NZ500534A - Improved storage and maintenance of blood products using a solution of L-carnitine or a derivative - Google Patents
Improved storage and maintenance of blood products using a solution of L-carnitine or a derivativeInfo
- Publication number
- NZ500534A NZ500534A NZ500534A NZ50053498A NZ500534A NZ 500534 A NZ500534 A NZ 500534A NZ 500534 A NZ500534 A NZ 500534A NZ 50053498 A NZ50053498 A NZ 50053498A NZ 500534 A NZ500534 A NZ 500534A
- Authority
- NZ
- New Zealand
- Prior art keywords
- carnitine
- rbc
- blood
- alkanoyl
- mixtures
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 94
- 238000003860 storage Methods 0.000 title claims abstract description 39
- 238000012423 maintenance Methods 0.000 title claims abstract description 11
- 239000010836 blood and blood product Substances 0.000 title claims description 27
- 229940125691 blood product Drugs 0.000 title claims description 27
- 230000001976 improved effect Effects 0.000 title description 7
- 239000012528 membrane Substances 0.000 claims abstract description 38
- 206010018910 Haemolysis Diseases 0.000 claims abstract description 29
- 230000008588 hemolysis Effects 0.000 claims abstract description 29
- -1 alkanoyl L-carnitines Chemical class 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 239000003634 thrombocyte concentrate Substances 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 230000000087 stabilizing effect Effects 0.000 claims abstract description 8
- 210000003743 erythrocyte Anatomy 0.000 claims description 90
- 239000008280 blood Substances 0.000 claims description 35
- 210000004369 blood Anatomy 0.000 claims description 34
- 210000000265 leukocyte Anatomy 0.000 claims description 12
- 210000002381 plasma Anatomy 0.000 claims description 11
- 210000001772 blood platelet Anatomy 0.000 claims description 10
- 229960004203 carnitine Drugs 0.000 claims description 10
- 230000006378 damage Effects 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 3
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 230000001678 irradiating effect Effects 0.000 claims description 3
- LRCNOZRCYBNMEP-SECBINFHSA-N O-isobutyryl-L-carnitine Chemical group CC(C)C(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C LRCNOZRCYBNMEP-SECBINFHSA-N 0.000 claims 2
- IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 210000004027 cell Anatomy 0.000 description 39
- 235000011468 Albizia julibrissin Nutrition 0.000 description 25
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- 239000000243 solution Substances 0.000 description 24
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- 238000000338 in vitro Methods 0.000 description 14
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- 102000001554 Hemoglobins Human genes 0.000 description 6
- 108010054147 Hemoglobins Proteins 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- 208000021187 Transfusion associated graft versus host disease Diseases 0.000 description 4
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- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
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- RSGFPIWWSCWCFJ-VAXZQHAWSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O RSGFPIWWSCWCFJ-VAXZQHAWSA-N 0.000 description 2
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
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- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- 208000018240 Bone Marrow Failure disease Diseases 0.000 description 1
- 206010065553 Bone marrow failure Diseases 0.000 description 1
- 102000002666 Carnitine O-palmitoyltransferase Human genes 0.000 description 1
- 108010018424 Carnitine O-palmitoyltransferase Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
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- 102000018697 Membrane Proteins Human genes 0.000 description 1
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- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- XOTMZTIJOSMYFJ-MGLUWQALSA-K [Na+].[Na+].[Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].[Na+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XOTMZTIJOSMYFJ-MGLUWQALSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0047—Ultraviolet radiation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0029—Radiation
- A61L2/0035—Gamma radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/22—Blood or products thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- External Artificial Organs (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Packages (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/840,765 US6482585B2 (en) | 1997-04-16 | 1997-04-16 | Storage and maintenance of blood products including red blood cells and platelets |
| PCT/IT1998/000086 WO1998046073A1 (en) | 1997-04-16 | 1998-04-15 | Improved storage and maintenance of blood products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ500534A true NZ500534A (en) | 2001-05-25 |
