YU8402A - Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina - Google Patents

Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina

Info

Publication number
YU8402A
YU8402A YU8402A YUP8402A YU8402A YU 8402 A YU8402 A YU 8402A YU 8402 A YU8402 A YU 8402A YU P8402 A YUP8402 A YU P8402A YU 8402 A YU8402 A YU 8402A
Authority
YU
Yugoslavia
Prior art keywords
ratio
avermectins
streptomyces avermitilis
gene directing
avermitilis
Prior art date
Application number
YU8402A
Other languages
English (en)
Inventor
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of YU8402A publication Critical patent/YU8402A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ovaj pronalazak se odnosi na polinukleotidne molekule koji sadrže nukleotidne sekvence koje kodiraju produkt aveC gena, gde ti polinukelotidni molekuli mogu biti korišćeni da izmene odnos ili količinu klase 2:1 avermektina proizvedenih u fermentacionim kulturama S. avermitilis Ovaj pronalazak se dalje odnosi na vektore, ćelije domaćine, i mutante sojeve S. avermitilis u kojima je aveC gen inaktiviran, ili mutiran tako da menja odnos ili količinu klase 2:1 proizvedenih avermektina.[The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
YU8402A 1999-08-12 2000-07-19 Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina YU8402A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/372,934 US6248579B1 (en) 1998-02-13 1999-08-12 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

Publications (1)

Publication Number Publication Date
YU8402A true YU8402A (sh) 2006-03-03

Family

ID=23470234

Family Applications (1)

Application Number Title Priority Date Filing Date
YU8402A YU8402A (sh) 1999-08-12 2000-07-19 Gen streptomyces avermitilis koji usmerava odnos b2:b1 avermektina

Country Status (37)

Country Link
US (8) US6248579B1 (sh)
EP (1) EP1200605B1 (sh)
JP (2) JP3688640B2 (sh)
KR (1) KR100486006B1 (sh)
CN (1) CN1186447C (sh)
AP (2) AP2002002419A0 (sh)
AR (1) AR021450A1 (sh)
AT (1) ATE283363T1 (sh)
AU (1) AU779756B2 (sh)
BG (1) BG106478A (sh)
BR (1) BR0013093A (sh)
CA (1) CA2381427A1 (sh)
CO (1) CO5290296A1 (sh)
CZ (1) CZ2002297A3 (sh)
DE (1) DE60016231T2 (sh)
EA (1) EA004569B1 (sh)
ES (1) ES2231214T3 (sh)
GT (2) GT200000138A (sh)
HK (1) HK1046536B (sh)
HR (1) HRP20020131A2 (sh)
HU (1) HUP0202517A2 (sh)
IL (1) IL147562A0 (sh)
IS (1) IS6249A (sh)
MA (1) MA26811A1 (sh)
MX (1) MXPA02001514A (sh)
NO (1) NO20020665L (sh)
OA (1) OA11997A (sh)
PA (1) PA8499201A1 (sh)
PE (1) PE20010697A1 (sh)
PL (1) PL353770A1 (sh)
PT (1) PT1200605E (sh)
SK (1) SK1382002A3 (sh)
TN (1) TNSN00170A1 (sh)
UY (1) UY26287A1 (sh)
WO (1) WO2001012822A1 (sh)
YU (1) YU8402A (sh)
ZA (1) ZA200201071B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3884651B2 (ja) * 1999-08-12 2007-02-21 ファイザー・プロダクツ・インク Ｂ２アベルメクチン：ｂ１アベルメクチンの比を指示するストレプトミセス・アベルミティリス遺伝子
WO2003065991A2 (en) 2002-02-05 2003-08-14 Bristol-Myers Squibb Company N-substituted3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
RU2293117C2 (ru) * 2002-02-12 2007-02-10 Пфайзер Продактс Инк. Ген streptomyces avermitilis и его применение для изменения соотношения авермектинов b2:b1
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
WO2004067549A2 (de) * 2003-01-31 2004-08-12 Max-Delbrück-Centrum für Molekulare Medizin Peptide gegen kälteunverträglichkeit hervorrufende autoantikörper und ihre verwendung
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
CN106148216B (zh) 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ES2054822T3 (es) 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
WO1995004150A1 (en) 1993-07-30 1995-02-09 Pfizer Inc. Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
UA45957C2 (uk) * 1993-10-05 2002-05-15 Пфайзер, Інк. Проміжні сполуки для одержання дорамектину, яким властива антипаразитарна активність, спосіб їх одержання, спосіб одержання дорамектину та спосіб лікування
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
BR9907893A (pt) * 1998-02-13 2000-11-14 Pfizer Prod Inc Gene de streptomyces avermitilis que dirige a proporção de avermectinas b2:b1

Also Published As

Publication number Publication date
PT1200605E (pt) 2005-04-29
CN1370239A (zh) 2002-09-18
US20010024818A1 (en) 2001-09-27
KR20020022809A (ko) 2002-03-27
AP2002002419A0 (en) 2002-03-31
EA200200057A1 (ru) 2002-06-27
HK1046536B (zh) 2005-05-13
US20030129636A1 (en) 2003-07-10
PE20010697A1 (es) 2001-07-05
CZ2002297A3 (cs) 2002-08-14
AP2002002417A0 (en) 2002-03-31
TNSN00170A1 (fr) 2005-11-10
US7259241B2 (en) 2007-08-21
AR021450A1 (es) 2002-07-17
DE60016231D1 (de) 2004-12-30
ZA200201071B (en) 2003-06-25
US6248579B1 (en) 2001-06-19
ATE283363T1 (de) 2004-12-15
US6509159B2 (en) 2003-01-21
SK1382002A3 (en) 2002-11-06
IL147562A0 (en) 2002-08-14
AU5702100A (en) 2001-03-13
GT200000138CA (es) 2002-02-02
US20030134313A1 (en) 2003-07-17
US7029887B2 (en) 2006-04-18
PL353770A1 (en) 2003-12-01
OA11997A (en) 2006-04-18
UY26287A1 (es) 2001-03-16
WO2001012822A1 (en) 2001-02-22
BG106478A (bg) 2004-02-27
PA8499201A1 (es) 2001-12-14
EA004569B1 (ru) 2004-06-24
ES2231214T3 (es) 2005-05-16
US20050196777A1 (en) 2005-09-08
KR100486006B1 (ko) 2005-05-03
AU779756B2 (en) 2005-02-10
JP3688640B2 (ja) 2005-08-31
DE60016231T2 (de) 2005-12-08
NO20020665D0 (no) 2002-02-11
NO20020665L (no) 2002-02-11
GT200000138A (es) 2002-02-02
HK1046536A1 (en) 2003-01-17
HUP0202517A2 (hu) 2002-11-28
CO5290296A1 (es) 2003-06-27
JP2003507018A (ja) 2003-02-25
JP2005198658A (ja) 2005-07-28
US20010016350A1 (en) 2001-08-23
CA2381427A1 (en) 2001-02-22
EP1200605A1 (en) 2002-05-02
HRP20020131A2 (en) 2003-12-31
MXPA02001514A (es) 2002-07-02
MA26811A1 (fr) 2004-12-20
BR0013093A (pt) 2002-08-13
EP1200605B1 (en) 2004-11-24
IS6249A (is) 2002-01-25
US20030124607A1 (en) 2003-07-03
US6511841B2 (en) 2003-01-28
US6833263B2 (en) 2004-12-21
US20030129635A1 (en) 2003-07-10
CN1186447C (zh) 2005-01-26

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