NZ505676A - Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins - Google Patents
Streptomyces avermitilis gene directing the ratio of B2:B1 avermectinsInfo
- Publication number
- NZ505676A NZ505676A NZ505676A NZ50567699A NZ505676A NZ 505676 A NZ505676 A NZ 505676A NZ 505676 A NZ505676 A NZ 505676A NZ 50567699 A NZ50567699 A NZ 50567699A NZ 505676 A NZ505676 A NZ 505676A
- Authority
- NZ
- New Zealand
- Prior art keywords
- avermectins
- ratio
- streptomyces avermitilis
- gene directing
- avermitilis gene
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 2
- 241001468227 Streptomyces avermitilis Species 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ518657A NZ518657A (en) | 1998-02-13 | 1999-01-25 | Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7463698P | 1998-02-13 | 1998-02-13 | |
| PCT/IB1999/000130 WO1999041389A1 (en) | 1998-02-13 | 1999-01-25 | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ505676A true NZ505676A (en) | 2003-02-28 |
Family
ID=22120706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ505676A NZ505676A (en) | 1998-02-13 | 1999-01-25 | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| NZ518657A NZ518657A (en) | 1998-02-13 | 1999-01-25 | Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ518657A NZ518657A (en) | 1998-02-13 | 1999-01-25 | Streptomyces hygroscopicus directing the ratio of B2:B1 avermectins |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP1053335A1 (ref) |
| JP (2) | JP2002503473A (ref) |
| KR (3) | KR20040053390A (ref) |
| CN (2) | CN1521180A (ref) |
| AP (1) | AP9901463A0 (ref) |
| AR (1) | AR018085A1 (ref) |
| AU (1) | AU752343C (ref) |
| BG (1) | BG64911B1 (ref) |
| BR (1) | BR9907893A (ref) |
| CA (2) | CA2521289A1 (ref) |
| CO (1) | CO5070698A1 (ref) |
| DZ (1) | DZ2720A1 (ref) |
| EA (1) | EA003905B1 (ref) |
| GT (1) | GT199900014A (ref) |
| HN (1) | HN1999000008A (ref) |
| HR (1) | HRP20000539A2 (ref) |
| HU (1) | HUP0100784A3 (ref) |
| IL (2) | IL137610A0 (ref) |
| IS (1) | IS5567A (ref) |
| MA (1) | MA24760A1 (ref) |
| NO (1) | NO20004044L (ref) |
| NZ (2) | NZ505676A (ref) |
| OA (1) | OA11449A (ref) |
| PA (1) | PA8467601A1 (ref) |
| PE (1) | PE20000352A1 (ref) |
| PL (1) | PL194270B1 (ref) |
| SK (1) | SK11722000A3 (ref) |
| TN (1) | TNSN99017A1 (ref) |
| TW (1) | TW585910B (ref) |
| WO (1) | WO1999041389A1 (ref) |
| YU (1) | YU50900A (ref) |
| ZA (1) | ZA991138B (ref) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248579B1 (en) * | 1998-02-13 | 2001-06-19 | Pfizer Inc | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
| CN1521180A (zh) * | 1998-02-13 | 2004-08-18 | �Ʒ� | 介导除虫菌素b2：b1比例的除虫链霉菌基因 |
| BRPI0013119B8 (pt) | 1999-08-12 | 2021-05-25 | Pah Usa 15 Llc | molécula polinucleotídica isolada, vetor recombinante purificado, célula hospedeira procariótica e célula de streptomyces avermitilis mutada, método para obtenção de uma nova cepa de s. avermitilis e processo para produção de avermectinas |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| PT1476539E (pt) * | 2002-02-12 | 2009-04-09 | Pfizer Prod Inc | Gene streptomyces avermitilis que dirige a proporção de avermectinas b2:b1 |
| CN107338210B (zh) * | 2017-09-05 | 2021-08-17 | 天津科技大学 | 一种阿维链霉菌合成培养基及其发酵液的制备方法 |
| CN111269296B (zh) * | 2020-03-06 | 2021-11-05 | 山东大学 | 一种nLsA蛋白及其结构基因和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| IN167980B (ref) * | 1987-01-23 | 1991-01-19 | Pfizer | |
| DE3881147T2 (de) * | 1987-10-23 | 1993-09-02 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
| JPH0747171B2 (ja) * | 1988-09-20 | 1995-05-24 | 株式会社東芝 | 圧延機の設定方法および装置 |
| ES2079436T3 (es) * | 1989-03-31 | 1996-01-16 | Merck & Co Inc | Clonacion de genes de streptomyces avermitilis para biosintesis de avermectinas y procedimientos para su uso. |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| JP2888586B2 (ja) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法 |
| FI942725L (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| CN1521180A (zh) * | 1998-02-13 | 2004-08-18 | �Ʒ� | 介导除虫菌素b2：b1比例的除虫链霉菌基因 |
-
1999
- 1999-01-25 CN CNA2004100054154A patent/CN1521180A/zh active Pending
- 1999-01-25 BR BR9907893-7A patent/BR9907893A/pt not_active Application Discontinuation
- 1999-01-25 SK SK1172-2000A patent/SK11722000A3/sk unknown
- 1999-01-25 EP EP99900270A patent/EP1053335A1/en not_active Withdrawn
- 1999-01-25 YU YU50900A patent/YU50900A/sh unknown
- 1999-01-25 CA CA002521289A patent/CA2521289A1/en not_active Abandoned
- 1999-01-25 WO PCT/IB1999/000130 patent/WO1999041389A1/en not_active Ceased
- 1999-01-25 NZ NZ505676A patent/NZ505676A/xx unknown
- 1999-01-25 CN CN99805027A patent/CN1297485A/zh active Pending
- 1999-01-25 CA CA002320031A patent/CA2320031A1/en not_active Abandoned
- 1999-01-25 HU HU0100784A patent/HUP0100784A3/hu not_active Application Discontinuation
- 1999-01-25 PL PL99342468A patent/PL194270B1/pl not_active IP Right Cessation
- 1999-01-25 HR HR20000539A patent/HRP20000539A2/hr not_active Application Discontinuation
- 1999-01-25 AU AU18878/99A patent/AU752343C/en not_active Ceased
- 1999-01-25 JP JP2000531570A patent/JP2002503473A/ja active Pending
- 1999-01-25 EA EA200000758A patent/EA003905B1/ru not_active IP Right Cessation
- 1999-01-25 KR KR10-2004-7008310A patent/KR20040053390A/ko not_active Ceased
- 1999-01-25 NZ NZ518657A patent/NZ518657A/en unknown
- 1999-01-25 KR KR10-2004-7015691A patent/KR20040099389A/ko not_active Ceased
- 1999-01-25 IL IL13761099A patent/IL137610A0/xx unknown
- 1999-01-25 KR KR10-2000-7008870A patent/KR100499214B1/ko not_active Expired - Fee Related
- 1999-01-26 PA PA19998467601A patent/PA8467601A1/es unknown
- 1999-02-01 GT GT199900014A patent/GT199900014A/es unknown
- 1999-02-05 HN HN1991000008A patent/HN1999000008A/es unknown
- 1999-02-08 PE PE1999000099A patent/PE20000352A1/es not_active Application Discontinuation
- 1999-02-09 TW TW088102005A patent/TW585910B/zh active
- 1999-02-10 DZ DZ990021A patent/DZ2720A1/xx active
- 1999-02-10 MA MA25460A patent/MA24760A1/fr unknown
- 1999-02-10 TN TNTNSN99017A patent/TNSN99017A1/fr unknown
- 1999-02-11 AR ARP990100571A patent/AR018085A1/es unknown
- 1999-02-11 AP APAP/P/1999/001463A patent/AP9901463A0/en unknown
- 1999-02-12 ZA ZA9901138A patent/ZA991138B/xx unknown
- 1999-02-12 CO CO99008652A patent/CO5070698A1/es unknown
-
2000
- 2000-07-20 IS IS5567A patent/IS5567A/is unknown
- 2000-08-04 OA OA1200000217A patent/OA11449A/en unknown
- 2000-08-11 NO NO20004044A patent/NO20004044L/no not_active Application Discontinuation
- 2000-09-12 BG BG104759A patent/BG64911B1/bg unknown
-
2004
- 2004-04-27 JP JP2004130624A patent/JP4011036B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-31 IL IL183596A patent/IL183596A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| PSEA | Patent sealed |