KR920021493A - 페녹시페닐 유도체 - Google Patents

페녹시페닐 유도체 Download PDF

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Publication number
KR920021493A
KR920021493A KR1019920009092A KR920009092A KR920021493A KR 920021493 A KR920021493 A KR 920021493A KR 1019920009092 A KR1019920009092 A KR 1019920009092A KR 920009092 A KR920009092 A KR 920009092A KR 920021493 A KR920021493 A KR 920021493A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
phenoxyphenyl
acceptable salt
imidazole
derivative
Prior art date
Application number
KR1019920009092A
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English (en)
Inventor
스테파누스 프란시스쿠스 루이트 게라두스
리젠 디크
후베르투스 비에링가 요한네스
Original Assignee
에프.지.엠. 헤르만스 · 에이.지.제이.베르미렌
악조 엔. 브이.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프.지.엠. 헤르만스 · 에이.지.제이.베르미렌, 악조 엔. 브이. filed Critical 에프.지.엠. 헤르만스 · 에이.지.제이.베르미렌
Publication of KR920021493A publication Critical patent/KR920021493A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

내용 없음

Description

페녹시페닐 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기 일반식(Ⅰ)의 페녹시페닐 유도체 또는 그것의 약학적 허용 염:
    상기식에서 R은 한개 또는 두개의 할로겐 원자이고; A는 CH2NR1R2또는 4,5-디하이드로-1H-이미다졸이며, R1과 R2는 각각 수소 원자 및 저급 알킬기중에서 선택된다.
  2. 제1항에 있어서, R이 한개 또는 두개의 염소 원자인 페녹시페닐 유도체, 또는 그것의 약학적 허용 염.
  3. 제1항 또는 제2항에 있어서, A가 CH2NR(CH3)2, 또는 4-5디하이드로-1H-이미다졸인 페녹시페닐 유도체, 또는 그것의 약학적 허용 염.
  4. 2-(3,4-디클로로페녹시)벤젠메탄아민 또는 그것의 약학적 허용 염.
  5. 2-[2-(4-클로로페녹시)페닐]-4,5-디하이드록-1H-이미다졸 또는 그것의 약학적 허용 염.
  6. 치료에 유용한 제1항 내지 제5항중 어느 한 항의 페녹시페닐 유도체.
  7. 하기 일반식(Ⅱ)의 니트릴을 1,2-에탄디아민과 축합시키거나, 또는 환원시키고, 이어서 임의로 알킬화시키거나; A가 CH2NR1R2인 일반식(Ⅰ)의 화합물을 제조하고자 하는 경우에는, 하기 일반식(Ⅲ)의 아미드를 환원시키고; 그후에 수득한 화합물을 임의로 약학적 허용염으로 전환시키는 것을 특징으로 하는, 제1항의 페녹시페닐 유도체를 제조하는 방법:
    상기식에서 R은 한개 또는 두개의 할로겐 원자이고 R'는 NR1R2이며, R1과 R2는 각각 수소 원자 및 저급 알킬기 중에서 선택된다.
  8. 제1항의 페녹시페닐 유도체와 약학적 허용 보조제를 함유하는 약학제제.
  9. 제1항의 페녹시페닐 유도체를 장시간의 반감기 및 우울증에 대한 활성을 지니는 약제의 제조에 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920009092A 1991-05-29 1992-05-28 페녹시페닐 유도체 KR920021493A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91201288 1991-05-29
EP91201288.7 1991-05-29

Publications (1)

Publication Number Publication Date
KR920021493A true KR920021493A (ko) 1992-12-18

Family

ID=8207675

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920009092A KR920021493A (ko) 1991-05-29 1992-05-28 페녹시페닐 유도체

Country Status (15)