Family
ID=25283169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ500534A NZ500534A (en) | 1997-04-16 | 1998-04-15 | Improved storage and maintenance of blood products using a solution of L-carnitine or a derivative |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6482585B2 (enExample) |
| EP (1) | EP0975214B1 (enExample) |
| JP (1) | JP4467649B2 (enExample) |
| KR (1) | KR100508408B1 (enExample) |
| CN (2) | CN1252687A (enExample) |
| AT (1) | ATE257326T1 (enExample) |
| AU (1) | AU739842B2 (enExample) |
| BR (1) | BR9808911B1 (enExample) |
| CA (1) | CA2286721A1 (enExample) |
| CZ (1) | CZ298671B6 (enExample) |
| DE (1) | DE69821002T2 (enExample) |
| DK (1) | DK0975214T3 (enExample) |
| ES (1) | ES2212288T3 (enExample) |
| HU (1) | HUP0001936A3 (enExample) |
| IL (1) | IL132271A (enExample) |
| NZ (1) | NZ500534A (enExample) |
| PL (1) | PL192684B1 (enExample) |
| PT (1) | PT975214E (enExample) |
| SK (1) | SK284688B6 (enExample) |
| WO (1) | WO1998046073A1 (enExample) |
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| US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| US6403124B1 (en) * | 1997-04-16 | 2002-06-11 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| CZ303870B6 (cs) * | 1999-10-11 | 2013-06-05 | Sigma-Tau Industrie Farmaceutiche Riunite S. P. A. | Vyuzití L-karnitinu a jeho alkanoylderivátu jako osmotických prostredku v roztocích pro medicinální vyuzití |
| US8828226B2 (en) | 2003-03-01 | 2014-09-09 | The Trustees Of Boston University | System for assessing the efficacy of stored red blood cells using microvascular networks |
| RU2245145C1 (ru) * | 2003-10-01 | 2005-01-27 | Российский государственный медицинский университет | Средство нормализации агрегационных свойств тромбоцитов и эритроцитов и морфоденситометрических характеристик эритроцитов |
| ATE494777T1 (de) * | 2003-10-09 | 2011-01-15 | Core Dynamics Ltd | Verfahren zum tiefgefrieren, auftauen und transplantieren von lebensfähigem knorpel |
| JP4777908B2 (ja) * | 2004-02-02 | 2011-09-21 | コア・ダイナミクス・リミテッド | 生物学的材料ならびに生物学的材料の保存のための方法および溶液 |
| WO2005072790A1 (en) * | 2004-02-02 | 2005-08-11 | I.M.T. Interface Multigrad Technology Ltd. | Device for directional cooling of biological matter |
| EP1753472B1 (en) * | 2004-06-07 | 2010-03-17 | Core Dynamics Ltd | Method for sterilization of biological preparations |
| EP1778007A1 (en) * | 2004-08-12 | 2007-05-02 | I.M.T. Interface Multigrad Technology Ltd. | Method and apparatus for freezing or thawing of a biological material |
| US20080160496A1 (en) * | 2005-02-22 | 2008-07-03 | Victor Rzepakovsky | Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor |
| FR2884717B1 (fr) * | 2005-04-25 | 2009-07-03 | Erytech Pharma Soc Par Actions | Erythrocytes renfermant de l'arginine deiminase |
| US8198085B2 (en) * | 2005-08-03 | 2012-06-12 | Core Dynamics Limited | Somatic cells for use in cell therapy |
| US7462485B2 (en) * | 2005-10-07 | 2008-12-09 | Glaser Lawrence F | Modified erythrocytes and uses thereof |
| US8835104B2 (en) | 2007-12-20 | 2014-09-16 | Fenwal, Inc. | Medium and methods for the storage of platelets |
| US20090202978A1 (en) * | 2008-02-13 | 2009-08-13 | Ginadi Shaham | Method and apparatus for freezing of a biological material |
| US8968992B2 (en) * | 2008-03-21 | 2015-03-03 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| US8871434B2 (en) * | 2008-03-21 | 2014-10-28 | Fenwal, Inc. | Red blood cell storage medium for extended storage |
| JP6199557B2 (ja) | 2009-10-12 | 2017-09-20 | ニュー ヘルス サイエンシーズ、インク．Ｎｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 酸素及び二酸化炭素の減損能力をもつ血液保存袋システム及び減損装置 |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| BR112012008682A2 (pt) | 2009-10-12 | 2017-06-20 | New Health Sciences Inc | "dispositivo de depleção de oxigênio, e, método para remover oxigênio de células vermelhas do sangue." |
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US11864553B2 (en) | 2009-10-23 | 2024-01-09 | Fenwal, Inc. | Methods and systems for providing red blood cell products with reduced plasma |
| ES2959120T3 (es) | 2010-08-25 | 2024-02-20 | Hemanext Inc | Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento |
| EP3539381B1 (en) | 2010-11-05 | 2023-05-24 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| CA2826969C (en) | 2010-11-29 | 2019-02-19 | New York Blood Center, Inc. | Method of blood pooling and storage |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| AU2012240016B2 (en) | 2011-04-07 | 2016-11-10 | Fenwal, Inc. | Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates |
| EP4190154A1 (en) * | 2011-07-05 | 2023-06-07 | Hemanext Inc. | A system for extended storage of red blood cells |
| WO2013023156A1 (en) | 2011-08-10 | 2013-02-14 | New Health Sciences, Inc. | Integrated leukocyte, oxygen and/or co2 depletion, and plasma separation filter device |
