YU8402A - Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina - Google Patents
Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektinaInfo
- Publication number
- YU8402A YU8402A YU8402A YUP8402A YU8402A YU 8402 A YU8402 A YU 8402A YU 8402 A YU8402 A YU 8402A YU P8402 A YUP8402 A YU P8402A YU 8402 A YU8402 A YU 8402A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- ratio
- avermectins
- streptomyces avermitilis
- gene directing
- avermitilis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/372,934 US6248579B1 (en) | 1998-02-13 | 1999-08-12 | Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU8402A true YU8402A (sh) | 2006-03-03 |
Family
ID=23470234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU8402A YU8402A (sh) | 1999-08-12 | 2000-07-19 | Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina |
Country Status (37)
| Country | Link |
|---|---|
| US (8) | US6248579B1 (sh) |
| EP (1) | EP1200605B1 (sh) |
| JP (2) | JP3688640B2 (sh) |
| KR (1) | KR100486006B1 (sh) |
| CN (1) | CN1186447C (sh) |
| AP (2) | AP2002002417A0 (sh) |
| AR (1) | AR021450A1 (sh) |
| AT (1) | ATE283363T1 (sh) |
| AU (1) | AU779756B2 (sh) |
| BG (1) | BG106478A (sh) |
| BR (1) | BR0013093A (sh) |
| CA (1) | CA2381427A1 (sh) |
| CO (1) | CO5290296A1 (sh) |
| CZ (1) | CZ2002297A3 (sh) |
| DE (1) | DE60016231T2 (sh) |
| EA (1) | EA004569B1 (sh) |
| ES (1) | ES2231214T3 (sh) |
| GT (2) | GT200000138CA (sh) |
| HK (1) | HK1046536B (sh) |
| HR (1) | HRP20020131A2 (sh) |
| HU (1) | HUP0202517A2 (sh) |
| IL (1) | IL147562A0 (sh) |
| IS (1) | IS6249A (sh) |
| MA (1) | MA26811A1 (sh) |
| MX (1) | MXPA02001514A (sh) |
| NO (1) | NO20020665D0 (sh) |
| OA (1) | OA11997A (sh) |
| PA (1) | PA8499201A1 (sh) |
| PE (1) | PE20010697A1 (sh) |
| PL (1) | PL353770A1 (sh) |
| PT (1) | PT1200605E (sh) |
| SK (1) | SK1382002A3 (sh) |
| TN (1) | TNSN00170A1 (sh) |
| UY (1) | UY26287A1 (sh) |
| WO (1) | WO2001012822A1 (sh) |
| YU (1) | YU8402A (sh) |
| ZA (1) | ZA200201071B (sh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60031126T2 (de) * | 1999-08-12 | 2007-02-08 | Pfizer Products Inc., Groton | Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen |
| WO2003065991A2 (en) | 2002-02-05 | 2003-08-14 | Bristol-Myers Squibb Company | N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof |
| EP1476539B1 (en) | 2002-02-12 | 2009-03-25 | Pfizer Products Inc. | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins |
| US7943160B2 (en) * | 2002-05-09 | 2011-05-17 | Scimetrics Limited Corp. | Pest control methods |
| WO2004067549A2 (de) * | 2003-01-31 | 2004-08-12 | Max-Delbrück-Centrum für Molekulare Medizin | Peptide gegen kälteunverträglichkeit hervorrufende autoantikörper und ihre verwendung |
| KR100759130B1 (ko) | 2005-02-12 | 2007-09-19 | 휴메드 주식회사 | 항 인테그린 항체 코팅스텐트 및 그의 제조방법 |
| CN106148216B (zh) | 2015-03-27 | 2019-06-04 | 浙江海正药业股份有限公司 | 一种链霉菌及其生产米尔贝霉素a3的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5525506A (en) | 1987-01-23 | 1996-06-11 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| US5234831A (en) | 1987-01-23 | 1993-08-10 | Pfizer Inc | Cultures for production of B avermectins |
