ES2057216T3 - N-(1,4-benzodiazepin-3-il) amidas de acidos 1h-indol-2-carboxilicos condensados en posiciones 1,7. - Google Patents

N-(1,4-benzodiazepin-3-il) amidas de acidos 1h-indol-2-carboxilicos condensados en posiciones 1,7.

Info

Publication number
ES2057216T3
ES2057216T3 ES90103990T ES90103990T ES2057216T3 ES 2057216 T3 ES2057216 T3 ES 2057216T3 ES 90103990 T ES90103990 T ES 90103990T ES 90103990 T ES90103990 T ES 90103990T ES 2057216 T3 ES2057216 T3 ES 2057216T3
Authority
ES
Spain
Prior art keywords
lower alkyl
represents hydrogen
halogen
carbon atoms
benzodiazepin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90103990T
Other languages
English (en)
Inventor
Harald Waldeck
Werner Benson
Horst Zeugner
Klaus-Ullrich Wolf
Peter-Colin Gregory
Derk Hamminga
Wijngaarden Ineke Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3907389A external-priority patent/DE3907389A1/de
Priority claimed from DE3907390A external-priority patent/DE3907390A1/de
Application filed by Kali Chemie Pharma GmbH filed Critical Kali Chemie Pharma GmbH
Application granted granted Critical
Publication of ES2057216T3 publication Critical patent/ES2057216T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBEN COMPUESTOS DE FORMULA GENERAL I, (FORMULA I) EN LAS QUE: R1 = H, UN ALQUILO INFERIOR O UN CICLOALQUILO CON 4-7 ATOMOS DE C; R2 = H, HALOGENO, O UN ALQUILO INFERIOR, UN ALCOXI INFERIOR O TRIFLUOROMETILO; R3 = H, HALOGENO, UN ALQUILO INFERIOR O UN ALCOXI INFERIOR O FORMAN JUNTOS R2 Y R3 UN GRUPO DIOXI-ALQUILENO; R4 = CICLOALQUILO CON 5 A 6 ATOMOS DE C, TIOFENO, O EVENTUALMENTE UN FENILO SUSTITUIDO; R5 = HIDROGENO O HALOGENO; R6 = H, HALOGENO, ALQUILO INFERIOR, ALCOXI INFERIOR O TRIFLUOROMETILO Y Z SUSTITUYE A UNA CADENA DE ALQUILENO CON 2 A 4 ATOMOS DE C, LOS CUALES PUEDEN ESTAR MONO- O DI-SUSTITUIDOS EVENTUALMENTE POR UN ALQUILO INFERIOR, O CON LOS QUE PUEDE FORMAR UN ANILLO CARBOCICLICO DE 5-6 ESLABONES, O SIGNIFICA UNA CADENA -X-CH2-CH2-. ESTAS COMBINACIONES POSEEN VALIOSAS PROPIEDADES FARMACOLOGICAS.
ES90103990T 1989-03-08 1990-03-01 N-(1,4-benzodiazepin-3-il) amidas de acidos 1h-indol-2-carboxilicos condensados en posiciones 1,7. Expired - Lifetime ES2057216T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3907389A DE3907389A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-carbonsaeure-n-(5-alkyl-1,4-benzodiazepin-3-yl)amide
DE3907390A DE3907390A1 (de) 1989-03-08 1989-03-08 Neue 1,7-anellierte 1h-indol-2-carbonsaeure-n-(5-phenyl-1,4-benzodiazepin-3-yl)amide

Publications (1)

Publication Number Publication Date
ES2057216T3 true ES2057216T3 (es) 1994-10-16

Family

ID=25878542

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90103990T Expired - Lifetime ES2057216T3 (es) 1989-03-08 1990-03-01 N-(1,4-benzodiazepin-3-il) amidas de acidos 1h-indol-2-carboxilicos condensados en posiciones 1,7.

