DE102004063227A1 - Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer - Google Patents

Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer Download PDF

Info

Publication number
DE102004063227A1
DE102004063227A1 DE102004063227A DE102004063227A DE102004063227A1 DE 102004063227 A1 DE102004063227 A1 DE 102004063227A1 DE 102004063227 A DE102004063227 A DE 102004063227A DE 102004063227 A DE102004063227 A DE 102004063227A DE 102004063227 A1 DE102004063227 A1 DE 102004063227A1
Authority
DE
Germany
Prior art keywords
group
groups
alkyl
general formula
alkyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004063227A
Other languages
German (de)
English (en)
Inventor
Markus Dr. Berger
Norbert Dr. Schmees
Heike Dr. Schäcke
Stefan Dr. Bäurle
Hartmut Dr. Rehwinkel
Anne Dr. Mengel
Konrad Krolikiewicz
Danja Dr. Grossbach
David Dr. Voigtländer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE102004063227A priority Critical patent/DE102004063227A1/de
Priority to CNA2005800442843A priority patent/CN101087780A/zh
Priority to BRPI0519710-4A priority patent/BRPI0519710A2/pt
Priority to AU2005318354A priority patent/AU2005318354A1/en
Priority to MX2007007420A priority patent/MX2007007420A/es
Priority to PCT/EP2005/013943 priority patent/WO2006066950A2/de
Priority to JP2007547379A priority patent/JP2008524300A/ja
Priority to KR1020077014116A priority patent/KR20070089948A/ko
Priority to CA002586973A priority patent/CA2586973A1/en
Priority to US11/312,655 priority patent/US20060167025A1/en
Priority to PA20058657801A priority patent/PA8657801A1/es
Priority to ARP050105486A priority patent/AR055016A1/es
Priority to TW094145967A priority patent/TW200634005A/zh
Priority to GT200500385A priority patent/GT200500385A/es
Priority to PE2006000009A priority patent/PE20061197A1/es
Publication of DE102004063227A1 publication Critical patent/DE102004063227A1/de
Priority to IL183060A priority patent/IL183060A0/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE102004063227A 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer Withdrawn DE102004063227A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE102004063227A DE102004063227A1 (de) 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
KR1020077014116A KR20070089948A (ko) 2004-12-22 2005-12-20 트리시클릭 아미노 알콜, 이의 합성 방법 및 항염증약물로서의 이의 용도
BRPI0519710-4A BRPI0519710A2 (pt) 2004-12-22 2005-12-20 aminoÁlcoois tricÍclicos, processo para sua preparaÇço e seu emprego como anti-inflamatàrio
AU2005318354A AU2005318354A1 (en) 2004-12-22 2005-12-20 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents
MX2007007420A MX2007007420A (es) 2004-12-22 2005-12-20 Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso como inhibidores de inflamacion.
PCT/EP2005/013943 WO2006066950A2 (de) 2004-12-22 2005-12-20 Tricyclische aminoalkohole, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
JP2007547379A JP2008524300A (ja) 2004-12-22 2005-12-20 三環式アミノアルコール、それらの合成方法および抗炎症薬物としてのそれらの使用
CNA2005800442843A CN101087780A (zh) 2004-12-22 2005-12-20 三环氨基醇、其合成方法及其作为抗炎药的用途
CA002586973A CA2586973A1 (en) 2004-12-22 2005-12-20 Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
US11/312,655 US20060167025A1 (en) 2004-12-22 2005-12-21 Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
PA20058657801A PA8657801A1 (es) 2004-12-22 2005-12-22 Aminalcoholes triciclicos, procedimientos para su preparacion
ARP050105486A AR055016A1 (es) 2004-12-22 2005-12-22 Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso para la preparacion de medicamentos
TW094145967A TW200634005A (en) 2004-12-22 2005-12-22 Tricyclic amino alcohols, processes for synthesis of same and use of same as anti-inflammatory drugs
GT200500385A GT200500385A (es) 2004-12-22 2005-12-22 Aminoalcoholes triciclicos, procedimientos para su preparacion y su uso como inhibidores de inflamacion
PE2006000009A PE20061197A1 (es) 2004-12-22 2006-01-03 Aminoalcoholes triciclicos, como inhibidores de la secresion de citoquina il-8
IL183060A IL183060A0 (en) 2004-12-22 2007-05-08 Tricyclic aminoalcohols, methods for producing the same and their use as anti-inflammatory agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004063227A DE102004063227A1 (de) 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Publications (1)

Publication Number Publication Date
DE102004063227A1 true DE102004063227A1 (de) 2006-07-06

