DE69213544D1 - Benzisothiazol- und Benzisoxazol-3-carboxamide, Verfahren zu deren Herstellung und ihre Anwendung als antipsychotische Arzneimittel - Google Patents

Benzisothiazol- und Benzisoxazol-3-carboxamide, Verfahren zu deren Herstellung und ihre Anwendung als antipsychotische Arzneimittel

Info

Publication number
DE69213544D1
DE69213544D1 DE69213544T DE69213544T DE69213544D1 DE 69213544 D1 DE69213544 D1 DE 69213544D1 DE 69213544 T DE69213544 T DE 69213544T DE 69213544 T DE69213544 T DE 69213544T DE 69213544 D1 DE69213544 D1 DE 69213544D1
Authority
DE
Germany
Prior art keywords
loweralkyl
hydrogen
formula
benzisothiazole
benzisoxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69213544T
Other languages
English (en)
Other versions
DE69213544T2 (de
Inventor
Nicholas J Hrib
John G Jurcak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69213544D1 publication Critical patent/DE69213544D1/de
Publication of DE69213544T2 publication Critical patent/DE69213544T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
DE69213544T 1991-04-29 1992-04-27 Benzisothiazol- und Benzisoxazol-3-carboxamide, Verfahren zu deren Herstellung und ihre Anwendung als antipsychotische Arzneimittel Expired - Fee Related DE69213544T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90/002891A US5143923B1 (en) 1991-04-29 1991-04-29 Benzoisothiazole-and benzisoxazole-3-carboxamides

Publications (2)

Publication Number Publication Date
DE69213544D1 true DE69213544D1 (de) 1996-10-17
DE69213544T2 DE69213544T2 (de) 1997-02-27

Family

ID=24783602

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69213544T Expired - Fee Related DE69213544T2 (de) 1991-04-29 1992-04-27 Benzisothiazol- und Benzisoxazol-3-carboxamide, Verfahren zu deren Herstellung und ihre Anwendung als antipsychotische Arzneimittel

Country Status (21)

Country Link
US (1) US5143923B1 (de)
EP (1) EP0511610B1 (de)
JP (1) JP2656189B2 (de)
KR (1) KR100215345B1 (de)
AT (1) ATE142628T1 (de)
AU (1) AU644054B2 (de)
CA (1) CA2067404C (de)
CZ (1) CZ282764B6 (de)
DE (1) DE69213544T2 (de)
DK (1) DK0511610T3 (de)
ES (1) ES2094843T3 (de)
FI (1) FI921875A (de)
GR (1) GR3021211T3 (de)
HU (1) HU214032B (de)
IE (1) IE77036B1 (de)
IL (1) IL101700A (de)
MX (1) MX9201963A (de)
NO (1) NO180488C (de)
NZ (1) NZ242479A (de)
PL (2) PL168090B1 (de)
RU (1) RU2039057C1 (de)

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US5378714A (en) * 1991-11-27 1995-01-03 Novo Nordisk A/S Antipsychotic piperidine derivatives
SE9201138D0 (sv) * 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
GB9302622D0 (en) * 1993-02-10 1993-03-24 Wellcome Found Heteroaromatic compounds
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
US6096763A (en) * 1995-02-23 2000-08-01 Merck & Co., Inc. α1a adrenergic receptor antagonists
US5952351A (en) * 1995-02-23 1999-09-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
GB9603457D0 (de) * 1996-02-19 1996-04-17 Merck & Co Inc
TR199700873T1 (xx) 1995-02-28 1998-01-21 H. Lund-Beck A/S 4-Aminotetrahidrobenzizoksazol veya -izotiazol bile�ikleri.
EP0732332B1 (de) * 1995-03-17 2001-12-19 Aventis Pharmaceuticals Inc. Substituierte Benzylthienylpiperazine, ihre Anwendung als Arzneimittel und Verfahren für ihre Herstellung
GB9716101D0 (en) * 1997-07-30 1997-10-01 Pharmacia & Upjohn Spa Fused heterocyclic compounds
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
CA2350722A1 (en) * 1998-11-17 2000-05-25 Leyi Gong 4-aroyl-piperidin-ccr-3 receptor antagonists iii
BR9915735A (pt) 1998-11-20 2001-09-04 Hoffmann La Roche Antagonistas receptores de ccr-3 de piperidina
BR0009338A (pt) * 1999-03-26 2001-12-26 Astrazeneca Ab Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US6627645B2 (en) 2000-04-28 2003-09-30 Acadia Pharmaceuticals, Inc. Muscarinic agonists
EP1535912A1 (de) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinagonisten
GB0013060D0 (en) * 2000-05-31 2000-07-19 Astrazeneca Ab Chemical compounds
GB0021670D0 (en) * 2000-09-04 2000-10-18 Astrazeneca Ab Chemical compounds
ATE412638T1 (de) 2001-02-16 2008-11-15 Aventis Pharma Inc Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
GB0117899D0 (en) * 2001-07-23 2001-09-12 Astrazeneca Ab Chemical compounds
SE0102809D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab Novel compounds
CA2498936C (en) * 2002-09-14 2013-02-12 Gov't Of The Usa As Represented By The Secretary Of The Department Of Health & Human Services Structurally rigid dopamine d3 receptor selective ligands and process for making them
JP2006503106A (ja) * 2002-09-17 2006-01-26 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 統合失調症を処置するためのヘテロ環式置換ピペラジン
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain
KR20060061393A (ko) * 2003-10-24 2006-06-07 에프. 호프만-라 로슈 아게 Ｃｃｒ3 수용체 길항제
US20160296146A9 (en) * 2006-06-29 2016-10-13 Fred Wood Apparatus-Mounted Vein Contrast Enchancer