| US5238848A (en) | 1987-01-23 | 1993-08-24 | Pfizer Inc | Cultures for production of avermectins |
| US5240850A (en) | 1987-10-23 | 1993-08-31 | Pfizer Inc. | Cultures for production of avermectin aglycones |
| DE3881147T2 (de) | 1987-10-23 | 1993-09-02 | Pfizer | Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen. |
| US5252474A (en) | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| DE69023036T2 (de) | 1989-03-31 | 1996-06-13 | Merck & Co Inc | Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung. |
| ES2204914T3 (es) | 1993-07-30 | 2004-05-01 | Pfizer Inc. | Genes que codifican el complejo alfa cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis. |
| KR100186946B1 (ko) * | 1993-10-05 | 1999-04-01 | 알렌 제이.스피겔 | 도라멕틴의 구충활성 중간체 및 도라멕틴의 제조방법 |
| FI942725A (fi) | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| KR20040099389A (ko) * | 1998-02-13 | 2004-11-26 | 화이자 프로덕츠 인코포레이티드 | 스트렙토마이세스 하이그로스코피쿠스 유전자 |
-
1999
- 1999-08-12 US US09/372,934 patent/US6248579B1/en not_active Expired - Fee Related
-
2000
- 2000-07-19 CZ CZ2002297A patent/CZ2002297A3/cs unknown
- 2000-07-19 CA CA002381427A patent/CA2381427A1/en not_active Abandoned
- 2000-07-19 AT AT00942331T patent/ATE283363T1/de not_active IP Right Cessation
- 2000-07-19 MX MXPA02001514A patent/MXPA02001514A/es active IP Right Grant
- 2000-07-19 AP APAP/P/2002/002417A patent/AP2002002417A0/en unknown
- 2000-07-19 SK SK138-2002A patent/SK1382002A3/sk unknown
- 2000-07-19 CN CNB008117632A patent/CN1186447C/zh not_active Expired - Fee Related
- 2000-07-19 PT PT00942331T patent/PT1200605E/pt unknown
- 2000-07-19 YU YU8402A patent/YU8402A/sh unknown
- 2000-07-19 ES ES00942331T patent/ES2231214T3/es not_active Expired - Lifetime
- 2000-07-19 HU HU0202517A patent/HUP0202517A2/hu unknown
- 2000-07-19 WO PCT/IB2000/000996 patent/WO2001012822A1/en active IP Right Grant
- 2000-07-19 OA OA1200200024A patent/OA11997A/en unknown
- 2000-07-19 EA EA200200057A patent/EA004569B1/ru not_active IP Right Cessation
- 2000-07-19 EP EP00942331A patent/EP1200605B1/en not_active Expired - Lifetime
- 2000-07-19 KR KR10-2002-7001946A patent/KR100486006B1/ko not_active IP Right Cessation
- 2000-07-19 DE DE60016231T patent/DE60016231T2/de not_active Expired - Fee Related
- 2000-07-19 AP APAP/P/2002/002419A patent/AP2002002419A0/en unknown
- 2000-07-19 JP JP2001516909A patent/JP3688640B2/ja not_active Expired - Fee Related
- 2000-07-19 PL PL00353770A patent/PL353770A1/xx unknown
- 2000-07-19 IL IL14756200A patent/IL147562A0/xx unknown
- 2000-07-19 BR BR0013093-1A patent/BR0013093A/pt not_active Application Discontinuation
- 2000-07-19 AU AU57021/00A patent/AU779756B2/en not_active Ceased
- 2000-08-04 PA PA20008499201A patent/PA8499201A1/es unknown
- 2000-08-04 CO CO00058850A patent/CO5290296A1/es not_active Application Discontinuation
- 2000-08-10 UY UY26287A patent/UY26287A1/es not_active Application Discontinuation
- 2000-08-10 PE PE2000000813A patent/PE20010697A1/es not_active Application Discontinuation
- 2000-08-10 AR ARP000104129A patent/AR021450A1/es unknown
- 2000-08-11 GT GT200000138CM patent/GT200000138CA/es unknown
- 2000-08-11 TN TNTNSN00170A patent/TNSN00170A1/fr unknown
