PE20091393A1 - Antagonistas de glucagon - Google Patents
Antagonistas de glucagonInfo
- Publication number
- PE20091393A1 PE20091393A1 PE2008001856A PE2008001856A PE20091393A1 PE 20091393 A1 PE20091393 A1 PE 20091393A1 PE 2008001856 A PE2008001856 A PE 2008001856A PE 2008001856 A PE2008001856 A PE 2008001856A PE 20091393 A1 PE20091393 A1 PE 20091393A1
- Authority
- PE
- Peru
- Prior art keywords
- amino acid
- seq
- amino acids
- group
- glucagon
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
REFERIDO A ANALOGOS DE GLUCAGON QUE COMPRENDE: I) SEQ ID Nº 42 O DERIVADO OXI DE EL, QUE CONTIENE: i) AMINOACIDO DEL EXTREMO C TIENE UN GRUPO AMIDA EN LUGAR DEL GRUPO ACIDO CARBOXILICO QUE ESTA PRESENTE EN EL AMINOACIDO NATIVO; ii) EL AMINOACIDO DE SEQ ID Nº 19 FUSIONADO HACIA EL AMINOACIDO DEL EXTREMO DE CARBOXI DE SEQ. ID Nº 42; iii) GRUPO HIDROFILO (POLIETILENGLICOL) UNIDO EN FORMA COVALENTE A UN RESIDUO DE AMINOACIDO EN POSICION 11, 16 O 19 DE SEQ ID Nº 42, O EN EL AMINOACIDO DEL EXTREMO N O C DEL ANTAGONISTA DE GLUCAGON; II) SECUENCIA DE AMINOACIDOS DE GLUCAGON NATIVO MODIFICADO MEDIANTE ELIMINACION DE DOS A CINCO RESIDUOS DE AMINOACIDOS DEL EXTREMO N DE SEQ ID NO 1, DONDE DICHA SECUENCIA TIENE HASTA TRES MODIFICACIONES DE AMINOACIDOS; III) ANTAGONISTA DE GLUCAGON DE ESTRUCTURA A-B-C, DONDE (A) SE SELECCIONA DE a) ACIDO FENIL LACTICO (PLA); b) DERIVADO DE OXI DE PLA Y; c) PEPTIDO DE 2 A 6 AMINOACIDOS CONSECUTIVOS EN DONDE DOS AMINOACIDOS CONSECUTIVOS DEL PEPTIDO ESTAN UNIDOS A TRAVES DE UN ENLACE ESTER O ETER; (B) REPRESENTA AMINOACIDOS i A 26 SEQ ID NO: 1, DONDE i ES 3, 4, 5, 6 O 7, QUE OPCIONALMENTE COMPRENDE MODIFICACIONES DE AMINOACIDOS; Y (C) QUE SE SELECCIONA DE X, X-Y, X-Y-Z, X-Y-Z-R10, DONDE X ES Met, Leu O Nle; Y ES Asn O AMINOACIDO CON UNA CARGA; Z ES Thr, Gly, Cys, ENTRE OTROS, R10 SE SELECCIONA DEL GRUPO FORMADO POR SEQ. ID. Nº 19-21 Y 53. DICHOS COMPUESTOS SON DE UTILIDAD EN EL TRATAMIENTO DE LA HIPERGLUCEMIA (DIABETES)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98378307P | 2007-10-30 | 2007-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091393A1 true PE20091393A1 (es) | 2009-09-11 |
Family
ID=40591715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008001856A PE20091393A1 (es) | 2007-10-30 | 2008-10-30 | Antagonistas de glucagon |
Country Status (13)
Country | Link |
---|---|
US (1) | US8981047B2 (es) |
EP (1) | EP2217701B9 (es) |
JP (1) | JP5669582B2 (es) |
AR (1) | AR069110A1 (es) |
AU (1) | AU2008318986B2 (es) |
CA (1) | CA2707861A1 (es) |
CL (1) | CL2008003222A1 (es) |
ES (1) | ES2509883T3 (es) |
HK (1) | HK1143994A1 (es) |
MX (1) | MX2010004297A (es) |
PE (1) | PE20091393A1 (es) |
TW (1) | TW200920404A (es) |
WO (1) | WO2009058662A2 (es) |
Families Citing this family (53)
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EP2487184A1 (en) | 2007-02-15 | 2012-08-15 | Indiana University Research and Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
ES2558155T3 (es) | 2007-10-30 | 2016-02-02 | Indiana University Research And Technology Corporation | Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1 |
ES2509883T3 (es) | 2007-10-30 | 2014-10-20 | Indiana University Research And Technology Corporation | Antagonistas de glucagón |
AU2009260301B2 (en) | 2008-06-17 | 2015-09-03 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers |
CL2009001424A1 (es) | 2008-06-17 | 2010-04-30 | Univ Indiana Res & Tech Corp | Peptido tipo glucagon; dimero que comprende dos de dichos peptidos; composicion farmaceutica que lo comprende; y su uso para tratar diabetes o inducir perdida de peso. |
US9062124B2 (en) | 2008-06-17 | 2015-06-23 | Indiana University Research And Technology Corporation | GIP-based mixed agonists for treatment of metabolic disorders and obesity |
EP2376097A4 (en) | 2008-12-19 | 2012-10-03 | Univ Indiana Res & Tech Corp | AMID-BASED PEPTIDE PRODRUGS OF THE GLUCAGON SUPERFAMILY |
CA2765026A1 (en) | 2009-06-16 | 2010-12-23 | Indiana University Research And Technology Corporation | Gip receptor-active glucagon compounds |