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US2626260A (en) * 1951-09-05 1953-01-20 Sterling Drug Inc Nitrobenzisoxazoles
US3145215A (en) * 1961-12-19 1964-08-18 Sterling Drug Inc Indazole derivatives
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
US4021552A (en) * 1975-06-27 1977-05-03 A. H. Robins Company, Incorporated 10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES
US4327103A (en) * 1980-07-07 1982-04-27 Hoechst-Roussel Pharmaceuticals Incorporated 3-{3-[4-(4-Fluorobenzoyl)piperidyl]propyl}-2-methyl indole
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
DK169601B1 (da) * 1983-10-17 1994-12-19 Duphar Int Res Piperazinderivater og farmaceutisk præparat indeholdende et sådant derivat, samt piperazinderivater med mellemproduktanvendelse
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
JPS61219950A (ja) * 1985-03-26 1986-09-30 Fuji Photo Film Co Ltd 熱現像感光材料
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
EP0200444B1 (de) * 1985-04-27 1992-11-11 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-HT-antagonistischer Wirkung
FR2616149B1 (fr) * 1987-06-04 1990-10-19 Adir Nouveau derive de l'acide benzo (b) thiophene - 7 carboxylique, son procede de preparation et les compositions pharmaceutiques qui le contiennent
DE3827253A1 (de) * 1987-08-20 1989-03-02 Sandoz Ag Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives
CA1340113C (en) * 1988-05-24 1998-11-03 Magid A. Abou-Gharbia Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
GB8900382D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use

Also Published As

Publication number Publication date
NO180488C (no) 1997-04-30
NO180488B (no) 1997-01-20
EP0511610B1 (de) 1996-09-11
HUT62889A (en) 1993-06-28
US5143923B1 (en) 1993-11-02
CZ282764B6 (cs) 1997-10-15
HU9201414D0 (en) 1992-07-28
ATE142628T1 (de) 1996-09-15
FI921875A0 (fi) 1992-04-27
PL294358A1 (en) 1993-08-09
DK0511610T3 (de) 1997-06-16
CA2067404A1 (en) 1992-10-30
RU2039057C1 (ru) 1995-07-09
NO921654D0 (no) 1992-04-28
IL101700A (en) 1995-11-27
PL168090B1 (pl) 1996-01-31
NZ242479A (en) 1995-02-24
AU644054B2 (en) 1993-12-02
JP2656189B2 (ja) 1997-09-24
DE69213544T2 (de) 1997-02-27
AU1518792A (en) 1992-11-05
CA2067404C (en) 2003-08-19
CS129892A3 (en) 1992-11-18
IE77036B1 (en) 1997-11-19
MX9201963A (es) 1992-11-01
KR100215345B1 (ko) 1999-08-16
EP0511610A1 (de) 1992-11-04
ES2094843T3 (es) 1997-02-01
KR920019784A (ko) 1992-11-20
US5143923A (en) 1992-09-01
JPH05132472A (ja) 1993-05-28
HU214032B (en) 1997-12-29
NO921654L (no) 1992-10-30
IL101700A0 (en) 1992-12-30
IE921379A1 (en) 1992-11-04
FI921875A (fi) 1992-10-30
PL168870B1 (pl) 1996-04-30
GR3021211T3 (en) 1996-12-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee