KR920021493A - 페녹시페닐 유도체 - Google Patents
페녹시페닐 유도체 Download PDFInfo
- Publication number
- KR920021493A KR920021493A KR1019920009092A KR920009092A KR920021493A KR 920021493 A KR920021493 A KR 920021493A KR 1019920009092 A KR1019920009092 A KR 1019920009092A KR 920009092 A KR920009092 A KR 920009092A KR 920021493 A KR920021493 A KR 920021493A
- Authority
- KR
- South Korea
- Prior art keywords
- pharmaceutically acceptable
- phenoxyphenyl
- acceptable salt
- imidazole
- derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (9)
- 하기 일반식(Ⅰ)의 페녹시페닐 유도체 또는 그것의 약학적 허용 염:상기식에서 R은 한개 또는 두개의 할로겐 원자이고; A는 CH2NR1R2또는 4,5-디하이드로-1H-이미다졸이며, R1과 R2는 각각 수소 원자 및 저급 알킬기중에서 선택된다.
- 제1항에 있어서, R이 한개 또는 두개의 염소 원자인 페녹시페닐 유도체, 또는 그것의 약학적 허용 염.
- 제1항 또는 제2항에 있어서, A가 CH2NR(CH3)2, 또는 4-5디하이드로-1H-이미다졸인 페녹시페닐 유도체, 또는 그것의 약학적 허용 염.
- 2-(3,4-디클로로페녹시)벤젠메탄아민 또는 그것의 약학적 허용 염.
- 2-[2-(4-클로로페녹시)페닐]-4,5-디하이드록-1H-이미다졸 또는 그것의 약학적 허용 염.
- 치료에 유용한 제1항 내지 제5항중 어느 한 항의 페녹시페닐 유도체.
- 하기 일반식(Ⅱ)의 니트릴을 1,2-에탄디아민과 축합시키거나, 또는 환원시키고, 이어서 임의로 알킬화시키거나; A가 CH2NR1R2인 일반식(Ⅰ)의 화합물을 제조하고자 하는 경우에는, 하기 일반식(Ⅲ)의 아미드를 환원시키고; 그후에 수득한 화합물을 임의로 약학적 허용염으로 전환시키는 것을 특징으로 하는, 제1항의 페녹시페닐 유도체를 제조하는 방법:상기식에서 R은 한개 또는 두개의 할로겐 원자이고 R'는 NR1R2이며, R1과 R2는 각각 수소 원자 및 저급 알킬기 중에서 선택된다.
- 제1항의 페녹시페닐 유도체와 약학적 허용 보조제를 함유하는 약학제제.
- 제1항의 페녹시페닐 유도체를 장시간의 반감기 및 우울증에 대한 활성을 지니는 약제의 제조에 사용하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91201288.7 | 1991-05-29 | ||
EP91201288 | 1991-05-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR920021493A true KR920021493A (ko) | 1992-12-18 |
Family
ID=8207675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920009092A KR920021493A (ko) | 1991-05-29 | 1992-05-28 | 페녹시페닐 유도체 |
Country Status (15)
Country | Link |
---|---|
US (2) | US5190965A (ko) |
EP (1) | EP0516234B1 (ko) |
JP (1) | JPH05148197A (ko) |
KR (1) | KR920021493A (ko) |
AT (1) | ATE127777T1 (ko) |
AU (1) | AU650136B2 (ko) |
CA (1) | CA2068373A1 (ko) |
DE (1) | DE69204743T2 (ko) |
DK (1) | DK0516234T3 (ko) |
ES (1) | ES2079783T3 (ko) |
FI (1) | FI922433A (ko) |
GR (1) | GR3018357T3 (ko) |
IE (1) | IE67144B1 (ko) |
NO (1) | NO178395C (ko) |
ZA (1) | ZA923283B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
US5447948A (en) * | 1992-05-07 | 1995-09-05 | Yale University | Dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia |
OA11918A (en) * | 1999-02-23 | 2006-04-12 | Pfizer Prod Inc | Monoamine reuptake inhibitors for treatment of cnsdisorders. |
US7375125B2 (en) * | 1999-08-04 | 2008-05-20 | Ore Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
MXPA02001160A (es) * | 1999-08-04 | 2002-07-02 | Millennium Pharm Inc | Compuestos que se unen a los receptores para melanocortina-4, y metodo de uso de estos. |
US6410736B1 (en) * | 1999-11-29 | 2002-06-25 | Pfizer Inc. | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
NZ517696A (en) * | 1999-10-13 | 2004-12-24 | Pfizer Prod Inc | Biaryl ether derivatives useful as monoamine reuptake inhibitors |
GB0007884D0 (en) * | 2000-03-31 | 2000-05-17 | Pfizer Ltd | Diphenyl ether compounds useful in therapy |
