NZ543897A - Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases - Google Patents
Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseasesInfo
- Publication number
- NZ543897A NZ543897A NZ543897A NZ54389704A NZ543897A NZ 543897 A NZ543897 A NZ 543897A NZ 543897 A NZ543897 A NZ 543897A NZ 54389704 A NZ54389704 A NZ 54389704A NZ 543897 A NZ543897 A NZ 543897A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compositions
- methods
- treating cancer
- viral diseases
- triheterocyclic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47474103P | 2003-05-30 | 2003-05-30 | |
| PCT/CA2004/000793 WO2004106328A1 (en) | 2003-05-30 | 2004-05-28 | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ543897A true NZ543897A (en) | 2009-04-30 |
Family
ID=33490730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ543897A NZ543897A (en) | 2003-05-30 | 2004-05-28 | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US7425553B2 (OSRAM) |
| EP (1) | EP1644363B1 (OSRAM) |
| JP (1) | JP4980715B2 (OSRAM) |
| KR (1) | KR101168441B1 (OSRAM) |
| CN (1) | CN1832939B (OSRAM) |
| AT (1) | ATE546456T1 (OSRAM) |
| AU (1) | AU2004242928B2 (OSRAM) |
| BR (1) | BRPI0410870A (OSRAM) |
| CA (1) | CA2527583C (OSRAM) |
| CY (1) | CY1113038T1 (OSRAM) |
| DK (1) | DK1644363T3 (OSRAM) |
| ES (1) | ES2382377T3 (OSRAM) |
| HR (1) | HRP20120379T1 (OSRAM) |
| IL (1) | IL172189A (OSRAM) |
| MX (1) | MXPA05012799A (OSRAM) |
| NO (1) | NO333006B1 (OSRAM) |
| NZ (1) | NZ543897A (OSRAM) |
| PL (1) | PL1644363T3 (OSRAM) |
| PT (1) | PT1644363E (OSRAM) |
| RU (1) | RU2360913C2 (OSRAM) |
| SI (1) | SI1644363T1 (OSRAM) |
| WO (1) | WO2004106328A1 (OSRAM) |
| ZA (1) | ZA200509718B (OSRAM) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060035945A1 (en) * | 2003-05-30 | 2006-02-16 | Giorgio Attardo | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
| BRPI0410870A (pt) | 2003-05-30 | 2006-07-04 | Gemin X Biotechnologies Inc | compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais |
| WO2005112640A2 (en) * | 2004-05-13 | 2005-12-01 | Viropharma Incorporated | Compounds, compositions and methods for treatment and prophylaxis of hepatitis c viral infections and associated diseases |
| WO2006069441A1 (en) * | 2004-12-28 | 2006-07-06 | Gemin X Biotechnologies Inc. | Dipyrrole compounds, compositions, and methods for treating cancer or viral diseases |
| WO2006089397A1 (en) * | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
| US7994360B2 (en) | 2005-05-16 | 2011-08-09 | Xtl Biopharmaceuticals Ltd. | Benzofuran compounds |
| US20080051400A1 (en) * | 2006-07-06 | 2008-02-28 | Gemin X Biotechnologies Inc. | Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound |
| AU2007339382B2 (en) * | 2006-12-22 | 2013-05-02 | Merck Sharp & Dohme Llc | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| WO2008136815A2 (en) | 2006-12-22 | 2008-11-13 | Schering Corporation | 5, 6-ring annulated indole derivatives and use thereof |
| EP2064181A1 (en) | 2006-12-22 | 2009-06-03 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
| WO2008121814A1 (en) * | 2007-03-28 | 2008-10-09 | Ats Medical, Inc. | Method for inhibiting platelet interaction with biomaterial surfaces |
| AR068106A1 (es) | 2007-08-29 | 2009-11-04 | Schering Corp | Derivados de indol 2-carboxi sustituidos y una composicion farmaceutica |
| CN101842374A (zh) | 2007-08-29 | 2010-09-22 | 先灵公司 | 用于治疗病毒感染的2，3-取代的氮杂吲哚衍生物 |
| AR068107A1 (es) | 2007-08-29 | 2009-11-04 | Schering Corp | Derivados indolicos 2,3 sustituidos y una composicion farmaceutica |
| CN101130539B (zh) * | 2007-09-26 | 2012-05-30 | 浙江大学 | 吲哚取代咪唑啉-2-酮类衍生物及其制备方法和用途 |
| US20090098118A1 (en) | 2007-10-15 | 2009-04-16 | Thomas Friess | Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent |
| US8765757B2 (en) | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
| CN102317285A (zh) | 2007-11-16 | 2012-01-11 | 先灵公司 | 3-氨基磺酰基取代的吲哚衍生物及其使用方法 |
| MX2010013630A (es) | 2008-06-13 | 2010-12-21 | Schering Corp | Derivados triciclicos de indol y metodos de uso de los mismos. |
| CN103648491B (zh) * | 2011-04-08 | 2017-07-14 | 法国国家健康医学研究院 | 用于抑制流感病毒复制的方法和药物组合物 |
| CN104039797B (zh) * | 2011-10-12 | 2016-06-01 | 南京奥昭生物科技有限公司 | 作为细胞凋亡诱导剂的杂环分子 |
| EP2934531A4 (en) * | 2012-12-19 | 2016-06-15 | Glaxosmithkline Llc | COMBINATION |
| CN103044311B (zh) * | 2012-12-26 | 2015-04-22 | 山东大学 | 一种多取代吲哚类化合物及其制备方法和应用 |
| WO2014160071A1 (en) * | 2013-03-14 | 2014-10-02 | St. Jude Children's Research Hospital | Methods and compositions for the treatment of glutamine-addicted cancers |
| US9340540B2 (en) | 2014-02-28 | 2016-05-17 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| EP3708170A1 (en) | 2014-05-05 | 2020-09-16 | BioVentures, LLC | Compositions and methods for inhibiting antiapoptotic bcl-2 proteins as anti-aging agents |
| EP3177144A4 (en) | 2014-07-22 | 2018-01-24 | Bioventures, LLC. | Compositions and methods for selectively depleting senescent cells |
| CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
| RU2708459C2 (ru) | 2014-10-29 | 2019-12-09 | БайсиклРД Лимитед | Бициклические пептидные лиганды, специфичные для мт1-ммр |
| EP3262049B1 (en) | 2015-02-27 | 2022-07-20 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| EP3331546B1 (en) | 2015-08-03 | 2023-10-04 | Biokine Therapeutics Ltd. | Cxcr4 inhibitor for the treatment of cancer |
| WO2017040757A1 (en) | 2015-09-02 | 2017-03-09 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| JP7118888B2 (ja) | 2015-09-08 | 2022-08-16 | モナッシュ ユニバーシティ | リンパ指向性プロドラッグ |
| WO2017044720A1 (en) | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
| US20170087125A1 (en) * | 2015-09-30 | 2017-03-30 | Augusta University Research Institute, Inc. | Flavonoid compositions for the treatment of cancer |
| AU2016342027B2 (en) | 2015-10-23 | 2021-05-13 | Navitor Pharmaceuticals, Inc. | Modulators of Sestrin-GATOR2 interaction and uses thereof |
| EP3389664A4 (en) | 2015-12-14 | 2020-01-08 | Raze Therapeutics Inc. | MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF |
| HUE055197T2 (hu) | 2016-03-09 | 2021-11-29 | Raze Therapeutics Inc | 3-Foszfoglicerát-dehidrogenáz inhibitorok és alkalmazásuk |
| EP4234552A3 (en) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof |
| US11013698B2 (en) | 2016-03-15 | 2021-05-25 | Oryzon Genomics S.A. | Combinations of LSD1 inhibitors for the treatment of hematological malignancies |
| CN120661674A (zh) | 2016-03-15 | 2025-09-19 | 奥莱松基因组股份有限公司 | 用于治疗实体瘤的lsd1抑制剂的组合 |
| US10870640B2 (en) | 2016-04-08 | 2020-12-22 | Institute For Cancer Research | Prodigiosin analogs and methods of use |
| US10654801B2 (en) | 2016-04-08 | 2020-05-19 | Institute For Cancer Research | Prodigiosin analogs |
| JP2019510785A (ja) | 2016-04-08 | 2019-04-18 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 癌を処置する方法 |
| EP3445452A4 (en) | 2016-04-21 | 2019-10-30 | BioVentures, LLC | COMPOUNDS FOR INDUCING THE DEGRADATION OF ANTIAPOPTOTIC PROTEINS OF THE BCL-2 FAMILY AND USES THEREOF |
| CA3027498A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10988465B2 (en) | 2016-06-21 | 2021-04-27 | X4 Pharmaceuticals, Inc. | CXCR4 inhibitors and uses thereof |
| CN109952303B (zh) | 2016-10-14 | 2022-10-21 | 林伯士拉克许米公司 | Tyk2抑制剂及其用途 |
| WO2018075937A1 (en) | 2016-10-21 | 2018-04-26 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| EP3538091A4 (en) | 2016-11-08 | 2020-06-10 | Navitor Pharmaceuticals, Inc. | PHENYL AMINO PIPERIDINE MTORC INHIBITORS AND USES THEREOF |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| US11091451B2 (en) | 2016-12-05 | 2021-08-17 | Raze Therapeutics, Inc. | SHMT inhibitors and uses thereof |
| US10624968B2 (en) | 2017-01-06 | 2020-04-21 | Bicyclerd Limited | Compounds for treating cancer |
| IL269036B2 (en) | 2017-03-08 | 2023-03-01 | Nimbus Lakshmi Inc | tyk2 inhibitors, uses and methods for their production |
| EP3375778A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
| EP3375784A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridone derivatives |
| WO2018191146A1 (en) | 2017-04-10 | 2018-10-18 | Navitor Pharmaceuticals, Inc. | Heteroaryl rheb inhibitors and uses thereof |
| CN116370448A (zh) | 2017-04-26 | 2023-07-04 | 纳维托制药有限公司 | Sestrin-gator2相互作用的调节剂及其用途 |
| US11046698B2 (en) | 2017-07-28 | 2021-06-29 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| EP3675838A4 (en) | 2017-08-29 | 2021-04-21 | PureTech LYT, Inc. | LIPID PRODRUGS DIRECTED TO THE LYMPHATIC SYSTEM |
| US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
| WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
| CA3076613A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| EP3727362A4 (en) | 2017-12-19 | 2021-10-06 | PureTech LYT, Inc. | MYCOPHENOLIC ACID LIPID PRODRUGS AND THEIR USES |
| US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
| US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| EP3737675A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | Crbn ligands and uses thereof |
| US11485743B2 (en) | 2018-01-12 | 2022-11-01 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| CN112105360B (zh) | 2018-01-22 | 2024-01-30 | 生物风险投资有限责任公司 | 用于癌症治疗的bcl-2蛋白降解剂 |
| EP3746075B1 (en) | 2018-01-29 | 2025-09-03 | Merck Patent GmbH | Gcn2 inhibitors and uses thereof |
| IL312674A (en) | 2018-01-29 | 2024-07-01 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
| JP2021514953A (ja) | 2018-02-23 | 2021-06-17 | バイスクルテクス・リミテッド | 多量体二環式ペプチドリガンド |
| CN117304157A (zh) | 2018-02-27 | 2023-12-29 | 阿塔克斯生物制药有限公司 | 作为tcr-nck相互作用的抑制剂的色烯衍生物 |
| PT3784666T (pt) | 2018-04-24 | 2022-06-06 | Merck Patent Gmbh | Compostos antiproliferação e utilizações dos mesmos |
| EP3784669B1 (en) | 2018-04-24 | 2023-10-25 | Vertex Pharmaceuticals Incorporated | Pteridinone compounds and uses thereof |
| WO2019221755A1 (en) | 2018-05-18 | 2019-11-21 | Bioventures, Llc | Piperlongumine analogues and uses thereof |
| IL279329B2 (en) | 2018-06-15 | 2025-01-01 | Navitor Pharm Inc | Rapamycin analogs and their uses |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| EP3846793B1 (en) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
| US11414431B2 (en) | 2018-10-15 | 2022-08-16 | Nimbus Lakshmi, Inc. | Substituted pyrazolo[1,5-a]pyrimidines as TYK2 inhibitors |
| EP3870158A4 (en) | 2018-10-24 | 2022-08-10 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
| JP7623943B2 (ja) | 2018-11-30 | 2025-01-29 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| CN113271938A (zh) | 2018-11-30 | 2021-08-17 | 林伯士拉克许米公司 | Tyk2抑制剂和其用途 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| EP3670659A1 (en) | 2018-12-20 | 2020-06-24 | Abivax | Biomarkers, and uses in treatment of viral infections, inflammations, or cancer |
| EP3897849A1 (en) | 2018-12-21 | 2021-10-27 | BicycleTx Limited | Bicyclic peptide ligands specific for pd-l1 |
| CA3126034A1 (en) | 2019-01-23 | 2020-07-30 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
| EP3946462A1 (en) | 2019-04-02 | 2022-02-09 | BicycleTX Limited | Bicycle toxin conjugates and uses thereof |
| MX2021012216A (es) | 2019-04-05 | 2022-01-24 | Kymera Therapeutics Inc | Degradadores de transductores de señal y activadores de transcripción (stat) y usos de los mismos. |
| CA3141826A1 (en) | 2019-05-31 | 2020-12-03 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| US11845724B2 (en) | 2019-09-11 | 2023-12-19 | Vincere Biosciences, Inc. | USP30 inhibitors and uses thereof |
| US12215105B2 (en) | 2019-09-13 | 2025-02-04 | Nimbus Saturn, Inc. | HPK1 antagonists and uses thereof |
| WO2021087432A1 (en) | 2019-11-01 | 2021-05-06 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mtorc1 modulator |
| JP2023506410A (ja) | 2019-12-05 | 2023-02-16 | アナクリア セラピューティクス， インコーポレイテッド | ラパマイシン類似体及びその使用 |
| KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| WO2021133920A1 (en) | 2019-12-23 | 2021-07-01 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| CN115348864A (zh) | 2020-02-05 | 2022-11-15 | 纯技术Lyt股份有限公司 | 神经甾体的脂质前药 |
| US11753403B2 (en) | 2020-03-03 | 2023-09-12 | PIC Therapeutics, Inc. | EIF4E inhibitors and uses thereof |
| WO2021188948A1 (en) | 2020-03-19 | 2021-09-23 | Kymera Therapeutics, Inc. | Mdm2 degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| WO2021247897A1 (en) | 2020-06-03 | 2021-12-09 | Kymera Therapeutics, Inc. | Deuterated irak degraders and uses thereof |
| JP2023536462A (ja) | 2020-07-30 | 2023-08-25 | カイメラ セラピューティクス， インコーポレイテッド | 変異体リンパ腫を処置する方法 |
| KR20230074721A (ko) | 2020-08-17 | 2023-05-31 | 바이사이클티엑스 리미티드 | Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도 |
| JP2023546996A (ja) | 2020-10-23 | 2023-11-08 | ニンバス クロソー， インコーポレイテッド | Ｃｔｐｓ１阻害剤およびその使用 |
| WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| EP4255895A1 (en) | 2020-12-02 | 2023-10-11 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CN116490176A (zh) * | 2020-12-03 | 2023-07-25 | 埃尼奥制药公司 | 吡咯型化合物及其治疗病毒感染的用途 |
| EP4008324A1 (en) | 2020-12-07 | 2022-06-08 | Cellestia Biotech AG | Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer |
| EP4255409A1 (en) | 2020-12-07 | 2023-10-11 | Cellestia Biotech AG | Pharmaceutical combinations for treating cancer |
| AR124547A1 (es) | 2020-12-30 | 2023-04-05 | Kymera Therapeutics Inc | Degradadores de irak y sus usos |
| US12378229B2 (en) | 2021-02-02 | 2025-08-05 | Liminal Biosciences Limited | GPR84 antagonists and uses thereof |
| BR112023015590A2 (pt) | 2021-02-02 | 2023-10-17 | Liminal Biosciences Ltd | Antagonistas de gpr84 e usos dos mesmos |
| WO2022174253A1 (en) | 2021-02-12 | 2022-08-18 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
| US11773103B2 (en) | 2021-02-15 | 2023-10-03 | Kymera Therapeutics, Inc. | IRAK4 degraders and uses thereof |
| MX2023009527A (es) | 2021-02-15 | 2023-08-24 | Kymera Therapeutics Inc | Degradadores de la cinasa 4 asociada al receptor de interleucina 1 (irak4) y usos de los mismos. |
| EP4301756A4 (en) | 2021-03-05 | 2025-02-26 | Nimbus Saturn, Inc. | HPK1 ANTAGONISTS AND THEIR USES |
| US12071442B2 (en) | 2021-03-29 | 2024-08-27 | Nimbus Saturn, Inc. | Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists |
| BR112023020781A2 (pt) | 2021-04-09 | 2023-12-19 | Nimbus Clio Inc | Moduladores de cbl-b e usos dos mesmos |
| EP4323066A1 (en) | 2021-04-16 | 2024-02-21 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| AR125798A1 (es) | 2021-05-07 | 2023-08-16 | Kymera Therapeutics Inc | Degradadores cdk2 y usos de los mismos |
| CA3229560A1 (en) | 2021-08-25 | 2023-03-02 | Christopher L. Vandeusen | Eif4e inhibitors and uses thereof |
| JP2024532276A (ja) | 2021-08-25 | 2024-09-05 | ピク セラピューティクス， インコーポレイテッド | ｅＩＦ４Ｅ阻害剤及びその使用 |
| EP4422635A4 (en) | 2021-10-29 | 2025-11-26 | Kymera Therapeutics Inc | IRAQ4 DEGRADATION AGENTS AND THEIR SYNTHESIS |
| US20250154141A1 (en) | 2021-12-09 | 2025-05-15 | University Of Florida Research Foundation, Incorporated | Bcl-xl/bcl-2 dual degraders for treatment of cancers |
| WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
| CA3243560A1 (en) | 2022-01-31 | 2023-08-03 | Kymera Therapeutics, Inc. | Iraqi Degradation Agents and Their Uses |
| WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
| IL316768A (en) | 2022-05-25 | 2025-01-01 | Ikena Oncology Inc | MEK inhibitors and their uses |
| IL318575A (en) | 2022-08-02 | 2025-03-01 | Liminal Biosciences Ltd | HETEROARYL CARBOXAMIDE AND GPR84-RELATED ANTAGONISTS AND USES THEREOF |
| JP2025527248A (ja) | 2022-08-02 | 2025-08-20 | リミナル・バイオサイエンシーズ・リミテッド | 置換ピリドンｇｐｒ８４アンタゴニスト及びその使用 |
| IL318577A (en) | 2022-08-02 | 2025-03-01 | Liminal Biosciences Ltd | ARYL-TRIAZOLYL AND RELATED GPR84 ANTAGONISTS AND THEIR USES |
| AR131141A1 (es) | 2022-11-22 | 2025-02-19 | Pic Therapeutics Inc | Inhibidores de eif4e y usos de los mismos |
| EP4620470A3 (en) | 2023-06-23 | 2025-10-08 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2025062372A1 (en) | 2023-09-21 | 2025-03-27 | Takeda Pharmaceutical Company Limited | Tyk2 inhibitors for use in the treatment of inflammatory bowel disease |
| WO2025132801A1 (en) | 2023-12-19 | 2025-06-26 | Cimeio Therapeutics Ag | Discernible protein variants of bcl-2 for use in cell therapy |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6134403A (ja) | 1984-07-26 | 1986-02-18 | Nec Corp | 光干渉計 |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5326692B1 (en) | 1992-05-13 | 1996-04-30 | Molecular Probes Inc | Fluorescent microparticles with controllable enhanced stokes shift |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5338854A (en) | 1991-02-13 | 1994-08-16 | Molecular Probes, Inc. | Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes |
| JPH0586374A (ja) | 1991-09-26 | 1993-04-06 | Teikoku Sekiyu Kk | 炭水化物を可燃性のガスに分解する方法 |
| GB9326284D0 (en) | 1993-12-23 | 1994-02-23 | Erba Carlo Spa | Pyrrolydenemethyl-derivatives and process for their preparation |
| JP3357462B2 (ja) | 1994-06-21 | 2002-12-16 | 協和油化株式会社 | 立体障害性ニトロキシル化合物の製造方法 |
| US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
| EP0756200B1 (en) | 1995-07-26 | 1999-11-10 | Konica Corporation | Silver halide color photographic light-sensitive material |
| EP0878201B1 (en) | 1996-02-01 | 2002-06-19 | Chugai Seiyaku Kabushiki Kaisha | Medicaments for the treatment or prevention of thrombocytopenia |
| JP3949198B2 (ja) | 1996-10-23 | 2007-07-25 | 赤穂化成株式会社 | Ｖ−ＡＴＰａｓｅ 脱共役 Ｈ＋ ポンプ阻害剤 |
| JP3949196B2 (ja) | 1996-10-23 | 2007-07-25 | 赤穂化成株式会社 | 免疫抑制剤 |
| EP1754703A3 (en) * | 1997-02-19 | 2007-02-28 | Berlex, Inc. | N-Heterocyclic derivatives as nos inhibitors |
| GB9705035D0 (en) | 1997-03-11 | 1997-04-30 | Pharmacia & Upjohn Spa | Indolyl-pyrrolydenemethylpyrrole derivatives and process for their preparation |
| US6162520A (en) | 1997-09-17 | 2000-12-19 | Mitsui Chemicals, Inc. | Optical recording medium and dipyrromethene metal chelate compound for use therein |
| GB9726130D0 (en) * | 1997-12-10 | 1998-02-11 | Pharmacia & Upjohn Spa | 2,2'-BI-1H-pyrrole derivatives useful in the treatment of leukemia brought on by HTLV-I |
| JP2002508323A (ja) | 1997-12-17 | 2002-03-19 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
| ES2283139T5 (es) | 1998-10-23 | 2018-03-05 | Amgen Inc. | Métodos y composiciones para la prevención y tratamiento de la anemia |
| WO2000033836A1 (en) | 1998-12-04 | 2000-06-15 | Ontogen Corporation | 5-membered heterocycles for the treatment of human diseases involving modulators of selectins |
| JP2000275435A (ja) | 1999-03-25 | 2000-10-06 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
| JP4085574B2 (ja) | 2000-01-06 | 2008-05-14 | 東レ株式会社 | 発光素子 |
| US6407244B1 (en) | 2000-01-26 | 2002-06-18 | Gemin X Biotechnologies Inc. | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases |
| JP2001223081A (ja) | 2000-02-08 | 2001-08-17 | Toray Ind Inc | 発光素子 |
| JP2001223082A (ja) | 2000-02-08 | 2001-08-17 | Toray Ind Inc | 発光素子 |
| JP4058881B2 (ja) | 2000-04-12 | 2008-03-12 | 東レ株式会社 | 発光素子 |
| JP2001307884A (ja) | 2000-04-26 | 2001-11-02 | Toray Ind Inc | 発光素子 |
| JP2001330729A (ja) | 2000-05-23 | 2001-11-30 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
| JP2001330730A (ja) | 2000-05-23 | 2001-11-30 | Sumitomo Chem Co Ltd | 光学異方体フィルムおよび液晶表示装置 |
| US7087224B2 (en) | 2000-10-31 | 2006-08-08 | Amgen Inc. | Method of treating anemia by administering IL-1ra |
| US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
| ATE378329T1 (de) | 2001-07-18 | 2007-11-15 | Gemin X Biotechnologies Inc | Verbindungen vom pyrroltyp, zusammensetzungen und verfahren zur behandlung von krebs, zur behandlung von virenerkrankungen und zur unterdrückung der immunreaktion |
| IL166510A0 (en) | 2002-08-09 | 2006-01-15 | Nps Pharma Inc | 1,2,4"oxadiazole as modulators of metabotropic glutamate receptor-5 |
| BRPI0410870A (pt) | 2003-05-30 | 2006-07-04 | Gemin X Biotechnologies Inc | compostos trieterocìclicos, composições, e métodos para tratar cáncer ou doenças virais |
| US20060035945A1 (en) | 2003-05-30 | 2006-02-16 | Giorgio Attardo | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
| WO2005117908A2 (en) | 2004-05-28 | 2005-12-15 | Gemin X Biotechnologies, Inc. | Triheterocyclic compounds compositions, and methods for treating cancer or viral diseases |
| WO2006089397A1 (en) | 2005-02-22 | 2006-08-31 | Gemin X Biotechnologies Inc. | Methods for treating arthritis using triheterocyclic compounds |
| US20080051400A1 (en) | 2006-07-06 | 2008-02-28 | Gemin X Biotechnologies Inc. | Methods for treating or preventing anemia or thrombocytopenia using a triheterocyclic compound |
-
2004
- 2004-05-28 BR BRPI0410870-1A patent/BRPI0410870A/pt not_active IP Right Cessation
- 2004-05-28 AT AT04735171T patent/ATE546456T1/de active
- 2004-05-28 WO PCT/CA2004/000793 patent/WO2004106328A1/en not_active Ceased
- 2004-05-28 CN CN2004800222923A patent/CN1832939B/zh not_active Expired - Fee Related
- 2004-05-28 ZA ZA200509718A patent/ZA200509718B/en unknown
- 2004-05-28 EP EP04735171A patent/EP1644363B1/en not_active Expired - Lifetime
- 2004-05-28 US US10/857,458 patent/US7425553B2/en not_active Expired - Fee Related
- 2004-05-28 RU RU2005141553/04A patent/RU2360913C2/ru not_active IP Right Cessation
- 2004-05-28 MX MXPA05012799A patent/MXPA05012799A/es active IP Right Grant
