KR920019784A - 벤조이소티아졸 및 벤조이소옥사졸-3-카복스아미드, 이의 제조방법 및 약제로서의 용도 - Google Patents

벤조이소티아졸 및 벤조이소옥사졸-3-카복스아미드, 이의 제조방법 및 약제로서의 용도 Download PDF

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KR920019784A
KR920019784A KR1019920007140A KR920007140A KR920019784A KR 920019784 A KR920019784 A KR 920019784A KR 1019920007140 A KR1019920007140 A KR 1019920007140A KR 920007140 A KR920007140 A KR 920007140A KR 920019784 A KR920019784 A KR 920019784A
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South Korea
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compound
hydrogen
formula
lower alkyl
carboxamide
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KR1019920007140A
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KR100215345B1 (ko
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제이. 흐리브 니콜라스
지. 저칵 존
Original Assignee
빅터 제이. 바우어
훽스트-러셀 파마슈티칼즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

내용 없음

Description

벤조이소티아졸 및 벤조이소옥사졸-3-카복스아미드, 이의 제조방법 및 약조제로서의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 일반식 (I)의 화합물, 이의 기하 및 광학 이성체 또는 약제학적으로 허용되는 이의 염.
    상기식에서, R1은 수소 또는 저급 알킬이고, R2는 저급 알킬이거나,
    그룹이고, R3은 수소 또는 저급 알킬이고, A는 저급 알킬렌이거나, 일반식 -CHR4CH=CHCHR4-또는-CHR4C=CHR4-의 그룹이고, R4는 수소 또는 저급 알킬이고, R4는 수소 또는 저급 알킬이고, X는 O또는 S이고, W는 N 또는 CH이고, Y는 수소, 저급 알킬, 저급 알콕시, 하이드록시, 할로겐 또는 트리플루오로메틸이고, Z는 수소, 저급 알킬, 저급 알콕시, 하이드록시, 할로겐 또는 트리플루오로메틸이고, n은 1 또는 2이며, 실선(-)은 일반식의 지시된 원소에 대한 그룹의 부착점을 나타낸다.
  2. 제1항에 있어서, Y가 수소이고 Z는 수소, 저급 알콕시 또는 할로겐이며 n이 1인 화합물.
  3. 제2항에 있어서, X가 S이고 A가 C1-C4알킬렌이며 R2가 일반식.
    〔여기서, Z는 수소, 메톡시 또는 플루오로이다〕의 그룹인 화합물.
  4. 제1항에 있어서, N-메틸-N-〔4-(1-(2-메톡시페닐)-4-피페라지닐)부틸〕-1,2-벤즈이소티아졸-3-카복스아미드 또는 약제학적으로 허용되는 이의 염인 화합물.
  5. 제1항에 있어서, N-메틸-N-〔4-(1-(6-플로오로벤조〔b〕티오펜-3-일)-4-피페라진-일)부틸〕-1,2-벤즈이소티아졸-3-카복스아미드 또는 약제학적으로 허용되는 이의 염인 화합물.
  6. 제1항에 있어서, N-메틸-N-〔4-(1-(6-플로오로-1,2-벤조이소옥사졸-3-일)-4-피페라진-일)부틸〕-1,2-벤즈이소티아졸-3-카복스아미드 또는 약제학적으로 허용되는 이의 염인 화합물.
  7. 제1항에 있어서, N-〔2-(1-(4-플루오로벤조일-4-피페라지닐)에틸〕-1,2-벤즈이소티아졸-3-카복스아미드 또는 약제학적으로 허용되는 이의 염인 화합물.
  8. 제1항에 있어서, N-메틸-N-〔4-(1-(1,2-벤조이소옥사졸-3-일)-4-피페라진-일)부틸〕-1,2-벤즈이소티아졸-3-카복스아미드 또는 약제학적으로 허용되는 이의 염인 화합물.
  9. 활성 성분으로서 제1항에서 정의한 바와 같은 화합물 및 이의 적합한 담체를 포함하는 약제학적 조성물.
  10. 항정신병적 활성을 갖는 약제를 제조하기 위한 제1항의 화합물의 용도.
  11. a)일반식(I)의 화합물을 일반식(2)의 화합물과 반응시키거나, b)일반식(3)의 화합물을 일반식(2a)의 화합물과 반응시킴을 포함하는, 제1항의 화합물의 제조방법.
    상기식에서, R1, R2, A, X, Y, W 및 n은 제1항에서 정의한 바와 같고, R1은 클로로, 브로모 또는 요오도이거나, 그를 OSO2R6〔여기서, R6은 알킬, 페닐 또는 톨릴이다〕이며, Hal은 클로로 또는 브로모이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920007140A 1991-04-29 1992-04-28 벤조이소티아졸 및 벤조이소옥사졸-3-카복스아미드, 이의 제조방법 및 약제로서의 용도 KR100215345B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/693,168 1991-04-29
US7/693,168 1991-04-29
US90/002891A US5143923B1 (en) 1991-04-29 1991-04-29 Benzoisothiazole-and benzisoxazole-3-carboxamides