US6448293B1 (en) | 2000-03-31 | 2002-09-10 | Pfizer Inc. | Diphenyl ether compounds useful in therapy |
US6548484B1 (en) | 2000-04-12 | 2003-04-15 | International Medical Innovations, Inc. | Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation |
AP2001002265A0 (en) * | 2000-08-31 | 2001-09-30 | Pfizer | Phenoxybenzylamine derivatives as SSRIs. |
US6630504B2 (en) | 2000-08-31 | 2003-10-07 | Pfizer Inc. | Phenoxyphenylheterocyclyl derivatives as SSRIs |
ATE324365T1 (de) * | 2000-08-31 | 2006-05-15 | Pfizer | Phenoxyphenylheterozyklen als serotonin- wiederaufnahmehemmer |
US6610747B2 (en) | 2000-08-31 | 2003-08-26 | Pfizer Inc. | Phenoxybenzylamine derivatives as SSRIs |
US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
EP1260221A3 (en) * | 2001-05-23 | 2002-12-18 | Pfizer Products Inc. | Combination treatment for depression and anxiety |
EP1262196A3 (en) * | 2001-05-23 | 2002-12-18 | Pfizer Products Inc. | Combination of a monoamine reuptake inhibitor and an opioid antagonist for use in alcoholism and alcohol dependence |
US20020183306A1 (en) * | 2001-05-30 | 2002-12-05 | Pfizer Inc. | Combination treatment for sleep disorders including sleep apnea |
JP2006511606A (ja) | 2002-12-13 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 下部尿路症状を治療するα−2−δリガンド |
WO2007036781A1 (en) * | 2005-09-30 | 2007-04-05 | Pfizer Products Inc. | Diphenyl ether monoamine reuptake inhibitor |
EA017171B1 (ru) | 2006-12-22 | 2012-10-30 | Рекордати Айерленд Лимитед | КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП) |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3579582A (en) * | 1967-02-16 | 1971-05-18 | Universal Oil Prod Co | Hydroxy and/or hydrocarbyloxy and amino substituted tetrahydronaphthalenes |
GB1187200A (en) * | 1967-04-04 | 1970-04-08 | Dow Chemical Co | 2-[(Halophenoxy) Methyl]-2-Imidazolines |
NL7013566A (ko) * | 1969-09-29 | 1971-03-31 | ||
US3996279A (en) * | 1973-01-02 | 1976-12-07 | Gerot-Pharmazeutika Dr. Walter Otto K.G. | Novel 2-amino methyl-4,6-dihalogenphenol derivatives and methods for the preparation thereof |
AT332863B (de) * | 1973-01-02 | 1976-10-25 | Gerot Pharmazeutika | Verfahren zur herstellung von neuen 2-aminomethyl-4,6-dihalogenphenolderivaten sowie deren additionssalzen mit sauren |
DE2403138A1 (de) * | 1974-01-23 | 1975-07-31 | Hoechst Ag | Benzylaminderivate und verfahren zu ihrer herstellung |
DE2418502C3 (de) * | 1974-04-11 | 1980-04-24 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Dichlorbenzyl- [2-( a -imidazolylbutyl)-phenyl] -äther und -thioäther, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
IE40911B1 (en) * | 1974-04-11 | 1979-09-12 | Schering Ag | Imidazole derivatives and process for their manufacture |
US4055665A (en) * | 1974-11-25 | 1977-10-25 | Merck & Co., Inc. | Treating arrythmia with phenylthioaralkylamines |
US3946119A (en) * | 1974-12-23 | 1976-03-23 | Sandoz, Inc. | Optionally substituted α-tertiary butyl-p-phenoxybenzylamines and their use as hypolipidemic agents |
US4151302A (en) * | 1975-06-28 | 1979-04-24 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Araliphatic dihalogen compounds composition and method of use |
