PE20010171A1 - Derivados de 13-metil eritromicina - Google Patents

Derivados de 13-metil eritromicina

Info

Publication number
PE20010171A1
PE20010171A1 PE2000000491A PE0004912000A PE20010171A1 PE 20010171 A1 PE20010171 A1 PE 20010171A1 PE 2000000491 A PE2000000491 A PE 2000000491A PE 0004912000 A PE0004912000 A PE 0004912000A PE 20010171 A1 PE20010171 A1 PE 20010171A1
Authority
PE
Peru
Prior art keywords
alkyl
members
dirradical
heterociclic
nr8r9
Prior art date
Application number
PE2000000491A
Other languages
English (en)
Inventor
Yong-Jin Wu
John Philip Dirlam
Takushi Kaneko
Hamish Alastair Irvine Mcarthur
Wei-Guo Su
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20010171A1 publication Critical patent/PE20010171A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE RERIERE A MACROLIDOS DE FORMULA I DONDE A ES H, HALOGENO; X ES -CO-, -CH(NR8R9)-, ENTRE OTROS; DONDE EL PRIMER GUION ESTA LIGADO AL C10 Y EL ULTIMO GUION ESTA LIGADO AL C8; Y ES CH2, CO, C=C(RaRb), CHSR7, C=S, -C(=N-OR8), GRUPO a, ENTRE OTROS; R1 ES OR8, NR8C(O)NR8R9, ENTRE OTROS; n ES 0-10; R2 ES OR8, O-MESILO, O-TOSILO, OC(O)NR8R9, S(CRaRb)nAr, ENTRE OTROS; Ra Y Rb SON H, HALO, ALQUILO C1-C6; JUNTO CON C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; (CRaRb)n ES ALQUILENO, R1 Y R2 FORMAN UN GRUPO b; B1 ES O, (CRaaRbb)m, SO2, O, NR7; m ES 0-1; Z ES (CRaaRbb)m, C(O), C(NRaa), P-ORaa, ENTRE OTROS; m ES 1-2; Raa Y Rbb SON H, ALQUILO C1-C6; O JUNTO A C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; R1, R2, X FORMAN UN ANILLO DE FORMULA c; UNO DE E, D, F, G SON H, HALO, ALQUILO C1-C12, ENTRE OTROS; D Y E o F Y G JUNTO A C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; R4 ES H, CO-ALQUILO C1-C18, COAr, OC(O)-ALQUILO C1-C18, ENTRE OTROS; R5 ES H, ALQUILO C1-C10, -C(RaRb)-C(Ra)=C(Rb)-Ar, ENTRE OTROS; R6 ES H, ALQUILO C1-C12, ENTRE OTROS; R7, R8, R9 SON H, ALQUILO C1-C12, ENTRE OTROS; R11, R12, R13 JUNTO A C FORMAN CO, C(=NR8), C(=NOR8), ENTRE OTROS; Ar ES HETEROCICLO DE 4-10 MIEMBROS. LOS COMPUESTOS DE FORMULA I SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
PE2000000491A 1999-05-24 2000-05-23 Derivados de 13-metil eritromicina PE20010171A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13546899P 1999-05-24 1999-05-24

Publications (1)

Publication Number Publication Date
PE20010171A1 true PE20010171A1 (es) 2001-02-10

Family

ID=22468240

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000491A PE20010171A1 (es) 1999-05-24 2000-05-23 Derivados de 13-metil eritromicina

Country Status (32)

Country Link
US (2) US20030100518A1 (es)
EP (1) EP1180110A1 (es)
JP (1) JP2003500414A (es)
KR (1) KR20020016799A (es)
CN (1) CN1351608A (es)
AP (1) AP2001002302A0 (es)
AR (1) AR020032A1 (es)
AU (1) AU3832100A (es)
BG (1) BG106127A (es)
BR (1) BR0010938A (es)
CA (1) CA2373117C (es)
CZ (1) CZ20013733A3 (es)
DZ (1) DZ3045A1 (es)
EA (1) EA200100983A1 (es)
EE (1) EE200100613A (es)
HK (1) HK1045523A1 (es)
HR (1) HRP20010866A2 (es)
HU (1) HUP0201516A3 (es)
IL (1) IL145739A0 (es)
IS (1) IS6128A (es)
MA (1) MA26740A1 (es)
NO (1) NO20015172L (es)
OA (1) OA11945A (es)
PA (1) PA8495101A1 (es)
PE (1) PE20010171A1 (es)
PL (1) PL352720A1 (es)
SK (1) SK15162001A3 (es)
TN (1) TNSN00108A1 (es)
TR (1) TR200103395T2 (es)
UY (1) UY26161A1 (es)
WO (1) WO2000071557A1 (es)
ZA (1) ZA200109595B (es)

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CN101175322B (zh) * 2007-11-16 2010-12-15 华为技术有限公司 一种小区选择的方法
KR101043637B1 (ko) * 2009-07-13 2011-06-24 태석정공 주식회사 휴대용 듀얼 모니터의 카메라 모듈 결합구조
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EA201500699A1 (ru) 2012-12-24 2015-12-30 Рамот Эт Тель-Авив Юниверсити Лтд. Агенты для лечения генетических заболеваний, возникающих в результате нонсенс-мутаций, и способы идентификации этих агентов
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CN107530365A (zh) 2015-03-25 2018-01-02 哈佛大学的校长及成员们 具有修饰的脱氧糖胺糖的大环内酯及其用途

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DZ3045A1 (fr) 2004-03-27
EA200100983A1 (ru) 2002-10-31
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IS6128A (is) 2001-10-26
PA8495101A1 (es) 2002-08-26
CA2373117A1 (en) 2000-11-30
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EP1180110A1 (en) 2002-02-20
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UY26161A1 (es) 2000-12-29
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