HUP0202517A2 - Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén - Google Patents

Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén

Info

Publication number
HUP0202517A2
HUP0202517A2 HU0202517A HUP0202517A HUP0202517A2 HU P0202517 A2 HUP0202517 A2 HU P0202517A2 HU 0202517 A HU0202517 A HU 0202517A HU P0202517 A HUP0202517 A HU P0202517A HU P0202517 A2 HUP0202517 A2 HU P0202517A2
Authority
HU
Hungary
Prior art keywords
ratio
avermectins
streptomyces avermitilis
subject
gene directing
Prior art date
Application number
HU0202517A
Other languages
English (en)
Inventor
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of HUP0202517A2 publication Critical patent/HUP0202517A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát olyan polinukleotid molekulák képezik, amelyekAveC génterméket kódoló nukleotid szekvenciákat tartalmaznak, és arrahasználhatók, hogy a Streptomyces avermitilis tenyészeteinekfermentálásával előállított avermektinek B2:B1 arányát befolyásolják,valamint a találmány tárgyát képezik az ilyen polinukleotid molekulákszűrővizsgálatára szolgáló készítmények és eljárások is. A találmánytárgyát képezik továbbá vektorok, transzformált gazdasejtek és aStreptomyces avermitilis új mutáns törzsei, amelyekben az aveC gén úgymutált, hogy az előállított avermektinek B2:B1 aránya ezáltalbefolyásolódik. Ó
HU0202517A 1999-08-12 2000-07-19 Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén HUP0202517A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/372,934 US6248579B1 (en) 1998-02-13 1999-08-12 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins

Publications (1)

Publication Number Publication Date
HUP0202517A2 true HUP0202517A2 (hu) 2002-11-28

Family

ID=23470234

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202517A HUP0202517A2 (hu) 1999-08-12 2000-07-19 Az avermektinek B2:B1 arányát befolyásoló Streptomyces avermitilis gén

Country Status (37)

Country Link
US (8) US6248579B1 (hu)
EP (1) EP1200605B1 (hu)
JP (2) JP3688640B2 (hu)
KR (1) KR100486006B1 (hu)
CN (1) CN1186447C (hu)
AP (2) AP2002002419A0 (hu)
AR (1) AR021450A1 (hu)
AT (1) ATE283363T1 (hu)
AU (1) AU779756B2 (hu)
BG (1) BG106478A (hu)
BR (1) BR0013093A (hu)
CA (1) CA2381427A1 (hu)
CO (1) CO5290296A1 (hu)
CZ (1) CZ2002297A3 (hu)
DE (1) DE60016231T2 (hu)
EA (1) EA004569B1 (hu)
ES (1) ES2231214T3 (hu)
GT (2) GT200000138CA (hu)
HK (1) HK1046536B (hu)
HR (1) HRP20020131A2 (hu)
HU (1) HUP0202517A2 (hu)
IL (1) IL147562A0 (hu)
IS (1) IS6249A (hu)
MA (1) MA26811A1 (hu)
MX (1) MXPA02001514A (hu)
NO (1) NO20020665L (hu)
OA (1) OA11997A (hu)
PA (1) PA8499201A1 (hu)
PE (1) PE20010697A1 (hu)
PL (1) PL353770A1 (hu)
PT (1) PT1200605E (hu)
SK (1) SK1382002A3 (hu)
TN (1) TNSN00170A1 (hu)
UY (1) UY26287A1 (hu)
WO (1) WO2001012822A1 (hu)
YU (1) YU8402A (hu)
ZA (1) ZA200201071B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778837B2 (en) * 1999-08-12 2004-12-23 Zoetis Services Llc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
DE60316410T2 (de) 2002-02-05 2008-06-19 Bristol-Myers Squibb Co. N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika
ATE530645T1 (de) * 2002-02-12 2011-11-15 Pfizer Prod Inc Streptomyces avermitilis gen zur regulierung des verhältnisses der b2:b1 avermectine
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US8440609B2 (en) * 2003-01-31 2013-05-14 Gerd Wallukat Peptides against autoantibodies causing intolerance to cold and use thereof
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
CN106148216B (zh) * 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
EP0313297B1 (en) 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
ATE129286T1 (de) 1989-03-31 1995-11-15 Merck & Co Inc Klonierung von streptomyces avermitilis genen zur biosynthese von avermectin und verfahren zu ihrer verwendung.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
PT711349E (pt) 1993-07-30 2003-12-31 Pfizer Genes que codificam para o complexo desidrogenase de acido alfa-cetonico de cadeia ramificada a partir de streptomyces avermitilis
CA2173494C (en) * 1993-10-05 1999-04-13 Thomas C. Crawford Process and antiparasitic intermediates for doramectin
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
WO1999041389A1 (en) * 1998-02-13 1999-08-19 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Also Published As

Publication number Publication date
CN1186447C (zh) 2005-01-26
JP3688640B2 (ja) 2005-08-31
HRP20020131A2 (en) 2003-12-31
ES2231214T3 (es) 2005-05-16
NO20020665D0 (no) 2002-02-11
JP2005198658A (ja) 2005-07-28
MA26811A1 (fr) 2004-12-20
US20050196777A1 (en) 2005-09-08
DE60016231T2 (de) 2005-12-08
AP2002002417A0 (en) 2002-03-31
GT200000138CA (es) 2002-02-02
IS6249A (is) 2002-01-25
EP1200605A1 (en) 2002-05-02
OA11997A (en) 2006-04-18
EP1200605B1 (en) 2004-11-24
EA200200057A1 (ru) 2002-06-27
AU779756B2 (en) 2005-02-10
US20010016350A1 (en) 2001-08-23
KR100486006B1 (ko) 2005-05-03
US6509159B2 (en) 2003-01-21
PA8499201A1 (es) 2001-12-14
AR021450A1 (es) 2002-07-17
WO2001012822A1 (en) 2001-02-22
US6833263B2 (en) 2004-12-21
HK1046536B (zh) 2005-05-13
US6511841B2 (en) 2003-01-28
US7029887B2 (en) 2006-04-18
CO5290296A1 (es) 2003-06-27
AP2002002419A0 (en) 2002-03-31
CZ2002297A3 (cs) 2002-08-14
US20030129635A1 (en) 2003-07-10
DE60016231D1 (de) 2004-12-30
ZA200201071B (en) 2003-06-25
US20030124607A1 (en) 2003-07-03
US7259241B2 (en) 2007-08-21
YU8402A (sh) 2006-03-03
EA004569B1 (ru) 2004-06-24
HK1046536A1 (en) 2003-01-17
US20010024818A1 (en) 2001-09-27
MXPA02001514A (es) 2002-07-02
SK1382002A3 (en) 2002-11-06
PL353770A1 (en) 2003-12-01
JP2003507018A (ja) 2003-02-25
PT1200605E (pt) 2005-04-29
US6248579B1 (en) 2001-06-19
US20030129636A1 (en) 2003-07-10
UY26287A1 (es) 2001-03-16
CA2381427A1 (en) 2001-02-22
ATE283363T1 (de) 2004-12-15
AU5702100A (en) 2001-03-13
BG106478A (bg) 2004-02-27
CN1370239A (zh) 2002-09-18
NO20020665L (no) 2002-02-11
KR20020022809A (ko) 2002-03-27
BR0013093A (pt) 2002-08-13
GT200000138A (es) 2002-02-02
US20030134313A1 (en) 2003-07-17
PE20010697A1 (es) 2001-07-05
TNSN00170A1 (fr) 2005-11-10
IL147562A0 (en) 2002-08-14

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Legal Events

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FD9A Lapse of provisional protection due to non-payment of fees