BRPI0612069A2 - compostos e seus efeitos sobre o comportamento de alimentaÇço - Google Patents
compostos e seus efeitos sobre o comportamento de alimentaÇçoInfo
- Publication number
- BRPI0612069A2 BRPI0612069A2 BRPI0612069-5A BRPI0612069A BRPI0612069A2 BR PI0612069 A2 BRPI0612069 A2 BR PI0612069A2 BR PI0612069 A BRPI0612069 A BR PI0612069A BR PI0612069 A2 BRPI0612069 A2 BR PI0612069A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acids
- oxm
- compounds
- peptide
- effects
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
Abstract
COMPOSTOS E SEUS EFEITOS SOBRE O COMPORTAMENTO DE ALIMENTAÇçO. Compostos da invenção são novos análogos peptídicos de oxintomodulina (oxm) nos quais um ou mais aminoácidos da seqúência da oxm foram alterados. Troca dos aminoácidos 15-24 da oxm pelos aminoácidos 968-977 do peptídeo de <244>-latrotoxina (e variações da mesma) ou aminoácidos 15-24 da exendina-4 (e variações da mesma) ou combinações de seqúências dessas fontes e/ou troca dos aminoácidos 27-33 da exendina-4 e/ou a adição de aminoácidos ao C-término do peptídeo, resulta em uma série de análogos de oxm que demonstram atividade semelhante à oxm e, em determinadas modalidades, uma maior capacidade de diminuir a ingestão de alimentos.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0511998A GB0511998D0 (en) | 2005-06-13 | 2005-06-13 | Novel compounds and their effects on feeding behaviour |
GB0511990A GB0511990D0 (en) | 2005-06-13 | 2005-06-13 | Novel compounds and their effects on feeding behaviour |
GBGB0511986.2A GB0511986D0 (en) | 2005-06-13 | 2005-06-13 | Novel compounds and their effects on feeding behaviour |
GB0511988A GB0511988D0 (en) | 2005-06-13 | 2005-06-13 | Novel compounds and their effects on feeding behaviour |
GB0602567A GB0602567D0 (en) | 2006-02-08 | 2006-02-08 | Novel compounds and their effects on feeding behaviour |
PCT/GB2006/002155 WO2006134340A2 (en) | 2005-06-13 | 2006-06-13 | Oxyntomodulin analogues and their effects on feeding behaviour |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0612069A2 true BRPI0612069A2 (pt) | 2009-01-20 |
Family
ID=37195703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0612069-5A BRPI0612069A2 (pt) | 2005-06-13 | 2006-06-13 | compostos e seus efeitos sobre o comportamento de alimentaÇço |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP2351776A1 (pt) |
JP (1) | JP2008543816A (pt) |
KR (1) | KR101349808B1 (pt) |
AT (1) | ATE553124T1 (pt) |
AU (1) | AU2006258841B2 (pt) |
BR (1) | BRPI0612069A2 (pt) |
CA (1) | CA2612063A1 (pt) |
CY (1) | CY1113014T1 (pt) |
DK (1) | DK1891105T3 (pt) |
ES (1) | ES2385093T3 (pt) |
HK (1) | HK1109906A1 (pt) |
IL (1) | IL186802A0 (pt) |
PL (1) | PL1891105T3 (pt) |
PT (1) | PT1891105E (pt) |
RU (1) | RU2485135C2 (pt) |
SI (1) | SI1891105T1 (pt) |
WO (1) | WO2006134340A2 (pt) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
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GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
AU2002332054B2 (en) | 2001-09-24 | 2007-11-08 | Imperial Innovations Limited | Modification of feeding behavior |
WO2007056362A2 (en) | 2005-11-07 | 2007-05-18 | Indiana University Research And Technology Corporation | Glucagon analogs exhibiting physiological solubility and stability |
US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
CN101389648B (zh) * | 2006-02-22 | 2013-07-17 | 默沙东公司 | 肽胃泌酸调节素衍生物 |
TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
