NO20020665D0 - Streptomyces Avermitilis gen som bestemmer forholdet til B2:B1 avermectiner - Google Patents

Streptomyces Avermitilis gen som bestemmer forholdet til B2:B1 avermectiner

Info

Publication number
NO20020665D0
NO20020665D0 NO20020665A NO20020665A NO20020665D0 NO 20020665 D0 NO20020665 D0 NO 20020665D0 NO 20020665 A NO20020665 A NO 20020665A NO 20020665 A NO20020665 A NO 20020665A NO 20020665 D0 NO20020665 D0 NO 20020665D0
Authority
NO
Norway
Prior art keywords
avermectins
determines
ratio
streptomyces avermitilis
avermitilis gene
Prior art date
Application number
NO20020665A
Other languages
English (en)
Other versions
NO20020665L (no
Inventor
Kim Jonelle Stutzman-Engwall
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20020665L publication Critical patent/NO20020665L/no
Publication of NO20020665D0 publication Critical patent/NO20020665D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO20020665A 1999-08-12 2002-02-11 Streptomyces Avermitilis gen som bestemmer forholdet til B2:B1 avermectiner NO20020665D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/372,934 US6248579B1 (en) 1998-02-13 1999-08-12 Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
PCT/IB2000/000996 WO2001012822A1 (en) 1999-08-12 2000-07-19 Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins

Publications (2)

Publication Number Publication Date
NO20020665L NO20020665L (no) 2002-02-11
NO20020665D0 true NO20020665D0 (no) 2002-02-11

Family

ID=23470234

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020665A NO20020665D0 (no) 1999-08-12 2002-02-11 Streptomyces Avermitilis gen som bestemmer forholdet til B2:B1 avermectiner

Country Status (37)

Country Link
US (8) US6248579B1 (no)
EP (1) EP1200605B1 (no)
JP (2) JP3688640B2 (no)
KR (1) KR100486006B1 (no)
CN (1) CN1186447C (no)
AP (2) AP2002002417A0 (no)
AR (1) AR021450A1 (no)
AT (1) ATE283363T1 (no)
AU (1) AU779756B2 (no)
BG (1) BG106478A (no)
BR (1) BR0013093A (no)
CA (1) CA2381427A1 (no)
CO (1) CO5290296A1 (no)
CZ (1) CZ2002297A3 (no)
DE (1) DE60016231T2 (no)
EA (1) EA004569B1 (no)
ES (1) ES2231214T3 (no)
GT (2) GT200000138A (no)
HK (1) HK1046536B (no)
HR (1) HRP20020131A2 (no)
HU (1) HUP0202517A2 (no)
IL (1) IL147562A0 (no)
IS (1) IS6249A (no)
MA (1) MA26811A1 (no)
MX (1) MXPA02001514A (no)
NO (1) NO20020665D0 (no)
OA (1) OA11997A (no)
PA (1) PA8499201A1 (no)
PE (1) PE20010697A1 (no)
PL (1) PL353770A1 (no)
PT (1) PT1200605E (no)
SK (1) SK1382002A3 (no)
TN (1) TNSN00170A1 (no)
UY (1) UY26287A1 (no)
WO (1) WO2001012822A1 (no)
YU (1) YU8402A (no)
ZA (1) ZA200201071B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU778837B2 (en) * 1999-08-12 2004-12-23 Zoetis Services Llc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
JP2005516987A (ja) 2002-02-05 2005-06-09 ブリストル−マイヤーズ　スクイブ　カンパニー Ｎ−置換された３−ヒドロキシ−４−ピリジノン化合物およびそれを含む医薬
IL162866A0 (en) 2002-02-12 2005-11-20 Pfizer Prod Inc Streptomyces a vermitilis gene directing the ratioof b2:b1 avermectins
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
EP1597271B1 (de) * 2003-01-31 2013-03-06 Max-Delbrück-Centrum Für Molekulare Medizin Peptide gegen kälteunverträglichkeit hervorrufende autoantikörper und ihre verwendung
KR100759130B1 (ko) 2005-02-12 2007-09-19 휴메드 주식회사 항 인테그린 항체 코팅스텐트 및 그의 제조방법
CN106148216B (zh) 2015-03-27 2019-06-04 浙江海正药业股份有限公司 一种链霉菌及其生产米尔贝霉素a3的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
ES2054822T3 (es) 1987-10-23 1994-08-16 Pfizer Procedimiento para la produccion de agliconas de avermectinas y sus cultivos.
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
EP0391594B1 (en) 1989-03-31 1995-10-18 Merck & Co. Inc. Cloning genes from streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
BR9407211A (pt) 1993-07-30 1996-09-17 Pfizer Genes codificadores do complexo de desidrogenase de alfa- cetoácidos de cadeia ramificada derivados de streptomyces avermitilis
CN1040113C (zh) * 1993-10-05 1998-10-07 美国辉瑞有限公司 抗寄生虫药物多哇麦汀(doramectin)的中间体及其制备方法
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
KR100499214B1 (ko) * 1998-02-13 2005-07-07 화이자 프로덕츠 인코포레이티드 아베르멕틴의 b2:b1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Also Published As