| CA2902061C (en) | 2013-02-28 | 2023-08-08 | New Health Sciences, Inc. | Gas depletion and gas addition devices for blood treatment |
| WO2016145210A1 (en) | 2015-03-10 | 2016-09-15 | New Health Sciences, Inc. | Oxygen reduction disposable kits, devices and methods of use thereof |
| IL285359B2 (en) | 2015-04-23 | 2024-01-01 | Hemanext Inc | Anaerobic blood storage containers |
| PT3297641T (pt) | 2015-05-18 | 2025-10-09 | Hemanext Inc | Métodos de armazenamento de sangue total e respetivas composições |
| CN109195632A (zh) | 2016-05-27 | 2019-01-11 | 新健康科学股份有限公司 | 厌氧血液储存和病原体失活方法 |
| DE102017218847A1 (de) | 2017-10-23 | 2019-04-25 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten |
| US20220378840A1 (en) * | 2019-11-29 | 2022-12-01 | Rutgers, The State University Of New Jersey | Compositions, kits and methods for storage of blood products and methods of use thereof |
| CN116115753A (zh) * | 2021-11-15 | 2023-05-16 | 上海循曜生物科技有限公司 | 一种新的改善血小板质量的方法 |
| CN114600872A (zh) * | 2022-04-13 | 2022-06-10 | 西安北光医学生物技术有限公司 | 一种细胞、组织或器官的抗损伤保存的方法及保存系统 |
| WO2024206693A1 (en) * | 2023-03-31 | 2024-10-03 | Hemerus Medical, Llc | Formulations and methods for collecting and storing blood and blood products |
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| US3729947A (en) * | 1970-12-04 | 1973-05-01 | Alza Corp | Process for storing blood platelets |
| US3792947A (en) * | 1972-07-10 | 1974-02-19 | A Diehl | Molding apparatus |
| DE3277609D1 (en) * | 1982-01-07 | 1987-12-17 | Fresenius Ag | Preservation bag |
| US4613322A (en) * | 1982-12-08 | 1986-09-23 | Edelson Richard Leslie | Method and system for externally treating the blood |
| US5149682A (en) * | 1987-09-11 | 1992-09-22 | W. R. Grace & Co. -Conn. | Manufacturing method for superconducting ceramics and products thereof |
| US5232844A (en) * | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
| US5120649A (en) * | 1990-05-15 | 1992-06-09 | New York Blood Center, Inc. | Photodynamic inactivation of viruses in blood cell-containing compositions |
| US5376524A (en) | 1991-04-01 | 1994-12-27 | Thomas Jefferson University | Platelet storage medium containing acetate and phosphate |
| IT1261695B (it) * | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
| US5362442A (en) * | 1993-07-22 | 1994-11-08 | 2920913 Canada Inc. | Method for sterilizing products with gamma radiation |
| WO1996039820A1 (en) * | 1995-06-07 | 1996-12-19 | Cerus Corporation | Methods of inactivating leukocytes and inhibiting cytokine production in blood products |
| WO1997016967A1 (en) * | 1995-11-09 | 1997-05-15 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for promoting blood component survival |
| IT1277953B1 (it) * | 1995-12-21 | 1997-11-12 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per |
| US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| US6010890A (en) * | 1997-04-29 | 2000-01-04 | New York Blood Center, Inc. | Method for viral inactivation and compositions for use in same |
-
1997
- 1997-04-16 US US08/840,765 patent/US6482585B2/en not_active Expired - Fee Related
-
1998
- 1998-04-15 IL IL13227198A patent/IL132271A/xx not_active IP Right Cessation
- 1998-04-15 CZ CZ0368199A patent/CZ298671B6/cs not_active IP Right Cessation
- 1998-04-15 PL PL336294A patent/PL192684B1/pl not_active IP Right Cessation
- 1998-04-15 PT PT98917604T patent/PT975214E/pt unknown
- 1998-04-15 DK DK98917604T patent/DK0975214T3/da active
- 1998-04-15 CN CN98804212A patent/CN1252687A/zh active Pending
- 1998-04-15 WO PCT/IT1998/000086 patent/WO1998046073A1/en not_active Ceased
- 1998-04-15 HU HU0001936A patent/HUP0001936A3/hu unknown
- 1998-04-15 AT AT98917604T patent/ATE257326T1/de active
- 1998-04-15 CA CA002286721A patent/CA2286721A1/en not_active Abandoned
- 1998-04-15 CN CNA2005100674289A patent/CN1698430A/zh active Pending
- 1998-04-15 DE DE69821002T patent/DE69821002T2/de not_active Expired - Lifetime
- 1998-04-15 ES ES98917604T patent/ES2212288T3/es not_active Expired - Lifetime
- 1998-04-15 KR KR10-1999-7009554A patent/KR100508408B1/ko not_active Expired - Fee Related
- 1998-04-15 AU AU70781/98A patent/AU739842B2/en not_active Ceased
- 1998-04-15 JP JP54369498A patent/JP4467649B2/ja not_active Expired - Lifetime
- 1998-04-15 NZ NZ500534A patent/NZ500534A/en not_active IP Right Cessation
- 1998-04-15 EP EP98917604A patent/EP0975214B1/en not_active Expired - Lifetime
- 1998-04-15 SK SK1427-99A patent/SK284688B6/sk not_active IP Right Cessation
- 1998-04-15 BR BRPI9808911-0A patent/BR9808911B1/pt not_active IP Right Cessation
-
2002
- 2002-08-01 US US10/208,834 patent/US6960428B2/en not_active Expired - Fee Related
Also Published As
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| PSEA | Patent sealed | ||
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| EXPY | Patent expired |