MXPA06003474A - Agonistas de receptores de melanocortina. - Google Patents
Agonistas de receptores de melanocortina.Info
- Publication number
- MXPA06003474A MXPA06003474A MXPA06003474A MXPA06003474A MXPA06003474A MX PA06003474 A MXPA06003474 A MX PA06003474A MX PA06003474 A MXPA06003474 A MX PA06003474A MX PA06003474 A MXPA06003474 A MX PA06003474A MX PA06003474 A MXPA06003474 A MX PA06003474A
- Authority
- MX
- Mexico
- Prior art keywords
- receptor agonists
- melanocortin receptor
- peptides
- obesity
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Se describen peptidos ciclicos de cadena corta de la formula X1-X2-X3-X4-X5-X6-X7-R1 que comprenden 7-12 residuos de aminoacidos. Estos peptidos son agonistas para el receptor de MC4 y por lo tanto, utiles para el tratamiento contra la obesidad y enfermedades relacionadas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200301417 | 2003-09-30 | ||
PCT/DK2004/000657 WO2005030797A2 (en) | 2003-09-30 | 2004-09-29 | Melanocortin receptor agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA06003474A true MXPA06003474A (es) | 2006-06-05 |
Family
ID=34384508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA06003474A MXPA06003474A (es) | 2003-09-30 | 2004-09-29 | Agonistas de receptores de melanocortina. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7517854B2 (es) |
EP (1) | EP1670815A2 (es) |
JP (1) | JP2007532471A (es) |
KR (1) | KR20060089874A (es) |
CN (2) | CN101497654A (es) |
AU (1) | AU2004275928B2 (es) |
BR (1) | BRPI0414890A (es) |
CA (1) | CA2539596A1 (es) |
MX (1) | MXPA06003474A (es) |
RU (1) | RU2381233C2 (es) |
WO (1) | WO2005030797A2 (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080280820A1 (en) * | 2004-11-04 | 2008-11-13 | Ulrich Sensfuss | Novel Peptides for Use in the Treatment of Obesity |
WO2006048450A2 (en) * | 2004-11-04 | 2006-05-11 | Novo Nordisk A/S | Peptides for use in the treating obesity |
EP1809667A1 (en) * | 2004-11-04 | 2007-07-25 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
US20080207493A1 (en) * | 2005-03-17 | 2008-08-28 | Novo Nordisk A/S | Compounds for Use in the Treatment of Obesity |
US7754691B1 (en) | 2005-07-07 | 2010-07-13 | Palatin Technologies, Inc. | Linear melanocortin receptor-specific peptides for cachexia |
US8247530B2 (en) | 2005-11-08 | 2012-08-21 | Palatin Technologies, Inc. | N-alkylated cyclic peptide melanocortin agonists |
KR100822782B1 (ko) * | 2006-04-25 | 2008-04-17 | 재단법인서울대학교산학협력재단 | 개구린 5로부터 합성 및 제조된 항비만용 펩타이드유도체 |
MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
WO2008087188A2 (en) * | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2009151383A1 (en) * | 2008-06-09 | 2009-12-17 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for the treatment of obesity and other diseases associated with melanocortin receptor function |
EA018630B1 (ru) * | 2008-06-09 | 2013-09-30 | Палатин Текнолоджиз, Инк. | Специфичные к меланокортиновым рецепторам пептиды для лечения сексуальной дисфункции |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
EP2440572B1 (en) | 2009-06-08 | 2017-04-05 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
UY32690A (es) * | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
CN105037502A (zh) * | 2009-06-08 | 2015-11-11 | 帕拉丁科技公司 | 黑皮质素受体特异性肽 |
BR112012003973A2 (pt) | 2009-08-26 | 2015-09-08 | Sanofi Sa | hidratos de fluoroglicosídeo heteroaromático cristalinos, produtos farmacêuticos compreendendo estes compostos e seu uso |
PL2473518T3 (pl) * | 2009-08-31 | 2017-07-31 | Tensive Controls, Inc. | Stabilizowane ligandy melanokortyny |
CN101724026B (zh) * | 2009-11-06 | 2012-02-01 | 河南玄美生物科技有限公司 | 一种黑皮素类似物及其制备方法和应用 |