Country Status (20)

Country Link
US (1) US5010076A (es)
EP (1) EP0387618B1 (es)
JP (1) JP3010558B2 (es)
KR (1) KR920003627B1 (es)
CN (1) CN1032208C (es)
AT (1) ATE109146T1 (es)
AU (1) AU616835B2 (es)
CS (1) CS390091A3 (es)
DE (1) DE59006544D1 (es)
DK (1) DK0387618T3 (es)
ES (1) ES2057216T3 (es)
FI (1) FI92486C (es)
HK (1) HK1006570A1 (es)
HU (2) HU207317B (es)
IE (1) IE65030B1 (es)
IL (1) IL93401A (es)
NO (1) NO173869C (es)
NZ (1) NZ232774A (es)
PH (1) PH26955A (es)
PT (1) PT93360B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07103105B2 (ja) * 1989-05-12 1995-11-08 杏林製薬株式会社 インドール誘導体及びその製造方法
US5264419A (en) * 1990-08-31 1993-11-23 Warner-Lambert Company N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives
CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
DE4128015A1 (de) * 1991-08-23 1993-02-25 Kali Chemie Pharma Gmbh 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel
GB9203790D0 (en) * 1992-02-21 1992-04-08 Merck Sharp & Dohme Therapeutic agents
US5360802A (en) * 1992-05-11 1994-11-01 Merck Sharpe & Dohme Ltd. Benzodiazepine derivatives, compositions containing them and their use in therapy
DE4304806A1 (de) * 1993-02-17 1994-08-18 Kali Chemie Pharma Gmbh 5-Phenyl-pyrrolo-1,4-benzoxazin- und -thiazin-Derivate sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US5556969A (en) * 1994-12-07 1996-09-17 Merck Sharp & Dohme Ltd. Benzodiazepine derivatives
NZ314105A (en) * 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
AU758802B2 (en) * 1998-09-30 2003-03-27 Takeda Pharmaceutical Company Limited Drugs for improving vesical excretory strength
EP1392663A2 (fr) 2001-06-07 2004-03-03 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
US20060128695A1 (en) * 2002-10-30 2006-06-15 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses
FR2846653B1 (fr) * 2002-10-30 2007-04-20 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
WO2014098000A1 (en) * 2012-12-17 2014-06-26 Daiichi Sankyo Company, Limited Process for preparation of a tricyclic heterocycle

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139584B1 (fr) * 1983-10-17 1988-05-18 Synthelabo Dérivés d'imidazoline, leur préparation et leur application en thérapeutique
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
FR2567126B1 (fr) * 1984-07-06 1986-12-12 Synthelabo Derives de pyrrolo(1,2,3-de) benzoxazine et benzothiazine, leur preparation et leur application en therapeutique
US4628084A (en) * 1986-01-02 1986-12-09 Merck & Co., Inc. Process for 3-acylamino benzodiazepines
ZA889166B (en) * 1987-12-10 1990-05-30 Duphar Int Res 1,7-annelated indolecarboxylic acid esters and -amides
FR2630440B1 (fr) * 1988-04-25 1991-09-20 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique
IL91361A (en) * 1988-09-09 1994-10-07 Fujisawa Pharmaceutical Co Benzodiazepinone compounds [4,1] connected via positions 1 and 9 and carrying two transducers, processes for their preparation and pharmaceutical preparations containing them
FR2652352A1 (fr) * 1989-09-28 1991-03-29 Jouveinal Sa Benzodiazepines, leur procede et intermediaires de preparation et leurs applications en therapeutique.

Also Published As

Publication number Publication date
CN1045392A (zh) 1990-09-19
PH26955A (en) 1992-12-03
FI92486C (fi) 1994-11-25
CS390091A3 (en) 1992-06-17
HUT53641A (en) 1990-11-28
HU207317B (en) 1993-03-29
NO901083D0 (no) 1990-03-07
AU5075390A (en) 1990-09-13
NZ232774A (en) 1991-04-26
NO173869C (no) 1994-02-16
EP0387618A1 (de) 1990-09-19
DE59006544D1 (de) 1994-09-01
HU210354A9 (en) 1995-03-28
HK1006570A1 (en) 1999-03-05
IE65030B1 (en) 1995-10-04
FI901154A0 (fi) 1990-03-07
HU901333D0 (en) 1990-05-28
FI92486B (fi) 1994-08-15
NO901083L (no) 1990-09-10
US5010076A (en) 1991-04-23
IL93401A (en) 1994-08-26
JP3010558B2 (ja) 2000-02-21
IL93401A0 (en) 1990-11-29
PT93360B (pt) 1996-02-29
NO173869B (no) 1993-11-08
DK0387618T3 (da) 1994-08-22
ATE109146T1 (de) 1994-08-15
KR900014391A (ko) 1990-10-23
JPH02273678A (ja) 1990-11-08
CN1032208C (zh) 1996-07-03
IE900813L (en) 1990-09-08
EP0387618B1 (de) 1994-07-27
AU616835B2 (en) 1991-11-07
PT93360A (pt) 1990-11-07
KR920003627B1 (ko) 1992-05-04

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