NO173869C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider

Info

Publication number
NO173869C
NO173869C NO901083A NO901083A NO173869C NO 173869 C NO173869 C NO 173869C NO 901083 A NO901083 A NO 901083A NO 901083 A NO901083 A NO 901083A NO 173869 C NO173869 C NO 173869C
Authority
NO
Norway
Prior art keywords
lower alkyl
represents hydrogen
preparation
halogen
benzodiazepin
Prior art date
Application number
NO901083A
Other languages
English (en)
Other versions
NO901083L (no
NO173869B (no
NO901083D0 (no
Inventor
Harald Waldeck
Werner Benson
Horst Zeugner
Klaus-Ullrich Wolf
Peter-Colin Gregory
Derk Hamminga
Van Ineke Wijngaarden
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3907390A external-priority patent/DE3907390A1/de
Priority claimed from DE3907389A external-priority patent/DE3907389A1/de
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of NO901083D0 publication Critical patent/NO901083D0/no
Publication of NO901083L publication Critical patent/NO901083L/no
Publication of NO173869B publication Critical patent/NO173869B/no
Publication of NO173869C publication Critical patent/NO173869C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems
NO901083A 1989-03-08 1990-03-07 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider NO173869C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3907390A DE3907390A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide
DE3907389A DE3907389A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide

Publications (4)

Publication Number Publication Date
NO901083D0 NO901083D0 (no) 1990-03-07
NO901083L NO901083L (no) 1990-09-10
NO173869B NO173869B (no) 1993-11-08
NO173869C true NO173869C (no) 1994-02-16

Family

ID=25878542

Family Applications (1)

Application Number Title Priority Date Filing Date
NO901083A NO173869C (no) 1989-03-08 1990-03-07 Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,7-kondenserte 1h-indol-2-carboxylsre-n-(1,4-benzodiazepin-3-yl)-amider

Country Status (20)

Country Link
US (1) US5010076A (no)
EP (1) EP0387618B1 (no)
JP (1) JP3010558B2 (no)
KR (1) KR920003627B1 (no)
CN (1) CN1032208C (no)
AT (1) ATE109146T1 (no)
AU (1) AU616835B2 (no)
CS (1) CS390091A3 (no)
DE (1) DE59006544D1 (no)
DK (1) DK0387618T3 (no)
ES (1) ES2057216T3 (no)
FI (1) FI92486C (no)
HK (1) HK1006570A1 (no)
HU (2) HU207317B (no)
IE (1) IE65030B1 (no)
IL (1) IL93401A (no)
NO (1) NO173869C (no)
NZ (1) NZ232774A (no)
PH (1) PH26955A (no)
PT (1) PT93360B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
CA2195697A1 (en) 1996-02-02 1997-08-03 Masahumi Kitano Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof
WO2000018391A1 (fr) * 1998-09-30 2000-04-06 Takeda Chemical Industries, Ltd. Medicaments qui ameliorent le pouvoir de vidange de la vessie
CA2446696A1 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
FR2846653B1 (fr) * 2002-10-30 2007-04-20 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
ATE412415T1 (de) * 2002-10-30 2008-11-15 Via Pharmaceuticals Inc Inhibitoren der phosphodiesterase der zyklischen nucleotiden, mit einer benzodiazepinischen struktur, und deren verwendung in therapie
WO2014098000A1 (en) * 2012-12-17 2014-06-26 Daiichi Sankyo Company, Limited Process for preparation of a tricyclic heterocycle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139584B1 (fr) * 1983-10-17 1988-05-18 Synthelabo Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
FR2567126B1 (fr) * 1984-07-06 1986-12-12 Synthelabo Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
DK680788A (da) * 1987-12-10 1989-06-11 Duphar Int Res Indolcarboxylsyreestere og -amider, deres fremstilling of laegemidler indeholdende forbindelserne
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

Also Published As

Publication number Publication date
NO901083L (no) 1990-09-10
FI92486C (fi) 1994-11-25
HU901333D0 (en) 1990-05-28
HU210354A9 (en) 1995-03-28
IE65030B1 (en) 1995-10-04
NO173869B (no) 1993-11-08
PT93360A (pt) 1990-11-07
CN1045392A (zh) 1990-09-19
DE59006544D1 (de) 1994-09-01
CS390091A3 (en) 1992-06-17
EP0387618B1 (de) 1994-07-27
KR900014391A (ko) 1990-10-23
HK1006570A1 (en) 1999-03-05
NZ232774A (en) 1991-04-26
NO901083D0 (no) 1990-03-07
FI901154A0 (fi) 1990-03-07
US5010076A (en) 1991-04-23
FI92486B (fi) 1994-08-15
AU616835B2 (en) 1991-11-07
AU5075390A (en) 1990-09-13
DK0387618T3 (da) 1994-08-22
IL93401A0 (en) 1990-11-29
IE900813L (en) 1990-09-08
ES2057216T3 (es) 1994-10-16
JP3010558B2 (ja) 2000-02-21
HUT53641A (en) 1990-11-28
EP0387618A1 (de) 1990-09-19
JPH02273678A (ja) 1990-11-08
IL93401A (en) 1994-08-26
HU207317B (en) 1993-03-29
CN1032208C (zh) 1996-07-03
PT93360B (pt) 1996-02-29
ATE109146T1 (de) 1994-08-15
PH26955A (en) 1992-12-03
KR920003627B1 (ko) 1992-05-04

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