NZ720301A - Deuterated tetrabenazine compounds - Google Patents
Deuterated tetrabenazine compoundsInfo
- Publication number
- NZ720301A NZ720301A NZ720301A NZ72030114A NZ720301A NZ 720301 A NZ720301 A NZ 720301A NZ 720301 A NZ720301 A NZ 720301A NZ 72030114 A NZ72030114 A NZ 72030114A NZ 720301 A NZ720301 A NZ 720301A
- Authority
- NZ
- New Zealand
- Prior art keywords
- tetrabenazine
- deuterated
- deuterated tetrabenazine
- tetrabenazine compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
- C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911214P | 2013-12-03 | 2013-12-03 | |
| PCT/US2014/067117 WO2015084622A1 (en) | 2013-12-03 | 2014-11-24 | Methods of manufacturing benzoquinoline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ720301A true NZ720301A (en) | 2022-01-28 |
Family
ID=53264424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ720301A NZ720301A (en) | 2013-12-03 | 2014-11-24 | Deuterated tetrabenazine compounds |
Country Status (14)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116768882A (zh) | 2012-09-18 | 2023-09-19 | 奥斯拜客斯制药有限公司 | 化合物、及其药物组合物及治疗方法 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| MX369956B (es) | 2013-12-03 | 2019-11-27 | Auspex Pharmaceuticals Inc | Metodos para preparar compuestos de benzoquinolina. |
| US20160287574A1 (en) | 2015-03-06 | 2016-10-06 | Auspex Pharmaceuticals, Inc. | Methods for the treatment of abnormal involuntary movement disorders |
| WO2017182916A1 (en) | 2016-04-22 | 2017-10-26 | Lupin Limited | Novel process for preparation of tetrabenazine and deutetrabenazine |
| US10703750B2 (en) | 2017-01-10 | 2020-07-07 | Sandoz Ag | Crystalline valbenazine free base |
| JP2020508337A (ja) | 2017-02-27 | 2020-03-19 | サンド・アクチエンゲゼルシヤフト | バルベナジン塩の結晶形態 |
| UA127052C2 (uk) * | 2017-03-15 | 2023-03-29 | Оспекс Фармасьютікалс, Інк. | Аналоги деутетрабеназину, їхнє отримання та застосування |
| WO2019130252A2 (en) * | 2017-12-29 | 2019-07-04 | Mylan Laboratories Ltd | Methods and intermediates for preparing deutetrabenazine |
| US11505549B2 (en) * | 2018-02-01 | 2022-11-22 | Lakshmi Prasad ALAPARTHI | Process for preparation of Deutetrabenazine |
| FI3866931T3 (fi) | 2018-10-18 | 2023-05-10 | Oncopeptides Ab | Deuteriumia sisältäviä yhdisteitä |
| WO2020086765A1 (en) * | 2018-10-24 | 2020-04-30 | Neurocrine Biosciences, Inc. | Processes for preparing a vmat2 inhibitor |
| CN111960999B (zh) * | 2020-07-20 | 2021-11-02 | 暨明医药科技（苏州）有限公司 | 一种丁苯那嗪中间体的合成方法 |
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| CN116768882A (zh) | 2012-09-18 | 2023-09-19 | 奥斯拜客斯制药有限公司 | 化合物、及其药物组合物及治疗方法 |
| CN102936246A (zh) * | 2012-11-08 | 2013-02-20 | 江苏暨明医药科技有限公司 | 丁苯那嗪的合成方法 |
| EA201500801A1 (ru) | 2013-01-31 | 2016-01-29 | Ауспекс Фармацетикалс, Инк. | Бензохинолоновые ингибиторы vmat2 |
| US20160207917A1 (en) | 2013-09-27 | 2016-07-21 | Auspex Pharmaceuticals, Inc. | Benzoquinolone inhibitors of vmat2 |
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| MX369956B (es) | 2013-12-03 | 2019-11-27 | Auspex Pharmaceuticals Inc | Metodos para preparar compuestos de benzoquinolina. |
| KR20160111999A (ko) | 2014-01-27 | 2016-09-27 | 오스펙스 파마슈티칼스, 인코포레이티드 | 소포성 모노아민 수송체 2의 벤조퀴놀린 억제제 |
-
2014
- 2014-11-24 MX MX2016007056A patent/MX369956B/es active IP Right Grant
- 2014-11-24 CA CA2930744A patent/CA2930744A1/en not_active Abandoned
- 2014-11-24 NZ NZ720301A patent/NZ720301A/en unknown
- 2014-11-24 US US14/551,909 patent/US20150152099A1/en not_active Abandoned
- 2014-11-24 WO PCT/US2014/067117 patent/WO2015084622A1/en not_active Ceased
- 2014-11-24 CN CN201480066154.9A patent/CN105873589B/zh active Active
- 2014-11-24 EA EA201791466A patent/EA201791466A1/ru unknown
- 2014-11-24 KR KR1020167017402A patent/KR102391134B1/ko active Active
- 2014-11-24 EP EP18179389.4A patent/EP3424504A1/en not_active Withdrawn
- 2014-11-24 EP EP14867514.3A patent/EP3076970A4/en not_active Withdrawn
- 2014-11-24 EA EA201691162A patent/EA032920B1/ru not_active IP Right Cessation
- 2014-11-24 BR BR112016012747-1A patent/BR112016012747B1/pt active IP Right Grant
- 2014-11-24 JP JP2016536571A patent/JP6542222B2/ja active Active
- 2014-11-24 AU AU2014357518A patent/AU2014357518A1/en not_active Abandoned
- 2014-11-24 HK HK16112664.2A patent/HK1224222A1/zh unknown
-
2016
- 2016-05-08 IL IL245539A patent/IL245539B/en active IP Right Grant
-
2017
- 2017-03-21 US US15/464,938 patent/US20170190654A1/en not_active Abandoned
- 2017-03-29 US US15/472,779 patent/US10513488B2/en active Active
-
2018
- 2018-04-12 US US15/952,031 patent/US20180230083A1/en not_active Abandoned
- 2018-11-30 US US16/205,525 patent/US20190092719A1/en not_active Abandoned
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2019
- 2019-11-12 US US16/680,674 patent/US20200331846A1/en not_active Abandoned
-
2020
- 2020-02-14 AU AU2020201091A patent/AU2020201091B2/en active Active
- 2020-04-15 US US16/849,603 patent/US20200347008A1/en not_active Abandoned
-
2021
- 2021-07-26 AU AU2021209150A patent/AU2021209150A1/en not_active Abandoned
-
2022
- 2022-08-02 US US17/879,600 patent/US12077487B2/en active Active
-
2023
- 2023-05-23 AU AU2023203246A patent/AU2023203246B2/en active Active
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