IL128828A0 - Peptide prodrugs containing an alpha-hydroxy acid linker - Google Patents

Peptide prodrugs containing an alpha-hydroxy acid linker

Info

Publication number
IL128828A0
IL128828A0 IL12882897A IL12882897A IL128828A0 IL 128828 A0 IL128828 A0 IL 128828A0 IL 12882897 A IL12882897 A IL 12882897A IL 12882897 A IL12882897 A IL 12882897A IL 128828 A0 IL128828 A0 IL 128828A0
Authority
IL
Israel
Prior art keywords
alpha
hydroxy acid
acid linker
prodrugs containing
peptide prodrugs
Prior art date
Application number
IL12882897A
Original Assignee
Zealand Pharmaceuticals As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zealand Pharmaceuticals As filed Critical Zealand Pharmaceuticals As
Publication of IL128828A0 publication Critical patent/IL128828A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL12882897A 1996-09-09 1997-09-09 Peptide prodrugs containing an alpha-hydroxy acid linker IL128828A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK97296 1996-09-09
PCT/DK1997/000376 WO1998011126A1 (en) 1996-09-09 1997-09-09 Peptide prodrugs containing an alpha-hydroxyacid linker

Publications (1)

Publication Number Publication Date
IL128828A0 true IL128828A0 (en) 2000-01-31

Family

ID=8099572

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12882897A IL128828A0 (en) 1996-09-09 1997-09-09 Peptide prodrugs containing an alpha-hydroxy acid linker

Country Status (8)

Country Link
EP (1) EP0932614A1 (en)
JP (1) JP2001505872A (en)
KR (1) KR20000036015A (en)
AU (1) AU724326B2 (en)
CA (1) CA2265454A1 (en)
IL (1) IL128828A0 (en)
NZ (1) NZ334595A (en)
WO (1) WO1998011126A1 (en)

Families Citing this family (74)

