SG11202010016QA - Lixisenatide synthesis with capping - Google Patents
Lixisenatide synthesis with cappingInfo
- Publication number
- SG11202010016QA SG11202010016QA SG11202010016QA SG11202010016QA SG11202010016QA SG 11202010016Q A SG11202010016Q A SG 11202010016QA SG 11202010016Q A SG11202010016Q A SG 11202010016QA SG 11202010016Q A SG11202010016Q A SG 11202010016QA SG 11202010016Q A SG11202010016Q A SG 11202010016QA
- Authority
- SG
- Singapore
- Prior art keywords
- lixisenatide
- capping
- synthesis
- lixisenatide synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/066—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amido functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18166551 | 2018-04-10 | ||
| PCT/EP2019/059090 WO2019197469A1 (en) | 2018-04-10 | 2019-04-10 | Lixisenatide synthesis with capping |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202010016QA true SG11202010016QA (en) | 2020-11-27 |
Family
ID=62002530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202010016QA SG11202010016QA (en) | 2018-04-10 | 2019-04-10 | Lixisenatide synthesis with capping |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11028123B2 (en) |
| EP (1) | EP3774838B1 (en) |
| JP (1) | JP7332620B2 (en) |
| KR (1) | KR20200142032A (en) |
| CN (1) | CN112218876A (en) |
| AU (1) | AU2019250362A1 (en) |
| BR (1) | BR112020020647A2 (en) |
| CA (1) | CA3096495A1 (en) |
| DK (1) | DK3774838T3 (en) |
| ES (1) | ES2928207T3 (en) |
| HU (1) | HUE059777T2 (en) |
| IL (1) | IL277836A (en) |
| MX (1) | MX2020010715A (en) |
| SG (1) | SG11202010016QA (en) |
| WO (1) | WO2019197469A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2928207T3 (en) | 2018-04-10 | 2022-11-16 | Sanofi Aventis Deutschland | Synthesis of lixisenatide with hooding |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| JP3107488B2 (en) | 1993-09-29 | 2000-11-06 | 株式会社資生堂 | Sustained-release preparation and embolic agent using cross-linked hyaluronic acid |
| CA2262647C (en) | 1996-08-08 | 2007-12-04 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| AR010744A1 (en) | 1996-12-09 | 2000-07-12 | Guildford Pharmaceuticals Inc | CYCLOPHILINE POLYPROPYL INHIBITORS |
| ES2425559T5 (en) | 1997-01-07 | 2018-02-02 | Amylin Pharmaceuticals, Llc | Pharmaceutical compositions comprising exendins and their agonists |
| PT1019077E (en) | 1997-08-08 | 2008-02-21 | Amylin Pharmaceuticals Inc | Novel exendin agonist compounds |
| DK1032587T4 (en) | 1997-11-14 | 2013-04-08 | Amylin Pharmaceuticals Llc | New exendin agonist compounds |
| JP2003522721A (en) | 1997-11-14 | 2003-07-29 | アミリン・ファーマシューティカルズ，インコーポレイテッド | New exendin agonist compounds |
| JP2002521319A (en) * | 1998-07-23 | 2002-07-16 | メタファー・インコーポレイテッド | Library of polyhydroxamates and their analogs |
| GB9818730D0 (en) * | 1998-08-27 | 1998-10-21 | Univ Portsmouth | Collections of compounds |
| EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
| US6528486B1 (en) | 1999-07-12 | 2003-03-04 | Zealand Pharma A/S | Peptide agonists of GLP-1 activity |
| US7431685B2 (en) | 2000-03-28 | 2008-10-07 | Laser- Und Medizin Technologie Gmbh | Method and device for investigating substance libraries |
| AU2003243929B2 (en) | 2002-07-04 | 2009-06-04 | Zp Holding Spv K/S | GLP-1 and methods for treating diabetes |
