US3595955A
(en)
*
|
1969-03-26 |
1971-07-27 |
Upjohn Co |
Geldanamycin and process for producing same
|
US4261989A
(en)
*
|
1979-02-19 |
1981-04-14 |
Kaken Chemical Co. Ltd. |
Geldanamycin derivatives and antitumor drug
|
IL64501A
(en)
*
|
1980-12-22 |
1985-07-31 |
Astra Laekemedel Ab |
9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
|
US4533254A
(en)
*
|
1981-04-17 |
1985-08-06 |
Biotechnology Development Corporation |
Apparatus for forming emulsions
|
US4699877A
(en)
*
|
1982-11-04 |
1987-10-13 |
The Regents Of The University Of California |
Methods and compositions for detecting human tumors
|
US4921859A
(en)
*
|
1983-10-31 |
1990-05-01 |
Warner-Lambert Company |
Purine derivatives
|
US4806642A
(en)
*
|
1984-10-05 |
1989-02-21 |
Warner-Lambert Company |
Purine derivatives
|
US5098906A
(en)
*
|
1983-10-31 |
1992-03-24 |
Warner-Lambert Company |
Purine derivatives
|
US4547573A
(en)
*
|
1983-12-02 |
1985-10-15 |
Ici Pharma |
Process for preparing cephalosporin derivatives
|
EP0151528B1
(en)
|
1984-02-02 |
1990-07-04 |
Merck & Co. Inc. |
5-(amino or substituted amino)-1,2,3-triazoles
|
US4748177A
(en)
*
|
1984-03-26 |
1988-05-31 |
Warner-Lambert Company |
Guanine derivatives
|
US4617304A
(en)
|
1984-04-10 |
1986-10-14 |
Merck & Co., Inc. |
Purine derivatives
|
IT1196261B
(it)
*
|
1984-09-20 |
1988-11-16 |
Pierrel Spa |
Derivati nucleosidici e purinici 8-sostituiti
|
US4772606A
(en)
*
|
1985-08-22 |
1988-09-20 |
Warner-Lambert Company |
Purine derivatives
|
IL76546A
(en)
|
1984-10-12 |
1988-12-30 |
Warner Lambert Co |
9-(heteroarylalkyl)-6-purine(thi)one derivatives,their preparation and pharmaceutical compositions containing them
|
JO1406B1
(en)
|
1984-11-02 |
1986-11-30 |
سميث كلاين اند فرينش لابوراتوريز ليمتد |
Chemical compounds
|
ATE124999T1
(de)
|
1985-03-15 |
1995-07-15 |
Antivirals Inc |
Immunotestmittel für polynukleotid und verfahren.
|
US5217866A
(en)
*
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
DE3512194A1
(de)
*
|
1985-04-03 |
1986-10-09 |
Hoechst Ag, 6230 Frankfurt |
Ein neues ansamycin-antibiotikum, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel
|
GB8515934D0
(en)
|
1985-06-24 |
1985-07-24 |
Janssen Pharmaceutica Nv |
(4-piperidinomethyl and-hetero)purines
|
US4918162A
(en)
*
|
1986-05-06 |
1990-04-17 |
The Regents Of The University Of California |
Assays and antibodies for N-MYC proteins
|
US5002950A
(en)
*
|
1986-10-24 |
1991-03-26 |
Warner-Lambert Co. |
7-deazaguanines as immunomodulators
|
US4968603A
(en)
*
|
1986-12-31 |
1990-11-06 |
The Regents Of The University Of California |
Determination of status in neoplastic disease
|
US5204353A
(en)
*
|
1987-04-07 |
1993-04-20 |
Ciba-Geigy Corporation |
3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith
|
SE8801729D0
(sv)
|
1988-05-06 |
1988-05-06 |
Astra Ab |
Purine derivatives for use in therapy
|
US4923885A
(en)
*
|
1988-08-19 |
1990-05-08 |
Merck & Co., Inc. |
5-amino-1-(4-naphthoylbenzyl)-1,2,3-triazole-4-carboxamides and analogs as antiproliferative agents
|
EP0363320A3
(de)
|
1988-10-06 |
1991-11-21 |
Ciba-Geigy Ag |
Substituierte 9H-Purine
|
US5332744A
(en)
*
|
1989-05-30 |
1994-07-26 |
Merck & Co., Inc. |
Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
|
DE69116750T2
(de)
|
1990-07-04 |
1996-11-14 |
Merrell Dow Pharma |
9-Purinyl-Phosphonsäurederivate
|
GB9020931D0
(en)
|
1990-09-26 |
1990-11-07 |
Wellcome Found |
Heterocyclic compounds
|
ATE187173T1
(de)
|
1991-03-05 |
1999-12-15 |
Ajinomoto Kk |
Cyclopropanderivat
|
WO1992021032A1
(en)
*
|
1991-05-24 |
1992-11-26 |
The Regents Of The University Of California |
Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients
|
US6025126A
(en)
*
|
1991-10-28 |
2000-02-15 |
Arch Development Corporation |
Methods and compositions for the detection of chromosomal aberrations
|
JPH06510913A
(ja)
|
1992-01-06 |
1994-12-08 |
フアイザー・インコーポレイテツド |
4,5‐ジヒドロゲルダナマイシン及びそのヒドロキノンの製造及び使用
|
CA2093403C
(en)
|
1992-04-08 |
1999-08-10 |
Fumio Suzuki |
Therapeutic agent for parkinson's disease
|
JPH0680670A
(ja)
|
1992-09-03 |
1994-03-22 |
Ajinomoto Co Inc |
シクロプロパン誘導体及びその製造法
|
GB9226879D0
(en)
*
|
1992-12-23 |
1993-02-17 |
Iaf Biochem Int |
Anti-viral compounds
|
US6444656B1
(en)
*
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
US6005107A
(en)
*
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
US5387584A
(en)
*
|
1993-04-07 |
1995-02-07 |
Pfizer Inc. |
Bicyclic ansamycins
|
US5602156A
(en)
*
|
1993-09-17 |
1997-02-11 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method for inhibiting metalloproteinase expression
|
US5744492A
(en)
|
1993-09-17 |
1998-04-28 |
United States Of America |
Method for inhibiting angiogenesis
|
GB9402161D0
(en)
*
|
1994-02-04 |
1994-03-30 |
Wellcome Found |
Chloropyrimidine intermediates
|
JP3769737B2
(ja)
|
1994-03-30 |
2006-04-26 |
味の素株式会社 |
シクロプロパン誘導体及びその製造法
|
US5932566A
(en)
*
|
1994-06-16 |
1999-08-03 |
Pfizer Inc. |
Ansamycin derivatives as antioncogene and anticancer agents
|
US6110923A
(en)
*
|
1994-06-22 |
2000-08-29 |
Biochem Pharma Inc. |
Method for treating cancer using novel substituted purinyl derivatives with immunomodulating activity
|
US5525606A
(en)
*
|
1994-08-01 |
1996-06-11 |
The United States Of America As Represented By The Department Of Health And Human Services |
Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
|
JPH0841035A
(ja)
|
1994-08-05 |
1996-02-13 |
Ajinomoto Co Inc |
シクロプロパン誘導体及びその製造法
|
US5846749A
(en)
*
|
1994-10-12 |
1998-12-08 |
The Regents Of The University Of California |
Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
|
JPH08208687A
(ja)
|
1994-11-25 |
1996-08-13 |
Sankyo Co Ltd |
グリセリルオリゴヌクレオチド
|
US5656629A
(en)
*
|
1995-03-10 |
1997-08-12 |
Sanofi Winthrop, Inc. |
6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof
|
US6177460B1
(en)
*
|
1995-04-12 |
2001-01-23 |
The Procter & Gamble Company |
Method of treatment for cancer or viral infections
|
JPH0920776A
(ja)
|
1995-06-30 |
1997-01-21 |
Nippon Paper Ind Co Ltd |
新規なプリンヌクレオシド誘導体、その製造方法及びその誘導体を有効成分とする抗ウイルス剤
|
JPH09169758A
(ja)
|
1995-10-18 |
1997-06-30 |
Nippon Paper Ind Co Ltd |
新規なプリンヌクレオシド誘導体、その製造方法、及びそれを用いた抗ウイルス剤
|
JPH1025294A
(ja)
|
1996-03-26 |
1998-01-27 |
Akira Matsuda |
縮合ヘテロ環誘導体、その製造法及びそれを含有する悪性腫瘍治療剤
|
TW552261B
(en)
|
1996-07-03 |
2003-09-11 |
Japan Energy Corp |
Novel purine derivative
|
US6723727B1
(en)
*
|
1996-12-20 |
2004-04-20 |
Hoechst Aktiengesellschaft |
Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them
|
WO1998039344A1
(en)
|
1997-03-07 |
1998-09-11 |
Metabasis Therapeutics, Inc. |
Novel purine inhibitors of fructose-1,6-bisphosphatase
|
US5861503A
(en)
*
|
1997-04-30 |
1999-01-19 |
The Regents Of The University Of California |
Process for producing 8-fluoropurines
|
DE69841549D1
(de)
|
1997-05-14 |
2010-04-22 |
Sloan Kettering Inst Cancer |
Verfahren und zubereitungen zur zerstörung bestimmter proteine
|
SK179899A3
(en)
|
1997-07-03 |
2001-12-03 |
Du Pont Pharm Co |
Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
|
EP1017394B1
(en)
|
1997-07-12 |
2005-12-07 |
Cancer Research Technology Limited |
Cyclin dependent kinase inhibiting purine derivatives
|
AUPO912997A0
(en)
|
1997-09-11 |
1997-10-02 |
Commonwealth Scientific And Industrial Research Organisation |
Antiviral agents
|
AU4656997A
(en)
|
1997-09-30 |
1999-04-23 |
Beth Israel Deaconess Medical Center |
Method for inhibiting tumor angiogenesis in a living subject
|
US5968921A
(en)
*
|
1997-10-24 |
1999-10-19 |
Orgegon Health Sciences University |
Compositions and methods for promoting nerve regeneration
|
EP1043324B1
(en)
|
1997-11-12 |
2004-06-16 |
Mitsubishi Chemical Corporation |
Purine derivatives and medicine containing the same as the active ingredient
|
TW572758B
(en)
|
1997-12-22 |
2004-01-21 |
Sumitomo Pharma |
Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives
|
WO1999051223A1
(en)
|
1998-04-03 |
1999-10-14 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
|
SI20022A
(sl)
|
1998-07-29 |
2000-02-29 |
Kemijski inštitut |
Alkilno substituirani purinovi derivati in njihova priprava
|
JP2000072773A
(ja)
|
1998-08-28 |
2000-03-07 |
Zeria Pharmaceut Co Ltd |
プリン誘導体
|
JP2000072733A
(ja)
|
1998-08-31 |
2000-03-07 |
Kanebo Ltd |
アミド化合物の製造法
|
US6140374A
(en)
*
|
1998-10-23 |
2000-10-31 |
Abbott Laboratories |
Propofol composition
|
US6369092B1
(en)
*
|
1998-11-23 |
2002-04-09 |
Cell Pathways, Inc. |
Method for treating neoplasia by exposure to substituted benzimidazole derivatives
|
CA2356959C
(en)
|
1998-12-22 |
2009-03-31 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Water-insoluble drug delivery system
|
US7122635B2
(en)
*
|
1999-01-06 |
2006-10-17 |
University Of Southern California |
Method and composition for angiogenesis inhibition
|
CN1353713A
(zh)
|
1999-02-01 |
2002-06-12 |
Cv治疗公司 |
依赖细胞周期蛋白的激酶2和IκB-α的嘌呤抑制剂
|
FR2790702B1
(fr)
|
1999-03-08 |
2001-07-20 |
Sidel Sa |
Unite de moulage et machine d'extrusion-soufflage munie d'une telle unite
|
US6174875B1
(en)
*
|
1999-04-01 |
2001-01-16 |
University Of Pittsburgh |
Benzoquinoid ansamycins for the treatment of cardiac arrest and stroke
|
AU769235B2
(en)
|
1999-04-09 |
2004-01-22 |
Sloan-Kettering Institute For Cancer Research |
Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
|
AU4589800A
(en)
|
1999-05-05 |
2000-11-21 |
Darwin Discovery Limited |
9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors
|
US6667300B2
(en)
*
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
AU2002228771B2
(en)
*
|
2000-11-02 |
2007-10-25 |
Sloan-Kettering Institute For Cancer Research |
Small molecule compositions for binding to HSP90