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CA2280957A1 (en) * 1997-02-14 1998-08-20 Leslie Orgel Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents
NZ506839A (en) * 1998-03-09 2003-05-30 Zealand Pharma As Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
EP1076066A1 (en) * 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
US6908900B2 (en) * 2001-01-17 2005-06-21 Zimmer & Associates Ag Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients
US7671029B2 (en) 1999-08-06 2010-03-02 Immupharma Sa Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances
US6939693B2 (en) 1999-10-29 2005-09-06 Novus International, Inc. Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids
CA2389233A1 (en) * 1999-10-29 2001-05-10 Paul K. S. Nam Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids
DE10018617A1 (en) * 2000-01-13 2001-10-31 Joerg G Moser Cyclodextrin dimers with peptide spacer structures for detoxification of active pharmaceutical ingredients with high potential for side effects
CA2423850C (en) 2000-10-09 2017-07-04 Isis Innovation Limited Therapeutic antibodies
US6881829B2 (en) * 2002-04-26 2005-04-19 Chimeracom, L.L.C. Chimeric hybrid analgesics
JP2009508885A (en) 2005-09-21 2009-03-05 ７ティーエム ファーマ エイ／エス Y4 selective receptor agonists for therapeutic intervention
ATE516301T1 (en) 2005-09-21 2011-07-15 7Tm Pharma As Y2-SELECTIVE RECEPTOR AGONISTS FOR THERAPEUTIC INTERVENTIONS
CA2913805A1 (en) 2005-11-07 2007-05-18 Indiana University Research And Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
WO2008086086A2 (en) 2007-01-05 2008-07-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
WO2008101017A2 (en) 2007-02-15 2008-08-21 Indiana Unversity Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
AU2008289441A1 (en) 2007-08-22 2009-02-26 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
CA2702289A1 (en) 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Compounds exhibiting glucagon antagonist and glp-1 agonist activity
US8981047B2 (en) 2007-10-30 2015-03-17 Indiana University Research And Technology Corporation Glucagon antagonists
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
JP5753779B2 (en) 2008-06-17 2015-07-22 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Glucagon analogs with improved solubility and stability in buffers at physiological pH
CN103641907A (en) 2008-06-17 2014-03-19 印第安纳大学研究及科技有限公司 Glucagon/glp-1 receptor co-agonists
EP2300035B1 (en) 2008-06-17 2015-08-12 Indiana University Research and Technology Corporation Gip-based mixed agonists for treatment of metabolic disorders and obesity
UA104605C2 (en) 2008-12-15 2014-02-25 Зіленд Фарма А/С Glucagon analogues
WO2010070252A1 (en) 2008-12-15 2010-06-24 Zealand Pharma A/S Glucagon analogues
ES2502218T3 (en) 2008-12-15 2014-10-03 Zealand Pharma A/S Glucagon analogues
JP5635531B2 (en) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ Glucagon analog
CA2744558A1 (en) 2008-12-19 2010-07-15 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
EP2376520B1 (en) 2008-12-19 2014-02-12 Indiana University Research&Technology Corporation Insulin analogs
WO2010071807A1 (en) * 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
BRPI1006141B8 (en) 2009-01-12 2021-05-25 Cytomx Therapeutics Llc modified antibody compositions, methods of making and using the same
PE20120914A1 (en) 2009-06-16 2012-08-22 Univ Indiana Res & Tech Corp GIP RECEIVER ACTIVE GLUCAGON COMPOUNDS
CA2767792A1 (en) 2009-07-13 2011-01-20 Zealand Pharma A/S Acylated glucagon analogues
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
MX2012008603A (en) 2010-01-27 2013-01-25 Univ Indiana Res & Tech Corp Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity.
CN103003300B (en) 2010-04-27 2017-06-09 西兰制药公司 Peptide conjugate of the receptor stimulating agents of GLP 1 and gastrin and application thereof
CA2797089A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
BR112012028704A2 (en) 2010-05-13 2019-09-24 Univ Indiana Res & Tech Corp a peptide superfamily glugagon compound displaying receptor activity with nuclear hormone, prodrug, dimer or multimer, pharmaceutical composition comprising it and method of administration thereof.
CA2802485C (en) 2010-06-16 2019-09-17 Indiana University Research And Technology Corporation Single chain insulin agonists exhibiting high activity at the insulin receptor
AR081975A1 (en) 2010-06-23 2012-10-31 Zealand Pharma As GLUCAGON ANALOGS
KR20130102470A (en) 2010-06-24 2013-09-17 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Amide based glucagon superfamily peptide prodrugs
US9169310B2 (en) 2010-06-24 2015-10-27 Zealand Pharma A/S Glucagon analogues
CA2803164C (en) 2010-06-24 2018-08-21 Indiana University Research And Technology Corporation Amide-based insulin prodrugs
MX2013006304A (en) 2010-12-22 2013-07-02 Univ Indiana Res & Tech Corp Glucagon analogs exhibiting gip receptor activity.
US9156902B2 (en) 2011-06-22 2015-10-13 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
JP6184404B2 (en) 2011-06-22 2017-08-23 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション Glucagon / GLP-1 receptor co-agonist
EP3643306A3 (en) * 2011-08-12 2020-08-26 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
US9259477B2 (en) 2011-11-03 2016-02-16 Zealand Pharma A/S GLP-1 receptor agonist peptide gastrin conjugates
KR20140097151A (en) 2011-11-17 2014-08-06 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
US9573987B2 (en) 2011-12-20 2017-02-21 Indiana University Research And Technology Corporation CTP-based insulin analogs for treatment of diabetes
US9120853B2 (en) 2012-04-27 2015-09-01 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
TR201815338T4 (en) 2012-05-03 2018-11-21 Zealand Pharma As Gip-glp-1 dual agonist compounds and methods.
CA2877358A1 (en) 2012-06-21 2013-12-27 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
DK2875043T3 (en) 2012-07-23 2017-03-27 Zealand Pharma As glucagon
TWI608013B (en) 2012-09-17 2017-12-11 西蘭製藥公司 Glucagon analogues
CN104981251B (en) 2012-09-26 2018-03-20 印第安纳大学研究及科技有限公司 Insulin analog dimer
JP6219308B2 (en) 2012-11-30 2017-10-25 株式会社糖鎖工学研究所 Glycosylation linker, compound containing glycosylation linker and physiologically active substance or salt thereof, and production method thereof
EP2970511B1 (en) 2013-03-14 2020-09-30 Indiana University Research and Technology Corporation Insulin-incretin conjugates
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
DK2976325T3 (en) 2013-03-21 2017-06-06 Sanofi Aventis Deutschland SYNTHESIS OF PEPTIDE PRODUCTS CONTAINING CYCLIC IMID
SI2994153T1 (en) * 2013-05-07 2018-12-31 Merck Patent Gmbh Peptides and peptide-active ingredient-conjugate for renal drug-targeting
JP6510493B2 (en) * 2013-05-07 2019-05-08 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Conjugates for protection from nephrotoxic active substances
DK3057984T3 (en) 2013-10-17 2018-10-08 Zealand Pharma As ACYLED GLUCAGON ANALOGS
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
WO2015066279A2 (en) 2013-10-30 2015-05-07 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
CN105829339B (en) 2013-11-06 2021-03-12 西兰制药公司 glucagon-GLP-1-GIP triple agonist compounds
JP6682432B2 (en) 2013-11-06 2020-04-15 ジーランド ファーマ アクティーゼルスカブ GIP-GLP-1 dual agonist compounds and methods
WO2015089283A1 (en) 2013-12-11 2015-06-18 Cytomx Therapeutics, Inc. Antibodies that bind activatable antibodies and methods of use thereof
US10232020B2 (en) 2014-09-24 2019-03-19 Indiana University Research And Technology Corporation Incretin-insulin conjugates
JP6701208B2 (en) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション Lipidated amide insulin prodrug
EP3212218B1 (en) 2014-10-29 2021-06-30 Zealand Pharma A/S Gip agonist compounds and methods
CA2980978A1 (en) 2015-04-16 2016-10-20 Zealand Pharma A/S Acylated glucagon analogue
RU2753193C2 (en) 2016-12-09 2021-08-12 Зилэнд Фарма А/С Acylated double agonists of glp-1/glp-2
CN111511757A (en) 2017-11-17 2020-08-07 细胞凝胶制药有限责任公司 Polymeric agonists of mu opioid receptors

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US5589356A (en) * 1993-06-21 1996-12-31 Vanderbilt University Litigation of sidechain unprotected peptides via a masked glycoaldehyde ester and O,N-acyl rearrangement

Also Published As

Publication number Publication date
EP0932614A1 (en) 1999-08-04
KR20000036015A (en) 2000-06-26
NZ334595A (en) 2000-08-25
AU724326B2 (en) 2000-09-14
AU4199497A (en) 1998-04-02
CA2265454A1 (en) 1998-03-19
WO1998011126A1 (en) 1998-03-19
JP2001505872A (en) 2001-05-08

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