| KR20050083713A (en) | 2002-10-02 | 2005-08-26 | 질랜드 파마 에이/에스 | Stabilized exendin-4 compounds |
| US20050106100A1 (en) | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| US20050176079A1 (en) | 2004-02-09 | 2005-08-11 | Chu Yong L. | Polypeptide bioconjugates, methods of making the bioconjugates and assays employing the bioconjugates |
| US20080019911A1 (en) | 2005-04-20 | 2008-01-24 | Aimin Xu | Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 |
| KR20080026117A (en) | 2005-05-26 | 2008-03-24 | 브리스톨-마이어스 스큅 컴퍼니 | N-terminally modified glp-1 receptor modulators |
| JP2008543816A (en) | 2005-06-13 | 2008-12-04 | インペリアル イノベーションズ リミテッド | Novel compounds and their effects on eating behavior |
| EP1905456A4 (en) | 2005-07-06 | 2010-12-22 | Seikagaku Kogyo Co Ltd | Drug-containing photocrosslinked hyaluronic acid derivative gel |
| CN101357938B (en) | 2007-07-31 | 2013-07-03 | 周逸明 | Method for synthesizing Exenatide from solid phase polypeptide |
| SI2237799T1 (en) | 2008-02-01 | 2019-07-31 | Ascendis Pharma A/S | Prodrug comprising a self-cleavable linker |
| TWI474835B (en) | 2008-06-17 | 2015-03-01 | Univ Indiana Res & Tech Corp | Gip-based mixed agonists for treatment of metabolic disorders and obesity |
| UA102432C2 (en) * | 2009-02-20 | 2013-07-10 | Іпсен Фарма С.А.С. | Neuropeptide y-cytotoxic conjugates |
| AU2010260058B2 (en) | 2009-06-16 | 2015-09-24 | Indiana University Research And Technology Corporation | GIP receptor-active glucagon compounds |
| WO2011012723A1 (en) | 2009-07-31 | 2011-02-03 | Ascendis Pharma As | Injectable sustained release compositions comprising a pramipexole prodrug |
| UY33462A (en) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | GLUCAGON ANALOGS |
| EA201390941A1 (en) | 2010-12-22 | 2013-12-30 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | GLUCAGON ANALOGUES, EXPERIENCING ACTIVITY ON GIP RECEPTOR |
| CN103282054A (en) * | 2011-01-03 | 2013-09-04 | 弗·哈夫曼-拉罗切有限公司 | A pharmaceutical composition of a complex of an anti-ig antibody and digoxigenin that is conjugated to a peptide |
| US20130289241A1 (en) | 2012-04-26 | 2013-10-31 | Shanghai Ambiopharm, Inc. | Method for preparing exenatide |
| ES2602486T3 (en) | 2012-06-21 | 2017-02-21 | Indiana University Research And Technology Corporation | Glucagon analogs showing GIP receptor activity |
| SG11201408491SA (en) | 2012-06-21 | 2015-01-29 | Univ Indiana Res & Tech Corp | Analogs of glucagon exhibiting gip receptor activity |
| CN103163233B (en) | 2012-07-12 | 2014-06-25 | 海南合瑞制药股份有限公司 | Deletion peptide and detection method for peptide phase 28 of solid-phase synthesis thymulin alpha1 |
| WO2014049610A2 (en) | 2012-09-26 | 2014-04-03 | Cadila Healthcare Limited | Peptides as gip, glp-1 and glucagon receptors triple-agonist |
| UA116217C2 (en) | 2012-10-09 | 2018-02-26 | Санофі | Exendin-4 derivatives as dual glp1/glucagon agonists |
| JP6499967B2 (en) | 2012-11-06 | 2019-04-10 | レ オピト ユニベルシテル ドゥ ジュネーブＬｅｓ Ｈｏｐｉｔａｕｘ Ｕｎｉｖｅｒｓｉｔａｉｒｅｓ Ｄｅ Ｇｅｎｅｖｅ | Mimetic peptide |
| AU2013366691A1 (en) | 2012-12-21 | 2015-07-09 | Sanofi | Exendin-4 derivatives |
| MX369770B (en) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Glucagon-glp-1-gip triple agonist compounds. |
| TW201609798A (en) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | EXENDIN-4 peptide analogues |
| TW201609797A (en) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | Dual GLP-1/glucagon receptor agonists |
| EP3080155A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists |
| CN103819553A (en) * | 2013-12-27 | 2014-05-28 | 苏贤斌 | Method for preparing lixisenatide by using solid phase and liquid phase combined technology |
| TW201625669A (en) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4 |
| CN104211801A (en) * | 2014-07-25 | 2014-12-17 | 杭州诺泰制药技术有限公司 | Method for preparing lixisenatide |
| CN104844706B (en) | 2015-06-10 | 2018-08-03 | 成都圣诺生物科技股份有限公司 | A method of synthesis lixisenatide |
| WO2016198624A1 (en) | 2015-06-12 | 2016-12-15 | Sanofi | Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists |
| AU2016343775B2 (en) * | 2015-10-28 | 2021-07-29 | Tufts Medical Center | Novel polypeptides with improved proteolytic stability, and methods of preparing and using same |
| CA3018618A1 (en) * | 2016-03-23 | 2017-09-28 | Bachem Holding Ag | Method for preparing glucagon-like peptides |
| WO2017189925A1 (en) | 2016-04-28 | 2017-11-02 | C S Bio Co. | Methods of preparing peptides |
| TW201821434A (en) | 2016-10-10 | 2018-06-16 | 法商賽諾菲公司 | Method of preparing peptides comprising a lipophilically modified lysine side chain |
| AR110300A1 (en) | 2016-12-02 | 2019-03-13 | Sanofi Sa | COMPOUNDS AS TRIGONAL PEPTIDE AGONISTS OF GLP1 / GLUCAGÓN / GIP RECEPTORS |
| US11560402B2 (en) * | 2018-04-10 | 2023-01-24 | Sanofi-Aventis Deutschland Gmbh | Method for cleavage of solid phase-bound peptides from the solid phase |
| ES2928207T3 (en) | 2018-04-10 | 2022-11-16 | Sanofi Aventis Deutschland | Synthesis of lixisenatide with hooding |
-
2019
- 2019-04-10 ES ES19715517T patent/ES2928207T3/en active Active
- 2019-04-10 MX MX2020010715A patent/MX2020010715A/en unknown
- 2019-04-10 HU HUE19715517A patent/HUE059777T2/en unknown
- 2019-04-10 JP JP2020555311A patent/JP7332620B2/en active Active
- 2019-04-10 CN CN201980037082.8A patent/CN112218876A/en active Pending
- 2019-04-10 WO PCT/EP2019/059090 patent/WO2019197469A1/en active Search and Examination
- 2019-04-10 SG SG11202010016QA patent/SG11202010016QA/en unknown
- 2019-04-10 EP EP19715517.9A patent/EP3774838B1/en active Active
- 2019-04-10 DK DK19715517.9T patent/DK3774838T3/en active
- 2019-04-10 CA CA3096495A patent/CA3096495A1/en active Pending
- 2019-04-10 US US16/380,321 patent/US11028123B2/en active Active
- 2019-04-10 KR KR1020207032151A patent/KR20200142032A/en active Search and Examination
- 2019-04-10 BR BR112020020647-4A patent/BR112020020647A2/en unknown
- 2019-04-10 AU AU2019250362A patent/AU2019250362A1/en active Pending
-
2020
- 2020-10-07 IL IL277836A patent/IL277836A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112020020647A2 (en) | 2021-02-23 |
| ES2928207T3 (en) | 2022-11-16 |
| CA3096495A1 (en) | 2019-10-17 |
| EP3774838B1 (en) | 2022-08-10 |
| WO2019197469A1 (en) | 2019-10-17 |
| US11028123B2 (en) | 2021-06-08 |
| CN112218876A (en) | 2021-01-12 |
| US20190330263A1 (en) | 2019-10-31 |
| AU2019250362A1 (en) | 2020-11-26 |
| IL277836A (en) | 2020-11-30 |
| JP7332620B2 (en) | 2023-08-23 |
| EP3774838A1 (en) | 2021-02-17 |
| HUE059777T2 (en) | 2022-12-28 |
| JP2021521144A (en) | 2021-08-26 |
| DK3774838T3 (en) | 2022-10-31 |
| MX2020010715A (en) | 2021-01-08 |
| KR20200142032A (en) | 2020-12-21 |
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