PE20170684A1 - Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias - Google Patents
Derivados de heterociclilo opcionalmente condensados de pirimidina utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitariasInfo
- Publication number
- PE20170684A1 PE20170684A1 PE2017000166A PE2017000166A PE20170684A1 PE 20170684 A1 PE20170684 A1 PE 20170684A1 PE 2017000166 A PE2017000166 A PE 2017000166A PE 2017000166 A PE2017000166 A PE 2017000166A PE 20170684 A1 PE20170684 A1 PE 20170684A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- metabolic
- inflammatory
- treatment
- autoimmune diseases
- Prior art date
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- C07D471/10—Spiro-condensed systems
Abstract
Se refiere a un derivado de heterociclilo opcionalmente condensado de pirimidina de formula (I) o las sales, hidratos, solvatos, polimorfos y estereoisomeros de los mismos, donde: Y es NR u O; R es H o alquilo C1-C4 opcionalmente sustituido; R1 es H, -OH, entre otros; R2 es H, halogeno, entre otros; R3a es alquilo C1-C6, alcoxi C1-C6 opcionalmente sustituidos, entre otros; R3b y R3c son H, -CN, entre otros o se combinan para formar un grupo oxo; R4a es H, halogeno, entre otros; R4b es H, oxo, entre otros; R5 es (CR8R9)pOR12, entre otros; n y p son enteros de 0 a 4; R6a y R6b son H, halogeno, alquilo C1-C6, entre otros; R8, R9 y R12 son H, alquilo C1-C6 opcionalmente sustituido, entre otros; B es un sistema de anillo tal como arilo, heteroarilo, entre otros. Es un compuesto seleccionado: N6-ciclopropil-5-fluoro-N4-[[4-(1H-tetrazol-5-ilmetil)fenil]metil]-N6-[[4-(trifluorometil)fenil]metil]pirimidina-4,6-diamina; entre otros. Tambien se refiere a una composicion. Estos compuestos modulan la actividad de un receptor huerfano relacionado con el receptor de acido retinoico (ROR). Dicho compuesto es util en el tratamiento de enfermedades inflamatorias, metabolicas y autoinmunes
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