GB1561411A (en) * | 1977-02-25 | 1980-02-20 | Science Union & Cie | 2-phenoxyphenyl pyrrolidines and pharmaceutical compositions containing them |
JPS55104240A (en) * | 1979-02-07 | 1980-08-09 | Idemitsu Kosan Co Ltd | N-(alpha,alpha-dimethylbenzyl)-acetamide derivative and herbicide containing the same |
JPS56108752A (en) * | 1980-01-28 | 1981-08-28 | Sumitomo Chem Co Ltd | N-substituted benzylphenylacetamide derivative, its preparation and herbicide containing the same as active constituent |
US5149714A (en) * | 1987-08-14 | 1992-09-22 | Merrell Dow Pharmaceuticals Inc. | Antidepressants |
JPH0791249B2 (ja) * | 1988-11-10 | 1995-10-04 | 北興化学工業株式会社 | メタアリールオキシアラルキルアミン誘導体および除草剤 |
JPH07103079B2 (ja) * | 1988-11-21 | 1995-11-08 | 北興化学工業株式会社 | パラアリールオキシアラルキルアミン誘導体および殺虫・殺ダニ剤 |
ZA899033B (en) * | 1988-12-01 | 1990-09-26 | Merrell Dow Pharma | Phenoxy and phenylthio,amino substituted benzocycloalkane derivatives in the treatment and prevention of drug-resistant protozoal infections |
ZA923283B (en) * | 1991-05-29 | 1993-01-27 | Akzo Nv | Phenoxyphenyl derivatives |
-
1992
- 1992-05-06 ZA ZA923283A patent/ZA923283B/xx unknown
- 1992-05-11 CA CA002068373A patent/CA2068373A1/en not_active Abandoned
- 1992-05-22 AU AU17104/92A patent/AU650136B2/en not_active Ceased
- 1992-05-25 EP EP92201484A patent/EP0516234B1/en not_active Expired - Lifetime
- 1992-05-25 DE DE69204743T patent/DE69204743T2/de not_active Expired - Fee Related
- 1992-05-25 AT AT92201484T patent/ATE127777T1/de active
- 1992-05-25 DK DK92201484.0T patent/DK0516234T3/da active
- 1992-05-25 ES ES92201484T patent/ES2079783T3/es not_active Expired - Lifetime
- 1992-05-27 NO NO922110A patent/NO178395C/no unknown
- 1992-05-27 FI FI922433A patent/FI922433A/fi not_active Application Discontinuation
- 1992-05-28 JP JP4137276A patent/JPH05148197A/ja active Pending
- 1992-05-28 KR KR1019920009092A patent/KR920021493A/ko not_active Application Discontinuation
- 1992-05-29 US US07/891,545 patent/US5190965A/en not_active Expired - Fee Related
- 1992-07-01 IE IE921422A patent/IE67144B1/en not_active IP Right Cessation
-
1993
- 1993-02-03 US US08/012,700 patent/US5430063A/en not_active Expired - Fee Related
-
1995
- 1995-12-11 GR GR950403478T patent/GR3018357T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO178395B (no) | 1995-12-11 |
EP0516234A1 (en) | 1992-12-02 |
IE67144B1 (en) | 1996-03-06 |
NO922110L (no) | 1992-11-30 |
AU650136B2 (en) | 1994-06-09 |
US5430063A (en) | 1995-07-04 |
NO922110D0 (no) | 1992-05-27 |
DK0516234T3 (da) | 1996-01-29 |
NO178395C (no) | 1996-03-20 |
JPH05148197A (ja) | 1993-06-15 |
DE69204743T2 (de) | 1996-04-04 |
FI922433A (fi) | 1992-11-30 |
EP0516234B1 (en) | 1995-09-13 |
FI922433A0 (fi) | 1992-05-27 |
ATE127777T1 (de) | 1995-09-15 |
GR3018357T3 (en) | 1996-03-31 |
DE69204743D1 (de) | 1995-10-19 |
CA2068373A1 (en) | 1992-11-30 |
AU1710492A (en) | 1992-12-03 |
ES2079783T3 (es) | 1996-01-16 |
ZA923283B (en) | 1993-01-27 |
US5190965A (en) | 1993-03-02 |
IE921422A1 (en) | 1992-12-02 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |