AR055016A1 - Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos - Google Patents
Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentosInfo
- Publication number
- AR055016A1 AR055016A1 ARP050105486A ARP050105486A AR055016A1 AR 055016 A1 AR055016 A1 AR 055016A1 AR P050105486 A ARP050105486 A AR P050105486A AR P050105486 A ARP050105486 A AR P050105486A AR 055016 A1 AR055016 A1 AR 055016A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- groups
- alkyl
- atoms
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedimientos para la preparacion de los impulsos y su uso para la preparacion de medicamentos. Estos compuestos pueden ser utilizados como antiinflamatorios. Reivindicacion 1: Estereoisomeros de la formula general (1), en donde: R1 y R2 son, independientemente entre sí, un átomo de hidrogeno, un grupo hidroxi, un átomo de halogeno, un grupo alquilo C1-10 eventualmente sustituido, un grupo alcoxi C1-10, un grupo alquiltio C1-10, un grupo perfluoroalquilo C1-5, un grupo ciano, un grupo nitro; o R1 y R2 son juntos un grupo seleccionado de los grupos -O-(CH2)n-O-, -O-(CH2) n-CH2-, -O-CH=CH-, -(CH2)n+2-, -NH-(CH2)n+1, N(alquilC1-3)-(CH2)n+1, -NH-N=CH-, en donde n = 1 o 2 y los átomos terminales están unidos con átomos de carbono del anillo directamente adyacentes, o NR8R9, en donde R8 y R9 pueden ser, independientemente entre sí, hidrogeno, alquilo C1-5 o (CO)-alquiloC1-5; R3 es un átomo de hidrogeno, un grupo hidroxi, un átomo de halogeno, un grupo alquilo C1-10 eventualmente sustituido, un grupo alcoxi C1-10, un grupo alquiltio C1-10, un grupo perfluoroalquilo C1-5, un grupo ciano; R4 es un grupo alquilo C1-10, un grupo alquilo C1-10 sustituido con uno o varios grupos seleccionados de 1-3 grupos hidroxi, átomos de halogeno, 1-3 grupos alcoxi C1-5; un grupo cicloalquilo C3-7 eventualmente sustituido; un grupo heterociclilo eventualmente sustituido; un grupo arilo eventualmente sustituido; un grupo heteroarilo mono- o bicíclico eventualmente sustituido con uno o varios grupos seleccionados de grupos alquilo C1-5 (que puede estar eventualmente sustituido con 1-3 grupos hidroxi o 1-3 grupos COOR10, en donde R10 significa alquilo C1-6 o bencilo), grupos alcoxi C1-5, grupos hidroxi, átomos de halogeno, grupos exoalquilideno C1-3, que eventualmente contiene 1-4 átomos de nitrogeno y/o 1-2 átomos de oxígeno y/o 1-2 átomos de azufre y/o 1-2 grupos ceto, en donde este grupo puede estar unido a través de cualquier posicion con la amina del sistema tricíclico y eventualmente hidrogenado en uno o varios sitios; R5 es un grupo alquilo C1-5 o un grupo alquilo C1-5 eventualmente fluorado de modo parcial o total, un grupo cicloalquilo C3-7, un grupo cicloalquilC3-7-alquiloC1-8, un grupo cicloalquilC3-7- alqueniloC2-8, un grupo heterociclilo, un grupo heterociclilalquilo C1-8, un grupo heterociclilalquenilo C2-8, un grupo arilo, un grupo arilalquilo C1-8, un grupo arilalquenilo C2-8, un grupo arilalquinilo C2-8, un grupo heteroarilo mono- o bicíclico eventualmente sustituido con uno o varios grupos ceto, grupos alquilo C1-5, grupos alcoxi C1-5, átomos de halogeno, grupos exoalquilideno C1-3, que contiene uno o varios átomos de nitrogeno y/o átomos de oxígeno y/o átomos de azufre, un grupo heteroarilalquilo C1-8 o un grupo heteroarilalquenilo C2-8, en donde estos grupos pueden estar unidos a través de cualquier posicion con la amina del sistema tricíclico y eventualmente hidrogenados en uno o varios sitios; R6 y R7 son, independientemente entre sí, un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo C1-5, que puede estar sustituido con OR8, SR8, NR8R9; o es 1, 2 o 3; y X es un átomo de oxígeno, un átomo de azufre, un grupo CH2 o un grupo NR9.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004063227A DE102004063227A1 (de) | 2004-12-22 | 2004-12-22 | Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055016A1 true AR055016A1 (es) | 2007-08-01 |
Family
ID=36250953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105486A AR055016A1 (es) | 2004-12-22 | 2005-12-22 | Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JP2008524300A (es) |
| KR (1) | KR20070089948A (es) |
| CN (1) | CN101087780A (es) |
| AR (1) | AR055016A1 (es) |
| AU (1) | AU2005318354A1 (es) |
| BR (1) | BRPI0519710A2 (es) |
| CA (1) | CA2586973A1 (es) |
| DE (1) | DE102004063227A1 (es) |
| GT (1) | GT200500385A (es) |
| IL (1) | IL183060A0 (es) |
| MX (1) | MX2007007420A (es) |
| PA (1) | PA8657801A1 (es) |
| PE (1) | PE20061197A1 (es) |
| WO (1) | WO2006066950A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662821B2 (en) | 2003-10-08 | 2010-02-16 | Bayer Schering Pharma Ag | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7638515B2 (en) | 2003-10-08 | 2009-12-29 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| JP4638438B2 (ja) | 2003-10-08 | 2011-02-23 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | テトラヒドロナフタレン誘導体類、それらの生成方法及び抗−炎症剤としてのそれらの使用 |
| US20080153859A1 (en) | 2004-04-05 | 2008-06-26 | Hartmut Rehwinkel | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents |
| US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
| EP1834948A1 (de) | 2006-03-15 | 2007-09-19 | Bayer Schering Pharma Aktiengesellschaft | Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| EP1917963A1 (en) * | 2006-10-31 | 2008-05-07 | Bayer Schering Pharma Aktiengesellschaft | Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents |
| EP2072509A1 (en) | 2007-12-18 | 2009-06-24 | Bayer Schering Pharma Aktiengesellschaft | 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents |
| JP6250561B2 (ja) | 2012-02-08 | 2017-12-20 | サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | ヘテロアリール化合物およびそれらの使用方法 |
| US10196403B2 (en) | 2016-07-29 | 2019-02-05 | Sunovion Pharmaceuticals Inc. | Compounds and compositions and uses thereof |
| BR112019001407A2 (pt) | 2016-07-29 | 2019-07-09 | Pgi Drug Discovery Llc | compostos e composições e usos dos mesmos |
| JP7191085B2 (ja) | 2017-08-02 | 2022-12-16 | サノビオン ファーマシューティカルズ インク | イソクロマン化合物およびその使用 |
| JP2022525169A (ja) | 2019-03-14 | 2022-05-11 | サノビオン ファーマシューティカルズ インク | イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物 |
| KR102462991B1 (ko) * | 2020-11-02 | 2022-11-04 | 한국해양과학기술원 | 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
| UA80120C2 (en) * | 2002-03-26 | 2007-08-27 | Boehringer Ingelheim Pharma | Glucocorticoid mimetics, pharmaceutical composition based thereon |
| DE10215316C1 (de) * | 2002-04-02 | 2003-12-18 | Schering Ag | Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer |
| JP4638438B2 (ja) * | 2003-10-08 | 2011-02-23 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | テトラヒドロナフタレン誘導体類、それらの生成方法及び抗−炎症剤としてのそれらの使用 |
| GB0418045D0 (en) * | 2004-08-12 | 2004-09-15 | Glaxo Group Ltd | Compounds |
| DE102004044680B3 (de) * | 2004-09-09 | 2006-06-08 | Schering Ag | Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate |
-
2004
- 2004-12-22 DE DE102004063227A patent/DE102004063227A1/de not_active Withdrawn
-
2005
- 2005-12-20 WO PCT/EP2005/013943 patent/WO2006066950A2/de not_active Application Discontinuation
- 2005-12-20 CA CA002586973A patent/CA2586973A1/en not_active Abandoned
- 2005-12-20 AU AU2005318354A patent/AU2005318354A1/en not_active Abandoned
- 2005-12-20 BR BRPI0519710-4A patent/BRPI0519710A2/pt not_active Application Discontinuation
- 2005-12-20 MX MX2007007420A patent/MX2007007420A/es not_active Application Discontinuation
- 2005-12-20 JP JP2007547379A patent/JP2008524300A/ja active Pending
- 2005-12-20 CN CNA2005800442843A patent/CN101087780A/zh active Pending
- 2005-12-20 KR KR1020077014116A patent/KR20070089948A/ko not_active Application Discontinuation
- 2005-12-22 AR ARP050105486A patent/AR055016A1/es not_active Application Discontinuation
- 2005-12-22 PA PA20058657801A patent/PA8657801A1/es unknown
- 2005-12-22 GT GT200500385A patent/GT200500385A/es unknown
-
2006
- 2006-01-03 PE PE2006000009A patent/PE20061197A1/es not_active Application Discontinuation
-
2007
- 2007-05-08 IL IL183060A patent/IL183060A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006066950A2 (de) | 2006-06-29 |
| CN101087780A (zh) | 2007-12-12 |
| DE102004063227A1 (de) | 2006-07-06 |
| MX2007007420A (es) | 2007-07-17 |
| IL183060A0 (en) | 2007-09-20 |
| WO2006066950A3 (de) | 2006-08-17 |
| AU2005318354A1 (en) | 2006-06-29 |
| GT200500385A (es) | 2006-08-03 |
| BRPI0519710A2 (pt) | 2009-03-10 |
| PE20061197A1 (es) | 2006-12-07 |
| JP2008524300A (ja) | 2008-07-10 |
| KR20070089948A (ko) | 2007-09-04 |
| CA2586973A1 (en) | 2006-06-29 |
| PA8657801A1 (es) | 2006-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |