NZ536606A - Reconstituted surfactants comprising the peptide SP-C in combination with dipalmitoyl phophatidylcholine, DPPC, and palmitoyl oleyl phosphatidylglycerol, POPG and/or POPC for treating respiratory distress syndrome - Google Patents
Reconstituted surfactants comprising the peptide SP-C in combination with dipalmitoyl phophatidylcholine, DPPC, and palmitoyl oleyl phosphatidylglycerol, POPG and/or POPC for treating respiratory distress syndromeInfo
- Publication number
- NZ536606A NZ536606A NZ536606A NZ53660603A NZ536606A NZ 536606 A NZ536606 A NZ 536606A NZ 536606 A NZ536606 A NZ 536606A NZ 53660603 A NZ53660603 A NZ 53660603A NZ 536606 A NZ536606 A NZ 536606A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dppc
- popg
- popc
- reconstituted surfactant
- surfactant
- Prior art date
Links
- 239000004094 surface-active agent Substances 0.000 title claims abstract description 63
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 27
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 title claims abstract description 21
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 title claims abstract description 17
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 title claims abstract description 12
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 title claims abstract description 12
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 title claims abstract description 8
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 title claims abstract description 8
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 title claims description 43
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 title claims description 43
- 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 title claims description 10
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 title claims description 9
- PAZGBAOHGQRCBP-DDDNOICHSA-N 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-DDDNOICHSA-N 0.000 title abstract 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 29
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 15
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- 230000004064 dysfunction Effects 0.000 claims abstract description 5
- 239000003580 lung surfactant Substances 0.000 claims abstract description 5
- 150000001413 amino acids Chemical group 0.000 claims description 14
- 150000002632 lipids Chemical class 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- -1 palmitoyl oleyl phospholipid Chemical class 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 3
- LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 claims description 3
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 3
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229960003104 ornithine Drugs 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 29
- 235000021314 Palmitic acid Nutrition 0.000 description 14
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 8
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 108010093965 Polymyxin B Proteins 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229920000024 polymyxin B Polymers 0.000 description 4
- 229960005266 polymyxin b Drugs 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229940092456 curosurf Drugs 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 230000010349 pulsation Effects 0.000 description 2
- 229940063649 survanta Drugs 0.000 description 2
- PAZGBAOHGQRCBP-HGWHEPCSSA-N 1-hexadecanoyl-2-[(9Z)-octadec-9-enoyl]-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-HGWHEPCSSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000004405 Collectins Human genes 0.000 description 1
- 108090000909 Collectins Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000007615 Pulmonary Surfactant-Associated Protein A Human genes 0.000 description 1
- 108010007100 Pulmonary Surfactant-Associated Protein A Proteins 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 150000001263 acyl chlorides Chemical class 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000011363 dried mixture Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009802 hysterectomy Methods 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000015227 regulation of liquid surface tension Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000007966 viscous suspension Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- General Preparation And Processing Of Foods (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI001058A ITMI20021058A1 (it) | 2002-05-17 | 2002-05-17 | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| PCT/EP2003/004937 WO2003097695A1 (en) | 2002-05-17 | 2003-05-12 | Improved synthetic lipid mixtures for the preparation of a reconstituted surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ536606A true NZ536606A (en) | 2006-10-27 |
Family
ID=11449919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ536606A NZ536606A (en) | 2002-05-17 | 2003-05-12 | Reconstituted surfactants comprising the peptide SP-C in combination with dipalmitoyl phophatidylcholine, DPPC, and palmitoyl oleyl phosphatidylglycerol, POPG and/or POPC for treating respiratory distress syndrome |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7511011B2 (https=) |
| EP (1) | EP1506234B1 (https=) |
| JP (1) | JP4883906B2 (https=) |
| KR (1) | KR101028927B1 (https=) |