EP2124974B1 (en) | 2007-01-05 | 2017-03-15 | Indiana University Research and Technology Corporation | Glucagon analogs exhibiting enhanced solubility in physiological ph buffers |
EP2111414B1 (en) | 2007-02-15 | 2014-07-02 | Indiana University Research and Technology Corporation | Glucagon/glp-1 receptor co-agonists |
ATE520714T1 (de) * | 2007-06-15 | 2011-09-15 | Zealand Pharma As | Glucagonanaloga |
EP2025684A1 (en) * | 2007-08-15 | 2009-02-18 | Zealand Pharma A/S | Glucagon analogues |
WO2009058734A1 (en) | 2007-10-30 | 2009-05-07 | Indiana University Research And Technology Corporation | Compounds exhibiting glucagon antagonist and glp-1 agonist activity |
ES2509883T3 (es) | 2007-10-30 | 2014-10-20 | Indiana University Research And Technology Corporation | Antagonistas de glucagón |
EA019203B9 (ru) | 2008-06-17 | 2014-03-31 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Коагонисты глюкагонового рецептора/glp-1-рецептора |
US9062124B2 (en) | 2008-06-17 | 2015-06-23 | Indiana University Research And Technology Corporation | GIP-based mixed agonists for treatment of metabolic disorders and obesity |
KR20110039230A (ko) | 2008-06-17 | 2011-04-15 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 생리학적 pH 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체 |
JO2870B1 (en) | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
EA020537B1 (ru) | 2008-12-15 | 2014-11-28 | Зилэнд Фарма А/С | Аналоги глюкагона |
AU2008365556A1 (en) | 2008-12-15 | 2011-07-21 | Zealand Pharma A/S | Glucagon analogues |
US8680049B2 (en) | 2008-12-15 | 2014-03-25 | Zealand Pharma A/S | Glucagon analogues |
EP2370461B1 (en) | 2008-12-15 | 2013-10-02 | Zealand Pharma A/S | Glucagon analogues |
TWI489992B (zh) | 2008-12-19 | 2015-07-01 | 印地安那大學研究及技術公司 | 醯胺系胰高血糖素超級家族之胜肽前驅藥物 |
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MX2011013625A (es) | 2009-06-16 | 2012-01-20 | Univ Indiana Res & Tech Corp | Compuestos glucagon activo de receptor de gip. |
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CN102595897A (zh) | 2009-09-02 | 2012-07-18 | 默沙东公司 | 作为用于糖尿病的治疗或预防的二肽基肽酶-iv抑制剂的氨基四氢吡喃 |
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EP2512503A4 (en) | 2009-12-18 | 2013-08-21 | Univ Indiana Res & Tech Corp | COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR |
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ES2661228T3 (es) | 2010-05-13 | 2018-03-28 | Indiana University Research And Technology Corporation | Péptidos de la superfamilia de glucagón que muestran actividad de receptor nuclear de hormona |
EP2568993A4 (en) | 2010-05-13 | 2014-02-19 | Univ Indiana Res & Tech Corp | GLUCAGON SUPERFAMILY PEPTIDES EXPRESSING G PROTEIN-COUPLED RECEPTOR ACTIVITY |
EP2571876B1 (en) | 2010-05-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
AR081975A1 (es) | 2010-06-23 | 2012-10-31 | Zealand Pharma As | Analogos de glucagon |
WO2011163012A2 (en) | 2010-06-24 | 2011-12-29 | Indiana University Research And Technology Corporation | Amide based glucagon superfamily peptide prodrugs |
EA201291234A1 (ru) | 2010-06-24 | 2013-07-30 | Зилэнд Фарма А/С | Аналоги глюкагона |
PE20140186A1 (es) | 2010-12-22 | 2014-02-13 | Univ Indiana Res & Tech Corp | Analogos de glucagon que presentan actividad de receptor de gip |
BR112013018269A2 (pt) | 2011-01-20 | 2017-06-06 | Zealand Pharma As | combinação de análogos acilados do glucagon com análogos da insulina |
WO2012150503A2 (en) | 2011-05-03 | 2012-11-08 | Zealand Pharma A/S | Glu-glp-1 dual agonist signaling-selective compounds |
