PT93360A - Processo para a preparacao de n-(1,4-benzo-diazepin-3-il)amidas de acidos 1h-indol-2-carboxilicos condensados nas posicoes 1,7 e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de n-(1,4-benzo-diazepin-3-il)amidas de acidos 1h-indol-2-carboxilicos condensados nas posicoes 1,7 e de composicoes farmaceuticas que as contem

Info

Publication number
PT93360A
PT93360A PT93360A PT9336090A PT93360A PT 93360 A PT93360 A PT 93360A PT 93360 A PT93360 A PT 93360A PT 9336090 A PT9336090 A PT 9336090A PT 93360 A PT93360 A PT 93360A
Authority
PT
Portugal
Prior art keywords
lower alkyl
represents hydrogen
preparation
halogen
diazepin
Prior art date
Application number
PT93360A
Other languages
English (en)
Other versions
PT93360B (pt
Inventor
Harald Waldeck
Werner Benson
Horst Zeugner
Klaus-Ullrich Wolf
Peter-Colin Gregory
Derk Hamminga
Ineke Van Wijngaarden
Original Assignee
Kali Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3907390A external-priority patent/DE3907390A1/de
Priority claimed from DE3907389A external-priority patent/DE3907389A1/de
Application filed by Kali Chemie Pharma Gmbh filed Critical Kali Chemie Pharma Gmbh
Publication of PT93360A publication Critical patent/PT93360A/pt
Publication of PT93360B publication Critical patent/PT93360B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PT93360A 1989-03-08 1990-03-07 Processo para a preparacao de n-(1,4-benzo-diazepin-3-il)amidas de acidos 1h-indol-2-carboxilicos condensados nas posicoes 1,7 e de composicoes farmaceuticas que as contem PT93360B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3907390A DE3907390A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide
DE3907389A DE3907389A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide

Publications (2)

Publication Number Publication Date
PT93360A true PT93360A (pt) 1990-11-07
PT93360B PT93360B (pt) 1996-02-29

Family

ID=25878542

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93360A PT93360B (pt) 1989-03-08 1990-03-07 Processo para a preparacao de n-(1,4-benzo-diazepin-3-il)amidas de acidos 1h-indol-2-carboxilicos condensados nas posicoes 1,7 e de composicoes farmaceuticas que as contem

Country Status (20)

Country Link
US (1) US5010076A (pt)
EP (1) EP0387618B1 (pt)
JP (1) JP3010558B2 (pt)
KR (1) KR920003627B1 (pt)
CN (1) CN1032208C (pt)
AT (1) ATE109146T1 (pt)
AU (1) AU616835B2 (pt)
CS (1) CS390091A3 (pt)
DE (1) DE59006544D1 (pt)
DK (1) DK0387618T3 (pt)
ES (1) ES2057216T3 (pt)
FI (1) FI92486C (pt)
HK (1) HK1006570A1 (pt)
HU (2) HU207317B (pt)
IE (1) IE65030B1 (pt)
IL (1) IL93401A (pt)
NO (1) NO173869C (pt)
NZ (1) NZ232774A (pt)
PH (1) PH26955A (pt)
PT (1) PT93360B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
EP1891954A3 (en) * 1998-09-30 2009-01-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
FR2846653B1 (fr) * 2002-10-30 2007-04-20 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
AU2003288352A1 (en) * 2002-10-30 2004-06-07 Centre National De La Recherche Scientifique (Cnrs) Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses
WO2014098000A1 (en) * 2012-12-17 2014-06-26 Daiichi Sankyo Company, Limited Process for preparation of a tricyclic heterocycle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3471308D1 (en) * 1983-10-17 1988-06-23 Synthelabo Imidazoline derivatives, their preparation and therapeutical use
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
FR2567126B1 (fr) * 1984-07-06 1986-12-12 Synthelabo Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
ZA889166B (en) * 1987-12-10 1990-05-30 Duphar Int Res 1,7-annelated indolecarboxylic acid esters and -amides
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

