PE20010171A1 - Derivados de 13-metil eritromicina - Google Patents
Derivados de 13-metil eritromicinaInfo
- Publication number
- PE20010171A1 PE20010171A1 PE2000000491A PE0004912000A PE20010171A1 PE 20010171 A1 PE20010171 A1 PE 20010171A1 PE 2000000491 A PE2000000491 A PE 2000000491A PE 0004912000 A PE0004912000 A PE 0004912000A PE 20010171 A1 PE20010171 A1 PE 20010171A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- members
- dirradical
- heterociclic
- nr8r9
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE RERIERE A MACROLIDOS DE FORMULA I DONDE A ES H, HALOGENO; X ES -CO-, -CH(NR8R9)-, ENTRE OTROS; DONDE EL PRIMER GUION ESTA LIGADO AL C10 Y EL ULTIMO GUION ESTA LIGADO AL C8; Y ES CH2, CO, C=C(RaRb), CHSR7, C=S, -C(=N-OR8), GRUPO a, ENTRE OTROS; R1 ES OR8, NR8C(O)NR8R9, ENTRE OTROS; n ES 0-10; R2 ES OR8, O-MESILO, O-TOSILO, OC(O)NR8R9, S(CRaRb)nAr, ENTRE OTROS; Ra Y Rb SON H, HALO, ALQUILO C1-C6; JUNTO CON C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; (CRaRb)n ES ALQUILENO, R1 Y R2 FORMAN UN GRUPO b; B1 ES O, (CRaaRbb)m, SO2, O, NR7; m ES 0-1; Z ES (CRaaRbb)m, C(O), C(NRaa), P-ORaa, ENTRE OTROS; m ES 1-2; Raa Y Rbb SON H, ALQUILO C1-C6; O JUNTO A C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; R1, R2, X FORMAN UN ANILLO DE FORMULA c; UNO DE E, D, F, G SON H, HALO, ALQUILO C1-C12, ENTRE OTROS; D Y E o F Y G JUNTO A C FORMAN UN DIRRADICAL CICLICO O HETEROCICLICO DE 3-10 MIEMBROS; R4 ES H, CO-ALQUILO C1-C18, COAr, OC(O)-ALQUILO C1-C18, ENTRE OTROS; R5 ES H, ALQUILO C1-C10, -C(RaRb)-C(Ra)=C(Rb)-Ar, ENTRE OTROS; R6 ES H, ALQUILO C1-C12, ENTRE OTROS; R7, R8, R9 SON H, ALQUILO C1-C12, ENTRE OTROS; R11, R12, R13 JUNTO A C FORMAN CO, C(=NR8), C(=NOR8), ENTRE OTROS; Ar ES HETEROCICLO DE 4-10 MIEMBROS. LOS COMPUESTOS DE FORMULA I SON AGENTES ANTIBACTERIANOS Y ANTIPROTOZOARIOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13546899P | 1999-05-24 | 1999-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010171A1 true PE20010171A1 (es) | 2001-02-10 |
Family
ID=22468240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000491A PE20010171A1 (es) | 1999-05-24 | 2000-05-23 | Derivados de 13-metil eritromicina |
Country Status (32)
Country | Link |
---|---|
US (2) | US20030100518A1 (es) |
EP (1) | EP1180110A1 (es) |
JP (1) | JP2003500414A (es) |
KR (1) | KR20020016799A (es) |
CN (1) | CN1351608A (es) |
AP (1) | AP2001002302A0 (es) |
AR (1) | AR020032A1 (es) |
AU (1) | AU3832100A (es) |
BG (1) | BG106127A (es) |
BR (1) | BR0010938A (es) |
CA (1) | CA2373117C (es) |
CZ (1) | CZ20013733A3 (es) |
DZ (1) | DZ3045A1 (es) |
EA (1) | EA200100983A1 (es) |
EE (1) | EE200100613A (es) |
HK (1) | HK1045523A1 (es) |
HR (1) | HRP20010866A2 (es) |
HU (1) | HUP0201516A3 (es) |
IL (1) | IL145739A0 (es) |
IS (1) | IS6128A (es) |
MA (1) | MA26740A1 (es) |
NO (1) | NO20015172L (es) |
OA (1) | OA11945A (es) |
PA (1) | PA8495101A1 (es) |
PE (1) | PE20010171A1 (es) |
PL (1) | PL352720A1 (es) |
SK (1) | SK15162001A3 (es) |
TN (1) | TNSN00108A1 (es) |
TR (1) | TR200103395T2 (es) |
UY (1) | UY26161A1 (es) |
WO (1) | WO2000071557A1 (es) |
ZA (1) | ZA200109595B (es) |
Families Citing this family (27)
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AP1060A (en) | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
AP9801420A0 (en) | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
CA2349338C (en) | 1998-11-03 | 2005-12-06 | Pfizer Products Inc. | Novel macrolide antibiotics |
BR9916969A (pt) | 1999-01-27 | 2001-11-06 | Pfizer Prod Inc | Antibióticos cetólidos |
AU4354900A (en) | 1999-04-16 | 2000-11-02 | Kosan Biosciences, Inc. | Ketolide antibacterials |
ES2272273T3 (es) | 1999-04-16 | 2007-05-01 | Kosan Biosciences, Inc. | Agentes antiinfecciosos macrolidos. |
US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
US6451768B1 (en) | 1999-04-16 | 2002-09-17 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6514944B2 (en) | 1999-04-16 | 2003-02-04 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6939861B2 (en) | 1999-04-16 | 2005-09-06 | Kosan Biosciences, Inc. | Amido macrolides |