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GEP20176629B (en) | 2011-06-22 | 2017-02-27 | Indiana Unversity Research And Tech Corporation | Glucagon/glp-1 receptor co-agonists |
MX2013015168A (es) | 2011-06-22 | 2014-03-31 | Univ Indiana Res & Tech Corp | Co-agonista del receptor de glucagon/glp-1. |
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KR20140097151A (ko) | 2011-11-17 | 2014-08-06 | 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 | 글루코코르티코이드 수용체 활성을 나타내는 글루카곤 슈퍼패밀리 펩티드 |
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JP6290193B2 (ja) * | 2012-06-04 | 2018-03-07 | オプコ バイオロジクス リミテッド | ペグ化oxm変異体 |
CA2875743A1 (en) * | 2012-06-14 | 2013-12-19 | Sanofi | Exendin-4 peptide analogues |
JP6311708B2 (ja) * | 2012-06-21 | 2018-04-18 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | Gip受容体活性を示すグルカゴンアナローグ |
CA2878991C (en) | 2012-07-23 | 2021-12-07 | Zealand Pharma A/S | Glucagon analogues |
KR101968344B1 (ko) * | 2012-07-25 | 2019-04-12 | 한미약품 주식회사 | 옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물 |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
AR092873A1 (es) | 2012-09-26 | 2015-05-06 | Cadila Healthcare Ltd | Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon |
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EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
TW201609798A (zh) * | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Exendin-4胜肽類似物 |
EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
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2006
- 2006-06-13 KR KR1020087000871A patent/KR101349808B1/ko not_active IP Right Cessation
- 2006-06-13 EP EP10195787A patent/EP2351776A1/en not_active Withdrawn
- 2006-06-13 CA CA002612063A patent/CA2612063A1/en not_active Abandoned
- 2006-06-13 PL PL06744197T patent/PL1891105T3/pl unknown
- 2006-06-13 PT PT06744197T patent/PT1891105E/pt unknown
- 2006-06-13 DK DK06744197.2T patent/DK1891105T3/da active
- 2006-06-13 AU AU2006258841A patent/AU2006258841B2/en not_active Ceased
- 2006-06-13 WO PCT/GB2006/002155 patent/WO2006134340A2/en active Application Filing
- 2006-06-13 BR BRPI0612069-5A patent/BRPI0612069A2/pt not_active IP Right Cessation
- 2006-06-13 SI SI200631355T patent/SI1891105T1/sl unknown
- 2006-06-13 JP JP2008516398A patent/JP2008543816A/ja not_active Withdrawn
- 2006-06-13 RU RU2008100238/04A patent/RU2485135C2/ru not_active IP Right Cessation
- 2006-06-13 ES ES06744197T patent/ES2385093T3/es active Active
- 2006-06-13 AT AT06744197T patent/ATE553124T1/de active
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2007
- 2007-10-21 IL IL186802A patent/IL186802A0/en unknown
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2008
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EP1891105B1 (en) | 2012-04-11 |
SI1891105T1 (sl) | 2012-07-31 |
WO2006134340A3 (en) | 2007-06-28 |
PT1891105E (pt) | 2012-06-27 |
IL186802A0 (en) | 2008-02-09 |
RU2485135C2 (ru) | 2013-06-20 |
RU2008100238A (ru) | 2009-07-20 |
HK1109906A1 (en) | 2008-06-27 |
PL1891105T3 (pl) | 2012-09-28 |
ES2385093T3 (es) | 2012-07-18 |
WO2006134340A9 (en) | 2009-03-05 |
CA2612063A1 (en) | 2006-12-21 |
EP2351776A1 (en) | 2011-08-03 |
AU2006258841B2 (en) | 2012-05-03 |
JP2008543816A (ja) | 2008-12-04 |
AU2006258841A1 (en) | 2006-12-21 |
KR101349808B1 (ko) | 2014-02-13 |
EP1891105A2 (en) | 2008-02-27 |
KR20080039375A (ko) | 2008-05-07 |
CY1113014T1 (el) | 2016-04-13 |
DK1891105T3 (da) | 2012-07-16 |
WO2006134340A2 (en) | 2006-12-21 |
ATE553124T1 (de) | 2012-04-15 |
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