Country Link
US (2) US5190965A (ko)
EP (1) EP0516234B1 (ko)
JP (1) JPH05148197A (ko)
KR (1) KR920021493A (ko)
AT (1) ATE127777T1 (ko)
AU (1) AU650136B2 (ko)
CA (1) CA2068373A1 (ko)
DE (1) DE69204743T2 (ko)
DK (1) DK0516234T3 (ko)
ES (1) ES2079783T3 (ko)
FI (1) FI922433A (ko)
GR (1) GR3018357T3 (ko)
IE (1) IE67144B1 (ko)
NO (1) NO178395C (ko)
ZA (1) ZA923283B (ko)

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ZA923283B (en) * 1991-05-29 1993-01-27 Akzo Nv Phenoxyphenyl derivatives
US5447948A (en) * 1992-05-07 1995-09-05 Yale University Dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia
HUP0105488A3 (en) 1999-02-23 2005-07-28 Pfizer Prod Inc Monoamine reuptake inhibitors for treatment of cns disorders and pharmaceutical compositions containing the compounds
BR0012984A (pt) * 1999-08-04 2002-07-16 Millennium Pharm Inc Método para tratar um estado associado com o mc4-r em um mamìfero, composto de ligação ao mc4-r, e, composição farmacêutica
US7375125B2 (en) * 1999-08-04 2008-05-20 Ore Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
US6410736B1 (en) * 1999-11-29 2002-06-25 Pfizer Inc. Biaryl ether derivatives useful as monoamine reuptake inhibitors
AP2002002481A0 (en) * 1999-10-13 2002-06-30 Pfizer Prod Inc Biaryl ether derivatives useful as monoamine reuptake inhibitors.
GB0007884D0 (en) * 2000-03-31 2000-05-17 Pfizer Ltd Diphenyl ether compounds useful in therapy
US6448293B1 (en) 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
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US6610747B2 (en) 2000-08-31 2003-08-26 Pfizer Inc. Phenoxybenzylamine derivatives as SSRIs
BR0113610A (pt) * 2000-08-31 2003-06-24 Pfizer Derivados da fenoxibenzilamina como inibidores seletivos de recuperação de serotonina
DE60119047D1 (de) * 2000-08-31 2006-06-01 Pfizer Phenoxyphenylheterozyklen als Serotonin-Wiederaufnahmehemmer
US6630504B2 (en) 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
US20020165217A1 (en) * 2001-05-01 2002-11-07 Pfizer Inc. Combination treatment for anxiety and depression
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EP1260221A3 (en) * 2001-05-23 2002-12-18 Pfizer Products Inc. Combination treatment for depression and anxiety
US20020183306A1 (en) * 2001-05-30 2002-12-05 Pfizer Inc. Combination treatment for sleep disorders including sleep apnea
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WO2007036781A1 (en) * 2005-09-30 2007-04-05 Pfizer Products Inc. Diphenyl ether monoamine reuptake inhibitor
EA017171B1 (ru) 2006-12-22 2012-10-30 Рекордати Айерленд Лимитед КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП)

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Also Published As

Publication number Publication date
DK0516234T3 (da) 1996-01-29
AU650136B2 (en) 1994-06-09
NO922110L (no) 1992-11-30
US5190965A (en) 1993-03-02
DE69204743D1 (de) 1995-10-19
CA2068373A1 (en) 1992-11-30
US5430063A (en) 1995-07-04
GR3018357T3 (en) 1996-03-31
NO178395B (no) 1995-12-11
AU1710492A (en) 1992-12-03
ATE127777T1 (de) 1995-09-15
NO922110D0 (no) 1992-05-27
EP0516234B1 (en) 1995-09-13
EP0516234A1 (en) 1992-12-02
ZA923283B (en) 1993-01-27
FI922433A0 (fi) 1992-05-27
DE69204743T2 (de) 1996-04-04
ES2079783T3 (es) 1996-01-16
FI922433A (fi) 1992-11-30
IE67144B1 (en) 1996-03-06
NO178395C (no) 1996-03-20
JPH05148197A (ja) 1993-06-15
IE921422A1 (en) 1992-12-02

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