AU739842B2 - Improved storage and maintenance of blood products - Google Patents

Improved storage and maintenance of blood products Download PDF

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Publication number
AU739842B2
AU739842B2 AU70781/98A AU7078198A AU739842B2 AU 739842 B2 AU739842 B2 AU 739842B2 AU 70781/98 A AU70781/98 A AU 70781/98A AU 7078198 A AU7078198 A AU 7078198A AU 739842 B2 AU739842 B2 AU 739842B2
Authority
AU
Australia
Prior art keywords
carnitine
rbc
blood
alkanoyl
mixtures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU70781/98A
Other languages
English (en)
Other versions
AU7078198A (en
Inventor
Secondo Dottori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of AU7078198A publication Critical patent/AU7078198A/en
Application granted granted Critical
Publication of AU739842B2 publication Critical patent/AU739842B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0047—Ultraviolet radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A61L2/0035—Gamma radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/22—Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Packages (AREA)
AU70781/98A 1997-04-16 1998-04-15 Improved storage and maintenance of blood products Ceased AU739842B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/840,765 US6482585B2 (en) 1997-04-16 1997-04-16 Storage and maintenance of blood products including red blood cells and platelets
US08/840765 1997-04-16
PCT/IT1998/000086 WO1998046073A1 (en) 1997-04-16 1998-04-15 Improved storage and maintenance of blood products

Publications (2)

Publication Number Publication Date
AU7078198A AU7078198A (en) 1998-11-11
AU739842B2 true AU739842B2 (en) 2001-10-18

Family

ID=25283169

Family Applications (1)

Application Number Title Priority Date Filing Date
AU70781/98A Ceased AU739842B2 (en) 1997-04-16 1998-04-15 Improved storage and maintenance of blood products

Country Status (20)

Country Link
US (2) US6482585B2 (enExample)
EP (1) EP0975214B1 (enExample)
JP (1) JP4467649B2 (enExample)
KR (1) KR100508408B1 (enExample)
CN (2) CN1698430A (enExample)
AT (1) ATE257326T1 (enExample)
AU (1) AU739842B2 (enExample)
BR (1) BR9808911B1 (enExample)
CA (1) CA2286721A1 (enExample)
CZ (1) CZ298671B6 (enExample)
DE (1) DE69821002T2 (enExample)
DK (1) DK0975214T3 (enExample)
ES (1) ES2212288T3 (enExample)
HU (1) HUP0001936A3 (enExample)
IL (1) IL132271A (enExample)
NZ (1) NZ500534A (enExample)
PL (1) PL192684B1 (enExample)
PT (1) PT975214E (enExample)
SK (1) SK284688B6 (enExample)
WO (1) WO1998046073A1 (enExample)

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US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6403124B1 (en) * 1997-04-16 2002-06-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
AU1073400A (en) * 1999-10-11 2001-04-23 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
RU2245145C1 (ru) * 2003-10-01 2005-01-27 Российский государственный медицинский университет Средство нормализации агрегационных свойств тромбоцитов и эритроцитов и морфоденситометрических характеристик эритроцитов
WO2005032251A1 (en) * 2003-10-09 2005-04-14 I.M.T. Interface Multigrad Technology Ltd. Method for freezing, thawing and transplantation of viable cartilage
WO2005072790A1 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Device for directional cooling of biological matter
WO2005072523A2 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
ATE460947T1 (de) * 2004-06-07 2010-04-15 Core Dynamics Ltd Verfahren zur sterilisation von biologischen präparaten
EP1778007A1 (en) * 2004-08-12 2007-05-02 I.M.T. Interface Multigrad Technology Ltd. Method and apparatus for freezing or thawing of a biological material
EP1850661A2 (en) * 2005-02-22 2007-11-07 Interface Multigrad Technology (IMT) Ltd. Preserved viable cartilage, method for its preservation, and system and devices used therefor
FR2884717B1 (fr) * 2005-04-25 2009-07-03 Erytech Pharma Soc Par Actions Erythrocytes renfermant de l'arginine deiminase
US8198085B2 (en) * 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
US7462485B2 (en) * 2005-10-07 2008-12-09 Glaser Lawrence F Modified erythrocytes and uses thereof
US8835104B2 (en) 2007-12-20 2014-09-16 Fenwal, Inc. Medium and methods for the storage of platelets
US20090202978A1 (en) * 2008-02-13 2009-08-13 Ginadi Shaham Method and apparatus for freezing of a biological material
US8871434B2 (en) * 2008-03-21 2014-10-28 Fenwal, Inc. Red blood cell storage medium for extended storage
US8968992B2 (en) * 2008-03-21 2015-03-03 Fenwal, Inc. Red blood cell storage medium for extended storage
JP2013507447A (ja) 2009-10-12 2013-03-04 ニュー ヘルス サイエンシーズ、インク． 酸素減損装置及び赤血球から酸素を除去する方法
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
CN102711865B (zh) 2009-10-12 2015-08-19 新健康科学股份有限公司 具有氧和二氧化碳消耗能力的血液贮藏袋系统和消耗装置
WO2011049709A1 (en) 2009-10-23 2011-04-28 Fenwal, Inc. Methods and systems for providing red blood cell products with reduced plasma
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
WO2012061731A1 (en) 2010-11-05 2012-05-10 New Health Sciences Irradiation of red blood cells and anaerobic storage
EP2645854B1 (en) 2010-11-29 2017-10-18 New York Blood Center, Inc. Method of blood pooling and storage
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP2694131B1 (en) 2011-04-07 2019-08-28 Fenwal, Inc. Automated methods and systems for providing platelet concentrates with reduced residual plasma volumes and storage media for such platelet concentrates
AU2012279043B2 (en) * 2011-07-05 2016-07-07 Hemanext Inc. A system for extended storage of red blood cells and methods of use
ES2923571T3 (es) 2011-08-10 2022-09-28 Hemanext Inc Dispositivo integrado de filtrado de leucocitos, oxígeno y/o CO2 y separación de plasma
PT2961269T (pt) 2013-02-28 2021-12-16 Hemanext Inc Dispositivo de depleção de gás para produtos sanguíneos
ES2902499T3 (es) 2015-03-10 2022-03-28 Hemanext Inc Kits desechables de reducción de oxígeno, dispositivos y procedimientos de uso de los mismos
KR102845950B1 (ko) 2015-04-23 2025-08-12 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
KR102675532B1 (ko) 2015-05-18 2024-06-13 헤마넥스트 인코포레이티드 전혈의 저장 방법, 및 그것의 조성물
KR20240132129A (ko) 2016-05-27 2024-09-02 헤마넥스트 인코포레이티드 혐기성 혈액 저장 및 병원체 불활성화 방법
DE102017218847A1 (de) 2017-10-23 2019-04-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Verbesserung der Stabilität von Blut und Blutprodukten
WO2021108806A1 (en) * 2019-11-29 2021-06-03 Rutgers, The State University Of New Jersey Compositions, kits and methods for storage of blood products and methods of use thereof
CN116115753A (zh) * 2021-11-15 2023-05-16 上海循曜生物科技有限公司 一种新的改善血小板质量的方法
CN114600872A (zh) 2022-04-13 2022-06-10 西安北光医学生物技术有限公司 一种细胞、组织或器官的抗损伤保存的方法及保存系统
AU2024244509A1 (en) * 2023-03-31 2025-10-02 Hemerus Medical, Llc Formulations and methods for collecting and storing blood and blood products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627161A1 (en) * 1993-06-02 1994-12-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them