Publication number Publication date
EP1200605B1 (en) 2004-11-24
WO2001012822A1 (en) 2001-02-22
NO20020665L (no) 2002-02-11
AU779756B2 (en) 2005-02-10
CN1370239A (zh) 2002-09-18
EA004569B1 (ru) 2004-06-24
EA200200057A1 (ru) 2002-06-27
US20050196777A1 (en) 2005-09-08
KR20020022809A (ko) 2002-03-27
CO5290296A1 (es) 2003-06-27
US20030124607A1 (en) 2003-07-03
JP2005198658A (ja) 2005-07-28
JP3688640B2 (ja) 2005-08-31
US20010024818A1 (en) 2001-09-27
HRP20020131A2 (en) 2003-12-31
DE60016231T2 (de) 2005-12-08
PT1200605E (pt) 2005-04-29
HK1046536A1 (en) 2003-01-17
US20030129636A1 (en) 2003-07-10
US6511841B2 (en) 2003-01-28
US20030129635A1 (en) 2003-07-10
IL147562A0 (en) 2002-08-14
GT200000138CA (es) 2002-02-02
KR100486006B1 (ko) 2005-05-03
BR0013093A (pt) 2002-08-13
HK1046536B (zh) 2005-05-13
ZA200201071B (en) 2003-06-25
US7029887B2 (en) 2006-04-18
US6509159B2 (en) 2003-01-21
OA11997A (en) 2006-04-18
MXPA02001514A (es) 2002-07-02
AU5702100A (en) 2001-03-13
US6833263B2 (en) 2004-12-21
ATE283363T1 (de) 2004-12-15
CA2381427A1 (en) 2001-02-22
IS6249A (is) 2002-01-25
AP2002002417A0 (en) 2002-03-31
CZ2002297A3 (cs) 2002-08-14
MA26811A1 (fr) 2004-12-20
CN1186447C (zh) 2005-01-26
DE60016231D1 (de) 2004-12-30
US20010016350A1 (en) 2001-08-23
AR021450A1 (es) 2002-07-17
US7259241B2 (en) 2007-08-21
PL353770A1 (en) 2003-12-01
PA8499201A1 (es) 2001-12-14
HUP0202517A2 (hu) 2002-11-28
AP2002002419A0 (en) 2002-03-31
JP2003507018A (ja) 2003-02-25
US6248579B1 (en) 2001-06-19
UY26287A1 (es) 2001-03-16
GT200000138A (es) 2002-02-02
PE20010697A1 (es) 2001-07-05
TNSN00170A1 (fr) 2005-11-10
BG106478A (bg) 2004-02-27
ES2231214T3 (es) 2005-05-16
SK1382002A3 (en) 2002-11-06
US20030134313A1 (en) 2003-07-17
YU8402A (sh) 2006-03-03
EP1200605A1 (en) 2002-05-02

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