| CN (1) | CN100347193C (https=) |
| AT (1) | ATE353919T1 (https=) |
| AU (1) | AU2003233320B2 (https=) |
| CA (1) | CA2486152C (https=) |
| CY (1) | CY1106667T1 (https=) |
| DE (1) | DE60311798T2 (https=) |
| DK (1) | DK1506234T3 (https=) |
| EA (1) | EA007928B1 (https=) |
| ES (1) | ES2282627T3 (https=) |
| HR (1) | HRP20041058B1 (https=) |
| IL (2) | IL165239A0 (https=) |
| IT (1) | ITMI20021058A1 (https=) |
| MA (1) | MA27960A1 (https=) |
| MX (1) | MXPA04011369A (https=) |
| NZ (1) | NZ536606A (https=) |
| PL (1) | PL209649B1 (https=) |
| PT (1) | PT1506234E (https=) |
| SI (1) | SI1506234T1 (https=) |
| TN (1) | TNSN04219A1 (https=) |
| UA (1) | UA79609C2 (https=) |
| WO (1) | WO2003097695A1 (https=) |
| ZA (1) | ZA200409215B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20021058A1 (it) * | 2002-05-17 | 2003-11-17 | Chiesi Farma Spa | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| CN102146053A (zh) | 2003-03-24 | 2011-08-10 | 阿克西金药品公司 | 治疗哮喘及其它炎症或免疫性疾病的具有ccr3拮抗活性的2-苯氧基-和2-苯基磺酰胺衍生物 |
| EP1481665A1 (en) * | 2003-05-30 | 2004-12-01 | CHIESI FARMACEUTICI S.p.A. | Novel lipid mixtures for synthetic surfactants |
| UA76074C2 (en) * | 2005-11-09 | 2006-06-15 | O V Palladin Inst Of Biochemis | Calmophil, pharmaceutical composition for substitution therapy aimed at recovering malfunctioned surfactant system of lungs |
| GEP20125531B (en) * | 2006-10-13 | 2012-05-25 | Chiesi Farma Spa | Reconstituted surfactants having improved properties |
| US8367643B2 (en) * | 2007-03-29 | 2013-02-05 | National Jewish Health | Surfactant lipids, compositions thereof and uses thereof |
| EP1997502A1 (en) * | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| EP2022798A1 (en) * | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetic pulmonary surfactant peptides |
| WO2009123119A1 (ja) | 2008-04-02 | 2009-10-08 | 国立大学法人徳島大学 | 合成ペプチドを含有する抗原薬物ビークルとこれを用いる粘膜ワクチン |
| US8399406B2 (en) * | 2009-06-05 | 2013-03-19 | Chiesi Farmaceutici S.P.A. | Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C) |
| MX2013002145A (es) * | 2010-08-30 | 2013-04-03 | Hoffmann La Roche | Tetranectina-apolipoproteina a-i, particulas lipidicas que la contienen y utilizacion de la misma. |
| BR112013033562A2 (pt) | 2011-08-25 | 2017-02-14 | Hoffmann La Roche | proteína de fusão de tetranectina-apolipoproteína a-i encurtada, uma partícula de lipídio que a contém e uso das mesmas |
| AR093569A1 (es) | 2012-11-21 | 2015-06-10 | Chiesi Farm Spa | Tensioactivos pulmonares reconstituidos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995001164A1 (en) * | 1993-06-30 | 1995-01-12 | Genentech, Inc. | Method for preparing liposomes |
| WO1997035882A1 (en) * | 1996-03-27 | 1997-10-02 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| WO2001076617A2 (en) * | 2000-03-15 | 2001-10-18 | Advanced Research And Technology Institute | Oral tolerance induction by collagen to prevent allograft rejection |
| JP2003530356A (ja) * | 2000-04-12 | 2003-10-14 | アルタナ ファルマ アクチエンゲゼルシャフト | 急性肺疾患の予防又は早期治療のための肺表面活性物質の新規使用 |
| ITMI20021058A1 (it) * | 2002-05-17 | 2003-11-17 | Chiesi Farma Spa | Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| EP2022798A1 (en) | 2007-08-09 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | Synthetic pulmonary surfactant peptides |
-
2002
- 2002-05-17 IT IT2002MI001058A patent/ITMI20021058A1/it unknown
-
2003
- 2003-05-12 KR KR1020047018528A patent/KR101028927B1/ko not_active Expired - Lifetime
- 2003-05-12 AT AT03727469T patent/ATE353919T1/de active
- 2003-05-12 NZ NZ536606A patent/NZ536606A/en not_active IP Right Cessation
- 2003-05-12 IL IL16523903A patent/IL165239A0/xx unknown
- 2003-05-12 PL PL372751A patent/PL209649B1/pl unknown
- 2003-05-12 MX MXPA04011369A patent/MXPA04011369A/es active IP Right Grant
- 2003-05-12 AU AU2003233320A patent/AU2003233320B2/en not_active Expired
- 2003-05-12 DE DE60311798T patent/DE60311798T2/de not_active Expired - Lifetime
- 2003-05-12 JP JP2004506367A patent/JP4883906B2/ja not_active Expired - Lifetime
- 2003-05-12 DK DK03727469T patent/DK1506234T3/da active
- 2003-05-12 SI SI200330756T patent/SI1506234T1/sl unknown
- 2003-05-12 ES ES03727469T patent/ES2282627T3/es not_active Expired - Lifetime
- 2003-05-12 CN CNB038112531A patent/CN100347193C/zh not_active Expired - Lifetime
- 2003-05-12 US US10/512,869 patent/US7511011B2/en not_active Expired - Lifetime
- 2003-05-12 EP EP03727469A patent/EP1506234B1/en not_active Expired - Lifetime
- 2003-05-12 HR HRP20041058AA patent/HRP20041058B1/hr not_active IP Right Cessation
- 2003-05-12 EA EA200401385A patent/EA007928B1/ru unknown
- 2003-05-12 CA CA2486152A patent/CA2486152C/en not_active Expired - Lifetime
- 2003-05-12 WO PCT/EP2003/004937 patent/WO2003097695A1/en not_active Ceased
- 2003-05-12 PT PT03727469T patent/PT1506234E/pt unknown
- 2003-12-05 UA UA20041109233A patent/UA79609C2/uk unknown
-
2004
- 2004-11-11 TN TNP2004000219A patent/TNSN04219A1/en unknown
- 2004-11-16 IL IL165239A patent/IL165239A/en active IP Right Grant
- 2004-11-16 MA MA27946A patent/MA27960A1/fr unknown
- 2004-11-17 ZA ZA200409215A patent/ZA200409215B/xx unknown
-
2007
- 2007-04-26 CY CY20071100558T patent/CY1106667T1/el unknown
-
2008
- 2008-03-06 US US12/043,177 patent/US7842664B2/en not_active Expired - Lifetime
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