KR950000146A - 테트라하이드로벤즈[cd]인돌-6-카복스아미드를 사용한 구토 예방 및 성기능부전의 치료방법 - Google Patents

테트라하이드로벤즈[cd]인돌-6-카복스아미드를 사용한 구토 예방 및 성기능부전의 치료방법 Download PDF

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KR950000146A
KR950000146A KR1019940012778A KR19940012778A KR950000146A KR 950000146 A KR950000146 A KR 950000146A KR 1019940012778 A KR1019940012778 A KR 1019940012778A KR 19940012778 A KR19940012778 A KR 19940012778A KR 950000146 A KR950000146 A KR 950000146A
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South Korea
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alkyl
hydrogen
tetrahydrobenz
carboxamide
indole
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KR1019940012778A
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KR100367792B1 (ko
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모튼슨 포어먼 마크
린더 제이.데이비드
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피터 지.스트링거
일라이 릴리 앤드 캄파니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 특정 테트라하이드로벤즈[cd]인돌을 사용하여 포유동물의 구토를 예방하고 성 기능부전을 치료하는 방법을 제공한다. 본 발명은 또한 상기 방법의 용도에 적합한 약학 제형을 제공한다.

Description

테트라하이드로벤즈[CD]인돌-6-카복스아미드를 사용한 구토 예방 및 성기능부전의 치료방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 구토 예방 또는 성 기능부전 치료용 약제를 제조하기 위한, 하기 일반식의 화합물 또는 그의 약학적으로 허용가능한 산 부가 염의 용도 :
    상기식에서, R1은 수소, C1-C4알킬 또는 알킬이고; R2는 수소, C1-C4알킬 또는 알릴이다.
  2. 제1항에 있어서, 상기 사용된 화합물이 (±)-4-디프로필아미노-1,3,4,5-테트라하이드로벤즈[cd]인돌-6-카복스아미드, (-)-4-디프로필아미노-1,3,4,5-테트라하이드로벤즈[cd]인돌-6-카복스아미드, (+)-4-디프로필아미노-1,3,4,5-테트라하이드로벤즈[cd]인돌-6-카복스아미드 또는 이들의 약학적으로 허용가능한 산 부가염의 용도.
  3. 구토 예방용 약제를 제조하기 위한, 하기 일반식의 화합물 또는 그의 약학적으로 허용가능한 산 부가염의 용도 :
    상기식에서, R1은 수소, C1-C4알킬 또는 알킬이고; R2는 수소, C1-C4알킬 또는 알릴이고; R3및 R4는 각각 독립적으로 수소, C1-C4알킬, 페닐기로 치환된 C1-C4알킬 또는 페닐이거나, 또는 이들의 결합된 질소 원자와 함께 C3-C5헤테로사이클릭 고리를 형성하나, 단 R3및 R4중의 단 하나만이 수소일 수 있고 나머지는 수소가 아니어야 한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940012778A 1993-06-10 1994-06-08 테트라하이드로벤즈[cd]인돌-6-카복스아미드를 포함하는 성기능부전 치료용 약제 KR100367792B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7519893A 1993-06-10 1993-06-10
US08/075.198 1993-06-10
US08/075,198 1993-06-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020020052257A Division KR100367791B1 (ko) 1993-06-10 2002-08-31 테트라하이드로벤즈[ｃｄ]인돌-6-카복스아미드를 포함하는구토 예방용 약제

Publications (2)

Publication Number Publication Date
KR950000146A true KR950000146A (ko) 1995-01-03
KR100367792B1 KR100367792B1 (ko) 2003-02-19

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Application Number Title Priority Date Filing Date
KR1019940012778A KR100367792B1 (ko) 1993-06-10 1994-06-08 테트라하이드로벤즈[cd]인돌-6-카복스아미드를 포함하는 성기능부전 치료용 약제
KR1020020052257A KR100367791B1 (ko) 1993-06-10 2002-08-31 테트라하이드로벤즈[ｃｄ]인돌-6-카복스아미드를 포함하는구토 예방용 약제

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Country Status (17)