- 2004-05-28 PT PT04735171T patent/PT1644363E/pt unknown
- 2004-05-28 DK DK04735171.3T patent/DK1644363T3/da active
- 2004-05-28 SI SI200431872T patent/SI1644363T1/sl unknown
- 2004-05-28 KR KR1020057022973A patent/KR101168441B1/ko not_active Expired - Fee Related
- 2004-05-28 JP JP2006529504A patent/JP4980715B2/ja not_active Expired - Fee Related
- 2004-05-28 ES ES04735171T patent/ES2382377T3/es not_active Expired - Lifetime
- 2004-05-28 PL PL04735171T patent/PL1644363T3/pl unknown
- 2004-05-28 NZ NZ543897A patent/NZ543897A/xx not_active IP Right Cessation
- 2004-05-28 AU AU2004242928A patent/AU2004242928B2/en not_active Ceased
- 2004-05-28 HR HRP20120379TT patent/HRP20120379T1/hr unknown
- 2004-05-28 CA CA2527583A patent/CA2527583C/en not_active Expired - Fee Related
-
2005
- 2005-11-24 IL IL172189A patent/IL172189A/en not_active IP Right Cessation
- 2005-12-20 NO NO20056057A patent/NO333006B1/no not_active IP Right Cessation
-
2008
- 2008-07-18 US US12/176,123 patent/US20080318902A1/en active Granted
- 2008-07-18 US US12/176,161 patent/US7709477B2/en not_active Expired - Fee Related
-
2011
- 2011-06-29 US US13/171,891 patent/US8420638B2/en not_active Expired - Fee Related
-
2012
- 2012-05-22 CY CY20121100466T patent/CY1113038T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ543897A (en) | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases | |
| CO2022017876A2 (es) | Compuestos de 4-oxo-3,4-dihidroquinazolinona para el tratamiento de enfermedades y trastornos asociados a braf | |
| ATE437872T1 (de) | Proteinkinaseinhibitoren | |
| NO20044475L (no) | 2-(2,6-diklorfenyl)-diarulimidazoler | |
| MX2009006742A (es) | Inhibidores acilaminopirazoles como fgfr. | |
| DE50311898D1 (de) | Fredericamycin-derivate als arzneimittel zur tumorbehandlung | |
| TNSN06033A1 (en) | Piperazine derivatives and their use as therapeutic agents | |
| GB0612423D0 (en) | Therapeutic agents | |
| WO2004018475A3 (en) | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | |
| MX2009003874A (es) | Derivados de espiro-oxindol triciclicos y sus usos como agentes terapeuticos. | |
| CY1108583T1 (el) | Μεθοδος για θεραπεια σοβαρης καρδιακης ανεπαρκειας και φαρμακο για αυτη | |
| MXPA04005156A (es) | Antagonistas del receptor de adenosina a2a. | |
| NO20051263L (no) | Ny anvendelse av benzotiazolderivater | |
| MX2009012613A (es) | Tiazoles substituidos por heteroarilo y su uso como agentes antivirales. | |
| TW200510317A (en) | Caspase inhibitors and uses thereof | |
| NZ702914A (en) | Ite for cancer intervention and eradication | |
| DK1653943T4 (da) | Catecholderivater til behandling af cancer | |
| MXPA05005790A (es) | Aminoalcoxiindoles como ligandos del receptor 5-ht6 para el tratamiento de enfermedades del sistema nervioso central. | |
| TW200616979A (en) | Non-nucleoside reverse transcriptase inhibitors | |
| MY133527A (en) | Isoquinoline derivatives | |
| TW200716547A (en) | Piperidin-4-yl-amide derivatives | |
| IL150817A0 (en) | Pyrrole-type compounds, compositions, and methods for treating cancer or viral diseases | |
| ATE424200T1 (de) | Solubilisierte topoisomerase-gift-mittel | |
| WO2004066952A3 (en) | Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases | |
| EA200870223A1 (ru) | Производные бензоизоиндола для лечения боли |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 28 MAY 2017 BY DENNEMEYER SA Effective date: 20140417 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 7 YEARS UNTIL 28 MAY 2024 BY DENNEMEYER + CO Effective date: 20140823 |
|
| EXPY | Patent expired |