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US3729947A (en) * 1970-12-04 1973-05-01 Alza Corp Process for storing blood platelets
US3792947A (en) * 1972-07-10 1974-02-19 A Diehl Molding apparatus
ATE30673T1 (de) * 1982-01-07 1987-11-15 Fresenius Ag Aufbewahrungsbeutel.
US4613322A (en) * 1982-12-08 1986-09-23 Edelson Richard Leslie Method and system for externally treating the blood
US5149682A (en) * 1987-09-11 1992-09-22 W. R. Grace & Co. -Conn. Manufacturing method for superconducting ceramics and products thereof
US5120649A (en) * 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5232844A (en) * 1990-05-15 1993-08-03 New York Blood Center Photodynamic inactivation of viruses in cell-containing compositions
US5376524A (en) 1991-04-01 1994-12-27 Thomas Jefferson University Platelet storage medium containing acetate and phosphate
US5362442A (en) * 1993-07-22 1994-11-08 2920913 Canada Inc. Method for sterilizing products with gamma radiation
AU6267496A (en) * 1995-06-07 1996-12-30 Steritech, Inc. Methods of inactivating leukocytes and inhibiting cytokine p roduction in blood products
WO1997016967A1 (en) * 1995-11-09 1997-05-15 Beth Israel Deaconess Medical Center, Inc. Compositions and methods for promoting blood component survival
IT1277953B1 (it) * 1995-12-21 1997-11-12 Sigma Tau Ind Farmaceuti Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627161A1 (en) * 1993-06-02 1994-12-07 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Use of L-carnitine and alkanoyl L-carnitines in the storage of blood for transfusions and stabilizing solutions containing them

Also Published As

Publication number Publication date
PT975214E (pt) 2004-05-31
CZ368199A3 (cs) 2000-04-12
CN1252687A (zh) 2000-05-10
NZ500534A (en) 2001-05-25
JP2001523225A (ja) 2001-11-20
PL192684B1 (pl) 2006-11-30
IL132271A (en) 2005-12-18
HUP0001936A3 (en) 2001-03-28
DE69821002D1 (de) 2004-02-12
ES2212288T3 (es) 2004-07-16
JP4467649B2 (ja) 2010-05-26
BR9808911B1 (pt) 2010-09-21
PL336294A1 (en) 2000-06-19
US6482585B2 (en) 2002-11-19
EP0975214B1 (en) 2004-01-07
AU7078198A (en) 1998-11-11
HUP0001936A2 (hu) 2000-10-28
HK1025477A1 (en) 2000-11-17
KR100508408B1 (ko) 2005-08-17
CA2286721A1 (en) 1998-10-22
BR9808911A (pt) 2000-08-01
SK142799A3 (en) 2000-05-16
CZ298671B6 (cs) 2007-12-19
US6960428B2 (en) 2005-11-01
US20030022228A1 (en) 2003-01-30
WO1998046073A1 (en) 1998-10-22
DK0975214T3 (da) 2004-05-10
CN1698430A (zh) 2005-11-23
ATE257326T1 (de) 2004-01-15
EP0975214A1 (en) 2000-02-02
IL132271A0 (en) 2001-03-19
KR20010006464A (ko) 2001-01-26
US20010049089A1 (en) 2001-12-06
SK284688B6 (sk) 2005-09-08
DE69821002T2 (de) 2004-07-08

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FGA Letters patent sealed or granted (standard patent)