Country Link
US (1) US5703112A (ko)
EP (2) EP1166783A3 (ko)
JP (1) JPH0748254A (ko)
KR (2) KR100367792B1 (ko)
CN (2) CN1072932C (ko)
AU (1) AU677317B2 (ko)
CA (1) CA2125088A1 (ko)
CZ (2) CZ285762B6 (ko)
HK (1) HK1043322B (ko)
HU (1) HUT71464A (ko)
IL (1) IL109872A (ko)
NO (4) NO321500B1 (ko)
NZ (2) NZ260667A (ko)
RU (1) RU2154476C2 (ko)
TW (1) TW258660B (ko)
UA (2) UA29415C2 (ko)
ZA (1) ZA943862B (ko)

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EP1173167A4 (en) 1999-04-30 2004-07-14 Lilly Icos Llc TREATMENT OF FEMALE SEXUAL STIMULATION DISORDERS
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EP1890684B1 (en) 2005-06-08 2013-08-14 SK Biopharmaceuticals Co., Ltd. Treatment of sleep-wake disorders
EP1893291B1 (en) * 2005-06-22 2010-03-03 SK Holdings Co., Ltd. Treatment of sexual dysfunction
KR102173587B1 (ko) 2009-06-22 2020-11-04 에스케이바이오팜 주식회사 피로의 치료 또는 예방 방법
KR101783633B1 (ko) 2009-11-06 2017-10-10 에스케이바이오팜 주식회사 섬유근육통 증후군의 치료 방법
US8895609B2 (en) 2009-11-06 2014-11-25 Sk Biopharmaceuticals Co., Ltd. Methods for treating attention-deficit/hyperactivity disorder
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
SG11201507121RA (en) 2013-03-13 2015-10-29 Aerial Biopharma Llc Treatment of cataplexy
PT3021838T (pt) 2013-07-18 2020-09-01 Sk Biopharmaceuticals Co Ltd Tratamento para a obesidade
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
AU2018278332B2 (en) 2017-06-02 2022-05-19 Jazz Pharmaceuticals Ireland Limited Methods and compositions for treating excessive sleepiness
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function

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Publication number Publication date
KR100367791B1 (ko) 2003-02-14
CZ285829B6 (cs) 1999-11-17
CN1342457A (zh) 2002-04-03
HK1043322A1 (en) 2002-09-13
KR100367792B1 (ko) 2003-02-19
UA37311C2 (uk) 2001-05-15
NO993461D0 (no) 1999-07-14
NO20015806L (no) 1994-12-12
IL109872A0 (en) 1994-10-07
NO321500B1 (no) 2006-05-15
NO20015806D0 (no) 2001-11-28
ZA943862B (en) 1995-12-04
EP0633023A2 (en) 1995-01-11
CN1170536C (zh) 2004-10-13
AU6460794A (en) 1994-12-15
NO991551D0 (no) 1999-03-30
HU9401730D0 (en) 1994-09-28
NO942143L (no) 1994-12-12
NZ260667A (en) 1997-05-26
UA29415C2 (uk) 2000-11-15
CZ285762B6 (cs) 1999-11-17
NO993461L (no) 1994-12-12
JPH0748254A (ja) 1995-02-21
EP1166783A3 (en) 2002-01-09
CN1100634A (zh) 1995-03-29
NZ314570A (en) 2000-11-24
IL109872A (en) 2000-12-06
HK1043322B (zh) 2005-06-03
AU677317B2 (en) 1997-04-17
HUT71464A (en) 1995-11-28
RU2154476C2 (ru) 2000-08-20
RU94020717A (ru) 1996-08-27
US5703112A (en) 1997-12-30
CN1072932C (zh) 2001-10-17
TW258660B (ko) 1995-10-01
NO308693B1 (no) 2000-10-16
CZ135494A3 (en) 1994-12-15
NO942143D0 (no) 1994-06-09
EP0633023A3 (en) 1995-03-29
NO991551L (no) 1994-12-12
EP1166783A2 (en) 2002-01-02
CA2125088A1 (en) 1994-12-11

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