DE69306467T2 - Benzo(b)thiophen-3-yl-piperazine, Verfahren zur deren Herstellung und ihre Verwendung als Arzneimittel - Google Patents

Benzo(b)thiophen-3-yl-piperazine, Verfahren zur deren Herstellung und ihre Verwendung als Arzneimittel

Info

Publication number
DE69306467T2
DE69306467T2 DE69306467T DE69306467T DE69306467T2 DE 69306467 T2 DE69306467 T2 DE 69306467T2 DE 69306467 T DE69306467 T DE 69306467T DE 69306467 T DE69306467 T DE 69306467T DE 69306467 T2 DE69306467 T2 DE 69306467T2
Authority
DE
Germany
Prior art keywords
integer
preparation
piperazines
medicaments
thiophene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306467T
Other languages
English (en)
Other versions
DE69306467D1 (de
Inventor
Nicholas J Hrib
John Gerard Jurcak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of DE69306467D1 publication Critical patent/DE69306467D1/de
Application granted granted Critical
Publication of DE69306467T2 publication Critical patent/DE69306467T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69306467T 1992-05-19 1993-05-13 Benzo(b)thiophen-3-yl-piperazine, Verfahren zur deren Herstellung und ihre Verwendung als Arzneimittel Expired - Fee Related DE69306467T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/885,331 US5240927A (en) 1992-05-19 1992-05-19 Benzo[β]thiophen-3-yl piperazines as antipsychotic agents

Publications (2)

Publication Number Publication Date
DE69306467D1 DE69306467D1 (de) 1997-01-23
DE69306467T2 true DE69306467T2 (de) 1997-05-28

Family

ID=25386664

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306467T Expired - Fee Related DE69306467T2 (de) 1992-05-19 1993-05-13 Benzo(b)thiophen-3-yl-piperazine, Verfahren zur deren Herstellung und ihre Verwendung als Arzneimittel

Country Status (14)

Country Link
US (1) US5240927A (de)
EP (1) EP0570850B1 (de)
JP (1) JP2673089B2 (de)
KR (1) KR100258395B1 (de)
AT (1) ATE146176T1 (de)
AU (1) AU653311B2 (de)
CA (1) CA2096515C (de)
DE (1) DE69306467T2 (de)
DK (1) DK0570850T3 (de)
ES (1) ES2096800T3 (de)
GR (1) GR3022788T3 (de)
MX (1) MX9302889A (de)
NZ (1) NZ247624A (de)
TW (1) TW232018B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128690A1 (de) * 1991-08-29 1993-03-04 Boehringer Mannheim Gmbh Bicyclische sulfone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
PT732332E (pt) * 1995-03-17 2002-06-28 Aventis Pharma Inc Benzotienilpiperazinas substituidas sua utilizacao como medicamentos e processos para a sua preparacao
TWI329641B (en) * 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CN105061414B (zh) * 2015-07-21 2019-01-01 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366162A (en) * 1977-11-09 1982-12-28 Ab Ferrosan Aryl ethers of N-alkyl-piperidines and acid addition salts thereof
FR2475898A1 (fr) * 1980-02-14 1981-08-21 Andre Buzas Medicament analgesique contenant de la 1-(3'-benzofuryl)-4-benzylpiperazine et son procede de preparation
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
EP0238545B1 (de) * 1985-09-12 1995-11-15 The Upjohn Company C20 bis C26 Aminosteroide
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4803203A (en) * 1986-11-05 1989-02-07 Warner-Lambert Company Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
ES2052675T3 (es) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3-(4-piperazinil-sustituido en 1)butil)-4-tiazolidinonas, un procedimiento para su preparacion y su uso como medicamentos.
GB8803419D0 (en) * 1988-02-15 1988-03-16 Erba Carlo Spa 1 4-benzoxazine & 1 4-benzothiazine derivatives & process for their preparation
DK158590D0 (da) * 1990-07-02 1990-07-02 Lundbeck & Co As H Indolderivater
US5143923B1 (en) * 1991-04-29 1993-11-02 Hoechst-Roussel Pharmaceuticals Incorporated Benzoisothiazole-and benzisoxazole-3-carboxamides
DE4128690A1 (de) * 1991-08-29 1993-03-04 Boehringer Mannheim Gmbh Bicyclische sulfone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
DK0570850T3 (da) 1997-06-16
AU3860493A (en) 1993-11-25
DE69306467D1 (de) 1997-01-23
GR3022788T3 (en) 1997-06-30
ES2096800T3 (es) 1997-03-16
KR100258395B1 (en) 2000-07-01
KR940005621A (ko) 1994-03-21
NZ247624A (en) 1995-03-28
CA2096515A1 (en) 1993-11-20
EP0570850A1 (de) 1993-11-24
US5240927A (en) 1993-08-31
ATE146176T1 (de) 1996-12-15
TW232018B (de) 1994-10-11
JP2673089B2 (ja) 1997-11-05
JPH069617A (ja) 1994-01-18
AU653311B2 (en) 1994-09-22
CA2096515C (en) 2003-11-04
MX9302889A (es) 1993-11-01
EP0570850B1 (de) 1996-12-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMACEUTICALS INC., BRIDGEWATER, N.J, US

8339 Ceased/non-payment of the annual fee