Also Published As

Publication number Publication date
ES2057216T3 (es) 1994-10-16
HK1006570A1 (en) 1999-03-05
NO901083D0 (no) 1990-03-07
IL93401A (en) 1994-08-26
US5010076A (en) 1991-04-23
DK0387618T3 (da) 1994-08-22
IE65030B1 (en) 1995-10-04
AU616835B2 (en) 1991-11-07
EP0387618A1 (de) 1990-09-19
PH26955A (en) 1992-12-03
ATE109146T1 (de) 1994-08-15
NO901083L (no) 1990-09-10
HU210354A9 (en) 1995-03-28
IE900813L (en) 1990-09-08
FI901154A0 (fi) 1990-03-07
NO173869C (no) 1994-02-16
HU901333D0 (en) 1990-05-28
IL93401A0 (en) 1990-11-29
CN1032208C (zh) 1996-07-03
JP3010558B2 (ja) 2000-02-21
PT93360B (pt) 1996-02-29
KR900014391A (ko) 1990-10-23
EP0387618B1 (de) 1994-07-27
JPH02273678A (ja) 1990-11-08
HU207317B (en) 1993-03-29
KR920003627B1 (ko) 1992-05-04
FI92486C (fi) 1994-11-25
AU5075390A (en) 1990-09-13
CS390091A3 (en) 1992-06-17
NO173869B (no) 1993-11-08
DE59006544D1 (de) 1994-09-01
NZ232774A (en) 1991-04-26
FI92486B (fi) 1994-08-15
CN1045392A (zh) 1990-09-19
HUT53641A (en) 1990-11-28

Similar Documents

Publication Publication Date Title
PT93360A (pt) Processo para a preparacao de n-(1,4-benzo-diazepin-3-il)amidas de acidos 1h-indol-2-carboxilicos condensados nas posicoes 1,7 e de composicoes farmaceuticas que as contem
EA200000391A1 (ru) Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
PT83725B (pt) Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
ES514816A0 (es) "procedimiento para la preparacion de compuestos de 1-fenil-2-aminocarbonilindol".
ES544417A0 (es) Procedimiento para preparar 8-alquiltio-2-piperazino-pirimido(5,4-d)pirimidinas.
BR8803402A (pt) Poliisocianatos aromaticos,processo para a sua preparacao e utilizacao
DE3561815D1 (en) 3-aminocarbonylmethoxy-5-phenylpyrazole compounds, process for their preparation and pharmaceutical compositions containing them
PT85100A (pt) Processo para a preparacao de novos tetra-hidro-benzotiazois e de composicoes farmaceuticas que os contem
PT99360A (pt) Processo para a preparacao de carbamatos de oxi-sulfonilo e de composicoes farmaceuticas que os contem
PT92494A (pt) Processo para a preparacao de novos derivados do indol
PT90614A (pt) Processo para a preparacao de tienil-piperazinonas e de composicoes farmaceuticas que os contem
ATE6635T1 (de) Biologisch aktive trizyklische amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
ES2071177T3 (es) Derivados substituidos de amidas de aminoacido, su obtencion y empleo.
ATE89282T1 (de) 1-dethia-2-thia-cephalosporansaeurederivate, verfahren zur herstellung, ihre verwendung als arzneimittel und sie enthaltende pharmazeutische zusammensetzungen.
ES518573A0 (es) Procedimiento para la preparacion de compuestos de 1,4-benzodiazepina.
BR8603202A (pt) Composicoes herbicidas a base de novos quinolino-8-acilazolidios,e,processo de obtencao destes compostos
ES2095242T3 (es) Arilaminas y heteroarilaminas sustituidas, procedimiento para su preparacion y composiciones farmaceuticas que las contengan.
CA2011658A1 (en) New 1,7-annelated 1h-indole-2-carboxylic acid-n-(1,4-benzodiazepin-3-yl) amides

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19951116

PD3A Change of proprietorship
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20020531