- 2000-08-11 GT GT200000138A patent/GT200000138A/es unknown
-
2001
- 2001-01-22 US US09/766,916 patent/US6509159B2/en not_active Expired - Fee Related
- 2001-01-22 US US09/766,898 patent/US6511841B2/en not_active Expired - Fee Related
-
2002
- 2002-01-25 IS IS6249A patent/IS6249A/is unknown
- 2002-02-07 MA MA26511A patent/MA26811A1/fr unknown
- 2002-02-07 ZA ZA200201071A patent/ZA200201071B/en unknown
- 2002-02-11 NO NO20020665A patent/NO20020665D0/no not_active Application Discontinuation
- 2002-02-12 HR HR20020131A patent/HRP20020131A2/hr not_active Application Discontinuation
- 2002-03-05 BG BG106478A patent/BG106478A/bg unknown
- 2002-10-30 HK HK02107834.3A patent/HK1046536B/zh not_active IP Right Cessation
- 2002-11-27 US US10/306,013 patent/US20030134313A1/en not_active Abandoned
- 2002-11-27 US US10/306,247 patent/US7029887B2/en not_active Expired - Fee Related
- 2002-11-27 US US10/306,246 patent/US20030129635A1/en not_active Abandoned
- 2002-11-27 US US10/306,249 patent/US6833263B2/en not_active Expired - Fee Related
-
2004
- 2004-12-14 US US11/011,960 patent/US7259241B2/en not_active Expired - Fee Related
-
2005
- 2005-02-16 JP JP2005039041A patent/JP2005198658A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9712878A (pt) | Variante de enzima subtilase, processos para a identificação de uma variante de protease apresentando estabilidade autoproteolìtica e paraq a produção de uma enzima subtilase mutante e de uma variante de subtilase, sequência de dna, vetor, célula hospedeira microbiana, composição e uso de uma variante de subtilase. | |
| AU3246300A (en) | Polypeptides having galactose oxidase activity and nucleic acids encoding same | |
| EP0346000A3 (en) | Macrolide biosynthetic genes for use in streptomyces and other organisms | |
| EP1700915A3 (en) | Enzymatic DNA molecules | |
| AU1231701A (en) | Production of polyketides | |
| Colby et al. | Insertional inactivation of the Streptococcus mutans dexA (dextranase) gene results in altered adherence and dextran catabolism | |
| PL343246A1 (en) | Bacteria attenuated by a non-reverting mutation in each of the aroc, ompf and ompc genes, useful as vaccines | |
| YU8402A (sh) | Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina | |
| ID27760A (id) | Poliketida-poliketida, pembuatannya, dan bahan-bahan untuk penggunaannya | |
| BG104759A (en) | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins | |
| CY1105778T1 (el) | Γονιδιο του streptomyces avermitilis που κατευθυνει την αναλογια των αβepμεκτινων β2:β1 | |
| RS70004A (en) | Streptomyces avermitilis gene directing the ratio of b2:b1 avermectin | |
| BR0110128A (pt) | Mutante de bactéria láctica superprodutora de exopolissacarìdeos, utilização do mesmo e ácido nucleico codificando uma alfa-fosfoglucomutase | |
| WO2000037608A3 (en) | Micromonospora echinospora genes encoding for biosynthesis of calicheamicin and self-resistance thereto | |
| WO2002010203A3 (en) | Daz genes | |
| WO2004108906A3 (de) | Bakterielle träger für nukleotidsequenzen kodierend für wirkstoffe | |
| RO116209B1 (ro) | Procedeu de obţinere a hemicelulazelor prin biosinteză bacteriană |