PE20080010A1 - Derivados de diazepina para el tratamiento de la depresion y composiciones farmaceuticas que los comprenden - Google Patents
Derivados de diazepina para el tratamiento de la depresion y composiciones farmaceuticas que los comprendenInfo
- Publication number
- PE20080010A1 PE20080010A1 PE2007000320A PE2007000320A PE20080010A1 PE 20080010 A1 PE20080010 A1 PE 20080010A1 PE 2007000320 A PE2007000320 A PE 2007000320A PE 2007000320 A PE2007000320 A PE 2007000320A PE 20080010 A1 PE20080010 A1 PE 20080010A1
- Authority
- PE
- Peru
- Prior art keywords
- diazepine
- quinoline
- depression
- treatment
- pharmaceutical compositions
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
REFERIDA A UNA COMPOSICION QUE COMPRENDE: a) UNO O MAS FARMACOS ANTIDEPRESIVOS, b) UN PORTADOR O VEHICULO FARMACEUTICAMENTE ACEPTABLE Y c) UN DERIVADO DIAZEPINO DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE SIMPLE O DOBLE; n ES 1 O 2; m ES 0 O 1; R1 Y R2 SON HALOGENO, CN, R, OR, ENTRE OTROS; R ES H O ALQUILO C1-C6; R3 Y R4 JUNTO CON LOS ATOMOS DE CARBONO A LOS CUALES ESTAN LIGADOS, FORMAN UN ANILLO DE 4 A 8 MIEMBROS, SATURADO O INSATURADO Y QUE OPCIONALMENTE ESTA SUSTITUIDO CON HALOGENO, R U OR; R5 Y R6 SON R. SON COMPUESTOS DE FORMULA (I) FAVORITOS: 2-BROMO-4,5,6,7,9,9a,10,11,12,13,14,14a-DODECAHIDROCICLOHEPTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-BROMO-4,5,6,7,9,,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, 2-CLORO-4,5,6,7,9,9a,10,11,12,12a-DECAHIDROCICLOPENTA[c][1,4]DIAZEPINO[6,7,1-ij]QUINOLINA, ENTRE OTROS. EL AGENTE ANTIDEPRESIVO ES ATIPAMEZOL, CITALOPRAM, FEMOXETINA, LITIO, FLUVOXAMINA, NORTRIPTILINA, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA DEPRESION U OTROS TRASTORNOS EMOCIONALES
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78545406P | 2006-03-24 | 2006-03-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080010A1 true PE20080010A1 (es) | 2008-03-10 |
Family
ID=38466269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000320A PE20080010A1 (es) | 2006-03-24 | 2007-03-23 | Derivados de diazepina para el tratamiento de la depresion y composiciones farmaceuticas que los comprenden |
Country Status (19)
Country | Link |
---|---|
US (1) | US20070225279A1 (es) |
EP (1) | EP1998773A2 (es) |
JP (1) | JP2009531435A (es) |
KR (1) | KR20080105104A (es) |
CN (1) | CN101410112A (es) |
AR (1) | AR060087A1 (es) |
AU (1) | AU2007231011A1 (es) |
BR (1) | BRPI0709159A2 (es) |
CA (1) | CA2644662A1 (es) |
CR (1) | CR10245A (es) |
EC (1) | ECSP088763A (es) |
IL (1) | IL193747A0 (es) |
MX (1) | MX2008012094A (es) |
NO (1) | NO20083758L (es) |
PA (1) | PA8720801A1 (es) |
PE (1) | PE20080010A1 (es) |
RU (1) | RU2008135326A (es) |
TW (1) | TW200806300A (es) |
WO (1) | WO2007112014A2 (es) |
Families Citing this family (18)
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US8158149B2 (en) | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
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TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
BRPI0709146A2 (pt) * | 2006-03-24 | 2011-06-28 | Wyeth Corp | métodos para tratar distúrbios cognitivos e outros distúrbios |
KR20080110759A (ko) * | 2006-03-24 | 2008-12-19 | 와이어쓰 | 통증 치료 |
JP2010520885A (ja) | 2007-03-09 | 2010-06-17 | チェルシー・セラピューティクス,インコーポレイテッド | 線維筋痛症の治療のためのドロキシドパ及びその医薬組成物 |
WO2008137923A2 (en) * | 2007-05-07 | 2008-11-13 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders |
CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
US8198268B2 (en) | 2008-10-31 | 2012-06-12 | Janssen Biotech, Inc. | Tianeptine sulfate salt forms and methods of making and using the same |
JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状(姿勢反射異常)の治療剤 |
UA116216C2 (uk) * | 2012-09-14 | 2018-02-26 | Еббві Дойчланд Гмбх Унд Ко. Кг | Трициклічні хінолінові і хіноксалінові похідні |
US20140080813A1 (en) | 2012-09-14 | 2014-03-20 | AbbVie Deutschland GmbH & Co. KG | Tricyclic quinoline and quinoxaline derivatives |
CN102977053B (zh) * | 2012-11-30 | 2015-04-15 | 山东诚创医药技术开发有限公司 | 一种噻奈普汀钠杂质d的制备方法 |
CA2933921A1 (en) * | 2016-06-17 | 2017-12-17 | S1 Biopharma, Inc. | Methods of treating women for hypoactive sexual desire disorder (hsdd) with bupropion and trazodone combination treatment |
KR20200026920A (ko) | 2017-06-30 | 2020-03-11 | 체이스 테라퓨틱스 코포레이션 | 우울증을 치료하기 위한 nk-1 길항제 조성물 및 우울증 치료에 사용하는 방법 |
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SE0201544D0 (sv) * | 2002-05-17 | 2002-05-17 | Biovitrum Ab | Novel compounds and thier use |
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GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
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BRPI0709146A2 (pt) * | 2006-03-24 | 2011-06-28 | Wyeth Corp | métodos para tratar distúrbios cognitivos e outros distúrbios |
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-
2007
- 2007-03-23 BR BRPI0709159-1A patent/BRPI0709159A2/pt not_active IP Right Cessation
- 2007-03-23 PE PE2007000320A patent/PE20080010A1/es not_active Application Discontinuation
- 2007-03-23 PA PA20078720801A patent/PA8720801A1/es unknown
- 2007-03-23 CN CNA2007800104992A patent/CN101410112A/zh active Pending
- 2007-03-23 EP EP07773638A patent/EP1998773A2/en not_active Withdrawn
- 2007-03-23 KR KR1020087023330A patent/KR20080105104A/ko not_active Application Discontinuation
- 2007-03-23 CA CA002644662A patent/CA2644662A1/en not_active Abandoned
- 2007-03-23 AR ARP070101209A patent/AR060087A1/es unknown
- 2007-03-23 TW TW096110149A patent/TW200806300A/zh unknown
- 2007-03-23 RU RU2008135326/15A patent/RU2008135326A/ru not_active Application Discontinuation
- 2007-03-23 US US11/726,928 patent/US20070225279A1/en not_active Abandoned
- 2007-03-23 JP JP2009502893A patent/JP2009531435A/ja not_active Withdrawn
- 2007-03-23 AU AU2007231011A patent/AU2007231011A1/en not_active Abandoned
- 2007-03-23 WO PCT/US2007/007272 patent/WO2007112014A2/en active Application Filing
- 2007-03-23 MX MX2008012094A patent/MX2008012094A/es unknown
-
2008
- 2008-08-26 CR CR10245A patent/CR10245A/es not_active Application Discontinuation
- 2008-08-28 IL IL193747A patent/IL193747A0/en unknown
- 2008-09-01 NO NO20083758A patent/NO20083758L/no not_active Application Discontinuation
- 2008-09-23 EC EC2008008763A patent/ECSP088763A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1998773A2 (en) | 2008-12-10 |
AR060087A1 (es) | 2008-05-21 |
ECSP088763A (es) | 2008-10-31 |
RU2008135326A (ru) | 2010-04-27 |
CN101410112A (zh) | 2009-04-15 |
WO2007112014A2 (en) | 2007-10-04 |
MX2008012094A (es) | 2008-10-03 |
CR10245A (es) | 2008-11-26 |
AU2007231011A1 (en) | 2007-10-04 |
WO2007112014A3 (en) | 2007-12-21 |
JP2009531435A (ja) | 2009-09-03 |
NO20083758L (no) | 2008-10-21 |
BRPI0709159A2 (pt) | 2011-06-28 |
KR20080105104A (ko) | 2008-12-03 |
US20070225279A1 (en) | 2007-09-27 |
PA8720801A1 (es) | 2008-11-19 |
IL193747A0 (en) | 2009-08-03 |
CA2644662A1 (en) | 2007-10-04 |
TW200806300A (en) | 2008-02-01 |
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