Family

ID=36250953

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102004063227A Withdrawn DE102004063227A1 (de) 2004-12-22 2004-12-22 Tricylische Aminoalkohole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Country Status (14)

Country Link
JP (1) JP2008524300A (es)
KR (1) KR20070089948A (es)
CN (1) CN101087780A (es)
AR (1) AR055016A1 (es)
AU (1) AU2005318354A1 (es)
BR (1) BRPI0519710A2 (es)
CA (1) CA2586973A1 (es)
DE (1) DE102004063227A1 (es)
GT (1) GT200500385A (es)
IL (1) IL183060A0 (es)
MX (1) MX2007007420A (es)
PA (1) PA8657801A1 (es)
PE (1) PE20061197A1 (es)
WO (1) WO2006066950A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
DE502004002403D1 (de) 2003-10-08 2007-02-01 Schering Ag Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1834948A1 (de) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
EP1917963A1 (en) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
EP2072509A1 (en) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents
CA3132120C (en) 2012-02-08 2023-10-24 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
KR102462991B1 (ko) * 2020-11-02 2022-11-04 한국해양과학기술원 남극-유래 진균 균주 아크레모늄(Acremonium sp.) SF-7394에서 분리한 화합물 및 이를 포함하는 항염증, 항암 또는 항당뇨용 조성물

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010143A1 (de) * 2000-07-28 2002-02-07 Schering Aktiengesellschaft Nichtsteroidale entzündungshemmer
WO2003082827A1 (de) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Chinolin- und isochinolin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
WO2005034939A1 (de) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1490062B1 (en) * 2002-03-26 2007-12-19 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
GB0418045D0 (en) * 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
DE102004044680B3 (de) * 2004-09-09 2006-06-08 Schering Ag Alkyliden-Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer sowie diese enthaltende pharmazeutische Präparate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010143A1 (de) * 2000-07-28 2002-02-07 Schering Aktiengesellschaft Nichtsteroidale entzündungshemmer
WO2003082827A1 (de) * 2002-04-02 2003-10-09 Schering Aktiengesellschaft Chinolin- und isochinolin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
WO2005034939A1 (de) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft Tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REGISTRY-Datenbankausdruck *

Also Published As

Publication number Publication date
GT200500385A (es) 2006-08-03
AU2005318354A1 (en) 2006-06-29
WO2006066950A3 (de) 2006-08-17
JP2008524300A (ja) 2008-07-10
CN101087780A (zh) 2007-12-12
BRPI0519710A2 (pt) 2009-03-10
IL183060A0 (en) 2007-09-20
PE20061197A1 (es) 2006-12-07
PA8657801A1 (es) 2006-12-07
WO2006066950A2 (de) 2006-06-29
KR20070089948A (ko) 2007-09-04
MX2007007420A (es) 2007-07-17
AR055016A1 (es) 2007-08-01
CA2586973A1 (en) 2006-06-29

Similar Documents

Publication Publication Date Title
DE10215316C1 (de) Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
WO2006066950A2 (de) Tricyclische aminoalkohole, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
EP1844039B1 (de) 5-substituierte chinolin- und isochinolin-derivate; ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
EP1638945A1 (de) Heterozyklisch substituierte pentanol-derivate, verfahren zu ihrer herstellung und ihre verwendung als entz ndungshemmer
DE102005014089A1 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP1670778B1 (de) Umgelagerte pentanole, ein verfahren zu ihrer herstellung und ihre verwendung als entz ndungshemmer
EP1786823B1 (de) Alkyliden-tetrahydronaphthalinderivate, verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
EP1834948A1 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005017286B3 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE10346939A1 (de) Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
WO2005035502A1 (de) 1- (chinolin-amino) -und 1- (isochinolin-amino) -substituierte pentan-2-ole, ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer
DE102005014090A1 (de) 5H-Benzocycloheptenderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005018026B4 (de) Substituierte Styrole, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005018025A1 (de) Mehrfach substituierte bizyklische Systeme, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102004017662B3 (de) Mehrfach substituierte Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005017326A1 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE10347386B4 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A1 (de) 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE10330358A1 (de) Heterozyklisch substituierte Pentanol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
WO2006108713A2 (de) 1-amino-1, 2, 3, 4-tetrahydro-naphtalin-2-ol derivate als entzündungshemmer
DE102005017301A1 (de) Substituierte Chromanderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102004025791A1 (de) Chromanol-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE10347383A1 (de) Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005018024A1 (de) Benzazepine als neue Glucocorticoidmimetika, Verfahren zu ihrer Herstellung und ihre Verwendung

Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
8127 New person/name/address of the applicant

Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE

8130 Withdrawal