WO2000071557A1 (en) | 1999-05-24 | 2000-11-30 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
GB0127349D0 (en) | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
BR0214748A (pt) | 2001-12-05 | 2004-11-23 | Ortho Mcneil Pharm Inc | Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos |
JP2005528409A (ja) * | 2002-04-25 | 2005-09-22 | アボット・ラボラトリーズ | オキソリド抗菌薬 |
WO2003090761A1 (en) * | 2002-04-25 | 2003-11-06 | Abbott Laboratories | 9-oxime macrolide antibacterials |
GB0225384D0 (en) | 2002-10-31 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
WO2005067564A2 (en) * | 2004-01-07 | 2005-07-28 | Enanta Pharmaceuticals, Inc. | 6-11 bicyclic erythromycin derivatives |
EP1836211B1 (en) * | 2004-12-21 | 2010-03-03 | Pfizer Products Inc. | Macrolides |
ATE468119T1 (de) | 2006-06-12 | 2010-06-15 | Univ Ramot | Verfahren zur behandlung von krebs |
CN101175322B (zh) * | 2007-11-16 | 2010-12-15 | 华为技术有限公司 | 一种小区选择的方法 |
KR101043637B1 (ko) * | 2009-07-13 | 2011-06-24 | 태석정공 주식회사 | 휴대용 듀얼 모니터의 카메라 모듈 결합구조 |
AR085286A1 (es) * | 2011-02-21 | 2013-09-18 | Taisho Pharmaceutical Co Ltd | Derivado de macrolido sustituido en la posicion c-4 |
EA201500699A1 (ru) | 2012-12-24 | 2015-12-30 | Рамот Эт Тель-Авив Юниверсити Лтд. | Агенты для лечения генетических заболеваний, возникающих в результате нонсенс-мутаций, и способы идентификации этих агентов |
US9982005B2 (en) | 2013-04-04 | 2018-05-29 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
WO2016057798A1 (en) * | 2014-10-08 | 2016-04-14 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
CN107530365A (zh) | 2015-03-25 | 2018-01-02 | 哈佛大学的校长及成员们 | 具有修饰的脱氧糖胺糖的大环内酯及其用途 |
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FR2789392B1 (fr) * | 1999-02-04 | 2001-10-05 | Hoechst Marion Roussel Inc | Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments |
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US20020077302A1 (en) | 1999-04-23 | 2002-06-20 | Yong-Jin Wu | Tricyclic erythromycin derivatives |
US20020061857A1 (en) | 1999-04-23 | 2002-05-23 | Yong-Jin Wu | 9-amino-3-oxo erythromycin derivatives |
US6355620B1 (en) * | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
WO2000071557A1 (en) | 1999-05-24 | 2000-11-30 | Pfizer Products Inc. | 13-methyl-erythromycin derivatives |
EP1114826A3 (en) | 1999-12-29 | 2001-10-31 | Pfizer Products Inc. | Novel antibacterial and prokinetic macrolides |
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DK1167376T3 (da) | 2000-06-30 | 2004-10-25 | Pfizer Prod Inc | Makrolidantibiotika |
US20020115621A1 (en) | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
US20020111317A1 (en) | 2000-09-25 | 2002-08-15 | Leonard Katz | Sixteen-membered macrolide compounds |
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2000
- 2000-04-25 WO PCT/IB2000/000502 patent/WO2000071557A1/en not_active Application Discontinuation
- 2000-04-25 EP EP00917230A patent/EP1180110A1/en not_active Withdrawn
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- 2000-04-25 KR KR1020017015049A patent/KR20020016799A/ko not_active Application Discontinuation
- 2000-04-25 CZ CZ20013733A patent/CZ20013733A3/cs unknown
- 2000-04-25 AP APAP/P/2001/002302A patent/AP2001002302A0/en unknown
- 2000-04-25 JP JP2000619813A patent/JP2003500414A/ja active Pending
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- 2000-04-25 AU AU38321/00A patent/AU3832100A/en not_active Abandoned
- 2000-04-25 CN CN00807992A patent/CN1351608A/zh active Pending
- 2000-04-25 PL PL00352720A patent/PL352720A1/xx not_active Application Discontinuation
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- 2000-05-23 PE PE2000000491A patent/PE20010171A1/es not_active Application Discontinuation
- 2000-05-23 TN TNTNSN00108A patent/TNSN00108A1/fr unknown
- 2000-05-23 DZ DZ000088A patent/DZ3045A1/xx active
- 2000-05-24 US US09/577,901 patent/US20030100518A1/en not_active Abandoned
- 2000-05-24 UY UY26161A patent/UY26161A1/es not_active Application Discontinuation
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2001
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2002
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