BR112012011780A2 (pt) | 2009-11-23 | 2019-09-24 | Palatin Technologies, Inc | peptídeo linear,composição farmacêutica,métodopara tratamento de umadoença,indicação,condição ou sídrome mediadsa por receptor de melanocortina emum mamífero humano ou não humano e método para tratamento de uma condição responsiva ás alterações em função de receptor de melanocortina em um mamifero humano ou não humano |
MX2012005862A (es) | 2009-11-23 | 2012-09-07 | Palatin Technologies Inc | Peptidos ciclicos especificos del receptor de melanocortina-1. |
CN102276698B (zh) * | 2010-06-10 | 2014-02-26 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种mc4-r环肽类激动剂及其用途 |
EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
WO2013138340A1 (en) * | 2012-03-13 | 2013-09-19 | Tensive Controls Inc. | Melanocortin analogs having enhanced activity and transport |
KR20180002713A (ko) * | 2015-05-11 | 2018-01-08 | 얀센 백신스 앤드 프리벤션 비.브이. | 인플루엔자 바이러스 중화 펩티드 모방 화합물 |
US20210221867A1 (en) | 2018-05-15 | 2021-07-22 | Novo Nordisk A/S | Compounds Capable of Binding to Melanocortin 4 Receptor |
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US5731408A (en) | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
CZ120398A3 (cs) | 1995-09-08 | 1998-12-16 | Novo Nordisk A/S | Použití 2-alkylpyrrolidinových derivátů pro přípravu léčiva pro léčbu diabetu, 2-alkylpyrrolidiné deriváty |
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AU2930797A (en) | 1997-05-02 | 1997-11-19 | Dr. Reddy's Research Foundation | Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
JP2003514508A (ja) | 1997-07-01 | 2003-04-15 | ノボ ノルディスク アクティーゼルスカブ | グルカゴン拮抗剤/逆作用剤 |
EP1000066A1 (en) | 1997-07-16 | 2000-05-17 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine derivatives, their preparation and use |
US6440961B1 (en) | 1997-10-27 | 2002-08-27 | Dr. Reddy's Research Foundation | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them |
WO1999019313A1 (en) | 1997-10-27 | 1999-04-22 | Dr. Reddy's Research Foundation | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them |
DE69803750T2 (de) | 1997-12-02 | 2002-09-12 | Reddy S Res Foundation Andhra | Thiazolidinedione- und oxazolidinedione-derivate mit antidiabetischen, hypolipidämischen und anti hypertensiven eigenschaften |
GB9808229D0 (en) * | 1998-04-17 | 1998-06-17 | Quadrant Holdings Cambridge | Melanocortin receptor ligands |
EP1123269A1 (en) | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
JP2002527520A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、その製造及び使用 |
JP2002527502A (ja) | 1998-10-21 | 2002-08-27 | ノボ ノルディスク アクティーゼルスカブ | 新規化合物、それらの調製及び使用 |
WO2000023415A1 (en) | 1998-10-21 | 2000-04-27 | Novo Nordisk A/S | New compounds, their preparation and use |
AU6190299A (en) | 1998-10-21 | 2000-05-08 | Dr. Reddy's Research Foundation | New compounds, their preparation and use |
EP1123292A1 (en) | 1998-10-21 | 2001-08-16 | Novo Nordisk A/S | New compounds, their preparation and use |
BR9916279A (pt) | 1998-12-18 | 2001-10-16 | Novo Nordisk As | Composto, composição farmacêutica, uso de um composto, métodos de tratar ou prevenir doenças do sistema endocrinológico e diabetes melittus não dependente de insulina em um paciente em necessidade deste, e de tratar glicose de resistência prejudicada (ifg) ou tolerância à glicose prejudica (igt) em um paciente em necessida deste, processo para a fabricação de um medicamento particular a ser usado no tratamento ou prevenção de doenças do sistema endocrinológico, e, métodos para preparar os compostos |
WO2000041121A1 (en) | 1999-01-07 | 2000-07-13 | Ccrewards.Com | Method and arrangement for issuance and management of digital coupons and sales offers |