GB0917072D0 (en) * | 2009-09-29 | 2009-11-11 | Univ Ulster | Peptide analogues of glucagon for diabetes therapy |
AU2010317842A1 (en) | 2009-11-16 | 2012-07-12 | Mellitech | [1,5]-diazocin derivatives |
US8703701B2 (en) | 2009-12-18 | 2014-04-22 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
BR112012018585A2 (pt) | 2010-01-27 | 2017-01-10 | Univ Indiana Res & Tech Corp | conjungados e composições de glucagon antagonista-gip agonista para o tratamento de distúrbios metabólicos e de obesidade |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US20130053310A1 (en) * | 2010-03-26 | 2013-02-28 | Novo Nordisk A/S | Novel glucagon analogues |
BR112012028707A2 (pt) | 2010-05-13 | 2019-09-24 | Univ Indiana Res & Tech Corp | composto de glucagon da superfamília de peptídeos exibindo atividade do receptor g com proteína acoplada, pró farmaco, dímero ou multímro, composição farmacêutica que o compreendem e método de administração do mesmo. |
US9127088B2 (en) | 2010-05-13 | 2015-09-08 | Indiana University Research And Technology Corporation | Glucagon superfamily peptides exhibiting nuclear hormone receptor activity |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
MX2012014576A (es) | 2010-06-24 | 2013-02-21 | Univ Indiana Res & Tech Corp | Profarmacos de peptido de la superfamilia de glucagon basado en amida. |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
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TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
KR101382593B1 (ko) | 2010-07-21 | 2014-04-10 | 한미사이언스 주식회사 | 신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물 |
ES2533601T3 (es) | 2010-11-03 | 2015-04-13 | Arecor Limited | Nueva composición que comprende glucagón |
EA201390941A1 (ru) | 2010-12-22 | 2013-12-30 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, проявляющие активность на рецепторе gip |
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EP2820038B1 (en) | 2012-03-01 | 2020-06-17 | Novo Nordisk A/S | Glp-1 prodrugs |
RU2015101697A (ru) | 2012-06-21 | 2016-08-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, обладающие активностью рецептора gip |
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TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽-4(exendin-4)胜肽類似物 |
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2008
- 2008-10-23 ES ES08845852.6T patent/ES2509883T3/es active Active
- 2008-10-23 EP EP08845852.6A patent/EP2217701B9/en active Active
- 2008-10-23 CA CA2707861A patent/CA2707861A1/en not_active Abandoned
- 2008-10-23 US US12/739,342 patent/US8981047B2/en not_active Expired - Fee Related
- 2008-10-23 MX MX2010004297A patent/MX2010004297A/es active IP Right Grant
- 2008-10-23 JP JP2010532154A patent/JP5669582B2/ja not_active Expired - Fee Related
- 2008-10-23 AU AU2008318986A patent/AU2008318986B2/en not_active Ceased
- 2008-10-23 WO PCT/US2008/080973 patent/WO2009058662A2/en active Application Filing
- 2008-10-29 CL CL2008003222A patent/CL2008003222A1/es unknown
- 2008-10-29 AR ARP080104739A patent/AR069110A1/es unknown
- 2008-10-30 TW TW097141806A patent/TW200920404A/zh unknown
- 2008-10-30 PE PE2008001856A patent/PE20091393A1/es not_active Application Discontinuation
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EP2217701A4 (en) | 2011-06-15 |
AU2008318986B2 (en) | 2014-12-04 |
EP2217701A2 (en) | 2010-08-18 |
AU2008318986A1 (en) | 2009-05-07 |
ES2509883T3 (es) | 2014-10-20 |
JP2011502155A (ja) | 2011-01-20 |
WO2009058662A2 (en) | 2009-05-07 |
US20120122783A1 (en) | 2012-05-17 |
EP2217701B1 (en) | 2014-07-02 |
US8981047B2 (en) | 2015-03-17 |
TW200920404A (en) | 2009-05-16 |
HK1143994A1 (en) | 2011-01-21 |
CA2707861A1 (en) | 2009-05-07 |
CL2008003222A1 (es) | 2009-02-27 |
WO2009058662A3 (en) | 2010-01-07 |
JP5669582B2 (ja) | 2015-02-12 |
MX2010004297A (es) | 2010-05-03 |
AR069110A1 (es) | 2009-12-30 |
EP2217701B9 (en) | 2015-02-18 |
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