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KR920019784A true KR920019784A (ko) 1992-11-20
KR100215345B1 KR100215345B1 (ko) 1999-08-16

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US (1) US5143923B1 (ko)
EP (1) EP0511610B1 (ko)
JP (1) JP2656189B2 (ko)
KR (1) KR100215345B1 (ko)
AT (1) ATE142628T1 (ko)
AU (1) AU644054B2 (ko)
CA (1) CA2067404C (ko)
CZ (1) CZ282764B6 (ko)
DE (1) DE69213544T2 (ko)
DK (1) DK0511610T3 (ko)
ES (1) ES2094843T3 (ko)
FI (1) FI921875A (ko)
GR (1) GR3021211T3 (ko)
HU (1) HU214032B (ko)
IE (1) IE77036B1 (ko)
IL (1) IL101700A (ko)
MX (1) MX9201963A (ko)
NO (1) NO180488C (ko)
NZ (1) NZ242479A (ko)
PL (2) PL168870B1 (ko)
RU (1) RU2039057C1 (ko)

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PL168870B1 (pl) 1996-04-30
EP0511610B1 (en) 1996-09-11
PL294358A1 (en) 1993-08-09
NO921654D0 (no) 1992-04-28
ES2094843T3 (es) 1997-02-01
MX9201963A (es) 1992-11-01
US5143923A (en) 1992-09-01
RU2039057C1 (ru) 1995-07-09
HU9201414D0 (en) 1992-07-28
CA2067404C (en) 2003-08-19
CZ282764B6 (cs) 1997-10-15
DE69213544D1 (de) 1996-10-17
JP2656189B2 (ja) 1997-09-24
NO921654L (no) 1992-10-30
HU214032B (en) 1997-12-29
IL101700A (en) 1995-11-27
HUT62889A (en) 1993-06-28
IE77036B1 (en) 1997-11-19
GR3021211T3 (en) 1996-12-31
DE69213544T2 (de) 1997-02-27
NZ242479A (en) 1995-02-24
FI921875A (fi) 1992-10-30
NO180488C (no) 1997-04-30
ATE142628T1 (de) 1996-09-15
KR100215345B1 (ko) 1999-08-16
NO180488B (no) 1997-01-20
AU1518792A (en) 1992-11-05
DK0511610T3 (ko) 1997-06-16
EP0511610A1 (en) 1992-11-04
CS129892A3 (en) 1992-11-18
CA2067404A1 (en) 1992-10-30
FI921875A0 (fi) 1992-04-27
IE921379A1 (en) 1992-11-04
AU644054B2 (en) 1993-12-02
IL101700A0 (en) 1992-12-30
JPH05132472A (ja) 1993-05-28
PL168090B1 (pl) 1996-01-31
US5143923B1 (en) 1993-11-02

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