2020-02-28 |
2024-03-13 |
Ionis Pharmaceuticals Inc |
COMPOUNDS AND METHODS FOR MODULATING PRE-MRNA SPLICEING
|