|
GB0100621D0
(en)
*
|
2001-01-10 |
2001-02-21 |
Vernalis Res Ltd |
Chemical compounds VI
|
GB0100624D0
(en)
*
|
2001-01-10 |
2001-02-21 |
Vernalis Res Ltd |
Chemical compounds VII
|
MY141789A
(en)
*
|
2001-01-19 |
2010-06-30 |
Lg Chem Investment Ltd |
Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
|
US20020156277A1
(en)
*
|
2001-04-20 |
2002-10-24 |
Fick David B. |
Synthesis and methods of use of purine analogues and derivatives
|
US20030022864A1
(en)
*
|
2001-04-24 |
2003-01-30 |
Ishaq Khalid S. |
9-[(5-dihydroxyboryl)-pentyl] purines, useful as an inhibitor of inflammatory cytokines
|
US6962991B2
(en)
*
|
2001-09-12 |
2005-11-08 |
Epoch Biosciences, Inc. |
Process for the synthesis of pyrazolopyrimidines
|
JP2003113181A
(ja)
|
2001-10-04 |
2003-04-18 |
Sumika Fine Chemicals Co Ltd |
6−ハロプリンの製造方法
|
US7241890B2
(en)
*
|
2001-10-30 |
2007-07-10 |
Conforma Therapeutics Corporation |
Purine analogs having HSP90-inhibiting activity
|
EP1529049B1
(en)
|
2002-08-08 |
2009-11-18 |
Memory Pharmaceuticals Corporation |
Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
|
GB0219746D0
(en)
*
|
2002-08-23 |
2002-10-02 |
Inst Of Ex Botany Ascr |
Azapurine derivatives
|
US20040241706A1
(en)
*
|
2002-09-13 |
2004-12-02 |
Irm, Llc |
Highly specific modulators of GTPases for target validation
|
RU2005108601A
(ru)
|
2002-09-26 |
2006-01-20 |
Эл Джи Лайф Сайенсиз Лтд. (Kr) |
(+)-транс-изомеры(1-фосфонометокси-2-алкилциклопропил)метилнуклеозидные производные, способ получения их стереоизомеров и применение указанных соединений в качестве противовирусных средств
|
US7601694B2
(en)
*
|
2003-02-20 |
2009-10-13 |
New York University |
CLK-peptide and SLK-peptide
|
JP2007500727A
(ja)
|
2003-07-30 |
2007-01-18 |
ギリアード サイエンシーズ, インコーポレイテッド |
抗ウイルス処置のための核酸塩基ホスホネートアナログ
|
WO2005016349A1
(en)
|
2003-08-14 |
2005-02-24 |
Icos Corporation |
Methods of inhibiting leukocyte accumulation
|
US20050043239A1
(en)
*
|
2003-08-14 |
2005-02-24 |
Jason Douangpanya |
Methods of inhibiting immune responses stimulated by an endogenous factor
|
BRPI0413861A
(pt)
*
|
2003-08-29 |
2006-10-24 |
Vernalis Cambridge Ltd |
compostos de pirimidotiofeno
|
KR20060070572A
(ko)
|
2003-09-18 |
2006-06-23 |
콘포마 세러퓨틱스 코포레이션 |
Hsp90-저해제로서의 신규 헤테로시클릭 화합물
|
US8026245B2
(en)
|
2003-09-25 |
2011-09-27 |
Janssen Pharmaceutica N.V. |
HIV replication inhibiting purine derivatives
|
KR20050062944A
(ko)
|
2003-12-19 |
2005-06-28 |
주식회사 엘지생명과학 |
디이소프로필((1-((2-아미노-6-클로로-9h-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
|
KR20050062940A
(ko)
|
2003-12-19 |
2005-06-28 |
주식회사 엘지생명과학 |
디이소프로필((1-((2-아미노-6-할로-9h-퓨린-9-일)메틸)사이클로프로필)옥시)-메틸포스포네이트의 새로운 제조방법
|
US20050239809A1
(en)
|
2004-01-08 |
2005-10-27 |
Watts Stephanie W |
Methods for treating and preventing hypertension and hypertension-related disorders
|
WO2005079812A1
(en)
|
2004-02-17 |
2005-09-01 |
Lg Life Sciences Ltd. |
Nucleoside phosphonate derivatives useful in the treatment of hiv infections
|
EP1728792A4
(en)
|
2004-03-26 |
2010-12-15 |
Dainippon Sumitomo Pharma Co |
8-OXOADENINE COMPOUND
|
NZ561939A
(en)
*
|
2005-03-30 |
2011-03-31 |
Conforma Therapeutics Corp |
Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
|