PE105399A1 - PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 3a-(R)-BENCIL-2-METIL-2,3,3a,4,5,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDINA-3-ONA - Google Patents

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 3a-(R)-BENCIL-2-METIL-2,3,3a,4,5,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDINA-3-ONA

Info

Publication number
PE105399A1
PE105399A1 PE1998000546A PE00054698A PE105399A1 PE 105399 A1 PE105399 A1 PE 105399A1 PE 1998000546 A PE1998000546 A PE 1998000546A PE 00054698 A PE00054698 A PE 00054698A PE 105399 A1 PE105399 A1 PE 105399A1
Authority
PE
Peru
Prior art keywords
alkyl
bencil
methyl
procedure
preparation
Prior art date
Application number
PE1998000546A
Other languages
English (en)
Spanish (es)
Inventor
Judith Lee Treadway
Bruce Allen Lefker
Charles Kwok-Fung Chiu
Michael Paul Zawistoski
Lydia Codetta Pan
Philip Albert Carpino
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE105399A1 publication Critical patent/PE105399A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
PE1998000546A 1997-06-25 1998-06-22 PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 3a-(R)-BENCIL-2-METIL-2,3,3a,4,5,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDINA-3-ONA PE105399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5079097P 1997-06-25 1997-06-25

Publications (1)

Publication Number Publication Date
PE105399A1 true PE105399A1 (es) 1999-11-04

Family

ID=21967444

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000546A PE105399A1 (es) 1997-06-25 1998-06-22 PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 3a-(R)-BENCIL-2-METIL-2,3,3a,4,5,6,7-HEXAHIDRO-PIRAZOLO[4,3-c]PIRIDINA-3-ONA

Country Status (40)

Country Link
US (3) US6448263B1 (OSRAM)
EP (1) EP1000085B1 (OSRAM)
JP (2) JP2000514099A (OSRAM)
KR (1) KR20010014224A (OSRAM)
CN (2) CN1530107A (OSRAM)
AP (1) AP1145A (OSRAM)
AR (1) AR012256A1 (OSRAM)
AT (1) ATE305477T1 (OSRAM)
AU (1) AU747510B2 (OSRAM)
BG (1) BG104008A (OSRAM)
BR (1) BR9810477A (OSRAM)
CA (1) CA2294464A1 (OSRAM)
CO (1) CO4950621A1 (OSRAM)
DE (1) DE69831745T2 (OSRAM)
DZ (1) DZ2539A1 (OSRAM)
EA (1) EA002089B1 (OSRAM)
EG (1) EG21712A (OSRAM)
ES (1) ES2248899T3 (OSRAM)
HN (1) HN1998000088A (OSRAM)
HR (1) HRP980361A2 (OSRAM)
HU (1) HUP0001922A3 (OSRAM)
ID (1) ID24345A (OSRAM)
IL (7) IL154115A0 (OSRAM)
IN (1) IN189724B (OSRAM)
IS (1) IS5275A (OSRAM)
MA (1) MA24581A1 (OSRAM)
NO (1) NO996205D0 (OSRAM)
NZ (1) NZ500655A (OSRAM)
OA (1) OA11242A (OSRAM)
PA (1) PA8452601A1 (OSRAM)
PE (1) PE105399A1 (OSRAM)
PL (1) PL337659A1 (OSRAM)
SK (1) SK175699A3 (OSRAM)
TN (1) TNSN98113A1 (OSRAM)
TR (1) TR199903257T2 (OSRAM)
TW (1) TW553943B (OSRAM)
UA (1) UA64751C2 (OSRAM)
WO (1) WO1998058949A1 (OSRAM)
YU (1) YU70199A (OSRAM)
ZA (1) ZA985546B (OSRAM)

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UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
US6541634B2 (en) 1999-02-26 2003-04-01 Pfizer Inc. Process for preparing growth hormone secretagogues
US7721948B1 (en) * 1999-05-25 2010-05-25 Silverbrook Research Pty Ltd Method and system for online payments
EP1132388A3 (en) * 2000-03-09 2004-03-03 Pfizer Products Inc. Hexahydropyrazolo[4,3-c]pyridine metabolites
DE60140285D1 (de) 2000-05-31 2009-12-10 Pfizer Prod Inc Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
IL145106A0 (en) * 2000-08-30 2002-06-30 Pfizer Prod Inc Intermittent administration of a geowth hormone secretagogue
KR20050071498A (ko) * 2002-09-18 2005-07-07 상트르 오스피딸리에 드 루니버시떼 드 몬트리알 성장 호르몬 방출 호르몬 유사체
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CN101120138B (zh) * 2004-12-21 2013-06-05 赫尔克里士公司 在含有亚硫酸盐离子的造纸体系中用作干和湿强度剂的活性阳离子树脂
US20070024388A1 (en) * 2005-07-27 2007-02-01 Hassan Tanbakuchi Slabline structure with rotationally offset ground
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
WO2008130464A1 (en) 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US7862825B2 (en) * 2007-02-21 2011-01-04 Mladen Vranic Method of controlling tight blood glucose by somatostatin receptor antagonists
RU2403902C1 (ru) * 2009-06-15 2010-11-20 Илья Николаевич Медведев Способ снижения биологического возраста при нарушении толерантности к глюкозе
AR086554A1 (es) 2011-05-27 2014-01-08 Novartis Ag Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
EA201491990A1 (ru) 2012-05-03 2015-02-27 Новартис Аг L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов
JP6337266B2 (ja) * 2013-05-28 2018-06-06 ラクオリア創薬株式会社 多形形態
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
ES2707124T3 (es) * 2014-08-05 2019-04-02 Raqualia Pharma Inc Derivados de serina como agonistas del receptor de grelina
JP2017532350A (ja) * 2014-10-31 2017-11-02 ラクオリア創薬株式会社 グレリン受容体アゴニストとしてのテトラヒドロピラゾロピリジン誘導体
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
WO2024217441A1 (zh) * 2023-04-21 2024-10-24 长春金赛药业有限责任公司 GHSR 1a激动剂、药物组合物及其制备方法和应用
CN119285632A (zh) * 2024-10-09 2025-01-10 威海中腾医药科技有限公司 一种基于酵母醇脱氢酶催化氧化的卡普瑞林中间体的制备方法

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BR9610277A (pt) 1995-08-31 1999-07-06 Schering Corp Derivados de piperazino como antagonistas de neurowuinina
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TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
DE69837264T2 (de) * 1997-06-25 2008-01-31 Pfizer Inc. Dipeptidverbindungen, die Wachstumshormon-Sekretagoga sind
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)

Also Published As

Publication number Publication date
AP1145A (en) 2003-02-14
DE69831745T2 (de) 2006-08-31
DE69831745D1 (de) 2006-02-09
NO996205L (no) 1999-12-15
PA8452601A1 (es) 2000-05-24
CN1152049C (zh) 2004-06-02
IS5275A (is) 1999-11-26
SK175699A3 (en) 2001-04-09
YU70199A (sh) 2003-01-31
IL154115A0 (en) 2003-07-31
HUP0001922A3 (en) 2001-02-28
US20030100561A1 (en) 2003-05-29
HK1028051A1 (en) 2001-02-02
IL154114A0 (en) 2003-07-31
BG104008A (en) 2000-07-31
US6867202B1 (en) 2005-03-15
EP1000085A1 (en) 2000-05-17
AU747510B2 (en) 2002-05-16
TR199903257T2 (xx) 2000-12-21
AU7445698A (en) 1999-01-04
EG21712A (en) 2002-02-27
JP3742643B2 (ja) 2006-02-08
HN1998000088A (es) 1999-01-08
OA11242A (en) 2003-07-23
NO996205D0 (no) 1999-12-15
HRP980361A2 (en) 1999-02-28
DZ2539A1 (fr) 2003-02-08
US6630487B2 (en) 2003-10-07
CO4950621A1 (es) 2000-09-01
ATE305477T1 (de) 2005-10-15
BR9810477A (pt) 2007-05-22
CN1259140A (zh) 2000-07-05
NZ500655A (en) 2002-02-01
CN1530107A (zh) 2004-09-22
IL154116A0 (en) 2003-07-31
ZA985546B (en) 2000-01-10
IN189724B (OSRAM) 2003-04-19
AP9801267A0 (en) 1998-06-30
CA2294464A1 (en) 1998-12-30
EA002089B1 (ru) 2001-12-24
ID24345A (id) 2000-07-13
UA64751C2 (uk) 2004-03-15
US6448263B1 (en) 2002-09-10
IL156465A0 (en) 2004-01-04
EA199901075A1 (ru) 2000-08-28
TNSN98113A1 (fr) 2005-03-15
IL154111A0 (en) 2003-07-31
KR20010014224A (ko) 2001-02-26
EP1000085B1 (en) 2005-09-28
IL133626A0 (en) 2001-04-30
IL156465A (en) 2004-07-25
JP2000514099A (ja) 2000-10-24
ES2248899T3 (es) 2006-03-16
AR012256A1 (es) 2000-09-27
WO1998058949A1 (en) 1998-12-30
JP2005097261A (ja) 2005-04-14
PL337659A1 (en) 2000-08-28
MA24581A1 (fr) 1998-12-31
HUP0001922A2 (hu) 2000-12-28
IL154112A0 (en) 2003-07-31
TW553943B (en) 2003-09-21

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