EP1147094A1 (en) | 1999-01-15 | 2001-10-24 | Novo Nordisk A/S | Non-peptide glp-1 agonists |
JP2002534511A (ja) | 1999-01-18 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 置換型イミダゾール、それらの調製及び使用 |
WO2000058361A1 (en) * | 1999-03-29 | 2000-10-05 | The Procter & Gamble Company | Melanocortin receptor ligands |
AU2953699A (en) | 1999-04-16 | 2000-11-02 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
AU4465200A (en) | 1999-04-16 | 2000-11-02 | Dr. Reddy's Research Foundation | Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them |
EP1173438A1 (en) | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
MXPA01010472A (es) | 1999-04-16 | 2002-05-06 | Reddy Research Foundation | Formas polimorficas novedosas de un agente contra la diabetes; procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
JP2002542237A (ja) | 1999-04-20 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 新規な化合物、それらの製造及び使用 |
KR20020005703A (ko) | 1999-04-20 | 2002-01-17 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 신규한 화합물, 그의 제법 및 용도 |
EP1171438A1 (en) | 1999-04-20 | 2002-01-16 | Novo Nordisk A/S | Compounds, their preparation and use |
WO2000064884A1 (en) | 1999-04-26 | 2000-11-02 | Novo Nordisk A/S | Piperidyl-imidazole derivatives, their preparations and therapeutic uses |
US6579968B1 (en) | 1999-06-29 | 2003-06-17 | Palatin Technologies, Inc. | Compositions and methods for treatment of sexual dysfunction |
WO2002008209A1 (en) | 2000-07-20 | 2002-01-31 | F. Hoffmann-La Roche Ag | Alpha-acyl and alpha-heteroatom-substituted benzene acetamide glucokinase activators |
CN100491396C (zh) * | 2000-08-30 | 2009-05-27 | 霍夫曼-拉罗奇有限公司 | 选择性环肽 |
ATE348097T1 (de) | 2001-04-09 | 2007-01-15 | Chiron Corp | Guanidinoverbindungen als melanocortin-4-rezeptor (mc4-r) agonisten |
CA2453609C (en) | 2001-07-18 | 2010-05-04 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
EP1625158A2 (en) * | 2003-05-09 | 2006-02-15 | Novo Nordisk A/S | Peptides for use in treating obesity |
-
2004
- 2004-09-29 MX MXPA06003474A patent/MXPA06003474A/es unknown
- 2004-09-29 BR BRPI0414890-8A patent/BRPI0414890A/pt not_active IP Right Cessation
- 2004-09-29 WO PCT/DK2004/000657 patent/WO2005030797A2/en active Application Filing
- 2004-09-29 RU RU2006109187/04A patent/RU2381233C2/ru not_active IP Right Cessation
- 2004-09-29 CN CNA2009100081826A patent/CN101497654A/zh active Pending
- 2004-09-29 CA CA002539596A patent/CA2539596A1/en not_active Abandoned
- 2004-09-29 EP EP04762877A patent/EP1670815A2/en not_active Withdrawn
- 2004-09-29 CN CNB2004800284826A patent/CN100482682C/zh not_active Expired - Fee Related
- 2004-09-29 JP JP2006529644A patent/JP2007532471A/ja active Pending
- 2004-09-29 KR KR1020067006233A patent/KR20060089874A/ko not_active Application Discontinuation
- 2004-09-29 AU AU2004275928A patent/AU2004275928B2/en not_active Ceased
-
2006
- 2006-03-30 US US11/278,014 patent/US7517854B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
RU2006109187A (ru) | 2007-11-10 |
WO2005030797A2 (en) | 2005-04-07 |
AU2004275928A1 (en) | 2005-04-07 |
JP2007532471A (ja) | 2007-11-15 |
US7517854B2 (en) | 2009-04-14 |
BRPI0414890A (pt) | 2006-12-12 |
CA2539596A1 (en) | 2005-04-07 |
AU2004275928B2 (en) | 2010-03-11 |
KR20060089874A (ko) | 2006-08-09 |
EP1670815A2 (en) | 2006-06-21 |
CN100482682C (zh) | 2009-04-29 |
CN1860128A (zh) | 2006-11-08 |
RU2381233C2 (ru) | 2010-02-10 |
WO2005030797A3 (en) | 2005-09-09 |
US20070027091A1 (en) | 2007-02-01 |
CN101497654A (zh) | 2009-08-05 |
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